{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:07:19Z","timestamp":1769144839545,"version":"3.49.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.mvr.2006.11.003","type":"journal-article","created":{"date-parts":[[2007,1,2]],"date-time":"2007-01-02T13:50:55Z","timestamp":1167745855000},"page":"214-223","source":"Crossref","is-referenced-by-count":19,"title":["Lymphangiogenesis following obstruction of large postnodal lymphatics in sheep"],"prefix":"10.1016","volume":"73","author":[{"given":"Azadeh","family":"Jila","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harold","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicky P.K.H","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel J.","family":"Dumont","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Semple","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianna","family":"Armstrong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Seto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miles","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2006.11.003_bib1","first-page":"562","article-title":"The role of lymphovenous communication in the development of postmastectomy lymphedema","volume":"95","author":"Aboul-Enein","year":"1984","journal-title":"Surgery"},{"key":"10.1016\/j.mvr.2006.11.003_bib2","first-page":"H616","article-title":"Modification of lymph by lymph nodes. II. Effect of increased lymph node venous blood pressure","volume":"245","author":"Adair","year":"1983","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mvr.2006.11.003_bib3","first-page":"H777","article-title":"Modification of lymph by lymph nodes. III. Effect of increased lymph hydrostatic pressure","volume":"249","author":"Adair","year":"1985","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mvr.2006.11.003_bib4","first-page":"H351","article-title":"Quantitation of changes in lymph protein concentration during lymph node transit","volume":"243","author":"Adair","year":"1982","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mvr.2006.11.003_bib5","first-page":"35","article-title":"The Secret epidemic: lymphedema","volume":"3","author":"Armer","year":"2001","journal-title":"J. Women's Cancer"},{"key":"10.1016\/j.mvr.2006.11.003_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1152\/physrev.1993.73.1.1","article-title":"Interstitial\u2013lymphatic mechanisms in the control of extracellular fluid volume","volume":"73","author":"Aukland","year":"1993","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mvr.2006.11.003_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/aja.1001890203","article-title":"Blood vascular network of the rat lymph node: tridimensional studies by light and scanning electron microscopy","volume":"189","author":"Belisle","year":"1990","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.mvr.2006.11.003_bib8","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1161\/01.RES.0000065621.69843.49","article-title":"Interstitial flow as a guide for lymphangiogenesis","volume":"92","author":"Boardman","year":"2003","journal-title":"Circ. Res."},{"key":"10.1016\/j.mvr.2006.11.003_bib9","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1006\/bbrc.2001.5869","article-title":"Lymphangiogenesis quantification using quantitative PCR and breast cancer as a model","volume":"288","author":"Cunnick","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mvr.2006.11.003_bib10","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/S1534-5807(02)00217-4","article-title":"Angiopoietin-2 is required for postnatal angiogenesis and lymphatic patterning, and only the latter role is rescued by Angiopoietin-1","volume":"3","author":"Gale","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.mvr.2006.11.003_bib11","first-page":"309","article-title":"Studies of the regeneration of the lymphatic vessels","volume":"74","author":"Gray","year":"1939","journal-title":"J. Anat."},{"key":"10.1016\/j.mvr.2006.11.003_bib12","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1096\/fj.02-0698fje","article-title":"Angiopoietin-1 activates both anti- and proapoptotic mitogen-activated protein kinases","volume":"17","author":"Harfouche","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.mvr.2006.11.003_bib13","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/ar.1092070308","article-title":"Lymphatic and blood vessels of the popliteal node in sheep","volume":"207","author":"Heath","year":"1983","journal-title":"Anat. Rec."},{"key":"10.1016\/j.mvr.2006.11.003_bib14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/dvdy.10163","article-title":"Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate","volume":"225","author":"Hong","year":"2002","journal-title":"Dev. Dyn."},{"key":"10.1016\/j.mvr.2006.11.003_bib15","doi-asserted-by":"crossref","first-page":"6820","DOI":"10.1158\/0008-5472.CAN-05-0522","article-title":"Angiopoietin 1 is mitogenic for cultured endothelial cells","volume":"65","author":"Kanda","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.mvr.2006.11.003_bib16","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1161\/01.RES.86.1.24","article-title":"Angiopoietin-1 regulates endothelial cell survival through the phosphatidylinositol 3\u2032-Kinase\/Akt signal transduction pathway","volume":"86","author":"Kim","year":"2000","journal-title":"Circ. Res."},{"key":"10.1016\/j.mvr.2006.11.003_bib17","doi-asserted-by":"crossref","first-page":"4549","DOI":"10.1038\/sj.onc.1203800","article-title":"Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3\u2032-Kinase\/Akt signal transduction pathway","volume":"19","author":"Kim","year":"2000","journal-title":"Oncogene"},{"key":"10.1016\/j.mvr.2006.11.003_bib18","first-page":"111","article-title":"Functional impact of lymphangiogenesis on fluid transport after lymph node excision","volume":"36","author":"Kim","year":"2003","journal-title":"Lymphology"},{"key":"10.1016\/j.mvr.2006.11.003_bib19","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1128\/MCB.18.7.4131","article-title":"Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt","volume":"18","author":"Kontos","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mvr.2006.11.003_bib20","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1182\/blood-2004-08-3382","article-title":"Angiopoietin-1 promotes LYVE-1-positive lymphatic vessel formation","volume":"105","author":"Morisada","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.mvr.2006.11.003_bib21","first-page":"789","article-title":"Local vascular access of radioprotein injected subcutaneously in healthy subjects and patients with breast cancer-related lymphedema","volume":"45","author":"Pain","year":"2004","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.mvr.2006.11.003_bib22","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1007\/BF02137266","article-title":"The resistance of in situ perfused lymph trunks and lymph nodes to flow","volume":"27","author":"Papp","year":"1971","journal-title":"Experientia"},{"key":"10.1016\/j.mvr.2006.11.003_bib23","series-title":"Experimental Lymphoedema: Its Applicability and Contribution to our Clinical Understanding","first-page":"189","author":"Piller","year":"1985"},{"key":"10.1016\/j.mvr.2006.11.003_bib24","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S0002-9343(00)00727-0","article-title":"Lymphedema","volume":"110","author":"Rockson","year":"2001","journal-title":"Am. J. Med."},{"key":"10.1016\/j.mvr.2006.11.003_bib25","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1126\/science.286.5445.1738","article-title":"Differentiation stage-specific inhibition of the Raf-MEK-ERK pathway by Akt","volume":"286","author":"Rommel","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.mvr.2006.11.003_bib26","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1084\/jem.20020587","article-title":"Lymphangiogenic gene therapy with minimal blood vascular side effects","volume":"196","author":"Saaristo","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mvr.2006.11.003_bib27","first-page":"37","article-title":"Microanatomy of the blood vasculature of lymph node follicles in the dog","volume":"25","author":"Salvador","year":"1992","journal-title":"Lymphology"},{"key":"10.1016\/j.mvr.2006.11.003_bib28","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1749-6632.2002.tb04880.x","article-title":"The role of interstitial stress in lymphatic function and lymphangiogenesis","volume":"979","author":"Swartz","year":"2002","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.mvr.2006.11.003_bib29","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1096\/fj.02-0401fje","article-title":"Therapeutic lymphangiogenesis with human recombinant VEGF-C","volume":"16","author":"Szuba","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.mvr.2006.11.003_bib30","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1182\/blood-2004-08-3327","article-title":"Angiopoietin-1 promotes lymphatic sprouting and hyperplasia","volume":"105","author":"Tammela","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.mvr.2006.11.003_bib31","doi-asserted-by":"crossref","first-page":"3831","DOI":"10.1128\/MCB.25.9.3831-3841.2005","article-title":"Dok-R mediates attenuation of epidermal growth factor-dependent mitogen-activated protein kinase and Akt activation through processive recruitment of c-Src and Csk","volume":"25","author":"Van Slyke","year":"2005","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.mvr.2006.11.003_bib32","doi-asserted-by":"crossref","first-page":"42843","DOI":"10.1074\/jbc.M102116200","article-title":"Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt","volume":"276","author":"Wick","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mvr.2006.11.003_bib33","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/S0092-8674(00)81511-1","article-title":"Prox1 function is required for the development of the murine lymphatic system","volume":"98","author":"Wigle","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.mvr.2006.11.003_bib34","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1093\/emboj\/21.7.1505","article-title":"An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype","volume":"21","author":"Wigle","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.mvr.2006.11.003_bib35","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/jemt.1163","article-title":"Lymphangiogenesis and lymphangiodysplasia: from molecular to clinical lymphology","volume":"55","author":"Witte","year":"2001","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.mvr.2006.11.003_bib36","series-title":"Lymphatics, Lymph and the Lymphomyeloid Complex","author":"Yoffey","year":"1970"},{"key":"10.1016\/j.mvr.2006.11.003_bib37","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1126\/science.286.5445.1741","article-title":"Phosphorylation and regulation of Raf by Akt (protein kinase B)","volume":"286","author":"Zimmermann","year":"1999","journal-title":"Science"}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286206001312?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286206001312?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,4,23]],"date-time":"2019-04-23T08:10:40Z","timestamp":1556007040000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286206001312"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S0026286206001312"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2006.11.003","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}