{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T18:58:46Z","timestamp":1778785126884,"version":"3.51.4"},"reference-count":27,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2015,5,1]],"date-time":"2015-05-01T00:00:00Z","timestamp":1430438400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31171211"],"award-info":[{"award-number":["31171211"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81300115"],"award-info":[{"award-number":["81300115"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2015,5]]},"DOI":"10.1016\/j.mvr.2015.02.003","type":"journal-article","created":{"date-parts":[[2015,2,21]],"date-time":"2015-02-21T02:00:41Z","timestamp":1424484041000},"page":"36-42","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["flg2 as a potential biomarker of acute cerebral ischemic-reperfusion injury"],"prefix":"10.1016","volume":"99","author":[{"given":"Ping","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nian","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinsha","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2015.02.003_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1559-0275-11-1","article-title":"Differential proteomic analysis of synovial fluid from rheumatoid arthritis and osteoarthritis patients","volume":"11","author":"Balakrishnan","year":"2014","journal-title":"Clin. Proteomics."},{"key":"10.1016\/j.mvr.2015.02.003_bb0010","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.pbb.2014.03.004","article-title":"Asiaticoside attenuates memory impairment induced by transient cerebral ischemia-reperfusion in mice through anti-inflammatory mechanism","volume":"122","author":"Chen","year":"2014","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.mvr.2015.02.003_bb0015","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1038\/jcbfm.2012.139","article-title":"Can restoring incomplete microcirculatory reperfusion improve stroke outcome after thrombolysis?","volume":"32","author":"Dalkara","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.mvr.2015.02.003_bb0020","doi-asserted-by":"crossref","first-page":"365","DOI":"10.2176\/nmc.53.365","article-title":"Anti-inflammatory effect of D-allose in cerebral ischemia\/reperfusion injury in rats","volume":"53","author":"Gao","year":"2013","journal-title":"Neurol. Med. Chir. (Tokyo)"},{"key":"10.1016\/j.mvr.2015.02.003_bb0025","doi-asserted-by":"crossref","first-page":"e28","DOI":"10.1161\/01.cir.0000441139.02102.80","article-title":"Heart disease and stroke statistics\u20142014 update: a report from the American Heart Association","volume":"129","author":"Go","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.mvr.2015.02.003_bb0030","doi-asserted-by":"crossref","first-page":"2007","DOI":"10.1073\/pnas.94.5.2007","article-title":"Inhibition of interleukin-1b converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage","volume":"94","author":"Hara","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mvr.2015.02.003_bb0035","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0166-2236(95)80029-2","article-title":"Cytokines and the nervous system. I: Expression and recognition","volume":"18","author":"Hopkins","year":"1995","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.mvr.2015.02.003_bb0040","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jjcc.2014.03.008","article-title":"The \u201cno reflow\u201d phenomenon following acute myocardial infarction: mechanisms and treatment options","volume":"64","author":"Kaul","year":"2014","journal-title":"J. Cardiol."},{"key":"10.1016\/j.mvr.2015.02.003_bb0045","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/1756-6606-7-28","article-title":"Intrathecal antagonism of microglial TLR4 reduces inflammatory damage to blood-spinal cord barrier following ischemia\/reperfusion injury in rats","volume":"7","author":"Li","year":"2014","journal-title":"Mol. Brain"},{"key":"10.1016\/j.mvr.2015.02.003_bb0050","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.biocel.2012.10.014","article-title":"Characterization of fibrinogen-like protein 2 (FGL2): monomeric FGL2 has enhanced immunosuppressive activity in comparison to oligomeric FGL2","volume":"45","author":"Liu","year":"2013","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.mvr.2015.02.003_bb0055","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1161\/01.STR.25.7.1469","article-title":"Correlation between myeloperoxidase-quantified neutrophil accumulation and ischemic brain injury in the rat. Effects of neutrophil depletion","volume":"25","author":"Matsuo","year":"1994","journal-title":"Stroke"},{"key":"10.1016\/j.mvr.2015.02.003_bb0060","doi-asserted-by":"crossref","first-page":"e98706","DOI":"10.1371\/journal.pone.0098706","article-title":"Neuroproteome changes after ischemia\/reperfusion injury and tissue plasminogen activator administration in rats: a quantitative iTRAQ proteomics study","volume":"9","author":"Merali","year":"2014","journal-title":"PLoS ONE"},{"issue":"9","key":"10.1016\/j.mvr.2015.02.003_bb0065","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s10072-014-1725-5","article-title":"Hesperidin attenuates oxidative and neuronal damage caused by global cerebral ischemia\/reperfusion in a C57BL\/J6 mouse model","volume":"35","author":"Oztanir","year":"2014","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.mvr.2015.02.003_bb0070","series-title":"Murine lymphoid procoagulant activity induced by bacterial lipopolysaccharide and immune complexes is a monocyte prothrombinase","first-page":"1464","volume":"155","author":"Schwartz","year":"1982"},{"key":"10.1016\/j.mvr.2015.02.003_bb0075","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1177\/1076029612437577","article-title":"The significance of microthrombosis and fgl2 in no-reflow phenomenon of rats with acute myocardial ischemia\/reperfusion","volume":"19","author":"Shao","year":"2013","journal-title":"Clin. Appl. Thromb. Hemost."},{"key":"10.1016\/j.mvr.2015.02.003_bb0080","doi-asserted-by":"crossref","first-page":"e26288","DOI":"10.1371\/journal.pone.0026288","article-title":"Attenuated inflammatory response in aged mice brains following stroke","volume":"6","author":"Sieber","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mvr.2015.02.003_bb0085","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1161\/STROKEAHA.113.003874","article-title":"Drivers of costs associated with reperfusion therapy in acute stroke: The Interventional Management of Stroke III Trial","volume":"45","author":"Simpson","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.mvr.2015.02.003_bb0090","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.nbd.2014.03.010","article-title":"Inhibition of junctional adhesion molecule-A\/LFA interaction attenuates leukocyte trafficking and inflammation in brain ischemia\/reperfusion injury","volume":"67","author":"Sladojevic","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.mvr.2015.02.003_bb0095","doi-asserted-by":"crossref","first-page":"5980","DOI":"10.3748\/wjg.14.5980","article-title":"Fibrinogen-like protein 2\/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-\u03b3","volume":"14","author":"Su","year":"2008","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.mvr.2015.02.003_bb0100","doi-asserted-by":"crossref","first-page":"e62448","DOI":"10.1371\/journal.pone.0062448","article-title":"Nelfinavir inhibits intra-mitochondrial calcium influx and protects brain against hypoxic\u2013ischemic injury in neonatal mice","volume":"8","author":"Utkina-Sosunova","year":"2013","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mvr.2015.02.003_bb0105","doi-asserted-by":"crossref","first-page":"e90107","DOI":"10.1371\/journal.pone.0090107","article-title":"Targeted delivery of erythropoietin by transcranial focused ultrasound for neuroprotection against ischemia\/reperfusion-induced neuronal injury: a long-term and short-term study","volume":"9","author":"Wu","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.mvr.2015.02.003_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/hep.27114","article-title":"C5a\/C5aR pathway is essential for the pathogenesis of murine viral fulminant hepatitis via potentiating Fgl2\/fibroleukin expression","author":"Xu","year":"2014","journal-title":"Hepatology"},{"key":"10.1016\/j.mvr.2015.02.003_bb0115","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.imlet.2013.11.008","article-title":"Tumor necrosis factor \u03b1 (TNF-\u03b1) receptor-I is required for TNF-\u03b1-mediated fulminant virus hepatitis caused by murine hepatitis virus strain-3 infection","volume":"158","author":"Xu","year":"2014","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.mvr.2015.02.003_bb0120","doi-asserted-by":"crossref","first-page":"85","DOI":"10.3892\/etm.2013.1354","article-title":"Correlation of fibrinogen-like protein 2 with disease progression in patients with severe acute pancreatitis","volume":"7","author":"Ye","year":"2014","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.mvr.2015.02.003_bb0125","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.brainres.2012.10.046","article-title":"Exogenous hydrogen sulfide protects against global cerebral ischemia\/reperfusion injury via its anti-oxidative, anti-inflammatory and anti-apoptotic effects in rats","volume":"491","author":"Yin","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.mvr.2015.02.003_bb0130","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1479-5876-12-53","article-title":"Increased peripheral and local soluble FGL2 in the recovery of renal ischemia reperfusion injury in a porcine kidney auto-transplantation model","volume":"12","author":"Zhao","year":"2014","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.mvr.2015.02.003_bb0135","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1179\/016164109X12581096796431","article-title":"Pre-ischemic exercise preserves cerebral blood flow during reperfusion in stroke","volume":"32","author":"Zwagerman","year":"2010","journal-title":"Neurol. Res."}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002628621500014X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002628621500014X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:10:51Z","timestamp":1566346251000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002628621500014X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":27,"alternative-id":["S002628621500014X"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2015.02.003","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2015,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"flg2 as a potential biomarker of acute cerebral ischemic-reperfusion injury","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2015.02.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}