{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:25:21Z","timestamp":1790616321241,"version":"4.1.0"},"reference-count":73,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2014,1]]},"DOI":"10.1016\/j.mvr.2013.11.003","type":"journal-article","created":{"date-parts":[[2013,11,27]],"date-time":"2013-11-27T00:42:50Z","timestamp":1385512970000},"page":"99-109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":51,"special_numbering":"C","title":["Tortuosity and other vessel attributes for arterioles and venules of the human cerebral cortex"],"prefix":"10.1016","volume":"91","author":[{"given":"Sylvie","family":"Lorthois","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Lauwers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis","family":"Cassot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2013.11.003_bb0005","series-title":"Handbook of Mathematical Functions","author":"Abramovitz","year":"1972"},{"key":"10.1016\/j.mvr.2013.11.003_bb0010","doi-asserted-by":"crossref","first-page":"014003","DOI":"10.1117\/1.2837411","article-title":"Clinical applicability of in vivo fluorescence confocal microscopy for noninvasive diagnosis and therapeutic monitoring of nonmelanoma skin cancer","volume":"13","author":"Astner","year":"2008","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.mvr.2013.11.003_bb0015","first-page":"3683","article-title":"Fractals and cancer","volume":"60","author":"Baish","year":"2000","journal-title":"Cancer Res."},{"key":"10.1016\/j.mvr.2013.11.003_bb0020","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/mvre.1996.0031","article-title":"Role of tumor vascular architecture in nutrient and drug delivery: an invasion percolation-based network model","volume":"51","author":"Baish","year":"1996","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2013.11.003_bb0025","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1161\/STROKEAHA.107.496091","article-title":"Retinal signs and stroke. Revisiting the link between the eye and brain","volume":"39","author":"Baker","year":"2008","journal-title":"Stroke"},{"key":"10.1016\/j.mvr.2013.11.003_bb0030","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jns.2009.02.328","article-title":"Microvascular changes in the white mater in dementia","volume":"283","author":"Brown","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.mvr.2013.11.003_bb0035","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1109\/TMI.2003.816964","article-title":"Measuring tortuosity of the intracerebral vasculature from MRA images","volume":"22","author":"Bullitt","year":"2003","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.mvr.2013.11.003_bb0040","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.media.2004.06.024","article-title":"Analyzing attributes of vessel populations","volume":"9","author":"Bullitt","year":"2005","journal-title":"Med. Image Anal."},{"key":"10.1016\/j.mvr.2013.11.003_bb0045","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1016\/j.acra.2005.05.027","article-title":"Vessel tortuosity and brain tumor malignancy: a blinded study","volume":"12","author":"Bullitt","year":"2005","journal-title":"Acad. Radiol."},{"key":"10.1016\/j.mvr.2013.11.003_bb0050","first-page":"561","article-title":"Tumor therapeutic response and vessel tortuosity: preliminary report in metastatic breast cancer","volume":"9","author":"Bullitt","year":"2006","journal-title":"Med. Image Comput. Comput. Assist. Interv."},{"key":"10.1016\/j.mvr.2013.11.003_bb0055","first-page":"612","article-title":"Malignancy-associated vessel tortuosity: a computer-assisted, MR angiographic study of choroid plexus carcinoma in genetically engineered mice","volume":"27","author":"Bullitt","year":"2006","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"10.1016\/j.mvr.2013.11.003_bb0060","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ymeth.2007.03.009","article-title":"Computer-assisted measurement of vessel shape from 3T magnetic resonance angiography of mouse brain","volume":"43","author":"Bullitt","year":"2007","journal-title":"Methods"},{"key":"10.1016\/j.mvr.2013.11.003_bb0065","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1148\/radiol.2453061889","article-title":"Blood vessel morphologic changes depicted with MR angiography during treatment of brain metastases: a feasibility study","volume":"245","author":"Bullitt","year":"2007","journal-title":"Radiology"},{"key":"10.1016\/j.mvr.2013.11.003_bb0070","series-title":"Surgical Pathology of the Nervous System and its Coverings","author":"Burger","year":"1991"},{"key":"10.1016\/j.mvr.2013.11.003_bb0075","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/nature04478","article-title":"Angiogenesis in life, disease and medicine","volume":"438","author":"Carmeliet","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.mvr.2013.11.003_bb0080","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/35025220","article-title":"Angiogenesis in cancer and other diseases","volume":"407","author":"Carmeliet","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.mvr.2013.11.003_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10739680500383407","article-title":"A novel three-dimensional computer-assisted method for a quantitative study of microvascular networks of the human cerebral cortex","volume":"13","author":"Cassot","year":"2006","journal-title":"Microcirculation"},{"key":"10.1016\/j.mvr.2013.11.003_bb0095","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/10739680802662607","article-title":"Scaling laws for branching vessels of human cerebral cortex","volume":"16","author":"Cassot","year":"2009","journal-title":"Microcirculation"},{"key":"10.1016\/j.mvr.2013.11.003_bb0085","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.brainres.2009.12.007","article-title":"Branching patterns for arterioles and venules of the human cerebral cortex","volume":"1313","author":"Cassot","year":"2010","journal-title":"Brain Res."},{"key":"10.1016\/j.mvr.2013.11.003_bb0100","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.medengphy.2007.02.009","article-title":"Clinical validation of three-dimensional tortuosity metrics based on the minimum curvature of approximating polynomial splines","volume":"30","author":"Dougherty","year":"2008","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.mvr.2013.11.003_bb0105","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0361-9230(81)90007-1","article-title":"Cortical blood vessels of the human brain","volume":"7","author":"Duvernoy","year":"1981","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.mvr.2013.11.003_bb0110","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1093\/jnci\/92.2.94","article-title":"Incipient angiogenesis","volume":"92","author":"Folkman","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.mvr.2013.11.003_bb0115","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1109\/TMI.2006.880670","article-title":"Blockwise processing applied to brain microvascular network study","volume":"25","author":"Fouard","year":"2006","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.mvr.2013.11.003_bb0120","doi-asserted-by":"crossref","first-page":"e233","DOI":"10.1038\/tp.2012.150","article-title":"Retinal vascular biomarkers for early detection and monitoring of Alzheimer's disease","volume":"3","author":"Frost","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.mvr.2013.11.003_bb0125","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1111\/j.1600-0463.2008.01148.x","article-title":"Imaging angiogenesis and the microenvironment","volume":"116","author":"Fukumura","year":"2008","journal-title":"Apmis"},{"key":"10.1016\/j.mvr.2013.11.003_bb0130","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1593\/neo.81400","article-title":"Blood supply in melanoma xenografts is governed by the morphology of the supplying arteries","volume":"11","author":"Gaustad","year":"2009","journal-title":"Neoplasia"},{"key":"10.1016\/j.mvr.2013.11.003_bb0135","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1016\/j.jaapos.2007.09.005","article-title":"Plus disease in retinopathy of prematurity: pilot study of computer-based and expert diagnosis","volume":"11","author":"Gelman","year":"2007","journal-title":"J. Aapos"},{"key":"10.1016\/j.mvr.2013.11.003_bb0140","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1006\/jtbi.2000.2113","article-title":"A computational study of the effect of capillary network anastomoses and tortuosity on oxygen transport","volume":"206","author":"Goldman","year":"2000","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.mvr.2013.11.003_bb0145","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1109\/TMI.2007.904657","article-title":"A novel method for the automatic grading of retinal vessel tortuosity","volume":"27","author":"Grisan","year":"2008","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.mvr.2013.11.003_bb0150","first-page":"459","article-title":"Automated measurement of retinal vascular tortuosity","author":"Hart","year":"1997","journal-title":"Proc. AMIA Annu. Fall Symp."},{"key":"10.1016\/j.mvr.2013.11.003_bb0155","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S1386-5056(98)00163-4","article-title":"Measurement and classification of retinal vascular tortuosity","volume":"53","author":"Hart","year":"1999","journal-title":"Int. J. Med. Inform."},{"key":"10.1016\/j.mvr.2013.11.003_bb0165","first-page":"1284","article-title":"Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism","volume":"8","author":"Helmlinger","year":"2002","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mvr.2013.11.003_bb0170","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1109\/TMI.2007.904665","article-title":"Analysis of tumor vascularity using three-dimensional power Doppler ultrasound images","volume":"27","author":"Huang","year":"2008","journal-title":"IEEE Trans. Med. Imaging"},{"key":"10.1016\/j.mvr.2013.11.003_bb0175","first-page":"2641","article-title":"Determinants of tumor blood flow: a review","volume":"48","author":"Jain","year":"1988","journal-title":"Cancer Res."},{"key":"10.1016\/j.mvr.2013.11.003_bb0185","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/nm0901-987","article-title":"Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy","volume":"7","author":"Jain","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.mvr.2013.11.003_bb0180","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.1104819","article-title":"Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy","volume":"307","author":"Jain","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.mvr.2013.11.003_bb0190","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.medengphy.2006.07.008","article-title":"Robust measures of three-dimensional vascular tortuosity based on the minimum curvature of approximating polynomial spline fits to the vessel mid-line","volume":"29","author":"Johnson","year":"2007","journal-title":"Med. Eng. Phys."},{"key":"10.1016\/j.mvr.2013.11.003_bb0195","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1152\/physiol.00012.2007","article-title":"Microvascular dysfunction in obesity: a potential mechanism in the pathogenesis of obesity-associated insulin resistance and hypertension","volume":"22","author":"Jonk","year":"2007","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.mvr.2013.11.003_bb0200","first-page":"H350","article-title":"Morphometry of pig coronary arterial trees","volume":"265","author":"Kassab","year":"1993","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mvr.2013.11.003_bb0205","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1542\/peds.2007-3667","article-title":"Systematic review of digital imaging screening strategies for retinopathy of prematurity","volume":"122","author":"Kemper","year":"2008","journal-title":"Pediatrics"},{"key":"10.1016\/j.mvr.2013.11.003_bb0215","series-title":"Mathematical handbook for scientists and engineers. Definitions, theorems and formulas for references and review","author":"Korn","year":"2000"},{"key":"10.1016\/j.mvr.2013.11.003_bb0220","doi-asserted-by":"crossref","first-page":"014003","DOI":"10.1117\/1.2837411","article-title":"Clinical applicability of in vivo fluorescence confocal microscopy for noninvasive diagnosis and therapeutic monitoring of nonmelanoma skin cancer","volume":"13","author":"Lademann","year":"2008","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.mvr.2013.11.003_bb0225","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1089\/cbr.1999.14.31","article-title":"Paclitaxel (Taxol): an inhibitor of angiogenesis in a highly vascularized transgenic breast cancer","volume":"14","author":"Lau","year":"1999","journal-title":"Cancer Biother. Radiopharm."},{"key":"10.1016\/j.mvr.2013.11.003_bb0230","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.neuroimage.2007.09.024","article-title":"Morphometry of the human cerebral cortex microcirculation: general characteristics and space-related profiles","volume":"39","author":"Lauwers","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.mvr.2013.11.003_bb0235","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1161\/CIRCULATIONAHA.107.763730","article-title":"Impaired tissue perfusion: a pathology common to hypertension, obesity, and diabetes mellitus","volume":"118","author":"Levy","year":"2008","journal-title":"Circulation"},{"key":"10.1016\/j.mvr.2013.11.003_bb0240","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/jnci\/92.2.143","article-title":"Initial stages of tumor cell-induced angiogenesis: evaluation via skin window chambers in rodent models","volume":"92","author":"Li","year":"2000","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.mvr.2013.11.003_bb0245","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1007\/s10439-013-0828-0","article-title":"Cerebral microcirculation and oxygen tension in the human secondary cortex","volume":"41","author":"Linninger","year":"2013","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.mvr.2013.11.003_bb0250","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.jtbi.2009.10.037","article-title":"Fractal analysis of vascular networks: insights from morphogenesis","volume":"262","author":"Lorthois","year":"2010","journal-title":"J. Theor. Biol."},{"key":"10.1016\/j.mvr.2013.11.003_bb0255","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/j.neuroimage.2010.09.032","article-title":"Simulation study of brain blood flow regulation by intra-cortical arterioles in an anatomically accurate large human vascular network: part I: methodology and baseline flow","volume":"54","author":"Lorthois","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.mvr.2013.11.003_bb0260","first-page":"2840","article-title":"Simulation study of brain blood flow regulation by intra-cortical arterioles in an anatomically accurate large human vascular network: part II: flow variations induced by global or localized modifications of arteriolar diameters","volume":"54","author":"Lorthois","year":"2011"},{"key":"10.1016\/j.mvr.2013.11.003_bb0265","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jneumeth.2004.03.011","article-title":"Analysis of cerebral microvascular architecture\u2014application to cortical and subcortical vessels in rat brain","volume":"138","author":"Lu","year":"2004","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.mvr.2013.11.003_bb0270","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1073\/pnas.0709788105","article-title":"Altered morphology and 3D architecture of brain vasculature in a mouse model for Alzheimer's disease","volume":"105","author":"Meyer","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mvr.2013.11.003_bb0275","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0076-6879(08)02812-7","article-title":"Chapter 12. Structure of microvascular networks in genetic hypertension","volume":"444","author":"Murfee","year":"2008","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.mvr.2013.11.003_bb0280","doi-asserted-by":"crossref","first-page":"061907-1","DOI":"10.1103\/PhysRevE.73.061907","article-title":"Dynamics of vascular branching morphogenesis: the effect of blood and tissue flow","volume":"73","author":"Nguyen","year":"2006","journal-title":"Phys. Rev. E"},{"key":"10.1016\/j.mvr.2013.11.003_bb0285","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1073\/pnas.0609551104","article-title":"Penetrating arterioles are a bottleneck in the perfusion of neocortex","volume":"104","author":"Nishimura","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mvr.2013.11.003_bb0290","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.1007\/s10439-007-9307-9","article-title":"Methods for three-dimensional geometric characterization of the arterial vasculature","volume":"35","author":"O'Flynn","year":"2007","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.mvr.2013.11.003_bb0300","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1469-7580.2005.00395.x","article-title":"Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures","volume":"206","author":"Patton","year":"2005","journal-title":"J. Anat."},{"key":"10.1016\/j.mvr.2013.11.003_bb0305","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/10739680802229076","article-title":"Modeling structural adaptation of microcirculation","volume":"15","author":"Pries","year":"2008","journal-title":"Microcirculation"},{"key":"10.1016\/j.mvr.2013.11.003_bb0310","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1161\/01.HYP.0000184428.16429.be","article-title":"Remodeling of blood vessels: responses of diameter and wall thickness to hemodynamic and metabolic stimuli","volume":"46","author":"Pries","year":"2005","journal-title":"Hypertension"},{"key":"10.1016\/j.mvr.2013.11.003_bb0315","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/(SICI)1097-0185(199805)251:1<87::AID-AR14>3.0.CO;2-7","article-title":"Morphological characteristics and distribution pattern of the arterial vessels in human cerebral cortex: a scanning electron microscope study","volume":"251","author":"Reina-De La Torre","year":"1998","journal-title":"Anat. Rec."},{"key":"10.1016\/j.mvr.2013.11.003_bb0320","first-page":"4","article-title":"Vascular targeting agents","volume":"3","author":"Siemann","year":"2002","journal-title":"Horiz. Cancer Ther."},{"key":"10.1016\/j.mvr.2013.11.003_bb0295","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1002\/uog.5150","article-title":"Contribution of morphological assessment of the vessel tree by three-dimensional ultrasound to a correct diagnosis of malignancy in ovarian masses","volume":"30","author":"Sladkevicius","year":"2007","journal-title":"Ultrasound Obstet. Gynecol."},{"key":"10.1016\/j.mvr.2013.11.003_bb9000","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1159\/000158993","article-title":"Two-dimensional tortuosity of the superficial femoral artery in early atherosclerosis","volume":"30","author":"Smedby","year":"1993","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.mvr.2013.11.003_bb0325","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/j.1549-8719.2011.00148.x","article-title":"The influence of network structure on the transport of blood in the human cerebral microvasculature","volume":"19","author":"Su","year":"2012","journal-title":"Microcirculation"},{"key":"10.1016\/j.mvr.2013.11.003_bb0330","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0039-6257(03)00029-8","article-title":"Familial retinal arteriolar tortuosity: a review","volume":"48","author":"Sutter","year":"2003","journal-title":"Surv. Ophthalmol."},{"key":"10.1016\/j.mvr.2013.11.003_bb0335","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.neuroimage.2009.05.051","article-title":"An integrative model for neuronal activity induced signal changes for gradient and spin echo functional imaging","volume":"48","author":"Uluda\u011f","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.mvr.2013.11.003_bb0340","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/ar.20862","article-title":"VESGEN 2D: automated, user-interactive software for quantification and mapping of angiogenic and lymphangiogenic trees and networks","volume":"292","author":"Vickerman","year":"2009","journal-title":"Anat. Rec. (Hoboken)"},{"key":"10.1016\/j.mvr.2013.11.003_bb0345","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1093\/cercor\/bhm259","article-title":"The microvascular system of the striate and extrastriate visual cortex of the macaque","volume":"18","author":"Weber","year":"2008","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.mvr.2013.11.003_bb0350","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1080\/10739680701285617","article-title":"Microcirculation and the metabolic syndrome","volume":"14","author":"Wiernsperger","year":"2007","journal-title":"Microcirculation"},{"key":"10.1016\/j.mvr.2013.11.003_bb0355","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1161\/01.HYP.0000216717.72048.6c","article-title":"Abnormalities of retinal microvascular structure and risk of mortality from ischemic heart disease and stroke","volume":"47","author":"Witt","year":"2006","journal-title":"Hypertension"},{"key":"10.1016\/j.mvr.2013.11.003_bb0365","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1016\/S0140-6736(01)06253-5","article-title":"Retinal microvascular abnormalities and incident stroke: the atherosclerosis risk in communities study","volume":"358","author":"Wong","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.mvr.2013.11.003_bb0360","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1001\/jama.287.19.2528","article-title":"Retinal arteriolar narrowing and risk of diabetes mellitus in middle-aged persons","volume":"287","author":"Wong","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.mvr.2013.11.003_bb0370","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/S0161-6420(03)00084-8","article-title":"Retinal microvascular abnormalities and 10-year cardiovascular mortality: a population-based case\u2013control study","volume":"110","author":"Wong","year":"2003","journal-title":"Ophthalmology"}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286213001994?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286213001994?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,4]],"date-time":"2019-08-04T00:33:05Z","timestamp":1564878785000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286213001994"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,1]]},"references-count":73,"alternative-id":["S0026286213001994"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2013.11.003","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2014,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Tortuosity and other vessel attributes for arterioles and venules of the human cerebral cortex","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2013.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}