{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:02:43Z","timestamp":1790262163907,"version":"4.1.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2013HQ050"],"award-info":[{"award-number":["ZR2013HQ050"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["LY19H090025"],"award-info":[{"award-number":["LY19H090025"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["LQ15H090003"],"award-info":[{"award-number":["LQ15H090003"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81101157"],"award-info":[{"award-number":["81101157"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.mvr.2019.01.001","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T13:34:00Z","timestamp":1546522440000},"page":"74-80","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":147,"special_numbering":"C","title":["Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke"],"prefix":"10.1016","volume":"123","author":[{"given":"Kaiming","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxiong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanzhu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2019.01.001_bb0005","doi-asserted-by":"crossref","first-page":"9864","DOI":"10.1038\/srep09864","article-title":"Mitochondrial DNA haplogroups and short-term neurological outcomes of ischemic stroke","volume":"5","author":"Cai","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mvr.2019.01.001_bb0010","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1161\/01.STR.32.4.1005","article-title":"Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats","volume":"32","author":"Chen","year":"2001","journal-title":"Stroke"},{"key":"10.1016\/j.mvr.2019.01.001_bb0015","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1161\/CIRCULATIONAHA.111.048264","article-title":"Multipotent vasculogenic pericytes from human pluripotent stem cells promote recovery of murine ischemic limb","volume":"125","author":"Dar","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.mvr.2019.01.001_bb0020","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1126\/science.1094884","article-title":"Ancient invasions: from endosymbionts to organelles","volume":"304","author":"Dyall","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.mvr.2019.01.001_bb0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/nature16187","article-title":"Autophagy maintains stemness by preventing senescence","volume":"529","author":"Garc\u00eda-Prat","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mvr.2019.01.001_bb0030","doi-asserted-by":"crossref","first-page":"7689","DOI":"10.1007\/s12035-016-0286-4","article-title":"Stem cells as a promising tool for the restoration of brain neurovascular unit and angiogenic orientation","volume":"54","author":"Geranmayeh","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.mvr.2019.01.001_bb0035","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/EJA.0000000000000260","article-title":"Real-time in-vivo imaging of pulmonary capillary perfusion using probe-based confocal laser scanning endomicroscopy in pigs: an interventional laboratory study","volume":"32","author":"Gruber","year":"2015","journal-title":"Eur. J. Anaesthesiol."},{"key":"10.1016\/j.mvr.2019.01.001_bb0040","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.expneurol.2011.11.038","article-title":"Cilostazol, a phosphodiesterase inhibitor, prevents no-reflow and hemorrhage in mice with focal cerebral ischemia","volume":"233","author":"Hase","year":"2012","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mvr.2019.01.001_bb0045","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/nature18928","article-title":"Transfer of mitochondria from astrocytes to neurons after stroke","volume":"535","author":"Hayakawa","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.mvr.2019.01.001_bb0050","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/nm.2736","article-title":"Mitochondrial transfer from bone-marrow\u2013derived stromal cells to pulmonary alveoli protects against acute lung injury","volume":"18","author":"Islam","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.mvr.2019.01.001_bb0055","doi-asserted-by":"crossref","first-page":"e2467","DOI":"10.1038\/cddis.2016.358","article-title":"Mitochondrial transfer of mesenchymal stem cells effectively protects corneal epithelial cells from mitochondrial damage","volume":"7","author":"Jiang","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.mvr.2019.01.001_bb0060","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1161\/01.STR.20.8.1027","article-title":"Brain perfusion in acute and chronic hyperglycemia in rats","volume":"20","author":"Kikano","year":"1989","journal-title":"Stroke"},{"key":"10.1016\/j.mvr.2019.01.001_bb0065","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1161\/01.RES.0000118601.37875.AC","article-title":"Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms","volume":"94","author":"Kinnaird","year":"2004","journal-title":"Circ. Res."},{"key":"10.1016\/j.mvr.2019.01.001_bb0070","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1161\/CIRCRESAHA.111.300233","article-title":"Mitochondria and endothelial function","volume":"112","author":"Kluge","year":"2013","journal-title":"Circ. Res."},{"key":"10.1016\/j.mvr.2019.01.001_bb0075","first-page":"2091","article-title":"Latrunculin a has a strong anticancer effect in a peritoneal dissemination model of human gastric cancer in mice","volume":"29","author":"Konishi","year":"2009","journal-title":"Anticancer Res."},{"key":"10.1016\/j.mvr.2019.01.001_bb0080","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1038\/jcbfm.2014.132","article-title":"A cognitive rehabilitation paradigm effective in male rats lacks efficacy in female rats","volume":"34","author":"Langdon","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.mvr.2019.01.001_bb0085","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1016\/j.jaci.2017.08.017","article-title":"Mesenchymal stem cells alleviate oxidative stress-induced mitochondrial dysfunction in the airways","volume":"141","author":"Li","year":"2018","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.mvr.2019.01.001_bb0090","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.neuron.2017.04.004","article-title":"Releasing syntaphilin removes stressed mitochondria from axons independent of mitophagy under pathophysiological conditions","volume":"94","author":"Lin","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.mvr.2019.01.001_bb0095","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.mvr.2007.06.003","article-title":"The interactions between brain microvascular endothelial cells and mesenchymal stem cells under hypoxic conditions","volume":"75","author":"Liu","year":"2008","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2019.01.001_bb0100","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.mvr.2014.01.008","article-title":"Mesenchymal stem cells rescue injured endothelial cells in an in vitro ischemia-reperfusion model via tunneling nanotube like structure-mediated mitochondrial transfer","volume":"92","author":"Liu","year":"2014","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2019.01.001_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033093","article-title":"Tunneling nanotubes provide a unique conduit for intercellular transfer of cellular contents in human malignant pleural mesothelioma","volume":"7","author":"Lou","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.mvr.2019.01.001_bb0110","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/febs.13946","article-title":"Lost in translation: applying 2D intercellular communication via tunneling nanotubes in cell culture to physiologically relevant 3D microenvironments","volume":"284","author":"Lou","year":"2017","journal-title":"FEBS J."},{"key":"10.1016\/j.mvr.2019.01.001_bb0115","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1038\/cdd.2017.51","article-title":"Mesenchymal stem cells sense mitochondria released from damaged cells as danger signals to activate their rescue properties","volume":"24","author":"Mahrouf-Yorgov","year":"2017","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mvr.2019.01.001_bb0120","doi-asserted-by":"crossref","first-page":"2777","DOI":"10.1161\/STROKEAHA.114.005341","article-title":"Altered astrocyte-neuronal interactions after hypoxia-ischemia in the neonatal brain in female and male rats","volume":"45","author":"Morken","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.mvr.2019.01.001_bb0125","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1089\/scd.2013.0419","article-title":"Interactions of mesenchymal stem cells with endothelial cells","volume":"23","author":"Nassiri","year":"2014","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.mvr.2019.01.001_bb0130","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1161\/STROKEAHA.109.575993","article-title":"Biodistribution of neural stem cells after intravascular therapy for hypoxic-ischemia","volume":"41","author":"Pendharkar","year":"2010","journal-title":"Stroke"},{"key":"10.1016\/j.mvr.2019.01.001_bb0135","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1002\/stem.2575","article-title":"Concise review: MSC-derived exosomes for cell-free therapy","volume":"35","author":"Phinney","year":"2017","journal-title":"Stem Cells"},{"key":"10.1016\/j.mvr.2019.01.001_bb0140","doi-asserted-by":"crossref","first-page":"21102","DOI":"10.1074\/jbc.M116.774836","article-title":"The natural product mensacarcin induces mitochondrial toxicity and apoptosis in melanoma cells","volume":"292","author":"Plitzko","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.mvr.2019.01.001_bb0150","doi-asserted-by":"crossref","first-page":"1882","DOI":"10.1002\/smll.201503606","article-title":"Intercellular transport of nanomaterials is mediated by membrane nanotubes in vivo","volume":"12","author":"Rehberg","year":"2016","journal-title":"Small"},{"key":"10.1016\/j.mvr.2019.01.001_bb0155","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0960-9822(95)00128-X","article-title":"Chimeric green fluorescent protein as a tool for visualizing subcellular organelles in living cells","volume":"5","author":"Rizzuto","year":"1995","journal-title":"Curr. Biol."},{"key":"10.1016\/j.mvr.2019.01.001_bb0160","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1080\/15384101.2018.1445906","article-title":"Intercellular mitochondria trafficking highlighting the dual role of mesenchymal stem cells as both sensors and rescuers of tissue injury","volume":"17","author":"Rodriguez","year":"2018","journal-title":"Cell Cycle"},{"key":"10.1016\/j.mvr.2019.01.001_bb0165","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1126\/science.1093133","article-title":"Nanotubular highways for intercellular organelle transport","volume":"303","author":"Rustom","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.mvr.2019.01.001_bb0170","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.cmet.2016.03.009","article-title":"Mitochondrial ROS produced via reverse electron transport extend animal lifespan","volume":"23","author":"Scial\u00f2","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.mvr.2019.01.001_bb0175","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.expneurol.2018.10.001","article-title":"A mesenchymal stem cell line (B10) increases angiogenesis in a rat MCAO model","volume":"311","author":"Sheikh","year":"2019","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.mvr.2019.01.001_bb0180","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1038\/nprot.2008.221","article-title":"A protocol for isolation and culture of mesenchymal stem cells from mouse bone marrow","volume":"4","author":"Soleimani","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.mvr.2019.01.001_bb0185","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1073\/pnas.0437997100","article-title":"Differentiation, cell fusion, and nuclear fusion during ex vivo repair of epithelium by human adult stem cells from bone marrow stroma","volume":"100","author":"Spees","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mvr.2019.01.001_bb0190","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1073\/pnas.0510511103","article-title":"Mitochondrial transfer between cells can rescue aerobic respiration","volume":"103","author":"Spees","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mvr.2019.01.001_bb0195","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/8973613","article-title":"Dental mesenchymal stem\/stromal cells and their exosomes","author":"Stanko","year":"2018","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.mvr.2019.01.001_bb0200","doi-asserted-by":"crossref","DOI":"10.1161\/STROKEAHA.118.020711","article-title":"Improving microcirculatory reperfusion reduces parenchymal oxygen radical formation and provides neuroprotection","author":"Taskiran-Sag","year":"2018","journal-title":"Stroke"},{"key":"10.1016\/j.mvr.2019.01.001_bb0205","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/nature730","article-title":"Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion","volume":"416","author":"Terada","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.mvr.2019.01.001_bb0210","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.stemcr.2018.01.010","article-title":"Neurons generated by mouse escs with hippocampal or cortical identity display distinct projection patterns when co-transplanted in the adult brain","volume":"10","author":"Terrigno","year":"2018","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.mvr.2019.01.001_bb0215","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.1161\/STROKEAHA.114.006553","article-title":"Inhibition of mitochondrial p53 abolishes the detrimental effects of social isolation on ischemic brain injury","volume":"45","author":"Venna","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.mvr.2019.01.001_bb0220","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/cdd.2010.147","article-title":"Tunneling-nanotube development in astrocytes depends on p53 activation","volume":"18","author":"Wang","year":"2011","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.mvr.2019.01.001_bb0225","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1016\/j.stemcr.2016.08.009","article-title":"iPSC-MSCs with high intrinsic MIRO1 and sensitivity to TNF-\u03b1 yield efficacious mitochondrial transfer to rescue anthracycline-induced cardiomyopathy","volume":"7","author":"Zhang","year":"2016","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.mvr.2019.01.001_bb0230","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.neuropharm.2014.07.002","article-title":"Mitochondria autophagy is induced after hypoxic\/ischemic stress in a Drp1 dependent manner: the role of inhibition of Drp1 in ischemic brain damage","volume":"86","author":"Zuo","year":"2014","journal-title":"Neuropharmacology"}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286218302425?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286218302425?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:45:21Z","timestamp":1565225121000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286218302425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":45,"alternative-id":["S0026286218302425"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2019.01.001","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mesenchymal stem cells transfer mitochondria into cerebral microvasculature and promote recovery from ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2019.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}