{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T05:31:47Z","timestamp":1782365507680,"version":"3.54.5"},"reference-count":57,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2013,7]]},"DOI":"10.1016\/j.mvr.2013.03.004","type":"journal-article","created":{"date-parts":[[2013,3,26]],"date-time":"2013-03-26T03:47:29Z","timestamp":1364269649000},"page":"48-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Rosuvastatin in experimental brain trauma: Improved capillary patency but no effect on edema or cerebral blood flow"],"prefix":"10.1016","volume":"88","author":[{"given":"M.","family":"Jungner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lundblad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Bentzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2013.03.004_bb0005","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1089\/neu.2004.21.1431","article-title":"The effects of traumatic brain injury on cerebral blood flow and brain tissue nitric oxide levels and cytokine expression","volume":"21","author":"Ahn","year":"2004","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.mvr.2013.03.004_bb0010","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.atherosclerosis.2009.11.021","article-title":"Early vascular and metabolic effects of rosuvastatin compared with simvastatin in patients with type 2 diabetes","volume":"2010","author":"Bellia","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.mvr.2013.03.004_bb0020","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1089\/08977150151070919","article-title":"Infusion of prostacyclin following experimental brain injury in the rat reduces cortical lesion volume","volume":"18","author":"Bentzer","year":"2001","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.mvr.2013.03.004_bb0015","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1089\/089771503765355522","article-title":"Low-dose prostacyclin improves cortical perfusion following experimental brain injury in the rat","volume":"2003","author":"Bentzer","year":"2003","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.mvr.2013.03.004_bb0025","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.neuropharm.2011.01.003","article-title":"Acute lipophilicity-dependent effect of intravascular simvastatin in the early phase of focal cerebral ischemia","volume":"60","author":"Beretta","year":"2011","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.mvr.2013.03.004_bb0030","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1097\/CCM.0b013e3182227e4a","article-title":"Simvastatin in traumatic brain injury: effect on brain edema mechanisms","volume":"39","author":"B\u00e9ziaud","year":"2011","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.mvr.2013.03.004_bb0035","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cardiores.2004.10.018","article-title":"Prostaglandins mediate the cardioprotective effects of atorvastatin against ischemia\u2013reperfusion injury","volume":"65","author":"Birnbaum","year":"2005","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mvr.2013.03.004_bb0040","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/jcbfm.1983.29","article-title":"Selection of experimental conditions for the accurate determination of blood\u2013brain transfer constants from single-time experiments: a theoretical analysis","volume":"3","author":"Blasberg","year":"1983","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.mvr.2013.03.004_bb0045","doi-asserted-by":"crossref","first-page":"H3158","DOI":"10.1152\/ajpheart.01354.2006","article-title":"Cardioprotective effect of rosuvastatin in vivo is dependent on inhibition of geranylgeranyl pyrophosphate and altered RhoA membrane translocation","volume":"292","author":"Bulhak","year":"2007","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mvr.2013.03.004_bb0050","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.lfs.2007.05.023","article-title":"Lovastatin improves histological and functional outcomes and reduces inflammation after experimental traumatic brain injury","volume":"81","author":"Chen","year":"2007","journal-title":"Life Sci."},{"key":"10.1016\/j.mvr.2013.03.004_bb0055","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1124\/jpet.108.140368","article-title":"Combination therapy with fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, and simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, on experimental traumatic brain injury","volume":"326","author":"Chen","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.mvr.2013.03.004_bb0060","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1089\/08977150360517209","article-title":"l-arginine and superoxide dismutase alter cerebral hemodynamics and reduction in nitric oxide concentration after controlled cortical impact injury","volume":"20","author":"Cherian","year":"2003","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.mvr.2013.03.004_bb0065","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1124\/jpet.102.043430","article-title":"Neuroprotective effects of l-arginine administration after cortical impact injury in rats: dose response and time window","volume":"304","author":"Cherian","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.mvr.2013.03.004_bb0070","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3171\/jns.2001.95.5.0756","article-title":"Cerebral autoregulation following head injury","volume":"95","author":"Czosnyka","year":"2001","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.mvr.2013.03.004_bb0075","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/sj.bjp.0706420","article-title":"Improvement of age-related endothelial dysfunction by simvastatin: effect on NO and COX pathways","volume":"146","author":"de Sotomayor","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mvr.2013.03.004_bb0080","doi-asserted-by":"crossref","first-page":"46849","DOI":"10.1074\/jbc.M104197200","article-title":"Modulation of COX-2 expression by statins in human aortic smooth muscle cells. Involvement of geranylgeranylated proteins","volume":"276","author":"Degraeve","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mvr.2013.03.004_bb0085","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.neulet.2006.07.022","article-title":"Reduction of cerebral infarct size by the AT1-receptor blocker candesartan, the HMG-CoA reductase inhibitor rosuvastatin and their combination. An experimental study in rats","volume":"406","author":"Engelhorn","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.mvr.2013.03.004_bb0090","first-page":"384","article-title":"Volume Regulation of the Central Nervous System","author":"Fenstermacher","year":"1984"},{"key":"10.1016\/j.mvr.2013.03.004_bb0095","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1161\/01.CIR.67.6.1174","article-title":"Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease","volume":"67","author":"Fitzgerald","year":"1983","journal-title":"Circulation"},{"key":"10.1016\/j.mvr.2013.03.004_bb0100","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1089\/neu.2011.2278","article-title":"Effects of hypothermia on cerebral autoregulatory vascular responses in two rodent models of traumatic brain injury","volume":"29","author":"Fujita","year":"2012","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.mvr.2013.03.004_bb0120","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/jcbfm.1989.72","article-title":"Lack of capillary recruitment in the brains of awake rats during hypercapnia","volume":"9","author":"G\u00f6bel","year":"1989","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.mvr.2013.03.004_bb0105","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/00004647-200302000-00008","article-title":"Segmental vascular resistance after mild controlled cortical impact injury in the rat","volume":"23","author":"Golding","year":"2003","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.mvr.2013.03.004_bb0110","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1136\/jnnp.52.3.346","article-title":"Ischaemic brain damage is still common in fatal non-missile head injury","volume":"52","author":"Graham","year":"1989","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.mvr.2013.03.004_bb0115","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s00134-006-0294-3","article-title":"The \u201cLund Concept\u201d for the treatment of severe head trauma\u2014physiological principles and clinical application","volume":"32","author":"Gr\u00e4nde","year":"2006","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.mvr.2013.03.004_bb0125","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1152\/physrev.1994.74.1.163","article-title":"Transport of macromolecules across microvascular walls: the two-pore theory","volume":"74","author":"Haraldsson","year":"1994","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mvr.2013.03.004_bb0130","doi-asserted-by":"crossref","first-page":"888","DOI":"10.3171\/jns.1985.62.6.0888","article-title":"Microvascular alterations following cerebral contusion in rats. Light, scanning, and electron microscope study","volume":"62","author":"Hekpatmanah","year":"1985","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.mvr.2013.03.004_bb0135","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0021-9150(01)00547-0","article-title":"Atorvastatin reduces the expression of cyclooxygenase-2 in a rabbit model of atherosclerosis and in cultured vascular smooth muscle cells","volume":"160","author":"Hern\u00e1ndez-Presa","year":"2002","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.mvr.2013.03.004_bb0140","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1097\/ALN.0b013e3181d94d6e","article-title":"Effects on brain edema of crystalloid and albumin fluid resuscitation after brain trauma and hemorrhage in the rat","volume":"112","author":"Jungner","year":"2010","journal-title":"Anesthesiology"},{"key":"10.1016\/j.mvr.2013.03.004_bb0145","doi-asserted-by":"crossref","first-page":"2442","DOI":"10.1161\/01.STR.31.10.2442","article-title":"Atorvastatin upregulates type III nitric oxide synthase in thrombocytes, decreases platelet activation, and protects from cerebral ischemia in normocholesterolemic mice","volume":"31","author":"Laufs","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.mvr.2013.03.004_bb0155","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.jacc.2009.11.046","article-title":"Rosuvastatin prevents conduit artery endothelial dysfunction induced by ischemia and reperfusion by a cyclooxygenase-2-dependent mechanism","volume":"55","author":"Liuni","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.mvr.2013.03.004_bb0160","doi-asserted-by":"crossref","first-page":"813","DOI":"10.3171\/jns.2004.101.5.0813","article-title":"Atorvastatin reduction of intravascular thrombosis, increase in cerebral microvascular patency and integrity, and enhancement of spatial learning in rats subjected to traumatic brain injury","volume":"101","author":"Lu","year":"2004","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.mvr.2013.03.004_bb0165","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1089\/neu.2007.0288","article-title":"Statins increase neurogenesis in the dentate gyrus, reduce delayed neuronal death in the hippocampal CA3 region, and improve spatial learning in rat after traumatic brain injury","volume":"24","author":"Lu","year":"2007","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.mvr.2013.03.004_bb0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mvr.2007.03.001","article-title":"Effects of l-arginine on cerebral blood flow, microvascular permeability, number of perfused capillaries, and brain water content in the traumatized mouse brain","volume":"74","author":"Lundblad","year":"2007","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2013.03.004_bb0175","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1089\/0897715041269614","article-title":"A mouse model for evaluation of capillary perfusion, microvascular permeability, cortical blood flow, and cortical edema in the traumatized brain","volume":"21","author":"Lundblad","year":"2004","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.mvr.2013.03.004_bb0180","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/sj.jcbfm.9600533","article-title":"Increased cortical cell loss and prolonged hemodynamic depression after traumatic brain injury in mice lacking the IP receptor for prostacyclin","volume":"28","author":"Lundblad","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.mvr.2013.03.004_bb0185","first-page":"102","article-title":"Hemodynamic depression and microthrombosis in the peripheral areas of contusion in the rat: role of platelet activating factor","volume":"70","author":"Maeda","year":"1997","journal-title":"Acta Neurochir. Suppl."},{"key":"10.1016\/j.mvr.2013.03.004_bb0190","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1073\/pnas.96.1.272","article-title":"Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2","volume":"96","author":"McAdam","year":"1999","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.mvr.2013.03.004_bb0195","doi-asserted-by":"crossref","first-page":"28B","DOI":"10.1016\/S0002-9149(01)01454-0","article-title":"Preclinical and clinical pharmacology of rosuvastatin, a new 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor","volume":"87","author":"McTaggart","year":"2001","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.mvr.2013.03.004_bb0200","first-page":"770","article-title":"Early insults to the injured brain","volume":"105","author":"Miller","year":"1978","journal-title":"JAMA"},{"key":"10.1016\/j.mvr.2013.03.004_bb0205","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/j.neuroscience.2005.08.030","article-title":"Experimental models of traumatic injury: do we really need to build a better mousetrap?","volume":"136","author":"Morales","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.mvr.2013.03.004_bb0210","doi-asserted-by":"crossref","first-page":"2024","DOI":"10.3748\/wjg.v12.i13.2024","article-title":"Rosuvastatin reduces rat intestinal ischemia\u2013reperfusion injury associated with the preservation of endothelial nitric oxide synthase protein","volume":"12","author":"Naito","year":"2006","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.mvr.2013.03.004_bb0215","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1213\/ane.0b013e3181a85d0e","article-title":"The acute (cerebro)vascular effects of statins","volume":"109","author":"Prinz","year":"2009","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.mvr.2013.03.004_bb0220","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1161\/STROKEAHA.107.492470","article-title":"Intravenous rosuvastatin for acute stroke treatment: an animal study","volume":"39","author":"Prinz","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.mvr.2013.03.004_bb0225","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1161\/01.RES.0000196564.18314.23","article-title":"Rho GTPases, statins, and nitric oxide","volume":"97","author":"Rikitake","year":"2005","journal-title":"Circ. Res."},{"key":"10.1016\/j.mvr.2013.03.004_bb0230","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1089\/neu.2010.1476","article-title":"Variants of the endothelial nitric oxid gene and cerebral blood flow after severe traumatic injury","volume":"28","author":"Robertson","year":"2011","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.mvr.2013.03.004_bb0235","first-page":"H59","article-title":"Measurement of local cerebral blood flow with iodo [14C] antipyrine","volume":"234","author":"Sakurada","year":"1978","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mvr.2013.03.004_bb0240","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/jcbfm.1987.8","article-title":"Head injury induces increased prostaglandin synthesis in rat brain","volume":"7","author":"Shohami","year":"1987","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.mvr.2013.03.004_bb0245","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jchromb.2006.07.054","article-title":"Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: appraisal of the Griess reaction in the l-arginine\/nitric oxide area of research","volume":"851","author":"Tsikas","year":"2007","journal-title":"J. Chromatogr. B. Analyt. Technol. Biomed. Life. Sci."},{"key":"10.1016\/j.mvr.2013.03.004_bb0250","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.surneu.2008.07.004","article-title":"Atorvastatin efficiency after traumatic brain injury in rats","volume":"72","author":"Turkoglu","year":"2009","journal-title":"Surg. Neurol."},{"key":"10.1016\/j.mvr.2013.03.004_bb0255","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/j.neuroscience.2004.06.046","article-title":"Edema and brain trauma","volume":"129","author":"Unterberg","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.mvr.2013.03.004_bb0260","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1161\/01.RES.75.1.55","article-title":"Capillary perfusion of the rat brain cortex. An in vivo confocal microscopy study","volume":"75","author":"Villringer","year":"1994","journal-title":"Circ. Res."},{"key":"10.1016\/j.mvr.2013.03.004_bb0265","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1097\/00006123-200204000-00019","article-title":"Blood flow and ischemia within traumatic cerebral contusions","volume":"50","author":"von Oettingen","year":"2002","journal-title":"Neurosurgery"},{"key":"10.1016\/j.mvr.2013.03.004_bb0270","doi-asserted-by":"crossref","first-page":"807","DOI":"10.3171\/jns.1998.89.5.0807","article-title":"Role of nitric oxide in traumatic brain injury in the rat","volume":"89","author":"Wada","year":"1998","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.mvr.2013.03.004_bb0275","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.expneurol.2007.03.031","article-title":"Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury","volume":"206","author":"Wang","year":"2007","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mvr.2013.03.004_bb0280","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1159\/000231969","article-title":"Anaphylactoid responses in rats","volume":"55","author":"West","year":"1977","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"key":"10.1016\/j.mvr.2013.03.004_bb0285","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/0090-6980(87)90068-2","article-title":"Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury","volume":"34","author":"Westcott","year":"1987","journal-title":"Prostaglandins"},{"key":"10.1016\/j.mvr.2013.03.004_bb0290","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1749-6632.2009.05359.x","article-title":"Statins and neuroprotection: a prescription to move the field forward","volume":"1199","author":"Wood","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286213000332?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286213000332?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,7,11]],"date-time":"2019-07-11T10:17:52Z","timestamp":1562840272000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286213000332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,7]]},"references-count":57,"alternative-id":["S0026286213000332"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2013.03.004","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2013,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rosuvastatin in experimental brain trauma: Improved capillary patency but no effect on edema or cerebral blood flow","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2013.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}