{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:32:55Z","timestamp":1786116775670,"version":"build-2736575974"},"reference-count":196,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:00:00Z","timestamp":1781827200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011684","name":"Crohn&apos;s &amp; Colitis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011684","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016036","name":"Health~Holland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016036","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.mucimm.2026.100365","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T16:36:43Z","timestamp":1782146203000},"page":"100365","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Adaptive immune responses against Lachnospiraceae-derived flagellins and their role in inflammatory bowel disease"],"prefix":"10.1016","author":[{"given":"Dani\u00eblle M.H.","family":"Barendregt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janneke N.","family":"Samsom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles O.","family":"Elson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.mucimm.2026.100365_bb0005","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1002533","article-title":"Revised estimates for the number of human and bacteria cells in the body","volume":"14","author":"Sender","year":"2016","journal-title":"PLoS Biol"},{"issue":"7415","key":"10.1016\/j.mucimm.2026.100365_bb0010","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/nature11550","article-title":"Diversity, stability and resilience of the human gut microbiota","volume":"489","author":"Lozupone","year":"2012","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.mucimm.2026.100365_bb0015","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/s41577-019-0261-1","article-title":"Rethinking mucosal antibody responses: IgM, IgG and IgD join IgA","volume":"20","author":"Chen","year":"2020","journal-title":"Nat Rev Immunol"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100365_bb0020","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/j.jaci.2018.09.036","article-title":"Synergistic convergence of microbiota-specific systemic IgG and secretory IgA","volume":"143","author":"Fadlallah","year":"2019","journal-title":"J Allergy Clin Immunol"},{"issue":"8","key":"10.1016\/j.mucimm.2026.100365_bb0025","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1038\/s41591-021-01409-3","article-title":"Population-wide diversity and stability of serum antibody epitope repertoires against human microbiota","volume":"27","author":"Vogl","year":"2021","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0030","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1053\/j.gastro.2017.07.047","article-title":"Circulating and tissue-resident CD4+ T cells with reactivity to intestinal microbiota are abundant in healthy individuals and function is altered during inflammation","volume":"153","author":"Hegazy","year":"2017","journal-title":"Gastroenterology"},{"issue":"21","key":"10.1016\/j.mucimm.2026.100365_bb0035","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1056\/NEJMra0804647","article-title":"Inflammatory bowel disease","volume":"361","author":"Abraham","year":"2009","journal-title":"New England J. Med."},{"issue":"12","key":"10.1016\/j.mucimm.2026.100365_bb0040","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1093\/ecco-jcc\/jjad119","article-title":"An intestinal Th17 subset is associated with inflammation in Crohn\u2019s disease and activated by adherent-invasive Escherichia coli","volume":"17","author":"Paroni","year":"2023","journal-title":"J Crohns Colitis"},{"issue":"10","key":"10.1016\/j.mucimm.2026.100365_bb0045","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/j.immuni.2022.08.016","article-title":"The CD4+ T cell response to a commensal-derived epitope transitions from a tolerant to an inflammatory state in Crohn\u2019s disease","volume":"55","author":"Pedersen","year":"2022","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.mucimm.2026.100365_bb0050","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.mucimm.2024.11.008","article-title":"Gut-homing and intestinal TIGITnegCD38+ memory T cells acquire an IL-12-induced, ex-Th17 pathogenic phenotype in a subgroup of Crohn\u2019s disease patients with a severe disease course","volume":"18","author":"Heredia","year":"2024","journal-title":"Mucosal Immunol"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0055","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1053\/j.gastro.2011.08.032","article-title":"Antibodies against tumor necrosis factor (TNF) induce T-cell apoptosis in patients with inflammatory bowel diseases via TNF receptor 2 and intestinal CD14+ macrophages","volume":"141","author":"Atreya","year":"2011","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0060","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1136\/gutjnl-2017-315671","article-title":"Expansion of IL-23 receptor bearing TNFR2+ T cells is associated with molecular resistance to anti-TNF therapy in Crohn\u2019s disease","volume":"68","author":"Schmitt","year":"2019","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0065","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/cells9010110","article-title":"Dissecting the heterogeneity in T-cell mediated inflammation in IBD","volume":"9","author":"Tindemans","year":"2020","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100365_bb0070","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1053\/j.gastro.2025.10.003","article-title":"Faecalibacterium prausnitzii induces an anti-inflammatory response and a metabolic reprogramming in human monocytes","volume":"170","author":"Danne","year":"2026","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.mucimm.2026.100365_bb0075","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1053\/j.gastro.2016.10.012","article-title":"Roles for intestinal bacteria, viruses, and fungi in pathogenesis of inflammatory bowel diseases and therapeutic approaches","volume":"152","author":"Sartor","year":"2017","journal-title":"Gastroenterology"},{"issue":"16","key":"10.1016\/j.mucimm.2026.100365_bb0080","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1016\/j.cell.2022.07.003","article-title":"Targeted suppression of human IBD-associated gut microbiota commensals by phage consortia for treatment of intestinal inflammation","volume":"185","author":"Federici","year":"2022","journal-title":"Cell"},{"issue":"26","key":"10.1016\/j.mucimm.2026.100365_bb0085","doi-asserted-by":"crossref","first-page":"12672","DOI":"10.1073\/pnas.1904099116","article-title":"Ruminococcus gnavus, a member of the human gut microbiome associated with Crohn\u2019s disease, produces an inflammatory polysaccharide","volume":"116","author":"Henke","year":"2019","journal-title":"Proc Natl Acad Sci"},{"issue":"10","key":"10.1016\/j.mucimm.2026.100365_bb0090","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1038\/s41591-023-02556-5","article-title":"Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic TH1 cell responses in Crohn\u2019s disease","volume":"29","author":"Martini","year":"2023","journal-title":"Nat Med"},{"issue":"6361","key":"10.1016\/j.mucimm.2026.100365_bb0095","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.aan4526","article-title":"Ectopic colonization of oral bacteria in the intestine drives T(H)1 cell induction and inflammation","volume":"358","author":"Atarashi","year":"2017","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0100","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.cell.2019.01.041","article-title":"Human anti-fungal Th17 immunity and pathology rely on cross-reactivity against Candida albicans","volume":"176","author":"Bacher","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.mucimm.2026.100365_bb0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/610393","article-title":"The role of Klebsiella in Crohn\u2019s disease with a potential for the use of antimicrobial measures","volume":"2013","author":"Rashid","year":"2013","journal-title":"Int J Rheumatol"},{"issue":"11","key":"10.1016\/j.mucimm.2026.100365_bb0110","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1136\/gut.2010.224774","article-title":"Systemic antibody responses to gut commensal bacteria during chronic HIV-1 infection","volume":"60","author":"Haas","year":"2011","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0115","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1053\/j.gastro.2006.02.009","article-title":"Candida albicans is an immunogen for anti\u2013Saccharomyces cerevisiae antibody markers of Crohn\u2019s disease","volume":"130","author":"Standaert\u2013Vitse","year":"2006","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.mucimm.2026.100365_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2023.103486","article-title":"From ASCA breakthrough in Crohn\u2019s disease and Candida albicans research to thirty years of investigations about their meaning in human health","volume":"23","author":"Sendid","year":"2024","journal-title":"Autoimmun Rev"},{"issue":"9","key":"10.1016\/j.mucimm.2026.100365_bb0125","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1172\/JCI200420295","article-title":"Bacterial flagellin is a dominant antigen in Crohn disease","volume":"113","author":"Lodes","year":"2004","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0130","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.jcmgh.2019.11.012","article-title":"Analysis of flagellin-specific adaptive immunity reveals links to dysbiosis in patients with inflammatory bowel disease","volume":"9","author":"Cook","year":"2020","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"12","key":"10.1016\/j.mucimm.2026.100365_bb0135","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1093\/ibd\/izac146","article-title":"Crohn\u2019s disease patients uniquely contain inflammatory responses to flagellin in a CD4 effector memory subset","volume":"28","author":"Morgan","year":"2022","journal-title":"Inflamm Bowel Dis"},{"issue":"2","key":"10.1016\/j.mucimm.2026.100365_bb0140","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1053\/j.gastro.2021.03.064","article-title":"Human microbiota flagellins drive adaptive immune responses in Crohn\u2019s disease","volume":"161","author":"Alexander","year":"2021","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.mucimm.2026.100365_bb0145","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1053\/j.gastro.2005.03.046","article-title":"Antibodies to CBir1 flagellin define a unique response that is associated independently with complicated Crohn\u2019s disease","volume":"128","author":"Targan","year":"2005","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.mucimm.2026.100365_bb0150","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1053\/j.gastro.2024.08.015","article-title":"Crohn\u2019s patients and healthy infants share immunodominant B cell response to commensal flagellin peptide epitopes","volume":"167","author":"Zhao","year":"2024","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.mucimm.2026.100365_bb0155","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1572-0241.2006.00456.x","article-title":"Serum immune responses predict rapid disease progression among children with Crohn\u2019s disease: immune responses predict disease progression","volume":"101","author":"Dubinsky","year":"2006","journal-title":"Am J Gastroenterol"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0160","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1155\/2011\/712350","article-title":"Assessing inflammatory bowel disease-associated antibodies in Caucasian and first nations cohorts","volume":"25","author":"Bernstein","year":"2011","journal-title":"Can J Gastroenterol"},{"issue":"9","key":"10.1016\/j.mucimm.2026.100365_bb0165","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1002\/ibd.20892","article-title":"Phenotypic associations of Crohn\u2019s disease with antibodies to flagellins A4-Fla2 and Fla-X, ASCA, p-ANCA, PAB, and NOD2 mutations in a Swiss cohort","volume":"15","author":"Schoepfer","year":"2009","journal-title":"Inflamm Bowel Dis"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100365_bb0170","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3892\/br.2017.860","article-title":"Serologic testing of a panel of five antibodies in inflammatory bowel diseases: diagnostic value and correlation with disease phenotype","volume":"6","author":"Wang","year":"2017","journal-title":"Biomed Rep"},{"issue":"10","key":"10.1016\/j.mucimm.2026.100365_bb0175","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1002\/ibd.20237","article-title":"Isolation of flagellated bacteria implicated in Crohn\u2019s disease","volume":"13","author":"Duck","year":"2007","journal-title":"Inflamm Bowel Dis"},{"issue":"10","key":"10.1016\/j.mucimm.2026.100365_bb0180","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1111\/j.1365-2982.2008.01166.x","article-title":"Antibodies to flagellin indicate reactivity to bacterial antigens in IBS patients","volume":"20","author":"Schoepfer","year":"2008","journal-title":"Neurogastroenterol Motil"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0185","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1186\/s40168-024-01858-1","article-title":"Systemic antibody responses against gut microbiota flagellins implicate shared and divergent immune reactivity in Crohn\u2019s disease and chronic fatigue syndrome","volume":"12","author":"Bourgonje","year":"2024","journal-title":"Microbiome"},{"issue":"38","key":"10.1016\/j.mucimm.2026.100365_bb0190","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abq2422","article-title":"Systemic antibody responses against human microbiota flagellins are overrepresented in chronic fatigue syndrome patients","volume":"8","author":"Vogl","year":"2022","journal-title":"Sci Adv"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0195","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.clim.2010.08.003","article-title":"High levels of Crohn\u2019s disease-associated anti-microbial antibodies are present and independent of colitis in chronic granulomatous disease","volume":"138","author":"Yu","year":"2011","journal-title":"Clin Immunol"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0200","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1097\/MPG.0b013e3181c15f78","article-title":"Antibodies to CBir1 are associated with glycogen storage disease type Ib","volume":"51","author":"Davis","year":"2010","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0205","doi-asserted-by":"crossref","first-page":"R177","DOI":"10.1186\/ar2866","article-title":"Inflammatory bowel disease serologies in ankylosing spondylitis patients: a pilot study","volume":"11","author":"Mundwiler","year":"2009","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0210","doi-asserted-by":"crossref","DOI":"10.1186\/ar4350","article-title":"Elevated serum anti-flagellin antibodies implicate subclinical bowel inflammation in ankylosing spondylitis: an observational study","volume":"15","author":"Wallis","year":"2013","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0215","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1016\/j.jaci.2015.03.036","article-title":"Human seroreactivity to gut microbiota antigens","volume":"136","author":"Christmann","year":"2015","journal-title":"J Allergy Clin Immunol"},{"issue":"12","key":"10.1016\/j.mucimm.2026.100365_bb0220","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/apt.13641","article-title":"Serologic microbial associated markers can predict Crohn\u2019s disease behaviour years before disease diagnosis","volume":"43","author":"Choung","year":"2016","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0225","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1053\/j.gastro.2020.03.007","article-title":"Serum biomarkers identify patients who will develop inflammatory bowel diseases up to 5 years before diagnosis","volume":"159","author":"Torres","year":"2020","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0230","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1053\/j.gastro.2021.07.009","article-title":"Anti-microbial antibody response is associated with future onset of Crohn\u2019s disease independent of biomarkers of altered gut barrier function, subclinical inflammation, and genetic risk","volume":"161","author":"Lee","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mucimm.2026.100365_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.cgh.2025.12.006","article-title":"Serum IgG response to a conserved domain of commensal flagellins predicts future risk of Crohn\u2019s disease in first-degree relatives","author":"Wu","year":"2026","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"10","key":"10.1016\/j.mucimm.2026.100365_bb0240","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/j.cgh.2008.04.032","article-title":"Increased immune reactivity predicts aggressive complicating Crohn\u2019s disease in children","volume":"6","author":"Dubinsky","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"12","key":"10.1016\/j.mucimm.2026.100365_bb0245","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1097\/MEG.0b013e328365a364","article-title":"The clinical significance of antimicrobial serologic responses within an Irish Crohn\u2019s disease population","volume":"25","author":"O\u2019Donnell","year":"2013","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0250","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1016\/j.immuni.2023.04.017","article-title":"Phage-display immunoprecipitation sequencing of the antibody epitope repertoire in inflammatory bowel disease reveals distinct antibody signatures","volume":"56","author":"Bourgonje","year":"2023","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0255","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1002\/ibd.20106","article-title":"Anti-flagellin (CBir1) phenotypic and genetic Crohn\u02bcs disease associations","volume":"13","author":"Papadakis","year":"2007","journal-title":"Inflamm Bowel Dis"},{"issue":"12","key":"10.1016\/j.mucimm.2026.100365_bb0260","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1002\/ibd.21661","article-title":"Combination of genetic and quantitative serological immune markers are associated with complicated Crohn\u2019s disease behavior","volume":"17","author":"Lichtenstein","year":"2011","journal-title":"Inflamm Bowel Dis"},{"issue":"10080","key":"10.1016\/j.mucimm.2026.100365_bb0265","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1016\/S0140-6736(17)30317-3","article-title":"Prediction of complicated disease course for children newly diagnosed with Crohn\u2019s disease: a multicentre inception cohort study","volume":"389","author":"Kugathasan","year":"2017","journal-title":"Lancet"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0270","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1111\/jgh.13677","article-title":"Serologic antibodies in relation to outcome in postoperative Crohn\u2019s disease","volume":"32","author":"Hamilton","year":"2017","journal-title":"J Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0275","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s10620-024-08732-y","article-title":"Serological markers as predictors of anti-TNF response in children with Crohn\u2019s disease","volume":"70","author":"Lisai-Goldstein","year":"2025","journal-title":"Dig Dis Sci"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0280","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0017447","article-title":"Metatranscriptomic approach to analyze the functional human gut microbiota","volume":"6","author":"Gosalbes","year":"2011","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0285","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/gbe\/evu050","article-title":"A phylogenomic view of ecological specialization in the Lachnospiraceae, a family of digestive tract-associated bacteria","volume":"6","author":"Meehan","year":"2014","journal-title":"Genome Biol Evol"},{"issue":"2","key":"10.1016\/j.mucimm.2026.100365_bb0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0047879","article-title":"Simultaneous amplicon sequencing to explore co-occurrence patterns of bacterial, archaeal and eukaryotic microorganisms in rumen microbial communities","volume":"8","author":"Kittelmann","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.mucimm.2026.100365_bb0295","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3389\/fped.2016.00057","article-title":"Infant early gut colonization by Lachnospiraceae: high frequency of Ruminococcus gnavus","volume":"4","author":"Sagheddu","year":"2016","journal-title":"Front Pediatr"},{"issue":"7","key":"10.1016\/j.mucimm.2026.100365_bb0300","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1177\/2050640619852255","article-title":"Composition of the mucosa-associated microbiota along the entire gastrointestinal tract of human individuals","volume":"7","author":"Vuik","year":"2019","journal-title":"United Eur Gastroenterol J"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100365_bb0305","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/ismej.2010.161","article-title":"Spatial organization of intestinal microbiota in the mouse ascending colon","volume":"5","author":"Nava","year":"2011","journal-title":"ISME J"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0310","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-18928-1","article-title":"Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization","volume":"11","author":"Pereira","year":"2020","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0315","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1038\/ismej.2012.158","article-title":"Butyrate-producing Clostridium cluster XIVa species specifically colonize mucins in an in vitro gut model","volume":"7","author":"Van Den Abbeele","year":"2013","journal-title":"ISME J"},{"issue":"114","key":"10.1016\/j.mucimm.2026.100365_bb0320","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adp8843","article-title":"Divergent immune responses to commensal bacteria bearing distinct motility signatures","volume":"10","author":"Duck","year":"2025","journal-title":"Sci Immunol"},{"issue":"7","key":"10.1016\/j.mucimm.2026.100365_bb0325","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0068919","article-title":"Pro-inflammatory flagellin proteins of prevalent motile commensal bacteria are variably abundant in the intestinal microbiome of elderly humans","volume":"8","author":"Neville","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.mucimm.2026.100365_bb0330","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.01166","article-title":"Human gut symbiont Roseburia hominis promotes and regulates innate immunity","volume":"8","author":"Patterson","year":"2017","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.mucimm.2026.100365_bb0335","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/S0016-5085(82)80339-9","article-title":"Utilization of nutrients by isolated epithelial cells of the rat colon","volume":"83","author":"Roediger","year":"1982","journal-title":"Gastroenterology"},{"issue":"9","key":"10.1016\/j.mucimm.2026.100365_bb0340","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.3945\/jn.109.104638","article-title":"Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers","volume":"139","author":"Peng","year":"2009","journal-title":"J Nutr"},{"issue":"7480","key":"10.1016\/j.mucimm.2026.100365_bb0345","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1038\/nature12721","article-title":"Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells","volume":"504","author":"Furusawa","year":"2013","journal-title":"Nature"},{"issue":"7480","key":"10.1016\/j.mucimm.2026.100365_bb0350","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/nature12726","article-title":"Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation","volume":"504","author":"Arpaia","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.mucimm.2026.100365_bb0355","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1146\/annurev.micro.57.030502.090832","article-title":"How bacteria assemble flagella","volume":"57","author":"Macnab","year":"2003","journal-title":"Annu Rev Microbiol"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100365_bb0360","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tim.2006.02.008","article-title":"Variation in bacterial flagellins: from sequence to structure","volume":"14","author":"Beatson","year":"2006","journal-title":"Trends Microbiol"},{"issue":"6949","key":"10.1016\/j.mucimm.2026.100365_bb0365","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nature01830","article-title":"Complete atomic model of the bacterial flagellar filament by electron cryomicroscopy","volume":"424","author":"Yonekura","year":"2003","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.mucimm.2026.100365_bb0370","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/ni.1622","article-title":"Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing toll-like receptor 5","volume":"9","author":"Uematsu","year":"2008","journal-title":"Nat Immunol"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0375","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.immuni.2018.07.016","article-title":"A map of toll-like receptor expression in the intestinal epithelium reveals distinct spatial, cell type-specific, and temporal patterns","volume":"49","author":"Price","year":"2018","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100365_bb0380","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.4049\/jimmunol.167.4.1882","article-title":"Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression","volume":"167","author":"Gewirtz","year":"2001","journal-title":"The Journal of Immunology"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0385","doi-asserted-by":"crossref","first-page":"5650","DOI":"10.1038\/s41467-019-13538-y","article-title":"Flagellin-elicited adaptive immunity suppresses flagellated microbiota and vaccinates against chronic inflammatory diseases","volume":"10","author":"Tran","year":"2019","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0390","doi-asserted-by":"crossref","first-page":"2810","DOI":"10.4049\/jimmunol.177.5.2810","article-title":"Humoral immune response to flagellin requires T cells and activation of innate immunity","volume":"177","author":"Sanders","year":"2006","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.mucimm.2026.100365_bb0395","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/ni1011","article-title":"Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility","volume":"4","author":"Smith","year":"2003","journal-title":"Nat Immunol"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0400","doi-asserted-by":"crossref","first-page":"083","DOI":"10.1385\/IR:33:1:083","article-title":"Effects of flagellin on innate and adaptive immunity","volume":"33","author":"Honko","year":"2005","journal-title":"Immunol Res"},{"issue":"79","key":"10.1016\/j.mucimm.2026.100365_bb0405","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abq7001","article-title":"Silent recognition of flagellins from human gut commensal bacteria by toll-like receptor 5","volume":"8","author":"Clasen","year":"2023","journal-title":"Sci Immunol"},{"issue":"26","key":"10.1016\/j.mucimm.2026.100365_bb0410","doi-asserted-by":"crossref","first-page":"9247","DOI":"10.1073\/pnas.0502040102","article-title":"Evasion of toll-like receptor 5 by flagellated bacteria","volume":"102","author":"Andersen-Nissen","year":"2005","journal-title":"Proc Natl Acad Sci"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0415","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/ni1344","article-title":"Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1\u03b2 via Ipaf","volume":"7","author":"Miao","year":"2006","journal-title":"Nat Immunol"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0420","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/ni1346","article-title":"Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1\u03b2 in salmonella-infected macrophages","volume":"7","author":"Franchi","year":"2006","journal-title":"Nat Immunol"},{"issue":"2","key":"10.1016\/j.mucimm.2026.100365_bb0425","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.chom.2014.07.001","article-title":"Epithelium-intrinsic NAIP\/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa","volume":"16","author":"Sellin","year":"2014","journal-title":"Cell Host Microbe"},{"issue":"50","key":"10.1016\/j.mucimm.2026.100365_bb0430","doi-asserted-by":"crossref","first-page":"13242","DOI":"10.1073\/pnas.1710433114","article-title":"Broad detection of bacterial type III secretion system and flagellin proteins by the human NAIP\/NLRC4 inflammasome","volume":"114","author":"Reyes Ruiz","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0435","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41594-023-01143-z","article-title":"Structural basis of the human NAIP\/NLRC4 inflammasome assembly and pathogen sensing","volume":"31","author":"Matico","year":"2024","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.mucimm.2026.100365_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100863","article-title":"The NAIP\/NLRC4 inflammasome in infection and pathology","volume":"76","author":"Bauer","year":"2020","journal-title":"Mol Aspects Med"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0445","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/eji.201040717","article-title":"TLR5 functions as an endocytic receptor to enhance flagellin-specific adaptive immunity","volume":"41","author":"Letran","year":"2011","journal-title":"Eur J Immunol"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0450","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.chom.2013.10.009","article-title":"Innate and adaptive immunity interact to quench microbiome flagellar motility in the gut","volume":"14","author":"Cullender","year":"2013","journal-title":"Cell Host Microbe"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100365_bb0455","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.4049\/jimmunol.1301893","article-title":"Flagellin induces antibody responses through a TLR5- and inflammasome-independent pathway","volume":"192","author":"L\u00f3pez-Yglesias","year":"2014","journal-title":"J. Immunol."},{"issue":"12","key":"10.1016\/j.mucimm.2026.100365_bb0460","doi-asserted-by":"crossref","first-page":"3528","DOI":"10.1002\/eji.201040421","article-title":"TLR5 or NLRC4 is necessary and sufficient for promotion of humoral immunity by flagellin","volume":"40","author":"Vijay-Kumar","year":"2010","journal-title":"Eur J Immunol"},{"issue":"10","key":"10.1016\/j.mucimm.2026.100365_bb0465","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1084\/jem.20031220","article-title":"A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires\u2019 disease","volume":"198","author":"Hawn","year":"2003","journal-title":"J Exp Med"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0470","doi-asserted-by":"crossref","first-page":"G1157","DOI":"10.1152\/ajpgi.00544.2005","article-title":"Dominant-negative TLR5 polymorphism reduces adaptive immune response to flagellin and negatively associates with Crohn\u2019s disease","volume":"290","author":"Gewirtz","year":"2006","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"9","key":"10.1016\/j.mucimm.2026.100365_bb0475","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1002\/ibd.22884","article-title":"Pattern recognition receptor and autophagy gene variants are associated with development of antimicrobial antibodies in Crohn\u2019s disease","volume":"18","author":"Murdoch","year":"2012","journal-title":"Inflamm Bowel Dis"},{"issue":"9","key":"10.1016\/j.mucimm.2026.100365_bb0480","doi-asserted-by":"crossref","first-page":"e373","DOI":"10.1038\/emm.2017.172","article-title":"Bacterial flagellin\u2014a potent immunomodulatory agent","volume":"49","author":"Hajam","year":"2017","journal-title":"Exp Mol Med"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100365_bb0485","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1189\/jlb.0105051","article-title":"Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions","volume":"78","author":"Tsujimoto","year":"2005","journal-title":"J Leukoc Biol"},{"issue":"9","key":"10.1016\/j.mucimm.2026.100365_bb0490","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.4049\/jimmunol.179.9.6169","article-title":"Salmonella flagellin induces bystander activation of splenic dendritic cells and hinders bacterial replication in vivo","volume":"179","author":"Salazar-Gonzalez","year":"2007","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0495","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.immuni.2007.04.014","article-title":"Intestinal bacteria trigger T cell-independent immunoglobulin A2 class switching by inducing epithelial-cell secretion of the cytokine APRIL","volume":"26","author":"He","year":"2007","journal-title":"Immunity"},{"issue":"12","key":"10.1016\/j.mucimm.2026.100365_bb0500","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.4049\/jimmunol.175.12.8051","article-title":"Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells","volume":"175","author":"Crellin","year":"2005","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.mucimm.2026.100365_bb0505","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/s41577-020-00479-7","article-title":"A guide to vaccinology: from basic principles to new developments","volume":"21","author":"Pollard","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.mucimm.2026.100365_bb0510","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jtbi.2019.01.017","article-title":"Dose finding for new vaccines: the role for immunostimulation\/immunodynamic modelling","volume":"465","author":"Rhodes","year":"2019","journal-title":"J Theor Biol"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0515","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00018-022-04303-4","article-title":"Trafficking and retention of protein antigens across systems and immune cell types","volume":"79","author":"Doan","year":"2022","journal-title":"Cell Mol Life Sci"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0520","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.celrep.2019.12.063","article-title":"Memory B cell activation, broad anti-influenza antibodies, and bystander activation revealed by single-cell transcriptomics","volume":"30","author":"Horns","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.mucimm.2026.100365_bb0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.06.012","article-title":"Bystander activation and autoimmunity","volume":"103","author":"Pacheco","year":"2019","journal-title":"J Autoimmun"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100365_bb0530","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/microorganisms8040573","article-title":"The controversial role of human gut Lachnospiraceae","volume":"8","author":"Vacca","year":"2020","journal-title":"Microorganisms"},{"issue":"34","key":"10.1016\/j.mucimm.2026.100365_bb0535","doi-asserted-by":"crossref","first-page":"13780","DOI":"10.1073\/pnas.0706625104","article-title":"Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases","volume":"104","author":"Frank","year":"2007","journal-title":"Proc Natl Acad Sci"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0540","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.chom.2014.02.005","article-title":"The treatment-naive microbiome in new-onset Crohn\u2019s disease","volume":"15","author":"Gevers","year":"2014","journal-title":"Cell Host Microbe"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0545","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1136\/gutjnl-2015-309940","article-title":"Oral versus intravenous iron replacement therapy distinctly alters the gut microbiota and metabolome in patients with IBD","volume":"66","author":"Lee","year":"2017","journal-title":"Gut"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0550","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1080\/19490976.2017.1421886","article-title":"Adaptation of adherent-invasive E. Coli to gut environment: impact on flagellum expression and bacterial colonization ability","volume":"11","author":"Sevrin","year":"2020","journal-title":"Gut Microbes"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0555","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.chom.2021.01.003","article-title":"Rapid transcriptional and metabolic adaptation of intestinal microbes to host immune activation","volume":"29","author":"Becattini","year":"2021","journal-title":"Cell Host Microbe"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0560","doi-asserted-by":"crossref","first-page":"1994832","DOI":"10.1080\/19490976.2021.1994832","article-title":"E.Coli Nissle increases transcription of flagella assembly and formate hydrogenlyase genes in response to colitis","volume":"13","author":"Dacquay","year":"2021","journal-title":"Gut Microbes"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100365_bb0565","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0168-6445(03)00064-0","article-title":"Regulation cascade of flagellar expression in gram-negative bacteria","volume":"27","author":"Soutourina","year":"2003","journal-title":"FEMS Microbiol Rev"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0570","doi-asserted-by":"crossref","first-page":"e00612","DOI":"10.1128\/msystems.00612-19","article-title":"Interactions between the gut microbiome and mucosal immunoglobulins A, M, and G in the developing infant gut","volume":"4","author":"Janzon","year":"2019","journal-title":"mSystems"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0575","doi-asserted-by":"crossref","first-page":"8124","DOI":"10.1038\/s41467-023-44007-2","article-title":"IgG and IgM cooperate in coating of intestinal bacteria in IgA deficiency","volume":"14","author":"Eriksen","year":"2023","journal-title":"Nat Commun"},{"issue":"11","key":"10.1016\/j.mucimm.2026.100365_bb0580","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015533","article-title":"Serological markers for inflammatory bowel disease in AIDS patients with evidence of microbial translocation","volume":"5","author":"Kamat","year":"2010","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0585","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/ecco-jcc\/jjw134","article-title":"Outcomes with anti-tumour necrosis factor-alpha therapy and serology in patients with de novo Crohn\u2019s disease after ileal pouch anal anastomosis","volume":"11","author":"Robbins","year":"2017","journal-title":"J Crohns Colitis"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0590","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1007\/s10620-012-2050-6","article-title":"ASCA IgG and CBir antibodies are associated with the development of Crohn\u2019s disease and fistulae following ileal pouch-anal anastomosis","volume":"57","author":"Coukos","year":"2012","journal-title":"Dig Dis Sci"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0595","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1016\/j.cgh.2011.09.016","article-title":"Antimicrobial antibodies are associated with a Crohn\u2019s disease-like phenotype after ileal pouch-anal anastomosis","volume":"10","author":"Tyler","year":"2012","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0600","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1007\/s10620-013-2866-8","article-title":"Serologic markers associated with development of Crohn\u2019s disease after ileal pouch anal anastomosis for ulcerative colitis","volume":"59","author":"Truta","year":"2014","journal-title":"Dig Dis Sci"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0605","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1016\/0016-5085(94)90813-3","article-title":"Spontaneous, heritable colitis in a new substrain of C3H\/HeJ mice","volume":"107","author":"Sundberg","year":"1994","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0610","doi-asserted-by":"crossref","first-page":"44","DOI":"10.4049\/jimmunol.159.1.44","article-title":"Spontaneously colitic C3H\/HeJBir mice demonstrate selective antibody reactivity to antigens of the enteric bacterial flora","volume":"159","author":"Brandwein","year":"1997","journal-title":"J Immunol"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0615","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1084\/jem.187.6.855","article-title":"CD4+ T cells reactive to enteric bacterial antigens in spontaneously colitic C3H\/HeJBir mice: increased T helper cell type 1 response and ability to transfer disease","volume":"187","author":"Cong","year":"1998","journal-title":"J.Exp. Med."},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0620","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3109\/08830180009048390","article-title":"The C3H\/HeJBir mouse model: a high susceptibility phenotype for colitis","volume":"19","author":"Elson","year":"2000","journal-title":"Int Rev Immunol"},{"issue":"5396","key":"10.1016\/j.mucimm.2026.100365_bb0625","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"issue":"24","key":"10.1016\/j.mucimm.2026.100365_bb0630","doi-asserted-by":"crossref","first-page":"13820","DOI":"10.1073\/pnas.241258698","article-title":"A major quantitative trait locus on chromosome 3 controls colitis severity in IL-10-deficient mice","volume":"98","author":"Farmer","year":"2001","journal-title":"Proc Natl Acad Sci"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0635","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/ibd.21895","article-title":"Strain-specific colitis susceptibility in IL10-deficient mice depends on complex gut microbiota-host interactions","volume":"18","author":"Buchler","year":"2012","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0640","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/ibd.21146","article-title":"Cdcs1 a major colitis susceptibility locus in mice; subcongenic analysis reveals genetic complexity","volume":"16","author":"Bleich","year":"2010","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0645","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1053\/j.gastro.2005.07.057","article-title":"Cdcs1, a major colitogenic locus in mice, regulates innate and adaptive immune response to enteric bacterial antigens","volume":"129","author":"Beckwith","year":"2005","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.mucimm.2026.100365_bb0650","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nri2655","article-title":"Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases","volume":"9","author":"Pasparakis","year":"2009","journal-title":"Nat Rev Immunol"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0655","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1038\/s41385-019-0133-9","article-title":"Analysis of Cdcs1 colitogenic effects in the hematopoietic compartment reveals distinct microbiome interaction and a new subcongenic interval active in T cells","volume":"12","author":"Bruesch","year":"2019","journal-title":"Mucosal Immunol"},{"issue":"2","key":"10.1016\/j.mucimm.2026.100365_bb0660","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1067\/mpd.2000.105232","article-title":"Neutropenia, neutrophil dysfunction, and inflammatory bowel disease in glycogen storage disease type Ib: results of the European study on glycogen storage disease type I","volume":"137","author":"Visser","year":"2000","journal-title":"J Pediatr"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0665","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1136\/gut.2008.156422","article-title":"Linkage of Crohn\u2019s disease-related serological phenotypes: NFKB1 haplotypes are associated with anti-CBir1 and ASCA, and show reduced NF-kB activation","volume":"58","author":"Takedatsu","year":"2009","journal-title":"Gut"},{"issue":"2","key":"10.1016\/j.mucimm.2026.100365_bb0670","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1053\/j.gastro.2006.11.013","article-title":"NOD2 variants and antibody response to microbial antigens in Crohn\u2019s disease patients and their unaffected relatives","volume":"132","author":"Devlin","year":"2007","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0675","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1053\/gast.2003.50019","article-title":"Crohn\u2019s disease-associated NOD2 variants share a signaling defect in response to lipopolysaccharide and peptidoglycan","volume":"124","author":"Bonen","year":"2003","journal-title":"Gastroenterology"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0680","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1093\/ibd\/izab318","article-title":"Deleterious genetic variation across the NOD signaling pathway is associated with reduced NFKB signaling transcription and upregulation of alternative inflammatory transcripts in pediatric inflammatory bowel disease","volume":"28","author":"Ashton","year":"2022","journal-title":"Inflamm Bowel Dis"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0685","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/ecco-jcc\/jjac124","article-title":"NOD2 in Crohn\u2019s disease\u2014unfinished business","volume":"17","author":"Ashton","year":"2023","journal-title":"J. Crohn\u2019s Colitis"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0690","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/ibd.20611","article-title":"MAGI2 genetic variation and inflammatory bowel disease","volume":"15","author":"McGovern","year":"2009","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0695","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1002\/eji.201243077","article-title":"Inefficient antimicrobial functions of innate phagocytes render infant mice more susceptible to bacterial infection","volume":"43","author":"Zhang","year":"2013","journal-title":"Eur J Immunol"},{"issue":"11","key":"10.1016\/j.mucimm.2026.100365_bb0700","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.4049\/jimmunol.0901481","article-title":"Neonatal innate TLR-mediated responses are distinct from those of adults","volume":"183","author":"Kollmann","year":"2009","journal-title":"J Immunol"},{"issue":"9","key":"10.1016\/j.mucimm.2026.100365_bb0705","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1586\/1744666X.2014.942288","article-title":"Immune responses in neonates","volume":"10","author":"Basha","year":"2014","journal-title":"Expert Rev Clin Immunol"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0710","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.immuni.2017.03.009","article-title":"Protecting the newborn and young infant from infectious diseases: lessons from immune ontogeny","volume":"46","author":"Kollmann","year":"2017","journal-title":"Immunity"},{"issue":"2","key":"10.1016\/j.mucimm.2026.100365_bb0715","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1023\/A:1023203118100","article-title":"pANCA represents a cross-reactivity to enteric bacterial antigens","volume":"18","author":"Seibold","year":"1998","journal-title":"J Clin Immunol"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0720","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1128\/IAI.68.3.1542-1548.2000","article-title":"Colonic bacteria express an ulcerative colitis pANCA-related protein epitope","volume":"68","author":"Cohavy","year":"2000","journal-title":"Infect Immun"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0725","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.4049\/jimmunol.155.6.3262","article-title":"Perinuclear anti-neutrophil cytoplasmic antibodies are spontaneously produced by mucosal B cells of ulcerative colitis patients","volume":"155","author":"Targan","year":"1995","journal-title":"J Immunol"},{"issue":"6656","key":"10.1016\/j.mucimm.2026.100365_bb0730","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1136\/bmj.297.6656.1105","article-title":"Antibody to Saccharomyces cerevisiae (bakers\u2019 yeast) in Crohn\u2019s disease","volume":"297","author":"Main","year":"1988","journal-title":"BMJ"},{"issue":"46","key":"10.1016\/j.mucimm.2026.100365_bb0735","doi-asserted-by":"crossref","first-page":"19256","DOI":"10.1073\/pnas.0812681106","article-title":"A dominant, coordinated T regulatory cell-IgA response to the intestinal microbiota","volume":"106","author":"Cong","year":"2009","journal-title":"Proc Natl Acad Sci"},{"issue":"9","key":"10.1016\/j.mucimm.2026.100365_bb0740","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/j.cell.2024.03.037","article-title":"Principles and therapeutic applications of adaptive immunity","volume":"187","author":"Chi","year":"2024","journal-title":"Cell"},{"issue":"6101","key":"10.1016\/j.mucimm.2026.100365_bb0745","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1126\/science.1220961","article-title":"Acute gastrointestinal infection induces long-lived microbiota-specific T cell responses","volume":"337","author":"Hand","year":"2012","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0750","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1053\/j.gastro.2016.05.050","article-title":"Commensal-specific CD4+ cells from patients with Crohn\u2019s disease have a T-helper 17 inflammatory profile","volume":"151","author":"Calder\u00f3n-G\u00f3mez","year":"2016","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0755","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.mucimm.2023.11.001","article-title":"Intestinal damage is required for the pro-inflammatory differentiation of commensal CBir1-specific T cells","volume":"17","author":"Sorini","year":"2024","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.mucimm.2026.100365_bb0760","doi-asserted-by":"crossref","DOI":"10.1016\/j.imlet.2025.107071","article-title":"B cells in inflammatory bowel disease","volume":"277","author":"Castillo","year":"2026","journal-title":"Immunol Lett"},{"issue":"11","key":"10.1016\/j.mucimm.2026.100365_bb0765","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1136\/gut.2010.225482","article-title":"Randomised placebo-controlled trial of rituximab (anti-CD20) in active ulcerative colitis","volume":"60","author":"Leiper","year":"2011","journal-title":"Gut"},{"key":"10.1016\/j.mucimm.2026.100365_bb0770","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.coph.2020.10.002","article-title":"Targeting B cells for inflammatory bowel disease treatment: back to the future","volume":"55","author":"Castro-Dopico","year":"2020","journal-title":"Curr Opin Pharmacol"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0775","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13577","article-title":"Efficient long-term depletion of CD20+ B cells by rituximab does not affect gut-resident plasma cells","volume":"1415","author":"Uzzan","year":"2018","journal-title":"Ann N Y Acad Sci"},{"issue":"12","key":"10.1016\/j.mucimm.2026.100365_bb0780","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1056\/NEJMc2508023","article-title":"CD19 CAR T-cell therapy in multidrug-resistant ulcerative colitis","volume":"393","author":"M\u00fcller","year":"2025","journal-title":"New England J. Med."},{"issue":"4","key":"10.1016\/j.mucimm.2026.100365_bb0785","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1080\/00365521.2020.1745879","article-title":"Serological antibodies and surgery in a population-based inception cohort of Crohn\u2019s disease patients \u2013 the IBSEN study","volume":"55","author":"Kristensen","year":"2020","journal-title":"Scand J Gastroenterol"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100365_bb0790","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1080\/00365521.2016.1259653","article-title":"Serological markers in diagnosis of pediatric inflammatory bowel disease and as predictors for early tumor necrosis factor blocker therapy","volume":"52","author":"Olbj\u00f8rn","year":"2017","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.mucimm.2026.100365_bb0795","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fcimb.2019.00029","article-title":"Adaptive immunity induces tolerance to flagellin by attenuating TLR5 and NLRC4-mediated innate immune responses","volume":"9","author":"Yeoh","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0800","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.4049\/jimmunol.181.3.2036","article-title":"Deletion of flagellin\u2019s hypervariable region abrogates antibody-mediated neutralization and systemic activation of TLR5-dependent immunity","volume":"181","author":"Nempont","year":"2008","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.mucimm.2026.100365_bb0805","doi-asserted-by":"crossref","first-page":"5406","DOI":"10.4049\/jimmunol.1003576","article-title":"TLR5-deficient mice lack basal inflammatory and metabolic defects but exhibit impaired CD4 T cell responses to a flagellated pathogen","volume":"186","author":"Letran","year":"2011","journal-title":"J Immunol"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0810","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1053\/j.gastro.2009.07.059","article-title":"An FcRn-dependent role for anti-flagellin immunoglobulin G in pathogenesis of colitis in mice","volume":"137","author":"Kobayashi","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.mucimm.2026.100365_bb0815","doi-asserted-by":"crossref","first-page":"520","DOI":"10.3389\/fimmu.2014.00520","article-title":"IgG subclasses and allotypes: from structure to effector functions","volume":"5","author":"Vidarsson","year":"2014","journal-title":"Front Immunol"},{"issue":"8","key":"10.1016\/j.mucimm.2026.100365_bb0820","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1182\/blood-2011-04-345579","article-title":"Human memory B cells originate from three distinct germinal center-dependent and -independent maturation pathways","volume":"118","author":"Berkowska","year":"2011","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.mucimm.2026.100365_bb0825","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1136\/ard-2023-224225","article-title":"T follicular helper cells and T peripheral helper cells in rheumatic and musculoskeletal diseases","volume":"82","author":"Akiyama","year":"2023","journal-title":"Ann Rheum Dis"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0830","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/imr.12859","article-title":"The role of B cell antigen presentation in the initiation of CD4+ T cell response","volume":"296","author":"Hua","year":"2020","journal-title":"Immunol Rev"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0835","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.1038\/s41467-025-57564-5","article-title":"Enzyme-activating B-cell receptors boost antigen presentation to pathogenic T cells in gluten-sensitive autoimmunity","volume":"16","author":"Iversen","year":"2025","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0840","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/s41385-021-00452-0","article-title":"Single-cell approaches to dissect adaptive immune responses involved in autoimmunity: the case of celiac disease","volume":"15","author":"Lindeman","year":"2022","journal-title":"Mucosal Immunol"},{"issue":"8","key":"10.1016\/j.mucimm.2026.100365_bb0845","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2025.103851","article-title":"Autoreactive B cells in autoimmune diseases: mechanisms, functions and clinical implications","volume":"24","author":"Collet","year":"2025","journal-title":"Autoimmun Rev"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100365_bb0850","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1038\/s41385-020-0259-9","article-title":"Selective deletion of MyD88 signaling in \u03b1-SMA positive cells ameliorates experimental intestinal fibrosis via post-transcriptional regulation","volume":"13","author":"Zhao","year":"2020","journal-title":"Mucosal Immunol"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0855","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/s41385-019-0138-4","article-title":"Flagellin-mediated activation of IL-33-ST2 signaling by a pathobiont promotes intestinal fibrosis","volume":"12","author":"Imai","year":"2019","journal-title":"Mucosal Immunol"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100365_bb0860","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1084\/jem.20092253","article-title":"Microbiota innate stimulation is a prerequisite for T cell spontaneous proliferation and induction of experimental colitis","volume":"207","author":"Feng","year":"2010","journal-title":"J. Experimental Med."},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0865","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4049\/jimmunol.1800236","article-title":"T cell proliferation and colitis are initiated by defined intestinal microbes","volume":"201","author":"Chiaranunt","year":"2018","journal-title":"J. Immunol."},{"issue":"7","key":"10.1016\/j.mucimm.2026.100365_bb0870","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1016\/j.immuni.2024.05.018","article-title":"Microbiota dictate T cell clonal selection to augment graft-versus-host disease after stem cell transplantation","volume":"57","author":"Yeh","year":"2024","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.mucimm.2026.100365_bb0875","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070783","article-title":"Intestinal microbiota composition of interleukin-10 deficient C57BL\/6J mice and susceptibility to Helicobacter hepaticus-induced colitis","volume":"8","author":"Yang","year":"2013","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.mucimm.2026.100365_bb0880","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1038\/ajg.2015.357","article-title":"Extensive modulation of the fecal metagenome in children with Crohn\u2019s disease during exclusive enteral nutrition","volume":"110","author":"Quince","year":"2015","journal-title":"Am J Gastroenterol"},{"issue":"11","key":"10.1016\/j.mucimm.2026.100365_bb0885","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1016\/j.chom.2024.10.001","article-title":"Exclusive enteral nutrition initiates individual protective microbiome changes to induce remission in pediatric Crohn\u2019s disease","volume":"32","author":"Hacker","year":"2024","journal-title":"Cell Host Microbe"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100365_bb0890","doi-asserted-by":"crossref","DOI":"10.3390\/nu16030363","article-title":"Exclusive enteral nutrition beneficially modulates gut microbiome in a preclinical model of Crohn\u2019s-like colitis","volume":"16","author":"Geesala","year":"2024","journal-title":"Nutrients"},{"issue":"8","key":"10.1016\/j.mucimm.2026.100365_bb0895","doi-asserted-by":"crossref","first-page":"1414","DOI":"10.1136\/gutjnl-2016-313099","article-title":"Dietary emulsifiers directly alter human microbiota composition and gene expression ex vivo potentiating intestinal inflammation","volume":"66","author":"Chassaing","year":"2017","journal-title":"Gut"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0900","doi-asserted-by":"crossref","first-page":"5030","DOI":"10.1038\/s41467-020-18614-2","article-title":"In situ reprogramming of gut bacteria by oral delivery","volume":"11","author":"Hsu","year":"2020","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0905","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1093\/ibd\/izac261","article-title":"Epicutaneous immunotherapy with CBir1 alleviates intestinal inflammation","volume":"29","author":"Chen","year":"2023","journal-title":"Inflamm Bowel Dis"},{"issue":"54","key":"10.1016\/j.mucimm.2026.100365_bb0910","doi-asserted-by":"crossref","first-page":"eabc6373","DOI":"10.1126\/sciimmunol.abc6373","article-title":"CD4+ T cell activation and concomitant mTOR metabolic inhibition can ablate microbiota-specific memory cells and prevent colitis","volume":"5","author":"Zhao","year":"2020","journal-title":"Sci Immunol"},{"key":"10.1016\/j.mucimm.2026.100365_bb0915","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2022.102961","article-title":"Flagellin-specific human CAR Tregs for immune regulation in IBD","volume":"134","author":"Boardman","year":"2023","journal-title":"J Autoimmun"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100365_bb0920","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0923-2508(02)01308-6","article-title":"Growth mechanism of the bacterial flagellar filament","volume":"153","author":"Yonekura","year":"2002","journal-title":"Res Microbiol"},{"key":"10.1016\/j.mucimm.2026.100365_bb0925","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0022-2836(64)80026-7","article-title":"Reconstitution of bacterial flagella in vitro","volume":"10","author":"Asakura","year":"1964","journal-title":"J Mol Biol"},{"key":"10.1016\/j.mucimm.2026.100365_bb0930","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1038\/204125a0","article-title":"Structure of filaments produced by re-aggregation of Salmonella flagellin","volume":"204","author":"Lowy","year":"1964","journal-title":"Nature"},{"issue":"6826","key":"10.1016\/j.mucimm.2026.100365_bb0935","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/35066504","article-title":"Structure of the bacterial flagellar protofilament and implications for a switch for supercoiling","volume":"410","author":"Samatey","year":"2001","journal-title":"Nature"},{"issue":"26","key":"10.1016\/j.mucimm.2026.100365_bb0940","doi-asserted-by":"crossref","first-page":"23624","DOI":"10.1074\/jbc.M303481200","article-title":"Identification of a sequence in human toll-like receptor 5 required for the binding of gram-negative flagellin","volume":"278","author":"Mizel","year":"2003","journal-title":"J Biol Chem"},{"issue":"11","key":"10.1016\/j.mucimm.2026.100365_bb0945","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.tim.2004.09.002","article-title":"Bacterial flagellins: mediators of pathogenicity and host immune responses in mucosa","volume":"12","author":"Ramos","year":"2004","journal-title":"Trends Microbiol"},{"issue":"6070","key":"10.1016\/j.mucimm.2026.100365_bb0950","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1126\/science.1215584","article-title":"Structural basis of TLR5-flagellin recognition and signaling","volume":"335","author":"Yoon","year":"2012","journal-title":"Science"},{"issue":"8","key":"10.1016\/j.mucimm.2026.100365_bb0955","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006574","article-title":"The role of the C-terminal D0 domain of flagellin in activation of toll like receptor 5","volume":"13","author":"Forstneri\u010d","year":"2017","journal-title":"PLoS Pathog"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100365_bb0960","doi-asserted-by":"crossref","first-page":"40878","DOI":"10.1038\/srep40878","article-title":"A conserved TLR5 binding and activation hot spot on flagellin","volume":"7","author":"Song","year":"2017","journal-title":"Sci Rep"},{"issue":"7421","key":"10.1016\/j.mucimm.2026.100365_bb0965","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nature11429","article-title":"Phosphorylation of NLRC4 is critical for inflammasome activation","volume":"490","author":"Qu","year":"2012","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.mucimm.2026.100365_bb0970","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1073\/pnas.1417945112","article-title":"Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5","volume":"112","author":"Matusiak","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.mucimm.2026.100365_bb0975","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/ni.1646","article-title":"Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin","volume":"9","author":"Lightfield","year":"2008","journal-title":"Nat Immunol"},{"issue":"49","key":"10.1016\/j.mucimm.2026.100365_bb0980","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adi8539","article-title":"Structural basis for flagellin-induced NAIP5 activation","volume":"9","author":"Paidimuddala","year":"2023","journal-title":"Sci Adv"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193302192600067X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S193302192600067X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T12:30:53Z","timestamp":1786019453000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S193302192600067X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":196,"alternative-id":["S193302192600067X"],"URL":"https:\/\/doi.org\/10.1016\/j.mucimm.2026.100365","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adaptive immune responses against Lachnospiraceae-derived flagellins and their role in inflammatory bowel disease","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mucimm.2026.100365","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of Society for Mucosal Immunology.","name":"copyright","label":"Copyright"}],"article-number":"100365"}}