{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:12:32Z","timestamp":1790338352892,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.mvr.2018.11.014","type":"journal-article","created":{"date-parts":[[2018,12,1]],"date-time":"2018-12-01T11:02:21Z","timestamp":1543662141000},"page":"111-116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Altered blood rheology and impaired pressure-induced cutaneous vasodilation in a mouse model of combined type 2 diabetes and sickle cell trait"],"prefix":"10.1016","volume":"122","author":[{"given":"Sarah","family":"Skinner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Connes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Sigaudo-Roussel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Lo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiao Ling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Nader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Audrey","family":"Josset-Lamaugarny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle","family":"Charrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camille","family":"Romanet-Faes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mor","family":"Diaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Pialoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9reng\u00e8re","family":"Fromy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2018.11.014_bb0005","doi-asserted-by":"crossref","DOI":"10.1038\/srep15873","article-title":"Assessment of red blood cell deformability in type 2 diabetes mellitus and diabetic retinopathy by dual optical tweezers stretching technique","volume":"6","author":"Agrawal","year":"2016","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.mvr.2018.11.014_bb0010","first-page":"273","article-title":"Influence of hyperglycemia on aggregation, deformability and shape parameters of erythrocytes","volume":"31","author":"Babu","year":"2004","journal-title":"Clin. Hemorheol. Microcirc."},{"issue":"5","key":"10.1016\/j.mvr.2018.11.014_bb0015","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1055\/s-2003-44551","article-title":"Blood rheology and hemodynamics","volume":"29","author":"Baskurt","year":"2003","journal-title":"Semin. Thromb. Hemost."},{"issue":"2","key":"10.1016\/j.mvr.2018.11.014_bb0020","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3233\/CH-2009-1202","article-title":"New guidelines for hemorheological laboratory techniques","volume":"42","author":"Baskurt","year":"2009","journal-title":"Clin. Hemorheol. Microcirc."},{"issue":"4","key":"10.1016\/j.mvr.2018.11.014_bb0025","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1034\/j.1600-0609.2003.00027.x","article-title":"Optical tweezers for measuring red blood cell elasticity: application to the study of drug response in sickle cell disease","volume":"70","author":"Brandao","year":"2003","journal-title":"Eur. J. Haematol."},{"key":"10.1016\/j.mvr.2018.11.014_bb0030","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.bcmd.2016.10.020","article-title":"Inflammatory and oxidative stress phenotypes in transgenic sickle cell mice","volume":"62","author":"Charrin","year":"2016","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.mvr.2018.11.014_bb0035","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1146\/annurev.ph.49.030187.001141","article-title":"Red cell deformability and its relevance to blood flow","volume":"49","author":"Chien","year":"1987","journal-title":"Annu. Rev. Physiol."},{"issue":"6","key":"10.1016\/j.mvr.2018.11.014_bb0040","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1177\/193229680800200622","article-title":"Hemorheological disorders in diabetes mellitus","volume":"2","author":"Cho","year":"2008","journal-title":"J. Diabetes Sci. Technol."},{"key":"10.1016\/j.mvr.2018.11.014_bb0045","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.diabres.2018.02.023","article-title":"IDF diabetes atlas: global estimates of diabetes prevalence for 2017 and projections for 2045","volume":"138","author":"Cho","year":"2018","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.mvr.2018.11.014_bb0050","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.smrv.2015.01.007","article-title":"Obstructive sleep apnea and sickle cell disease: towards hemorheological abnormalities and vascular dysfunction worsening","volume":"24","author":"Connes","year":"2015","journal-title":"Sleep Med. Rev."},{"issue":"6","key":"10.1016\/j.mvr.2018.11.014_bb0055","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2170\/jjphysiol.S653","article-title":"Does higher red blood cell (RBC) lactate transporter activity explain impaired RBC deformability in sickle cell trait?","volume":"55","author":"Connes","year":"2005","journal-title":"Jpn. J. Physiol."},{"issue":"1","key":"10.1016\/j.mvr.2018.11.014_bb0060","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cardiores.2005.09.005","article-title":"Preservation of pressure-induced cutaneous vasodilation by limiting oxidative stress in short-term diabetic mice","volume":"69","author":"Demiot","year":"2006","journal-title":"Cardiovasc. Res."},{"issue":"11","key":"10.1016\/j.mvr.2018.11.014_bb0065","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.2337\/dc15-0699","article-title":"Sickle cell trait worsens oxidative stress, abnormal blood rheology, and vascular dysfunction in type 2 diabetes","volume":"38","author":"Diaw","year":"2015","journal-title":"Diabetes Care"},{"issue":"6","key":"10.1016\/j.mvr.2018.11.014_bb0070","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/sj.bjp.0703685","article-title":"Mechanisms of the cutaneous vasodilator response to local external pressure application in rats: involvement of CGRP, neurokinins, prostaglandins and NO","volume":"131","author":"Fromy","year":"2000","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.mvr.2018.11.014_bb0075","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1186\/1746-6148-9-255","article-title":"Effects of some anesthetic agents on skin microcirculation evaluated by laser Doppler perfusion imaging in mice","volume":"9","author":"Gargiulo","year":"2013","journal-title":"BMC Vet. Res."},{"issue":"1","key":"10.1016\/j.mvr.2018.11.014_bb0080","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1002\/ajh.2830480105","article-title":"Sickle cell rheology is determined by polymer fraction\u2014not cell morphology","volume":"48","author":"Hiruma","year":"1995","journal-title":"Am. J. Hematol."},{"issue":"1","key":"10.1016\/j.mvr.2018.11.014_bb0085","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/bjh.13363","article-title":"Negative health implications of sickle cell trait in high income countries: from the football field to the laboratory","volume":"170","author":"Key","year":"2015","journal-title":"Br. J. Haematol."},{"issue":"6","key":"10.1016\/j.mvr.2018.11.014_bb0090","doi-asserted-by":"crossref","first-page":"446","DOI":"10.4162\/nrp.2013.7.6.446","article-title":"Chamnamul [Pimpinella brachycarpa (Kom.) Nakai] ameliorates hyperglycemia and improves antioxidant status in mice fed a high-fat, high-sucrose diet","volume":"7","author":"Lee","year":"2013","journal-title":"Nutr. Res. Pract."},{"issue":"1","key":"10.1016\/j.mvr.2018.11.014_bb0095","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/s41598-017-01036-4","article-title":"Refractive index tomograms and dynamic membrane fluctuations of red blood cells from patients with diabetes mellitus","volume":"7","author":"Lee","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mvr.2018.11.014_bb0100","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jtemb.2015.07.007","article-title":"Ameliorative effect of vanadyl(IV)-ascorbate complex on high-fat high-sucrose diet-induced hyperglycemia, insulin resistance, and oxidative stress in mice","volume":"32","author":"Liu","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"Suppl. 2","key":"10.1016\/j.mvr.2018.11.014_bb0105","doi-asserted-by":"crossref","first-page":"97","DOI":"10.2337\/diab.30.2.S97","article-title":"Physical factors important in the development of atherosclerosis in diabetes","volume":"30","author":"McMillan","year":"1981","journal-title":"Diabetes"},{"issue":"4","key":"10.1016\/j.mvr.2018.11.014_bb0110","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1152\/jappl.1967.22.4.772","article-title":"Influence of plasma osmolarity on the rheology of human blood","volume":"22","author":"Meiselman","year":"1967","journal-title":"J. Appl. Physiol."},{"issue":"3","key":"10.1016\/j.mvr.2018.11.014_bb0115","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1172\/JCI109888","article-title":"Analysis of factors regulating erythrocyte deformability","volume":"66","author":"Mohandas","year":"1980","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.mvr.2018.11.014_bb0120","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1182\/asheducation-2015.1.160","article-title":"Sickle cell trait diagnosis: clinical and social implications","volume":"2015","author":"Naik","year":"2015","journal-title":"Hematol. Am. Soc. Hematol. Educ. Program."},{"issue":"1","key":"10.1016\/j.mvr.2018.11.014_bb0125","first-page":"183","article-title":"The prevalence of the red cell morphology changes in patients with type 2 diabetes mellitus","volume":"56","author":"NeamTu","year":"2015","journal-title":"Romanian J. Morphol. Embryol."},{"issue":"21","key":"10.1016\/j.mvr.2018.11.014_bb0130","doi-asserted-by":"crossref","first-page":"4916","DOI":"10.1182\/blood.V124.21.4916.4916","article-title":"Phenotypic characterization the Townes sickle mice","volume":"124","author":"Nguyen","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.mvr.2018.11.014_bb0135","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.mvr.2013.10.001","article-title":"Skin microvascular response to pressure load in obese mice","volume":"90","author":"Nguyen-Tu","year":"2013","journal-title":"Microvasc. Res."},{"issue":"9861","key":"10.1016\/j.mvr.2018.11.014_bb0140","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/S0140-6736(12)61229-X","article-title":"Global epidemiology of sickle haemoglobin in neonates: a contemporary geostatistical model-based map and population estimates","volume":"381","author":"Piel","year":"2013","journal-title":"Lancet"},{"issue":"9757","key":"10.1016\/j.mvr.2018.11.014_bb0145","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/S0140-6736(10)61029-X","article-title":"Sickle-cell disease","volume":"376","author":"Rees","year":"2010","journal-title":"Lancet"},{"issue":"12","key":"10.1016\/j.mvr.2018.11.014_bb0150","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1016\/j.bbadis.2013.08.006","article-title":"Endothelial dysfunction - a major mediator of diabetic vascular disease","volume":"1832","author":"Sena","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"7","key":"10.1016\/j.mvr.2018.11.014_bb0155","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/mus.880110709","article-title":"Altered blood rheology in the pathogenesis of diabetic and other neuropathies","volume":"11","author":"Simpson","year":"1988","journal-title":"Muscle Nerve"},{"issue":"4","key":"10.1016\/j.mvr.2018.11.014_bb0160","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0891-6632(87)80072-7","article-title":"A reappraisal of the influence of blood rheology on glomerular filtration and its role in the pathogenesis of diabetic nephropathy","volume":"1","author":"Simpson","year":"1987","journal-title":"J. Diabet. Complicat."},{"issue":"7429","key":"10.1016\/j.mvr.2018.11.014_bb0165","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0140-6736(66)91264-5","article-title":"Blood-viscosity in diabetic patients","volume":"1","author":"Skovborg","year":"1966","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.mvr.2018.11.014_bb0170","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/bjh.12336","article-title":"Interplay between coagulation and vascular inflammation in sickle cell disease","volume":"162","author":"Sparkenbaugh","year":"2013","journal-title":"Br. J. Haematol."},{"issue":"4","key":"10.1016\/j.mvr.2018.11.014_bb0175","doi-asserted-by":"crossref","first-page":"H1730","DOI":"10.1152\/ajpheart.00998.2004","article-title":"Elevated plasma viscosity in extreme hemodilution increases perivascular nitric oxide concentration and microvascular perfusion","volume":"288","author":"Tsai","year":"2005","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.mvr.2018.11.014_bb0180","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.tcm.2008.02.001","article-title":"Current concepts in assessment of microvascular endothelial function using laser Doppler imaging and iontophoresis","volume":"18","author":"Turner","year":"2008","journal-title":"Trends Cardiovasc. Med."},{"key":"10.1016\/j.mvr.2018.11.014_bb0185","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.nbd.2015.10.004","article-title":"Cognitive and behavior deficits in sickle cell mice are associated with profound neuropathologic changes in hippocampus and cerebellum","volume":"85","author":"Wang","year":"2016","journal-title":"Neurobiol. Dis."},{"issue":"1","key":"10.1016\/j.mvr.2018.11.014_bb0190","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1111\/j.1464-5491.1993.tb01990.x","article-title":"Altered structural and dynamic properties of blood cell membranes in diabetes mellitus","volume":"10","author":"Watala","year":"1993","journal-title":"Diabet. Med."},{"issue":"3","key":"10.1016\/j.mvr.2018.11.014_bb0195","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/bjo.80.3.203","article-title":"Blood viscosity, coagulation, and activated protein C resistance in central retinal vein occlusion: a population controlled study","volume":"80","author":"Williamson","year":"1996","journal-title":"Br. J. Ophthalmol."}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286218302176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286218302176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T08:16:59Z","timestamp":1605514619000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286218302176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":39,"alternative-id":["S0026286218302176"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2018.11.014","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered blood rheology and impaired pressure-induced cutaneous vasodilation in a mouse model of combined type 2 diabetes and sickle cell trait","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2018.11.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}