{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:49:28Z","timestamp":1773301768056,"version":"3.50.1"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Defense Health Program","award":["603115HP.3730.001.A1247"],"award-info":[{"award-number":["603115HP.3730.001.A1247"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.mvr.2016.06.001","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T17:34:25Z","timestamp":1465320865000},"page":"83-90","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Sanguinate's effect on pial arterioles in healthy rats and cerebral oxygen tension after controlled cortical impact"],"prefix":"10.1016","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2694-7473","authenticated-orcid":false,"given":"Saad H.","family":"Mullah","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania","family":"Abutarboush","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9654-9740","authenticated-orcid":false,"given":"Paula F.","family":"Moon-Massat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biswajit K.","family":"Saha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashraful","family":"Haque","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter B.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles R.","family":"Auker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francoise G.","family":"Arnaud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard M.","family":"McCarron","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke H.","family":"Scultetus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2016.06.001_bb0005","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2174\/15701638113109990034","article-title":"Effects of N-acetyl-l-cysteine and hyaluronic acid on HBOC-201-induced systemic and cerebral vasoconstriction in the rat","volume":"10","author":"Abutarboush","year":"2013","journal-title":"Curr. Drug Discov. Technol."},{"key":"10.1016\/j.mvr.2016.06.001_bb0010","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1081\/BIO-200066365","article-title":"Enhanced molecular volume of conservatively pegylated Hb: (SP-PEG5K)6-HbA is non-hypertensive","volume":"33","author":"Acharya","year":"2005","journal-title":"Artif. Cells Blood Substit. Immobil. Biotechnol."},{"key":"10.1016\/j.mvr.2016.06.001_bb0015","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nrd1307","article-title":"Oxygen therapeutics: can we tame haemoglobin?","volume":"3","author":"Alayash","year":"2004","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.mvr.2016.06.001_bb0020","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1517\/14712598.7.5.665","article-title":"First-generation blood substitutes: what have we learned? Biochemical and physiological perspectives.","volume":"7","author":"Alayash","year":"2007","journal-title":"Expert. Opin. Biol. Ther."},{"key":"10.1016\/j.mvr.2016.06.001_bb0025","doi-asserted-by":"crossref","first-page":"12705","DOI":"10.1073\/pnas.1105860108","article-title":"Blast-induced phenotypic switching in cerebral vasospasm","volume":"108","author":"Alford","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mvr.2016.06.001_bb0030","doi-asserted-by":"crossref","first-page":"428","DOI":"10.3109\/21691401.2012.762370","article-title":"Carbon monoxide form of PEGylated hemoglobin protects myocardium against ischemia\/reperfusion injury in diabetic and normal mice","volume":"41","author":"Ananthakrishnan","year":"2013","journal-title":"Artif. Cells Nanomed. Biotechnol."},{"key":"10.1016\/j.mvr.2016.06.001_bb0035","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1001\/archsurg.2012.1560","article-title":"Association between early hyperoxia and worse outcomes after traumatic brain injury","volume":"147","author":"Brenner","year":"2012","journal-title":"Arch. Surg."},{"key":"10.1016\/j.mvr.2016.06.001_bb0040","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1097\/01.ta.0000196644.64653.d8","article-title":"Prehospital hypoxia affects outcome in patients with traumatic brain injury: a prospective multicenter study","volume":"61","author":"Chi","year":"2006","journal-title":"J. Trauma"},{"key":"10.1016\/j.mvr.2016.06.001_bb0045","doi-asserted-by":"crossref","first-page":"114","DOI":"10.4103\/1658-354X.125971","article-title":"Pre-hospital and initial management of head injury patients: an update","volume":"8","author":"Chowdhury","year":"2014","journal-title":"Saudi J. Anaesth."},{"key":"10.1016\/j.mvr.2016.06.001_bb0050","first-page":"238","article-title":"The effects of hemodilution with polyethylene glycol bovine hemoglobin (PEG-Hb) in a conscious porcine model","volume":"44","author":"Conover","year":"1996","journal-title":"J. Investig. Med."},{"key":"10.1016\/j.mvr.2016.06.001_bb0055","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1111\/j.1525-1594.1997.tb00733.x","article-title":"Physiological effect of polyethylene glycol conjugation on stroma-free bovine hemoglobin in the conscious dog after partial exchange transfusion","volume":"21","author":"Conover","year":"1997","journal-title":"Artif. Organs"},{"key":"10.1016\/j.mvr.2016.06.001_bb0060","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1227\/01.NEU.0000119238.68938.5D","article-title":"Perfluorocarbon emulsion improves cerebral oxygenation and mitochondrial function after fluid percussion brain injury in rats","volume":"54","author":"Daugherty","year":"2004","journal-title":"Neurosurgery"},{"key":"10.1016\/j.mvr.2016.06.001_bb0065","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1177\/0192623314538345","article-title":"Neuroanatomy-based matrix-guided trimming protocol for the rat brain","volume":"43","author":"Defazio","year":"2015","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.mvr.2016.06.001_bb0070","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1038\/nbt0798-672","article-title":"Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin","volume":"16","author":"Doherty","year":"1998","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.mvr.2016.06.001_bb0075","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0021-9258(18)74965-X","article-title":"Spectrophotometric studies II. Preparations from washed blood cells; nitric oxide hemoglobin and sulfhemoglobin","volume":"112","author":"Drabkin","year":"1935","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mvr.2016.06.001_bb0080","doi-asserted-by":"crossref","first-page":"8756","DOI":"10.1021\/ac2022234","article-title":"Two new \u201cprotected\u201d oxyphors for biological oximetry: properties and application in tumor imaging","volume":"83","author":"Esipova","year":"2011","journal-title":"Anal. Chem."},{"key":"10.1016\/j.mvr.2016.06.001_bb0085","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/S0021-9258(18)73873-8","article-title":"Microdetermination of oxyhemoglobin, methemoglobin, and sulfhemoglobin in a single sample of blood","volume":"126","author":"Evelyn","year":"1938","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mvr.2016.06.001_bb0090","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1213\/01.ANE.0000136769.65960.D1","article-title":"Increased cerebral tissue oxygen tension after extensive hemodilution with a hemoglobin-based oxygen carrier","volume":"99","author":"Hare","year":"2004","journal-title":"Anesth. Analg."},{"key":"10.1016\/j.mvr.2016.06.001_bb0095","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3109\/10731199.2010.488635","article-title":"Early treatment of transient focal cerebral ischemia with bovine PEGylated carboxy hemoglobin transfusion","volume":"38","author":"Klaus","year":"2010","journal-title":"Artif. Cells Blood Substit. Immobil. Biotechnol."},{"key":"10.1016\/j.mvr.2016.06.001_bb0100","doi-asserted-by":"crossref","first-page":"H1","DOI":"10.1152\/ajpheart.00230.2011","article-title":"Carbon monoxide as an endogenous vascular modulator","volume":"301","author":"Leffler","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mvr.2016.06.001_bb0105","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1161\/01.STR.6.3.308","article-title":"Detailed description of a cranial window technique for acute and chronic experiments","volume":"6","author":"Levasseur","year":"1975","journal-title":"Stroke"},{"key":"10.1016\/j.mvr.2016.06.001_bb0110","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1007\/s11910-012-0303-6","article-title":"Neuropathology of explosive blast traumatic brain injury","volume":"12","author":"Magnuson","year":"2012","journal-title":"Curr. Neurol. Neurosci. Rep."},{"key":"10.1016\/j.mvr.2016.06.001_bb0115","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/01.TA.0000103983.22362.67","article-title":"Laser Doppler flow and brain tissue PO2 after cortical impact injury complicated by secondary ischemia in rats treated with arginine","volume":"57","author":"Mendez","year":"2004","journal-title":"J. Trauma"},{"key":"10.1016\/j.mvr.2016.06.001_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/jns.1999.91.1.0001","article-title":"Increased inspired oxygen concentration as a factor in improved brain tissue oxygenation and tissue lactate levels after severe human head injury","volume":"91","author":"Menzel","year":"1999","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.mvr.2016.06.001_bb0125","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1097\/00008506-199910000-00003","article-title":"Cerebral oxygenation in patients after severe head injury: monitoring and effects of arterial hyperoxia on cerebral blood flow, metabolism and intracranial pressure","volume":"11","author":"Menzel","year":"1999","journal-title":"J. Neurosurg. Anesthesiol."},{"key":"10.1016\/j.mvr.2016.06.001_bb0130","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/aor.12341","article-title":"PEGylated carboxyhemoglobin bovine (SANGUINATE): results of a phase I clinical trial","volume":"38","author":"Misra","year":"2014","journal-title":"Artif. Organs"},{"key":"10.1016\/j.mvr.2016.06.001_bb0135","doi-asserted-by":"crossref","DOI":"10.1089\/neu.2015.3908","article-title":"Cerebral vasoactivity and oxygenation with oxygen carrier M101 in rats","author":"Moon-Massat","year":"2015","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.mvr.2016.06.001_bb0140","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/978-3-7091-1434-6_15","article-title":"A selective adenosine A2A receptor antagonist ameliorated hyperlocomotion in an animal model of lateral fluid percussion brain injury","volume":"118","author":"Mullah","year":"2013","journal-title":"Acta Neurochir. Suppl."},{"key":"10.1016\/j.mvr.2016.06.001_bb0145","first-page":"744","article-title":"Attenuation of brain injury induced cognitive dysfunction and hyperlocomotion: chronic administration enhanced the effects of adenosine A2A receptor antagonist","volume":"28","author":"Mullah","year":"2014","journal-title":"Brain Inj."},{"key":"10.1016\/j.mvr.2016.06.001_bb0150","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.brainres.2016.01.012","article-title":"Perfluorocarbon NVX-108 increased cerebral oxygen tension after traumatic brain injury in rats","volume":"1634","author":"Mullah","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.mvr.2016.06.001_bb0155","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3171\/2009.4.JNS081150","article-title":"Brain tissue oxygen monitoring in traumatic brain injury and major trauma: outcome analysis of a brain tissue oxygen-directed therapy","volume":"111","author":"Narotam","year":"2009","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.mvr.2016.06.001_bb0160","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1001\/jama.299.19.jrv80007","article-title":"Cell-free hemoglobin-based blood substitutes and risk of myocardial infarction and death: a meta-analysis","volume":"299","author":"Natanson","year":"2008","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.mvr.2016.06.001_bb0165","first-page":"511","article-title":"PEG-bovine hemoglobin: safety in a canine dehydrated hypovolemic-hemorrhagic shock model","volume":"20","author":"Nho","year":"1992","journal-title":"Biomater. Artif. Cells Immobil. Biotechnol."},{"key":"10.1016\/j.mvr.2016.06.001_bb0170","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.freeradbiomed.2003.11.030","article-title":"No scavenging and the hypertensive effect of hemoglobin-based blood substitutes","volume":"36","author":"Olson","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.mvr.2016.06.001_bb0175","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.trre.2011.01.004","article-title":"Use of carbon monoxide in minimizing ischemia\/reperfusion injury in transplantation","volume":"26","author":"Ozaki","year":"2012","journal-title":"Transplant. Rev. (Orlando)"},{"key":"10.1016\/j.mvr.2016.06.001_bb0180","doi-asserted-by":"crossref","first-page":"H1600","DOI":"10.1152\/ajpheart.00077.2003","article-title":"Cerebrovascular response to decreased hematocrit: effect of cell-free hemoglobin, plasma viscosity, and CO2","volume":"285","author":"Rebel","year":"2003","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mvr.2016.06.001_bb0185","doi-asserted-by":"crossref","first-page":"H1027","DOI":"10.1152\/ajpheart.00500.2005","article-title":"Dependence of acetylcholine and ADP dilation of pial arterioles on heme oxygenase after transfusion of cell-free polymeric hemoglobin","volume":"290","author":"Rebel","year":"2006","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mvr.2016.06.001_bb0190","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1161\/01.STR.7.3.283","article-title":"Pial arteriolar responses in the mouse brain revisited","volume":"7","author":"Rosenblum","year":"1976","journal-title":"Stroke"},{"key":"10.1016\/j.mvr.2016.06.001_bb0195","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1001\/archneur.1963.00460100102012","article-title":"Cerebral microcirculation in the mouse brain. Spontaneous and drug-induced changes in flow and vascular diameter","volume":"9","author":"Rosenblum","year":"1963","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.mvr.2016.06.001_bb0200","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3171\/SPI\/2008\/9\/8\/213","article-title":"Reduction of hypoxia by perfluorocarbon emulsion in a traumatic spinal cord injury model","volume":"9","author":"Schroeder","year":"2008","journal-title":"J. Neurosurg. Spine"},{"key":"10.1016\/j.mvr.2016.06.001_bb0205","doi-asserted-by":"crossref","first-page":"570","DOI":"10.7205\/MILMED-D-12-00408","article-title":"Effects of top-loading a zero-link bovine hemoglobin, OxyVita, on systemic and microcirculatory variables","volume":"178","author":"Song","year":"2013","journal-title":"Mil. Med."},{"key":"10.1016\/j.mvr.2016.06.001_bb0210","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3171\/JNS\/2008\/109\/9\/0424","article-title":"Increase in cerebral aerobic metabolism by normobaric hyperoxia after traumatic brain injury","volume":"109","author":"Tisdall","year":"2008","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.mvr.2016.06.001_bb0215","doi-asserted-by":"crossref","first-page":"435","DOI":"10.3171\/jns.2004.101.3.0435","article-title":"Normobaric hyperoxia\u2013induced improvement in cerebral metabolism and reduction in intracranial pressure in patients with severe head injury: a prospective historical cohort-matched study","volume":"101","author":"Tolias","year":"2004","journal-title":"J. Neurosurg."},{"key":"10.1016\/j.mvr.2016.06.001_bb0220","doi-asserted-by":"crossref","first-page":"H1730","DOI":"10.1152\/ajpheart.00998.2004","article-title":"Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion","volume":"288","author":"Tsai","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mvr.2016.06.001_bb0225","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1182\/blood-2006-02-005272","article-title":"Dissociation of local nitric oxide concentration and vasoconstriction in the presence of cell-free hemoglobin oxygen carriers","volume":"108","author":"Tsai","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.mvr.2016.06.001_bb0230","first-page":"115","article-title":"Intravascular retention and renal handling of purified natural and intramolecularly cross-linked hemoglobins","volume":"117","author":"Urbaitis","year":"1991","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.mvr.2016.06.001_bb0235","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1038\/bjp.2008.219","article-title":"CO-MP4, a polyethylene glycol-conjugated haemoglobin derivative and carbon monoxide carrier that reduces myocardial infarct size in rats","volume":"154","author":"Vandegriff","year":"2008","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mvr.2016.06.001_bb0240","series-title":"Use of Sanguinate in Encephalopathy from Severe Sickle Cell Disease Anemia","author":"Varelas","year":"2014"},{"key":"10.1016\/j.mvr.2016.06.001_bb0245","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0006-8993(02)03161-X","article-title":"Administration of adenosine receptor agonists or antagonists after controlled cortical impact in mice: Effects on function and histopathology","volume":"951","author":"Varma","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.mvr.2016.06.001_bb0250","doi-asserted-by":"crossref","first-page":"763","DOI":"10.3109\/10731199409117909","article-title":"Concepts of \u201ctissue PO2\u201d in relation to O2 delivery","volume":"22","author":"Weiner","year":"1994","journal-title":"Artif. Cells Blood Substit. Immobil. Biotechnol."},{"key":"10.1016\/j.mvr.2016.06.001_bb0255","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1097\/01.CCM.0000069340.16319.F2","article-title":"Resuscitation with polyethylene glycol-modified human hemoglobin improves microcirculatory blood flow and tissue oxygenation after hemorrhagic shock in awake hamsters","volume":"31","author":"Wettstein","year":"2003","journal-title":"Crit. Care Med."},{"issue":"101","key":"10.1016\/j.mvr.2016.06.001_bb0260","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1152\/japplphysiol.00394.2006","article-title":"Oxygen pressures in the interstitial space and their relationship to those in the blood plasma in resting skeletal muscle","volume":"1985","author":"Wilson","year":"2006","journal-title":"J. Appl. Physiol."},{"issue":"7","key":"10.1016\/j.mvr.2016.06.001_bb2000","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1111\/anae.12227","article-title":"Quantitative assessment of brain microvascular and tissue oxygenation during cardiac arrest andresuscitation in pigs","volume":"68","author":"Yu","year":"2013","journal-title":"Anaesthesia"},{"issue":"113","key":"10.1016\/j.mvr.2016.06.001_bb0265","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1152\/japplphysiol.01079.2012","article-title":"Transfusion of hemoglobin-based oxygen carriers in the carboxy state is beneficial during transient focal cerebral ischemia","volume":"1985","author":"Zhang","year":"2012","journal-title":"J. Appl. Physiol."}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0026286216300541?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0026286216300541?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,18]],"date-time":"2023-08-18T19:59:40Z","timestamp":1692388780000},"score":1,"resource":{"primary":{"URL":"http:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286216300541"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":54,"alternative-id":["S0026286216300541"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2016.06.001","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sanguinate's effect on pial arterioles in healthy rats and cerebral oxygen tension after controlled cortical impact","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"http:\/\/dx.doi.org\/10.1016\/j.mvr.2016.06.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}