{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T01:09:36Z","timestamp":1776820176898,"version":"3.51.2"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"MERST","award":["LR11IPT08"],"award-info":[{"award-number":["LR11IPT08"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2014,9]]},"DOI":"10.1016\/j.mvr.2014.08.006","type":"journal-article","created":{"date-parts":[[2014,8,28]],"date-time":"2014-08-28T12:13:45Z","timestamp":1409228025000},"page":"149-156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["PIVL, a snake venom Kunitz-type serine protease inhibitor, inhibits in vitro and in vivo angiogenesis"],"prefix":"10.1016","volume":"95","author":[{"given":"Maram","family":"Morjen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Honor\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amine","family":"Bazaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zaineb","family":"Abdelkafi-Koubaa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ameneallah","family":"Ellafi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kamel","family":"Mabrouk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Herv\u00e9","family":"Kovacic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"El Ayeb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naziha","family":"Marrakchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9","family":"Luis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2014.08.006_bb0005","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1517\/13543784.14.12.1475","article-title":"Targeting integrins for the control of tumour angiogenesis","volume":"14","author":"Akalu","year":"2005","journal-title":"Expert Opin. Investig. Drugs"},{"key":"10.1016\/j.mvr.2014.08.006_bb0010","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/10623320600698037","article-title":"Vascular integrins in tumor angiogenesis: mediators and therapeutic targets","volume":"13","author":"Alghisi","year":"2006","journal-title":"Endothelium"},{"key":"10.1016\/j.mvr.2014.08.006_bb0015","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s10911-010-9186-9","article-title":"The mammary gland vasculature revisited","volume":"15","author":"Andres","year":"2010","journal-title":"J. Mammary Gland Biol. Neoplasia"},{"key":"10.1016\/j.mvr.2014.08.006_bb0020","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.jss.2008.04.023","article-title":"The role of vascular endothelial growth factor in wound healing","volume":"153","author":"Bao","year":"2009","journal-title":"J. Surg. Res."},{"key":"10.1016\/j.mvr.2014.08.006_bb0025","first-page":"1843","article-title":"The microtubule-affecting drug paclitaxel has antiangiogenic activity","volume":"2","author":"Belotti","year":"1996","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.mvr.2014.08.006_bb0030","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1016\/j.toxicon.2005.02.024","article-title":"Snake venom disintegrins: evolution of structure and function","volume":"45","author":"Calvete","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.mvr.2014.08.006_bb0035","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1172\/JCI32239","article-title":"Angiogenesis modulates adipogenesis and obesity","volume":"117","author":"Cao","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mvr.2014.08.006_bb0040","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.toxicon.2009.08.012","article-title":"Structure-function studies on inhibitory activity of Bungarus multicinctus protease inhibitor-like protein on matrix metalloprotease-2, and invasion and migration of human neuroblastoma SK-N-SH cells","volume":"55","author":"Chou","year":"2010","journal-title":"Toxicon"},{"key":"10.1016\/j.mvr.2014.08.006_bb0045","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1091\/mbc.E02-01-0006","article-title":"Rac regulates endothelial morphogenesis and capillary assembly","volume":"13","author":"Connolly","year":"2002","journal-title":"Mol. Biol. Cell"},{"key":"10.1016\/j.mvr.2014.08.006_bb0050","doi-asserted-by":"crossref","first-page":"844","DOI":"10.2353\/ajpath.2009.080920","article-title":"Expression of integrin alpha6beta1 enhances tumorigenesis in glioma cells","volume":"175","author":"Delamarre","year":"2009","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mvr.2014.08.006_bb0055","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ceb.2006.12.013","article-title":"Integrins and the actin cytoskeleton","volume":"19","author":"Delon","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.mvr.2014.08.006_bb0060","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.acthis.2009.04.004","article-title":"Vasculogenesis and angiogenesis in the endometrium during menstrual cycle and implantation","volume":"112","author":"Demir","year":"2010","journal-title":"Acta Histochem."},{"key":"10.1016\/j.mvr.2014.08.006_bb0065","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.toxicon.2012.04.349","article-title":"Actions of the Kunitz-type serine protease inhibitor Amblyomin-X on VEGF-A-induced angiogenesis","volume":"60","author":"Drewes","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.mvr.2014.08.006_bb0070","doi-asserted-by":"crossref","first-page":"10931","DOI":"10.1016\/S0021-9258(19)49853-0","article-title":"Angiogenesis","volume":"267","author":"Folkman","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mvr.2014.08.006_bb0075","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1083\/jcb.200909003","article-title":"Plasticity of cell migration: a multiscale tuning model","volume":"188","author":"Friedl","year":"2010","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mvr.2014.08.006_bb0080","doi-asserted-by":"crossref","first-page":"43359","DOI":"10.1074\/jbc.M112.423905","article-title":"The role of microtubules and their dynamics in cell migration","volume":"287","author":"Ganguly","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mvr.2014.08.006_bb0085","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1089\/lrb.2008.1011","article-title":"Roles of integrins in tumor angiogenesis and lymphangiogenesis","volume":"6","author":"Garmy-Susini","year":"2008","journal-title":"Lymphat. Res. Biol."},{"key":"10.1016\/j.mvr.2014.08.006_bb0090","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/2191-0855-2-14","article-title":"High level expression of bikunin in Pichia pastoris by fusion of human serum albumin","volume":"2","author":"Gou","year":"2012","journal-title":"AMB Express"},{"key":"10.1016\/j.mvr.2014.08.006_bb0095","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/ijc.10907","article-title":"Comparison of antiangiogenic activities using paclitaxel (taxol) and docetaxel (taxotere)","volume":"104","author":"Grant","year":"2003","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.mvr.2014.08.006_bb0100","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nrm1490","article-title":"Integrin signalling during tumour progression","volume":"5","author":"Guo","year":"2004","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.mvr.2014.08.006_bb0105","first-page":"417","article-title":"In vitro pharmacological characterizations of the anti-angiogenic and anti-tumor cell migration properties mediated by microtubule-affecting drugs, with special emphasis on the organization of the actin cytoskeleton","volume":"21","author":"Hayot","year":"2002","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.mvr.2014.08.006_bb0110","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1158\/1535-7163.MCT-08-0156","article-title":"Antiangiogenic vinflunine affects EB1 localization and microtubule targeting to adhesion sites","volume":"7","author":"Honore","year":"2008","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.mvr.2014.08.006_bb0115","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1007\/s00018-005-5330-x","article-title":"Understanding microtubule dynamics for improved cancer therapy","volume":"62","author":"Honore","year":"2005","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mvr.2014.08.006_bb0120","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.mvr.2014.08.006_bb0125","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1006\/bbrc.1998.8536","article-title":"Effect of microtubule disruption on cell adhesion and spreading","volume":"246","author":"Kadi","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mvr.2014.08.006_bb0130","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1083\/jcb.146.5.1033","article-title":"Microtubule targeting of substrate contacts promotes their relaxation and dissociation","volume":"146","author":"Kaverina","year":"1999","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.mvr.2014.08.006_bb0135","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/labinvest.2009.137","article-title":"CC-PLA2-1 and CC-PLA2-2, two Cerastes cerastes venom-derived phospholipases A2, inhibit angiogenesis both in vitro and in vivo","volume":"90","author":"Kessentini-Zouari","year":"2010","journal-title":"Lab. Invest."},{"key":"10.1016\/j.mvr.2014.08.006_bb0140","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1172\/JCI8829","article-title":"Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity","volume":"105","author":"Klement","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mvr.2014.08.006_bb0145","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1093\/cvr\/cvm007","article-title":"Angiogenesis and obesity","volume":"78","author":"Lijnen","year":"2008","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mvr.2014.08.006_bb0150","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.matbio.2009.09.009","article-title":"Leberagin-C, a disintegrin-like\/cysteine-rich protein from Macrovipera lebetina transmediterranea venom, inhibits alphavbeta3 integrin-mediated cell adhesion","volume":"29","author":"Limam","year":"2010","journal-title":"Matrix Biol."},{"key":"10.1016\/j.mvr.2014.08.006_bb0155","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.toxicon.2005.02.022","article-title":"Snake venom C-type lectins interacting with platelet receptors. Structure\u2013function relationships and effects on haemostasis","volume":"45","author":"Lu","year":"2005","journal-title":"Toxicon"},{"key":"10.1016\/j.mvr.2014.08.006_bb0160","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2174\/1568006043335880","article-title":"Disintegrins","volume":"4","author":"McLane","year":"2004","journal-title":"Curr. Drug Targets Cardiovasc. Haematol. Disord."},{"key":"10.1016\/j.mvr.2014.08.006_bb0165","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.pep.2009.02.005","article-title":"High-yield production and characterization of biologically active recombinant aprotinin expressed in Saccharomyces cerevisiae","volume":"66","author":"Meta","year":"2009","journal-title":"Protein Expr. Purif."},{"key":"10.1016\/j.mvr.2014.08.006_bb0170","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.matbio.2012.11.015","article-title":"PIVL, a new serine protease inhibitor from Macrovipera lebetina transmediterranea venom, impairs motility of human glioblastoma cells","volume":"32","author":"Morjen","year":"2013","journal-title":"Matrix Biol."},{"key":"10.1016\/j.mvr.2014.08.006_bb0175","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.bcp.2012.05.010","article-title":"Epothilone B inhibits migration of glioblastoma cells by inducing microtubule catastrophes and affecting EB1 accumulation at microtubule plus ends","volume":"84","author":"Pagano","year":"2012","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mvr.2014.08.006_bb0180","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1158\/1535-7163.1301.3.10","article-title":"Antiangiogenic activity of paclitaxel is associated with its cytostatic effect, mediated by the initiation but not completion of a mitochondrial apoptotic signaling pathway","volume":"3","author":"Pasquier","year":"2004","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.mvr.2014.08.006_bb0185","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1158\/0008-5472.CAN-04-2624","article-title":"Antiangiogenic concentrations of paclitaxel induce an increase in microtubule dynamics in endothelial cells but not in cancer cells","volume":"65","author":"Pasquier","year":"2005","journal-title":"Cancer Res."},{"key":"10.1016\/j.mvr.2014.08.006_bb0190","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1002\/jcp.20935","article-title":"Lebectin, a Macrovipera lebetina venom-derived C-type lectin, inhibits angiogenesis both in vitro and in vivo","volume":"211","author":"Pilorget","year":"2007","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.mvr.2014.08.006_bb0195","doi-asserted-by":"crossref","first-page":"3256","DOI":"10.1158\/0008-5472.CAN-05-3885","article-title":"Antiangiogenic concentrations of vinflunine increase the interphase microtubule dynamics and decrease the motility of endothelial cells","volume":"66","author":"Pourroy","year":"2006","journal-title":"Cancer Res."},{"key":"10.1016\/j.mvr.2014.08.006_bb0200","doi-asserted-by":"crossref","first-page":"6458","DOI":"10.1038\/sj.onc.1206789","article-title":"Vinblastine inhibits the angiogenic response induced by adrenomedullin in vitro and in vivo","volume":"22","author":"Ribatti","year":"2003","journal-title":"Oncogene"},{"issue":"Pt 20","key":"10.1016\/j.mvr.2014.08.006_bb0205","doi-asserted-by":"crossref","first-page":"3119","DOI":"10.1242\/jcs.111.20.3119","article-title":"Integrin ligation and PKC activation are required for migration of colon carcinoma cells","volume":"111","author":"Rigot","year":"1998","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mvr.2014.08.006_bb0210","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/386671a0","article-title":"Mechanisms of angiogenesis","volume":"386","author":"Risau","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.mvr.2014.08.006_bb0215","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1007\/s10439-011-0325-2","article-title":"Angiogenesis-associated crosstalk between collagens, CXC chemokines, and thrombospondin domain-containing proteins","volume":"39","author":"Rivera","year":"2011","journal-title":"Ann. Biomed. Eng."},{"key":"10.1016\/j.mvr.2014.08.006_bb0220","doi-asserted-by":"crossref","first-page":"e65694","DOI":"10.1371\/journal.pone.0065694","article-title":"Anti-migratory effect of vinflunine in endothelial and glioblastoma cells is associated with changes in EB1 C-terminal detyrosinated\/tyrosinated status","volume":"8","author":"Rovini","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mvr.2014.08.006_bb0225","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.matbio.2007.01.001","article-title":"Lebectin and lebecetin, two C-type lectins from snake venom, inhibit alpha5beta1 and alphaV-containing integrins","volume":"26","author":"Sarray","year":"2007","journal-title":"Matrix Biol."},{"key":"10.1016\/j.mvr.2014.08.006_bb0230","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0070-2153(04)64009-9","article-title":"Integrins and angiogenesis","volume":"64","author":"Stupack","year":"2004","journal-title":"Curr. Top. Dev. Biol."},{"key":"10.1016\/j.mvr.2014.08.006_bb0235","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000092418","article-title":"Contortrostatin, a snake venom disintegrin with anti-angiogenic and anti-tumor activity","volume":"34","author":"Swenson","year":"2005","journal-title":"Pathophysiol. Haemost. Thromb."},{"key":"10.1016\/j.mvr.2014.08.006_bb0240","doi-asserted-by":"crossref","first-page":"2860","DOI":"10.2174\/138161207782023793","article-title":"Anti-angiogenesis and RGD-containing snake venom disintegrins","volume":"13","author":"Swenson","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.mvr.2014.08.006_bb0245","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/00001813-200301000-00003","article-title":"Paclitaxel at ultra low concentrations inhibits angiogenesis without affecting cellular microtubule assembly","volume":"14","author":"Wang","year":"2003","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.mvr.2014.08.006_bb0250","doi-asserted-by":"crossref","first-page":"692549","DOI":"10.1155\/2013\/692549","article-title":"Fucoidan inhibits the growth of hepatocellular carcinoma independent of angiogenesis","volume":"2013","author":"Zhu","year":"2013","journal-title":"Evid. Based Complement. Alternat. Med."}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286214001265?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286214001265?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,7,16]],"date-time":"2023-07-16T08:13:47Z","timestamp":1689495227000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286214001265"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9]]},"references-count":50,"alternative-id":["S0026286214001265"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2014.08.006","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2014,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PIVL, a snake venom Kunitz-type serine protease inhibitor, inhibits in vitro and in vivo angiogenesis","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2014.08.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}