{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:20:29Z","timestamp":1791274829638,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2014,3]]},"DOI":"10.1016\/j.mvr.2013.12.005","type":"journal-article","created":{"date-parts":[[2013,12,24]],"date-time":"2013-12-24T15:45:14Z","timestamp":1387899914000},"page":"50-55","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["Excessive mechanical stress increases HMGB1 expression in human lung microvascular endothelial cells via STAT3"],"prefix":"10.1016","volume":"92","author":[{"given":"Rachel K.","family":"Wolfson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Mapes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joe G.N.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2013.12.005_bb0010","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.4049\/jimmunol.165.6.2950","article-title":"HMG-1 as a mediator of acute lung inflammation","volume":"165","author":"Abraham","year":"2000","journal-title":"J. Immunol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0015","doi-asserted-by":"crossref","first-page":"L371","DOI":"10.1152\/ajplung.00308.2009","article-title":"Moderate oxygen augments lipopolysaccharide-induced lung injury in mice","volume":"298","author":"Aggarwal","year":"2010","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0020","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1056\/NEJM199802053380602","article-title":"Effect of a protective-ventilation strategy on mortality in the acute respiratory distress syndrome","volume":"338","author":"Amato","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mvr.2013.12.005_bb0025","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1159\/000339151","article-title":"The effect of pressure-induced mechanical stretch on vascular wall differential gene expression","volume":"49","author":"Anwar","year":"2012","journal-title":"J. Vasc. Res."},{"key":"10.1016\/j.mvr.2013.12.005_bb0005","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","article-title":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. The Acute Respiratory Distress Syndrome Network","volume":"342","author":"ARDSNET","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mvr.2013.12.005_bb0030","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ccc.2011.04.001","article-title":"Biomarkers in acute lung injury\u2014marking forward progress","volume":"27","author":"Barnett","year":"2011","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.mvr.2013.12.005_bb0035","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1146\/annurev-physiol-030212-183756","article-title":"Regulation and repair of the alveolar-capillary barrier in acute lung injury","volume":"75","author":"Bhattacharya","year":"2013","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0040","doi-asserted-by":"crossref","first-page":"L785","DOI":"10.1152\/ajplung.00336.2002","article-title":"Magnitude-dependent regulation of pulmonary endothelial cell barrier function by cyclic stretch","volume":"285","author":"Birukov","year":"2003","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0045","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.2353\/ajpath.2006.050431","article-title":"Differential regulation of pulmonary endothelial monolayer integrity by varying degrees of cyclic stretch","volume":"168","author":"Birukova","year":"2006","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0050","doi-asserted-by":"crossref","first-page":"3466","DOI":"10.1016\/j.yexcr.2008.09.003","article-title":"Long-term cyclic stretch controls pulmonary endothelial permeability at translational and post-translational levels","volume":"314","author":"Birukova","year":"2008","journal-title":"Exp. Cell Res."},{"issue":"6","key":"10.1016\/j.mvr.2013.12.005_bb0055","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3109\/01902148.2013.792881","article-title":"Moderate hypothermia attenuates oxidative stress injuries in alveolar epithelial A549 cells","volume":"39","author":"Chiou","year":"2013","journal-title":"Exp. Lung Res."},{"key":"10.1016\/j.mvr.2013.12.005_bb0060","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1183\/09031936.00141007","article-title":"Frequency and peak stretch magnitude affect alveolar epithelial permeability","volume":"32","author":"Cohen","year":"2008","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.mvr.2013.12.005_bb0065","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.ccc.2010.12.005","article-title":"Biomarkers in acute lung injury: insights into the pathogenesis of acute lung injury","volume":"27","author":"Cross","year":"2011","journal-title":"Crit. Care Clin."},{"key":"10.1016\/j.mvr.2013.12.005_bb0070","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1126\/science.277.5332.1630","article-title":"STATs and gene regulation","volume":"277","author":"Darnell","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.mvr.2013.12.005_bb0075","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1056\/NEJM198310133091502","article-title":"Pulmonary oxygen toxicity. Early reversible changes in human alveolar structures induced by hyperoxia","volume":"309","author":"Davis","year":"1983","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mvr.2013.12.005_bb0080","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1056\/NEJM198007103030204","article-title":"Normobaric oxygen toxicity of the lung","volume":"303","author":"Deneke","year":"1980","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mvr.2013.12.005_bb0085","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/bja\/54.7.737","article-title":"Oxygen toxicity of the lung: an update","volume":"54","author":"Deneke","year":"1982","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.mvr.2013.12.005_bb0090","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1152\/jappl.2000.89.4.1645","article-title":"Invited review: mechanisms of ventilator-induced lung injury: a perspective","volume":"89","author":"Dos Santos","year":"2000","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0095","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1007\/s001340051217","article-title":"Mechanotransduction, ventilator-induced lung injury and multiple organ dysfunction syndrome","volume":"26","author":"dos Santos","year":"2000","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.mvr.2013.12.005_bb0100","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s001340050529","article-title":"From ventilator-induced lung injury to multiple organ dysfunction?","volume":"24","author":"Dreyfuss","year":"1998","journal-title":"Intensive Care Med."},{"key":"10.1016\/j.mvr.2013.12.005_bb0105","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1152\/jappl.2001.91.4.1487","article-title":"Cytoskeletal regulation of pulmonary vascular permeability","volume":"91","author":"Dudek","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0110","doi-asserted-by":"crossref","first-page":"L1066","DOI":"10.1152\/ajplung.90486.2008","article-title":"Hyperoxia and acute lung injury","volume":"295","author":"Fisher","year":"2008","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0115","doi-asserted-by":"crossref","first-page":"2652","DOI":"10.1182\/blood-2002-05-1300","article-title":"Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells","volume":"101","author":"Fiuza","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.mvr.2013.12.005_bb0120","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.bbrc.2009.09.020","article-title":"Mechanical stretch enhances IL-8 production in pulmonary microvascular endothelial cells","volume":"389","author":"Iwaki","year":"2009","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mvr.2013.12.005_bb0125","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1152\/japplphysiol.01432.2011","article-title":"Atelectrauma disrupts pulmonary epithelial barrier integrity and alters the distribution of tight junction proteins ZO-1 and claudin 4","volume":"113","author":"Jacob","year":"2012","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0130","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1038\/nrm909","article-title":"Stats: transcriptional control and biological impact","volume":"3","author":"Levy","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0135","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/00075198-200502000-00013","article-title":"Overview of ventilator-induced lung injury mechanisms","volume":"11","author":"Lionetti","year":"2005","journal-title":"Curr. Opin. Crit. Care"},{"key":"10.1016\/j.mvr.2013.12.005_bb0140","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0167-4781(01)00243-3","article-title":"The human HMGB1 promoter is modulated by a silencer and an enhancer-containing intron","volume":"1520","author":"Lum","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.mvr.2013.12.005_bb0145","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1164\/rccm.200605-699OC","article-title":"Contribution of high-mobility group box-1 to the development of ventilator-induced lung injury","volume":"174","author":"Ogawa","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.mvr.2013.12.005_bb0150","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1161\/01.ATV.18.6.894","article-title":"Cyclic stretch upregulates production of interleukin-8 and monocyte chemotactic and activating factor\/monocyte chemoattractant protein-1 in human endothelial cells","volume":"18","author":"Okada","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0155","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1186\/cc8872","article-title":"Sepsis biomarkers: a review","volume":"14","author":"Pierrakos","year":"2010","journal-title":"Crit. Care"},{"key":"10.1016\/j.mvr.2013.12.005_bb0160","doi-asserted-by":"crossref","first-page":"L1282","DOI":"10.1152\/ajplung.00349.2003","article-title":"Activation of the STAT pathway in acute lung injury","volume":"286","author":"Severgnini","year":"2004","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0165","doi-asserted-by":"crossref","first-page":"L323","DOI":"10.1152\/ajplung.00442.2009","article-title":"cGMP increases antioxidant function and attenuates oxidant cell death in mouse lung microvascular endothelial cells by a protein kinase G-dependent mechanism","volume":"299","author":"Stephens","year":"2010","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0170","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1096\/fj.11-187955","article-title":"An essential role for Stat3 in regulating IgG immune complex-induced pulmonary inflammation","volume":"25","author":"Tang","year":"2011","journal-title":"FASEB J."},{"key":"10.1016\/j.mvr.2013.12.005_bb0175","first-page":"L1173","article-title":"Equibiaxial deformation-induced injury of alveolar epithelial cells in vitro","volume":"275","author":"Tschumperlin","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0180","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1152\/jappl.1999.86.6.2026","article-title":"Alveolar epithelial surface area\u2013volume relationship in isolated rat lungs","volume":"86","author":"Tschumperlin","year":"1999","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0185","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1164\/ajrccm.162.2.9807003","article-title":"Deformation-induced injury of alveolar epithelial cells. Effect of frequency, duration, and amplitude","volume":"162","author":"Tschumperlin","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.mvr.2013.12.005_bb0190","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1164\/rccm.200402-188OC","article-title":"Contributions of high mobility group box protein in experimental and clinical acute lung injury","volume":"170","author":"Ueno","year":"2004","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.mvr.2013.12.005_bb0195","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1097\/SHK.0b013e318157eddd","article-title":"Pulmonary levels of high-mobility group box 1 during mechanical ventilation and ventilator-associated pneumonia","volume":"29","author":"van Zoelen","year":"2008","journal-title":"Shock"},{"key":"10.1016\/j.mvr.2013.12.005_bb0200","first-page":"L150","article-title":"Hydrogen peroxide stimulates tyrosine phosphorylation of focal adhesion kinase in vascular endothelial cells","volume":"277","author":"Vepa","year":"1999","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0205","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1126\/science.285.5425.248","article-title":"HMG-1 as a late mediator of endotoxin lethality in mice","volume":"285","author":"Wang","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.mvr.2013.12.005_bb0210","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","article-title":"The acute respiratory distress syndrome","volume":"342","author":"Ware","year":"2000","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mvr.2013.12.005_bb0215","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.mvr.2010.11.010","article-title":"HMGB1 induces human lung endothelial cell cytoskeletal rearrangement and barrier disruption","volume":"81","author":"Wolfson","year":"2011","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2013.12.005_bb0220","doi-asserted-by":"crossref","first-page":"L881","DOI":"10.1152\/ajplung.90562.2008","article-title":"Influence of cytoskeletal structure and mechanics on epithelial cell injury during cyclic airway reopening","volume":"297","author":"Yalcin","year":"2009","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.mvr.2013.12.005_bb0225","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s11010-012-1226-x","article-title":"Heat shock transcription factor 1 inhibits H\u2082O\u2082-induced cardiomyocyte death through suppression of high-mobility group box 1","volume":"364","author":"Yu","year":"2012","journal-title":"Mol. Cell. Biochem."}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286213002069?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286213002069?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,5]],"date-time":"2019-08-05T09:28:56Z","timestamp":1564997336000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286213002069"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,3]]},"references-count":45,"alternative-id":["S0026286213002069"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2013.12.005","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2014,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Excessive mechanical stress increases HMGB1 expression in human lung microvascular endothelial cells via STAT3","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2013.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}