{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T04:18:23Z","timestamp":1782793103859,"version":"3.54.5"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81400335"],"award-info":[{"award-number":["81400335"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500214"],"award-info":[{"award-number":["81500214"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2015GXNSFBA139174"],"award-info":[{"award-number":["2015GXNSFBA139174"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science Research Project of High Education of Guangxi Province","award":["KY2015YB179"],"award-info":[{"award-number":["KY2015YB179"]}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2015GXNSFAA139145"],"award-info":[{"award-number":["2015GXNSFAA139145"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.mvr.2018.05.003","type":"journal-article","created":{"date-parts":[[2018,5,16]],"date-time":"2018-05-16T23:40:26Z","timestamp":1526514026000},"page":"8-12","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"special_numbering":"C","title":["Homocysteine induces vascular inflammatory response via SMAD7 hypermethylation in human umbilical vein smooth muscle cells"],"prefix":"10.1016","volume":"120","author":[{"given":"Li-hua","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-xia","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-ting","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-bo","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-yi","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-yuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2018.05.003_bb0005","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.toxlet.2013.10.038","article-title":"Repression of Smad7 mediated by DNMT1 determines hepatic stellate cell activation and liver fibrosis in rats","volume":"224","author":"Bian","year":"2014","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.mvr.2018.05.003_bb0010","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s13238-014-0130-4","article-title":"The role of Smad7 in oral mucositis","volume":"6","author":"Bian","year":"2015","journal-title":"Protein Cell."},{"key":"10.1016\/j.mvr.2018.05.003_bb0015","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.yexcr.2016.07.007","article-title":"miR-125b targets DNMT3b and mediates p53 DNA methylation involving in the vascular smooth muscle cells proliferation induced by homocysteine","volume":"347","author":"Cao","year":"2016","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.mvr.2018.05.003_bb0020","doi-asserted-by":"crossref","first-page":"590","DOI":"10.2337\/db10-0403","article-title":"The protective role of Smad7 in diabetic kidney disease: mechanism and therapeutic potential","volume":"60","author":"Chen","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.mvr.2018.05.003_bb0025","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00041433-199702000-00007","article-title":"Homocyst(e)ine: an important risk factor for atherosclerotic vascular disease","volume":"8","author":"Duell","year":"1997","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.mvr.2018.05.003_bb0030","doi-asserted-by":"crossref","first-page":"15785","DOI":"10.1073\/pnas.0507816102","article-title":"Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry","volume":"102","author":"Ehrich","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mvr.2018.05.003_bb0035","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.atherosclerosis.2017.05.022","article-title":"Association between DNA methylation and coronary heart disease or other atherosclerotic events: a systematic review","volume":"263","author":"Fern\u00e1ndez-Sanl\u00e9s","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.mvr.2018.05.003_bb0040","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/1475-2891-14-6","article-title":"Role of homocysteine in the development of cardiovascular disease","volume":"14","author":"Ganguly","year":"2015","journal-title":"Nutr. J."},{"key":"10.1016\/j.mvr.2018.05.003_bb0045","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3006133","article-title":"Transforming growth factor-\u03b2 signaling in T cells promotes stabilization of atherosclerotic plaques through an interleukin-17-dependent pathway","volume":"5","author":"Gister\u00e5","year":"2013","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.mvr.2018.05.003_bb0050","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.cca.2016.02.026","article-title":"Aberrant DNA methylation in the pathogenesis of atherosclerosis","volume":"456","author":"Hai","year":"2016","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.mvr.2018.05.003_bb0055","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/nm.3118","article-title":"Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis","volume":"19","author":"Han","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.mvr.2018.05.003_bb0060","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1161\/CIRCULATIONAHA.110.956839","article-title":"Epigenetic modifications: basic mechanisms and role in cardiovascular disease","volume":"123","author":"Handy","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.mvr.2018.05.003_bb0065","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.114","article-title":"BDNF promoter methylation and genetic variation in late-life depression","volume":"5","author":"Januar","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.mvr.2018.05.003_bb0070","doi-asserted-by":"crossref","first-page":"12560","DOI":"10.3390\/ijms160612560","article-title":"Homocysteine triggers inflammatory responses in macrophages through inhibiting CSE-H2S signaling via DNA hypermethylation of CSE promoter","volume":"16","author":"Li","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mvr.2018.05.003_bb0075","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1159\/000430214","article-title":"MicroRNA-21 negatively regulates Treg cells through a TGF-\u03b21\/Smad-independent pathway in patients with coronary heart disease","volume":"37","author":"Li","year":"2015","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.mvr.2018.05.003_bb0080","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1038\/nature01323","article-title":"Inflammation in atherosclerosis","volume":"420","author":"Libby","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.mvr.2018.05.003_bb0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5483\/BMBRep.2014.47.1.285","article-title":"Role of vascular smooth muscle cell in the inflammation of atherosclerosis","volume":"47","author":"Lim","year":"2014","journal-title":"BMB Rep."},{"key":"10.1016\/j.mvr.2018.05.003_bb0090","doi-asserted-by":"crossref","first-page":"3873","DOI":"10.1093\/nar\/gkv255","article-title":"Modeling the relationship of epigenetic modifications to transcription factor binding","volume":"43","author":"Liu","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mvr.2018.05.003_bb0095","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1161\/HYPERTENSIONAHA.117.09600","article-title":"Deletion of angiotensin-converting enzyme-2 promotes hypertensive nephropathy by targeting Smad7 for ubiquitin degradation","volume":"70","author":"Liu","year":"2017","journal-title":"Hypertension"},{"key":"10.1016\/j.mvr.2018.05.003_bb0100","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a022095","article-title":"Regulation of TGF-\u03b2 family signaling by inhibitory Smads","volume":"9","author":"Miyazawa","year":"2017","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.mvr.2018.05.003_bb0105","first-page":"889","article-title":"Tumor potential in rat wounds after short- and long-term administration of platelet-rich plasma","volume":"31","author":"Omar","year":"2017","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.mvr.2018.05.003_bb0110","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.atherosclerosis.2014.06.021","article-title":"Homocysteine induces the expression of C-reactive protein via NMDAr-ROS-MAPK-NF-\u03baB signal pathway in rat vascular smooth muscle cells","volume":"236","author":"Pang","year":"2014","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.mvr.2018.05.003_bb0115","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1177\/1074248413504994","article-title":"Inflammation and atherosclerosis\u2014revisited","volume":"19","author":"Pant","year":"2014","journal-title":"J. Cardiovasc. Pharmacol. Ther."},{"key":"10.1016\/j.mvr.2018.05.003_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/jcp.26479","article-title":"The multifaceted link between inflammation and human diseases","author":"Rajendran","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.mvr.2018.05.003_bb0125","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1056\/NEJM199901143400207","article-title":"Atheroslerosis-an inflammatory disease","volume":"340","author":"Ross","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.mvr.2018.05.003_bb0130","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.smim.2015.03.013","article-title":"Atherosclerosis-A matter of unresolved inflammation","volume":"27","author":"Viola","year":"2015","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.mvr.2018.05.003_bb0135","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/cvr\/cvt151","article-title":"Smad7 inhibits angiotensin II-induced hypertensive cardiac remodelling","volume":"99","author":"Wei","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.mvr.2018.05.003_bb0140","article-title":"Deficiency of Smad7 enhances cardiac remodeling induced by angiotensin II infusion in a mouse model of hypertension","volume":"8","author":"Wei","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mvr.2018.05.003_bb0145","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/j.bbrc.2018.01.121","article-title":"SMAD7 methylation as a novel marker in atherosclerosis","volume":"496","author":"Wei","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mvr.2018.05.003_bb0150","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s11302-015-9464-5","article-title":"Pathological concentrations of homocysteine increases IL-1\u03b2 production in macrophages in a P2X7, NF-\u0138B, and erk-dependent manner","volume":"11","author":"Zanin","year":"2015","journal-title":"Purinergic Signal"},{"key":"10.1016\/j.mvr.2018.05.003_bb0155","first-page":"697","article-title":"Targeted ultrasound molecular imaging in mouse atherosclerotic plaque model","volume":"31","author":"Zhou","year":"2017","journal-title":"J. Biol. Regul. Homeost. Agents"}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286218300475?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286218300475?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T10:36:34Z","timestamp":1539599794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286218300475"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":31,"alternative-id":["S0026286218300475"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2018.05.003","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Homocysteine induces vascular inflammatory response via SMAD7 hypermethylation in human umbilical vein smooth muscle cells","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2018.05.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}