{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:18:50Z","timestamp":1792873130315,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2018,11]]},"DOI":"10.1016\/j.mvr.2018.06.003","type":"journal-article","created":{"date-parts":[[2018,6,22]],"date-time":"2018-06-22T13:56:50Z","timestamp":1529675810000},"page":"59-66","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":72,"special_numbering":"C","title":["Exercise preconditioning and low dose copper nanoparticles exhibits cardioprotection through targeting GSK-3\u03b2 phosphorylation in ischemia\/reperfusion induced myocardial infarction"],"prefix":"10.1016","volume":"120","author":[{"given":"Arun K.","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashish","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megha","family":"Sahu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunjan","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok K.","family":"Datusalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satyendra K.","family":"Rajput","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2018.06.003_bb0005","author":"American Heart Association Annual Statistical Update Report"},{"key":"10.1016\/j.mvr.2018.06.003_bb0010","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1136\/heartjnl-2016-309573","article-title":"Trends in the epidemiology of cardiovascular disease in the UK","volume":"102","author":"Bhatnagar","year":"2016","journal-title":"Heart"},{"key":"10.1016\/j.mvr.2018.06.003_bb0015","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1165\/rcmb.2011-0296OC","article-title":"Copper dependence of angioproliferation in pulmonary arterial hypertension in rats and humans","volume":"46","author":"Bogaard","year":"2012","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.mvr.2018.06.003_bb0020","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1476-9255-9-23","article-title":"Role of glycogen synthase kinase-3 beta in the inflammatory response caused by bacterial pathogens","volume":"9","author":"Cort\u00e9s-Vieyra","year":"2012","journal-title":"J Inflamm"},{"key":"10.1016\/j.mvr.2018.06.003_bb0025","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1152\/ajpheart.00280.2007","article-title":"Exercise enhances myocardial ischemic tolerance via an opioid receptor-dependent mechanism","volume":"294","author":"Dickson","year":"2008","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mvr.2018.06.003_bb0030","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1242\/jcs.00384","article-title":"GSK-3: tricks of the trade for a multi-tasking kinase","volume":"116","author":"Doble","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.mvr.2018.06.003_bb0035","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fnmol.2011.00032","article-title":"GSK-3 inhibitors: preclinical and clinical focus on CNS","volume":"4","author":"Eldar-Finkelman","year":"2011","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.mvr.2018.06.003_bb0040","doi-asserted-by":"crossref","first-page":"16147","DOI":"10.1074\/jbc.M112363200","article-title":"Glycogen synthase kinase-3 beta mutagenesis identifies a common binding domain for GBP and Axin","volume":"277","author":"Ferkey","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mvr.2018.06.003_bb0045","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1007\/s00018-007-7045-7","article-title":"Glycogen synthase kinase 3: a key regulator of cellular fate","volume":"64","author":"Forde","year":"2007","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.mvr.2018.06.003_bb0050","article-title":"Antidiabetic and antioxidant properties of copper nanoparticles synthesized by medicinal plant Dioscorea bulbifera","author":"Ghosh","year":"2015","journal-title":"J. Nanosci. Nanotechnol."},{"key":"10.1016\/j.mvr.2018.06.003_bb0055","doi-asserted-by":"crossref","first-page":"58272","DOI":"10.1039\/C4RA10366A","article-title":"Prediabetes: ground of pitfall signaling alteration for cardiovascular disease","volume":"4","author":"Goyal","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.mvr.2018.06.003_bb0060","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1128\/AEM.02766-10","article-title":"Metallic copper as an antimicrobial surface","volume":"77","author":"Grass","year":"2011","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.mvr.2018.06.003_bb0065","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s00395-007-0651-6","article-title":"GSK3beta inhibition and K(ATP) channel opening mediate acute opioid-induced cardioprotection at reperfusion","volume":"102","author":"Gross","year":"2007","journal-title":"Basic Res. Cardiol."},{"key":"10.1016\/j.mvr.2018.06.003_bb0070","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1161\/CIRCRESAHA.107.160614","article-title":"Inhibition of glycogen synthase kinase 3beta during heart failure is protective","volume":"101","author":"Hirotani","year":"2007","journal-title":"Circ. Res."},{"key":"10.1016\/j.mvr.2018.06.003_bb0075","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/S0006-291X(02)00636-8","article-title":"Inhibition of glycogen synthase kinase-3beta by bivalent zinc ions: insight into the insulin-mimetic action of zinc","volume":"295","author":"Ilouz","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.mvr.2018.06.003_bb0080","first-page":"4609","article-title":"Effects of copper reduction on angiogenesis-related factors in recurrent glioblastoma cases","volume":"17","author":"Jazayeri","year":"2016","journal-title":"Asian Pac. J. Cancer Prev."},{"key":"10.1016\/j.mvr.2018.06.003_bb0085","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s11064-006-9128-5","article-title":"Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics","volume":"32","author":"Jope","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.mvr.2018.06.003_bb0090","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s11064-006-9128-5","article-title":"Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics","volume":"32","author":"Jope","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.mvr.2018.06.003_bb0095","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-394309-5.00006-7","article-title":"Cell biology of ischemia\/reperfusion injury","volume":"298","author":"Kalogeris","year":"2012","journal-title":"Int. Rev. Cell Mol. Biol."},{"key":"10.1016\/j.mvr.2018.06.003_bb0100","doi-asserted-by":"crossref","first-page":"3609","DOI":"10.1172\/JCI36245","article-title":"Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation","volume":"118","author":"Kerkela","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mvr.2018.06.003_bb0105","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0006-2952(02)01160-7","article-title":"Signaling cross-talk between hypoxia and glucose via hypoxia-inducible factor 1 and glucose response elements","volume":"64","author":"Kietzmann","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.mvr.2018.06.003_bb0110","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1146\/annurev-cellbio-101011-155739","article-title":"Cardiac regenerative capacity and mechanisms","volume":"28","author":"Kikuchi","year":"2012","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.mvr.2018.06.003_bb0115","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3858\/emm.2012.44.1.004","article-title":"The reno-protective effect of a phosphoinositide 3-kinase inhibitor wortmannin on streptozotocin-induced proteinuric renal disease rats","volume":"44","author":"Kim","year":"2012","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.mvr.2018.06.003_bb0120","article-title":"Roles of PI3K\/AKT\/GSK3\/mTOR pathway in cell signaling of mental illnesses","volume":"2012","author":"Kitagishi","year":"2012","journal-title":"Depress. Res. Treat."},{"key":"10.1016\/j.mvr.2018.06.003_bb0125","first-page":"001","article-title":"The role of glycogen synthase kinase 3 beta in neuroinflammation and pain","volume":"1","author":"Maixner","year":"2013","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.mvr.2018.06.003_bb0130","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/S0002-9440(10)63747-9","article-title":"Physiological and pathological responses to hypoxia","volume":"164","author":"Michiels","year":"2004","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mvr.2018.06.003_bb0135","doi-asserted-by":"crossref","first-page":"396","DOI":"10.21037\/cdt.2016.06.01","article-title":"Pathology of coronary atherosclerosis and thrombosis","volume":"6","author":"Otsuka","year":"2016","journal-title":"Cardiovasc. Diagn. Ther."},{"key":"10.1016\/j.mvr.2018.06.003_bb0140","doi-asserted-by":"crossref","first-page":"220","DOI":"10.2174\/1573403X113099990033","article-title":"Exercise and cardiac preconditioning against ischemia reperfusion injury","volume":"9","author":"Quindry","year":"2013","journal-title":"Curr. Cardiol. Rev."},{"key":"10.1016\/j.mvr.2018.06.003_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2007.03.002","article-title":"GSK-3 is a viable potential target for therapeutic intervention in bipolar disorder","volume":"31","author":"Rowe","year":"2007","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.mvr.2018.06.003_bb0150","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1248\/yakushi.132.285","article-title":"Copper compounds ameliorate cardiovasclur dysfunction and diabetes in animals","volume":"132","author":"Sakurai","year":"2012","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.mvr.2018.06.003_bb0155","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1113\/jphysiol.2010.187310","article-title":"Exercise training inhibits inflammatory cytokines and more than prevents myocardial dysfunction in rats with sustained beta-adrenergic hyperactivity","volume":"588","author":"Serra","year":"2010","journal-title":"J. Physiol."},{"key":"10.1016\/j.mvr.2018.06.003_bb0160","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.ijcard.2014.01.053","article-title":"Low-dose dipyridamole treatment partially prevents diabetes mellitus-induced vascular endothelial and renal abnormalities in rats","volume":"172","author":"Sharma","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.mvr.2018.06.003_bb0165","doi-asserted-by":"crossref","first-page":"57267","DOI":"10.1039\/C5RA07927F","article-title":"Reactive oxygen species: friend or foe?","volume":"5","author":"Sharma","year":"2015","journal-title":"RSC Adv."},{"key":"10.1016\/j.mvr.2018.06.003_bb0170","doi-asserted-by":"crossref","first-page":"36870","DOI":"10.1039\/C6RA03890E","article-title":"Synthesis and preliminary therapeutic evaluation of copper nanoparticles against diabetes mellitus and -induced micro- (renal) and macro-vascular (vascular endothelial and cardiovascular) abnormalities in rats","volume":"6","author":"Sharma","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.mvr.2018.06.003_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharep.2018.02.023","article-title":"Combined and individual strategy of exercise generated preconditioning and low dose copper nanoparticles serve as superlative approach to ameliorate ISO-induced myocardial infarction in rats","author":"Sharma","year":"2018","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.mvr.2018.06.003_bb0180","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3389\/fped.2015.00058","article-title":"Hypoxic conditioning as a new therapeutic modality","volume":"3","author":"Verges","year":"2015","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.mvr.2018.06.003_bb0185","first-page":"19859","article-title":"Physical exercise-induced protection on ischemic cardiovascular and cerebrovascular diseases","volume":"8","author":"Wang","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"key":"10.1016\/j.mvr.2018.06.003_bb0190","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s00775-015-1307-x","article-title":"SOD mimetic activity and antiproliferative properties of a novel tetra nuclear copper (II) complex","volume":"20","author":"Weintraub","year":"2015","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.mvr.2018.06.003_bb0195","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/198048","article-title":"Diabetic inhibition of preconditioning- and postconditioning-mediated myocardial protection against ischemia\/reperfusion injury","author":"Yin","year":"2012","journal-title":"Exp. Diabetes Res."},{"key":"10.1016\/j.mvr.2018.06.003_bb0200","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/481405","article-title":"Protective effects of kaempferol against myocardial ischemia\/reperfusion injury in isolated rat heart via antioxidant activity and inhibition of glycogen synthase kinase-3\u03b2","volume":"2015","author":"Zhou","year":"2015","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.mvr.2018.06.003_bb0205","doi-asserted-by":"crossref","first-page":"12211","DOI":"10.1523\/JNEUROSCI.3321-07.2007","article-title":"Activation of glycogen synthase kinase-3 inhibits long-term potentiation with synapse-associated impairments","volume":"27","author":"Zhu","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.mvr.2018.06.003_bb0210","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1152\/ajpheart.00860.2010","article-title":"Cardioprotection of the aged rat heart by GSK-3beta inhibitor is attenuated: age-related changes in mitochondrial permeability transition pore modulation","volume":"300","author":"Zhu","year":"2011","journal-title":"Am. J. Physiol. Heart Circ. Physiol."}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286218300864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286218300864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T10:36:53Z","timestamp":1539599813000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286218300864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11]]},"references-count":42,"alternative-id":["S0026286218300864"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2018.06.003","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2018,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exercise preconditioning and low dose copper nanoparticles exhibits cardioprotection through targeting GSK-3\u03b2 phosphorylation in ischemia\/reperfusion induced myocardial infarction","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2018.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}