{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:01:50Z","timestamp":1791460910458,"version":"4.3.4"},"reference-count":69,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T00:00:00Z","timestamp":1782691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"State Agency of Research","doi-asserted-by":"publisher","award":["PID2020-119567RB-I00"],"award-info":[{"award-number":["PID2020-119567RB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"State Agency of Research","doi-asserted-by":"publisher","award":["SAF2017-82905-R"],"award-info":[{"award-number":["SAF2017-82905-R"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011033","name":"State Agency of Research","doi-asserted-by":"publisher","award":["PID2023-151370OB-I00"],"award-info":[{"award-number":["PID2023-151370OB-I00"]}],"id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","mucosalimmunology.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Mucosal Immunology"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.mucimm.2026.100373","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:40:48Z","timestamp":1782852048000},"page":"100373","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["BAMBI: A novel regulator of intestinal epithelial integrity in the control of colitis and colon cancer progression"],"prefix":"10.1016","volume":"19","author":[{"given":"Marta","family":"Mu\u00f1oz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Gil-de-G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thais M.","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"P\u00e9rez-Adri\u00e1n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Gallego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Cappitelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"Cagigal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Andr\u00e9s","family":"Vazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Ignacio","family":"Raba-D\u00edez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Sauras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"Massonis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Luisa","family":"del Rio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ignacio","family":"Rodr\u00edguez-Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iv\u00e1n","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Merino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Merino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Casado-Medrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Merino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10114","key":"10.1016\/j.mucimm.2026.100373_bb0005","doi-asserted-by":"crossref","first-page":"2769","DOI":"10.1016\/S0140-6736(17)32448-0","article-title":"Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies","volume":"390","author":"Ng","year":"2017","journal-title":"Lancet Lond Engl"},{"key":"10.1016\/j.mucimm.2026.100373_bb0010","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/7247238","article-title":"A comprehensive review and update on the pathogenesis of inflammatory bowel disease","volume":"2019","author":"Guan","year":"2019","journal-title":"J Immunol Res"},{"issue":"10080","key":"10.1016\/j.mucimm.2026.100373_bb0015","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/S0140-6736(16)32126-2","article-title":"Ulcerative colitis","volume":"389","author":"Ungaro","year":"2017","journal-title":"Lancet Lond Engl"},{"key":"10.1016\/j.mucimm.2026.100373_bb0020","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1146\/annurev-immunol-030409-101225","article-title":"Inflammatory bowel disease","volume":"28","author":"Kaser","year":"2010","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100373_bb0025","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41572-020-0205-x","article-title":"Ulcerative colitis","volume":"6","author":"Kobayashi","year":"2020","journal-title":"Nat Rev Dis Primers"},{"issue":"10","key":"10.1016\/j.mucimm.2026.100373_bb0030","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1093\/ecco-jcc\/jjae061","article-title":"Colorectal Cancer in inflammatory bowel disease: a review of the role of gut microbiota and bacterial biofilms in disease pathogenesis","volume":"18","author":"Mu\u00f1iz Pedrogo","year":"2024","journal-title":"J Crohns Colitis"},{"issue":"12","key":"10.1016\/j.mucimm.2026.100373_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/genes13122388","article-title":"Genetic and epigenetic etiology of inflammatory bowel disease: an update","volume":"13","author":"Jarmakiewicz-Czaja","year":"2022","journal-title":"Genes"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100373_bb0040","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.chom.2008.05.001","article-title":"Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases","volume":"3","author":"Peterson","year":"2008","journal-title":"Cell Host Microbe"},{"issue":"9573","key":"10.1016\/j.mucimm.2026.100373_bb0045","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/S0140-6736(07)60750-8","article-title":"Inflammatory bowel disease: cause and immunobiology","volume":"369","author":"Baumgart","year":"2007","journal-title":"Lancet Lond Engl"},{"issue":"10","key":"10.1016\/j.mucimm.2026.100373_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.714","article-title":"The interaction of innate immune and adaptive immune system","volume":"5","author":"Wang","year":"2024","journal-title":"MedComm"},{"issue":"11","key":"10.1016\/j.mucimm.2026.100373_bb0055","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1038\/s41423-024-01218-x","article-title":"Type 17 immunity: novel insights into intestinal homeostasis and autoimmune pathogenesis driven by gut-primed T cells","volume":"21","author":"Ohara","year":"2024","journal-title":"Cell Mol Immunol"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100373_bb0060","first-page":"370","article-title":"Balancing benefit vs risk of immunosuppressive therapy for individual patients with inflammatory bowel diseases","volume":"17","author":"Beaugerie","year":"2019","journal-title":"Clin Gastroenterol Hepatol Off Clin Pract J Am Gastroenterol Assoc"},{"issue":"12","key":"10.1016\/j.mucimm.2026.100373_bb0065","doi-asserted-by":"crossref","first-page":"3146","DOI":"10.3748\/wjg.v20.i12.3146","article-title":"Immunosuppressive therapies for inflammatory bowel disease","volume":"20","author":"Zenlea","year":"2014","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.mucimm.2026.100373_bb0070","doi-asserted-by":"crossref","DOI":"10.7573\/dic.2021-11-4","article-title":"Tofacitinib and newer JAK inhibitors in inflammatory bowel disease-where we are and where we are going","volume":"11","author":"Liu","year":"2022","journal-title":"Drugs Context"},{"issue":"9","key":"10.1016\/j.mucimm.2026.100373_bb0075","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics16091185","article-title":"Advancements in inflammatory bowel disease management: from traditional treatments to monoclonal antibodies and future drug delivery systems","volume":"16","author":"Di Rienzo","year":"2024","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100373_bb0080","doi-asserted-by":"crossref","DOI":"10.1007\/s10238-025-01558-6","article-title":"Biosimilars versus biological therapy in inflammatory bowel disease: challenges and targeting strategies using drug delivery systems","volume":"25","author":"Aljabri","year":"2025","journal-title":"Clin Exp Med"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100373_bb0085","first-page":"445","article-title":"Regulation of homeostasis and regeneration in the adult intestinal epithelium by the TGF\u03b2 superfamily","volume":"252","author":"Fink","year":"2023","journal-title":"Dev Dyn Off Publ Am Assoc Anat"},{"issue":"6397","key":"10.1016\/j.mucimm.2026.100373_bb0090","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/359693a0","article-title":"Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease","volume":"359","author":"Shull","year":"1992","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100373_bb0095","first-page":"3","article-title":"Transforming growth factor-beta 1 knockout mice. A mutation in one cytokine gene causes a dramatic inflammatory disease","volume":"143","author":"Kulkarni","year":"1993","journal-title":"Am J Pathol"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100373_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/cti.2017.9","article-title":"Transforming growth factor \u03b2: a master regulator of the gut microbiota and immune cell interactions","volume":"6","author":"Bauch\u00e9","year":"2017","journal-title":"Clin Transl Immunol"},{"issue":"2","key":"10.1016\/j.mucimm.2026.100373_bb0105","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1084\/jem.20111703","article-title":"Microbiota-induced IL-1\u03b2, but not IL-6, is critical for the development of steady-state TH17 cells in the intestine","volume":"209","author":"Shaw","year":"2012","journal-title":"J Exp Med"},{"issue":"15","key":"10.1016\/j.mucimm.2026.100373_bb0110","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1016\/S1286-4579(99)00254-3","article-title":"The role of TGF-beta in growth, differentiation, and maturation of B lymphocytes","volume":"1","author":"Lebman","year":"1999","journal-title":"Microbes Infect"},{"key":"10.1016\/j.mucimm.2026.100373_bb0115","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev.immunol.24.021605.090737","article-title":"Transforming growth factor-beta regulation of immune responses","volume":"24","author":"Li","year":"2006","journal-title":"Annu Rev Immunol"},{"issue":"10","key":"10.1016\/j.mucimm.2026.100373_bb0120","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1002\/ibd.21247","article-title":"Intestinal dendritic cells: their role in bacterial recognition, lymphocyte homing, and intestinal inflammation","volume":"16","author":"Ng","year":"2010","journal-title":"Inflamm Bowel Dis"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100373_bb0125","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1016\/S0002-9440(10)61243-6","article-title":"Transforming growth factor-beta regulation of epithelial tight junction proteins enhances barrier function and blocks enterohemorrhagic Escherichia coli O157:H7-induced increased permeability","volume":"167","author":"Howe","year":"2005","journal-title":"Am J Pathol"},{"issue":"24","key":"10.1016\/j.mucimm.2026.100373_bb0130","doi-asserted-by":"crossref","first-page":"7423","DOI":"10.1158\/0008-5472.CAN-11-1895","article-title":"Smad7 expression in T cells prevents colitis-associated cancer","volume":"71","author":"Rizzo","year":"2011","journal-title":"Cancer Res"},{"issue":"19","key":"10.1016\/j.mucimm.2026.100373_bb0135","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1016\/j.cell.2023.07.036","article-title":"TGF\u03b2 signaling in health and disease","volume":"186","author":"Massagu\u00e9","year":"2023","journal-title":"Cell"},{"issue":"6752","key":"10.1016\/j.mucimm.2026.100373_bb0140","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/46794","article-title":"Silencing of TGF-beta signalling by the pseudoreceptor BAMBI","volume":"401","author":"Onichtchouk","year":"1999","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.mucimm.2026.100373_bb0145","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/art.41272","article-title":"Therapeutic effects of anti-bone morphogenetic protein and activin membrane-bound inhibitor treatment in psoriasis and arthritis","volume":"72","author":"Alvarez","year":"2020","journal-title":"Arthritis Rheumatol Hoboken NJ"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100373_bb0150","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1002\/art.39557","article-title":"Bone morphogenetic protein and activin membrane-bound inhibitor, a transforming growth factor \u03b2 rheostat that controls murine Treg cell\/Th17 cell differentiation and the development of autoimmune arthritis by reducing Interleukin-2 signaling","volume":"68","author":"Postigo","year":"2016","journal-title":"Arthritis Rheumatol Hoboken NJ"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100373_bb0155","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1523\/JNEUROSCI.2584-09.2010","article-title":"BAMBI (bone morphogenetic protein and activin membrane-bound inhibitor) reveals the involvement of the transforming growth factor-beta family in pain modulation","volume":"30","author":"Tramullas","year":"2010","journal-title":"J Neurosci"},{"issue":"7","key":"10.1016\/j.mucimm.2026.100373_bb0160","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.1021\/acs.jafc.1c07568","article-title":"Hydroxytyrosol alleviates dextran sulfate sodium-induced colitis by modulating inflammatory responses, intestinal barrier, and microbiome","volume":"70","author":"Wang","year":"2022","journal-title":"J Agric Food Chem"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100373_bb0165","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2144\/000114055","article-title":"Separation of intact intestinal epithelium from mesenchyme","volume":"55","author":"Nik","year":"2013","journal-title":"BioTechniques"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100373_bb0170","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/ni1439","article-title":"The adaptor Act1 is required for interleukin 17-dependent signaling associated with autoimmune and inflammatory disease","volume":"8","author":"Qian","year":"2026","journal-title":"Nat Immunol"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100373_bb0175","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/mi.2015.20","article-title":"T regulatory cells and B cells cooperate to form a regulatory loop that maintains gut homeostasis and suppresses dextran sulfate sodium-induced colitis","volume":"8","author":"Wang","year":"2015","journal-title":"Mucosal Immunol"},{"key":"10.1016\/j.mucimm.2026.100373_bb0180","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1201500","article-title":"A review on lymphocyte radiosensitivity and its impact on radiotherapy","volume":"13","author":"Paganetti","year":"2023","journal-title":"Front Oncol"},{"key":"10.1016\/j.mucimm.2026.100373_bb0185","series-title":"Bambi ENSMUSG00000024232 expression in Mus musculus (mouse)","article-title":"Bgee [Internet]","year":"2025"},{"key":"10.1016\/j.mucimm.2026.100373_bb0190","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2017.185","article-title":"An RNA-Seq atlas of gene expression in mouse and rat normal tissues","volume":"4","author":"S\u00f6llner","year":"2017","journal-title":"Sci Data"},{"issue":"31","key":"10.1016\/j.mucimm.2026.100373_bb0195","doi-asserted-by":"crossref","first-page":"4880","DOI":"10.3748\/wjg.14.4880","article-title":"Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer","volume":"14","author":"Togo","year":"2008","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100373_bb0200","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13059-020-01976-7","article-title":"Smarcad1 mediates microbiota-induced inflammation in mouse and coordinates gene expression in the intestinal epithelium","volume":"21","author":"Kazakevych","year":"2020","journal-title":"Genome Biol"},{"key":"10.1016\/j.mucimm.2026.100373_bb0205","series-title":"Visualizations","article-title":"Tabula Muris [Internet]","year":"2025"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100373_bb0215","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1038\/s41467-023-40156-6","article-title":"Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease","volume":"14","author":"Garrido-Trigo","year":"2023","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100373_bb0220","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/gutjnl-2020-320937","article-title":"NTPDase8 protects mice from intestinal inflammation by limiting P2Y6 receptor activation: identification of a new pathway of inflammation for the potential treatment of IBD","volume":"71","author":"Salem","year":"2022","journal-title":"Gut"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100373_bb0225","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2024508119","article-title":"Executioner caspases 3 and 7 are dispensable for intestinal epithelium turnover and homeostasis at steady state","volume":"119","author":"Ghazavi","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100373_bb0230","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1053\/j.gastro.2009.03.041","article-title":"A colorectal cancer expression profile that includes transforming growth factor beta inhibitor BAMBI predicts metastatic potential","volume":"137","author":"Fritzmann","year":"2009","journal-title":"Gastroenterology"},{"issue":"8","key":"10.1016\/j.mucimm.2026.100373_bb0235","doi-asserted-by":"crossref","first-page":"6840","DOI":"10.1074\/jbc.M310876200","article-title":"Identification of BMP and activin membrane-bound inhibitor (BAMBI), an inhibitor of transforming growth factor-beta signaling, as a target of the beta-catenin pathway in colorectal tumor cells","volume":"279","author":"Sekiya","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mucimm.2026.100373_bb0240","article-title":"TGF\u03b2\/BAMBI pathway dysfunction contributes to peripheral Th17\/Treg imbalance in chronic obstructive pulmonary disease","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100373_bb0245","first-page":"3960","article-title":"BAMBI promotes macrophage proliferation and differentiation in gliomas","volume":"17","author":"Wang","year":"2018","journal-title":"Mol Med Rep"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100373_bb0250","doi-asserted-by":"crossref","DOI":"10.1186\/s12931-019-0988-z","article-title":"BAMBI regulates macrophages inducing the differentiation of Treg through the TGF\u03b2 pathway in chronic obstructive pulmonary disease","volume":"20","author":"Sun","year":"2019","journal-title":"Respir Res"},{"issue":"12","key":"10.1016\/j.mucimm.2026.100373_bb0255","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1136\/gutjnl-2014-306890","article-title":"Pathobiont hypnotises enterocytes to promote tumour development","volume":"63","author":"Chassaing","year":"2014","journal-title":"Gut"},{"issue":"48","key":"10.1016\/j.mucimm.2026.100373_bb0260","doi-asserted-by":"crossref","first-page":"33053","DOI":"10.1074\/jbc.M804039200","article-title":"The pseudoreceptor BMP and activin membrane-bound inhibitor positively modulates Wnt\/beta-catenin signaling","volume":"283","author":"Lin","year":"2008","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100373_bb0265","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/ncb1117","article-title":"Akt interacts directly with Smad3 to regulate the sensitivity to TGF-beta induced apoptosis","volume":"6","author":"Conery","year":"2004","journal-title":"Nat Cell Biol"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100373_bb0270","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.bbrc.2007.05.117","article-title":"Blockade of TGF-beta accelerates mucosal destruction through epithelial cell apoptosis","volume":"359","author":"Sakuraba","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100373_bb0275","doi-asserted-by":"crossref","first-page":"869","DOI":"10.3892\/or.2010.869","article-title":"Increased apoptosis and decreased proliferation of colonic epithelium in dextran sulfate sodium-induced colitis in mice","volume":"24","author":"Araki","year":"2010","journal-title":"Oncol Rep"},{"issue":"11","key":"10.1016\/j.mucimm.2026.100373_bb0280","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1093\/ecco-jcc\/jjw096","article-title":"Germ-free and antibiotic-treated mice are highly susceptible to epithelial injury in DSS colitis","volume":"10","author":"Hern\u00e1ndez-Chirlaque","year":"2016","journal-title":"J Crohns Colitis"},{"issue":"3","key":"10.1016\/j.mucimm.2026.100373_bb0285","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/00042737-200012030-00002","article-title":"The role of the resident intestinal flora in acute and chronic dextran sulfate sodium-induced colitis in mice","volume":"12","author":"Hans","year":"2000","journal-title":"Eur J Gastroenterol Hepatol"},{"issue":"14","key":"10.1016\/j.mucimm.2026.100373_bb0290","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1093\/emboj\/cdf366","article-title":"TGF-beta receptor-activated p38 MAP kinase mediates Smad-independent TGF-beta responses","volume":"21","author":"Yu","year":"2002","journal-title":"EMBO J"},{"issue":"2","key":"10.1016\/j.mucimm.2026.100373_bb0295","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.bbadis.2012.11.007","article-title":"BAMBI (BMP and activin membrane-bound inhibitor) protects the murine heart from pressure-overload biomechanical stress by restraining TGF\u03b2 signaling","volume":"1832","author":"Villar","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"10.1016\/j.mucimm.2026.100373_bb0300","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/10533","article-title":"Blockade of the MAP kinase pathway suppresses growth of colon tumors in vivo","volume":"5","author":"Sebolt-Leopold","year":"1999","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100373_bb0305","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1053\/gast.2002.30770","article-title":"Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn\u2019s disease","volume":"122","author":"Hommes","year":"2002","journal-title":"Gastroenterology"},{"issue":"7","key":"10.1016\/j.mucimm.2026.100373_bb0310","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/s41580-018-0007-0","article-title":"Contextual determinants of TGF\u03b2 action in development, immunity and cancer","volume":"19","author":"David","year":"2018","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"12","key":"10.1016\/j.mucimm.2026.100373_bb0315","doi-asserted-by":"crossref","first-page":"23774","DOI":"10.3390\/ijms141223774","article-title":"The dual role of Smad7 in the control of cancer growth and metastasis","volume":"14","author":"Stolfi","year":"2013","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100373_bb0320","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.cels.2018.08.010","article-title":"A pan-cancer analysis reveals high-frequency genetic alterations in mediators of signaling by the TGF\u03b2 superfamily","volume":"7","author":"Korkut","year":"2018","journal-title":"Cell Syst"},{"issue":"1","key":"10.1016\/j.mucimm.2026.100373_bb0325","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-023-42228-z","article-title":"Sleeping beauty transposon mutagenesis identified genes and pathways involved in inflammation-associated colon tumor development","volume":"14","author":"Shimomura","year":"2023","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100373_bb0330","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.immuni.2004.07.020","article-title":"TGF-beta suppresses tumor progression in colon cancer by inhibition of IL-6 trans-signaling","volume":"21","author":"Becker","year":"2004","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.mucimm.2026.100373_bb0335","first-page":"1219","article-title":"Effect of Nma on growth inhibition by TGF-betaa in human gastric carcinoma cell lines","volume":"11","author":"Sasaki","year":"2004","journal-title":"Oncol Rep"},{"key":"10.1016\/j.mucimm.2026.100373_bb0340","doi-asserted-by":"crossref","first-page":"131","DOI":"10.2147\/OTT.S217335","article-title":"Long non-coding RNA PVT1 regulates BAMBI to promote tumor progression in non-small cell lung cancer by sponging miR-17-5p","volume":"13","author":"Wang","year":"2020","journal-title":"Onco Targets Ther"},{"issue":"4","key":"10.1016\/j.mucimm.2026.100373_bb0345","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1002\/(SICI)1097-0215(19960208)65:4<460::AID-IJC12>3.0.CO;2-E","article-title":"Expression of nma, a novel gene, inversely correlates with the metastatic potential of human melanoma cell lines and xenografts","volume":"65","author":"Degen","year":"1996","journal-title":"Int J Cancer"},{"issue":"2","key":"10.1016\/j.mucimm.2026.100373_bb0350","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/ijc.24318","article-title":"BAMBI gene is epigenetically silenced in subset of high-grade bladder cancer","volume":"125","author":"Khin","year":"2009","journal-title":"Int J Cancer"}],"container-title":["Mucosal Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021926000759?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1933021926000759?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:38:58Z","timestamp":1791459538000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1933021926000759"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":69,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S1933021926000759"],"URL":"https:\/\/doi.org\/10.1016\/j.mucimm.2026.100373","relation":{},"ISSN":["1933-0219"],"issn-type":[{"value":"1933-0219","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"BAMBI: A novel regulator of intestinal epithelial integrity in the control of colitis and colon cancer progression","name":"articletitle","label":"Article Title"},{"value":"Mucosal Immunology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mucimm.2026.100373","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Society for Mucosal Immunology.","name":"copyright","label":"Copyright"}],"article-number":"100373"}}