{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T15:19:51Z","timestamp":1791299991899,"version":"4.1.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.mvr.2020.104031","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T11:22:43Z","timestamp":1591701763000},"page":"104031","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":59,"special_numbering":"C","title":["Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype"],"prefix":"10.1016","volume":"131","author":[{"given":"Andrew P.","family":"Voigt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Scott","family":"Whitmore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Mulfaul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen R.","family":"Chirco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph C.","family":"Giacalone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miles J.","family":"Flamme-Wiese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Stockman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin M.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Budd A.","family":"Tucker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd E.","family":"Scheetz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Mullins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2020.104031_bb0005","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1101\/gad.1134603","article-title":"RhoB controls Akt trafficking and stage-specific survival of endothelial cells during vascular development","volume":"17","author":"Adini","year":"2003","journal-title":"Genes Dev."},{"key":"10.1016\/j.mvr.2020.104031_bb0010","doi-asserted-by":"crossref","unstructured":"Arya, M.; Sabrosa, A.S.; Duker, J.S.; Waheed, N.K. Choriocapillaris changes in dry age-related macular degeneration and geographic atrophy: a review. Eye and vision (London, England) 2018, 5, 22, doi:https:\/\/doi.org\/10.1186\/s40662-018-0118-x.","DOI":"10.1186\/s40662-018-0118-x"},{"key":"10.1016\/j.mvr.2020.104031_bb0015","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1177\/38.9.2201738","article-title":"Improved method for obtaining 3-microns cryosections for immunocytochemistry","volume":"38","author":"Barthel","year":"1990","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/j.mvr.2020.104031_bb0020","doi-asserted-by":"crossref","first-page":"2562","DOI":"10.1016\/j.neurobiolaging.2014.05.003","article-title":"Choriocapillaris breakdown precedes retinal degeneration in age-related macular degeneration","volume":"35","author":"Biesemeier","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.mvr.2020.104031_bb0025","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1186\/1471-2164-10-164","article-title":"Functional annotation of the human retinal pigment epithelium transcriptome","volume":"10","author":"Booij","year":"2009","journal-title":"BMC Genomics"},{"key":"10.1016\/j.mvr.2020.104031_bb0030","doi-asserted-by":"crossref","unstructured":"Booij, J.C.; ten Brink, J.B.; Swagemakers, S.M.; Verkerk, A.J.; Essing, A.H.; van der Spek, P.J.; Bergen, A.A. A new strategy to identify and annotate human RPE-specific gene expression. PLoS One 2010, 5, e9341, doi:https:\/\/doi.org\/10.1371\/journal.pone.0009341.","DOI":"10.1371\/journal.pone.0009341"},{"key":"10.1016\/j.mvr.2020.104031_bb0035","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.mvr.2020.104031_bb0040","doi-asserted-by":"crossref","first-page":"12272","DOI":"10.1038\/s41598-018-30739-5","article-title":"Isolation and differential transcriptome of vascular smooth muscle cells and mid-capillary pericytes from the rat brain","volume":"8","author":"Chasseigneaux","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mvr.2020.104031_bb0045","doi-asserted-by":"crossref","unstructured":"Chen, H.; Liu, B.; Lukas, T.J.; Neufeld, A.H. The aged retinal pigment epithelium\/choroid: a potential substratum for the pathogenesis of age-related macular degeneration. PLoS One 2008, 3, e2339, doi:https:\/\/doi.org\/10.1371\/journal.pone.0002339.","DOI":"10.1371\/journal.pone.0002339"},{"key":"10.1016\/j.mvr.2020.104031_bb0050","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.exer.2015.09.003","article-title":"Selective accumulation of the complement membrane attack complex in aging choriocapillaris","volume":"146","author":"Chirco","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mvr.2020.104031_bb0055","doi-asserted-by":"crossref","unstructured":"Chirco, K.R.; Flamme-Wiese, M.J.; Wiley, J.S.; Potempa, L.A.; Stone, E.M.; Tucker, B.A.; Mullins, R.F. Evaluation of serum and ocular levels of membrane attack complex and C-reactive protein in CFH-genotyped human donors. Eye (London, England) 2018, 32, 1740-1742, doi:https:\/\/doi.org\/10.1038\/s41433-018-0170-8.","DOI":"10.1038\/s41433-018-0170-8"},{"key":"10.1016\/j.mvr.2020.104031_bb0060","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1177\/1087057116659856","article-title":"Rethinking nuclear receptors as potential therapeutic targets for retinal diseases","volume":"21","author":"Choudhary","year":"2016","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.mvr.2020.104031_bb0065","doi-asserted-by":"crossref","first-page":"16193","DOI":"10.1038\/srep16193","article-title":"Venous endothelial marker COUP-TFII regulates the distinct pathologic potentials of adult arteries and veins","volume":"5","author":"Cui","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mvr.2020.104031_bb0070","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.mvr.2015.01.006","article-title":"ID3 contributes to the acquisition of molecular stem cell-like signature in microvascular endothelial cells: its implication for understanding microvascular diseases","volume":"98","author":"Das","year":"2015","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2020.104031_bb0075","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mvr.2020.104031_bb0080","doi-asserted-by":"crossref","unstructured":"Friedman, D.S.; O'Colmain, B.J.; Munoz, B.; Tomany, S.C.; McCarty, C.; de Jong, P.T.; Nemesure, B.; Mitchell, P.; Kempen, J. Prevalence of age-related macular degeneration in the United States. Archives of ophthalmology (Chicago, Ill. : 1960) 2004, 122, 564\u2013572, doi:https:\/\/doi.org\/10.1001\/archopht.122.4.564.","DOI":"10.1001\/archopht.122.4.564"},{"key":"10.1016\/j.mvr.2020.104031_bb0085","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.mvr.2018.12.002","article-title":"Generation of an immortalized human choroid endothelial cell line (iChEC-1) using an endothelial cell specific promoter","volume":"123","author":"Giacalone","year":"2019","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2020.104031_bb0090","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/s42255-020-0196-7","article-title":"Single-cell omics in ageing: a young and growing field","volume":"2","author":"He","year":"2020","journal-title":"Nature Metabolism"},{"key":"10.1016\/j.mvr.2020.104031_bb0095","doi-asserted-by":"crossref","unstructured":"Hu, Y.; Wang, X.; Hu, B.; Mao, Y.; Chen, Y.; Yan, L.; Yong, J.; Dong, J.; Wei, Y.; Wang, W., et al. Dissecting the transcriptome landscape of the human fetal neural retina and retinal pigment epithelium by single-cell RNA-seq analysis. PLoS Biol. 2019, 17, e3000365, doi:https:\/\/doi.org\/10.1371\/journal.pbio.3000365.","DOI":"10.1371\/journal.pbio.3000365"},{"key":"10.1016\/j.mvr.2020.104031_bb0100","doi-asserted-by":"crossref","first-page":"400","DOI":"10.2174\/1389201011314040003","article-title":"The potential roles of metallothionein as a therapeutic target for cerebral ischemia and retinal diseases","volume":"14","author":"Ito","year":"2013","journal-title":"Curr. Pharm. Biotechnol."},{"key":"10.1016\/j.mvr.2020.104031_bb0105","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.mvr.2016.02.004","article-title":"AP-1 transcription factor mediates VEGF-induced endothelial cell migration and proliferation","volume":"105","author":"Jia","year":"2016","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2020.104031_bb0110","doi-asserted-by":"crossref","first-page":"14821","DOI":"10.1038\/s41598-019-51379-3","article-title":"Tissue- and species-specific patterns of RNA metabolism in post-mortem mammalian retina and retinal pigment epithelium","volume":"9","author":"Kallestad","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mvr.2020.104031_bb0115","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1007\/s00018-016-2147-8","article-title":"Inflammation and its role in age-related macular degeneration","author":"Kauppinen","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mvr.2020.104031_bb0120","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.mod.2013.07.001","article-title":"Hes1 and Hes5 regulate vascular remodeling and arterial specification of endothelial cells in brain vascular development","volume":"130","author":"Kitagawa","year":"2013","journal-title":"Mech. Dev."},{"key":"10.1016\/j.mvr.2020.104031_bb0125","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20190730","article-title":"Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroid","volume":"217","author":"Lehmann","year":"2020","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mvr.2020.104031_bb0130","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1093\/hmg\/ddu114","article-title":"Comprehensive analysis of gene expression in human retina and supporting tissues","volume":"23","author":"Li","year":"2014","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mvr.2020.104031_bb0135","doi-asserted-by":"crossref","unstructured":"Liao, Y.; Smyth, G.K.; Shi, W. The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads. Nucleic Acids Res. 2019a, 47, e47, doi:https:\/\/doi.org\/10.1093\/nar\/gkz114.","DOI":"10.1093\/nar\/gkz114"},{"issue":"47","key":"10.1016\/j.mvr.2020.104031_bb0140","doi-asserted-by":"crossref","first-page":"W199","DOI":"10.1093\/nar\/gkz401","article-title":"Gene set analysis toolkit with revamped UIs and APIs","volume":"2019","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.mvr.2020.104031_bb0145","doi-asserted-by":"crossref","unstructured":"Luecken, M.D.; Theis, F.J. Current best practices in single-cell RNA-seq analysis: a tutorial. Mol Syst Biol 2019, 15, e8746, doi:10.15252\/msb.20188746.","DOI":"10.15252\/msb.20188746"},{"key":"10.1016\/j.mvr.2020.104031_bb0150","doi-asserted-by":"crossref","unstructured":"Lukowski, S.W.; Lo, C.Y.; Sharov, A.A.; Nguyen, Q.; Fang, L.; Hung, S.S.; Zhu, L.; Zhang, T.; Gr\u00fcnert, U.; Nguyen, T., et al. A single-cell transcriptome atlas of the adult human retina. Embo j 2019, 38, e100811, doi:10.15252\/embj.2018100811.","DOI":"10.15252\/embj.2018100811"},{"key":"10.1016\/j.mvr.2020.104031_bb0155","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1093\/biostatistics\/kxw055","article-title":"Overcoming confounding plate effects in differential expression analyses of single-cell RNA-seq data","volume":"18","author":"Lun","year":"2017","journal-title":"Biostatistics"},{"key":"10.1016\/j.mvr.2020.104031_bb0160","doi-asserted-by":"crossref","unstructured":"Lutty, G.A.; Hasegawa, T.; Baba, T.; Grebe, R.; Bhutto, I.; McLeod, D.S. Development of the human choriocapillaris. Eye (London, England) 2010, 24, 408\u2013415, doi:https:\/\/doi.org\/10.1038\/eye.2009.318.","DOI":"10.1038\/eye.2009.318"},{"key":"10.1016\/j.mvr.2020.104031_bb0165","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.1007\/s00018-014-1709-x","article-title":"Emerging roles for nuclear receptors in the pathogenesis of age-related macular degeneration","volume":"71","author":"Malek","year":"2014","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.mvr.2020.104031_bb0170","first-page":"642","article-title":"Enhanced expression of intracellular adhesion molecule-1 and P-selectin in the diabetic human retina and choroid","volume":"147","author":"McLeod","year":"1995","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mvr.2020.104031_bb0175","doi-asserted-by":"crossref","first-page":"5843","DOI":"10.1167\/iovs.16-20049","article-title":"Distribution and quantification of choroidal macrophages in human eyes with age-related macular degeneration","volume":"57","author":"McLeod","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mvr.2020.104031_bb0180","doi-asserted-by":"crossref","first-page":"4902","DOI":"10.1038\/s41467-019-12780-8","article-title":"Single-cell transcriptomic atlas of the human retina identifies cell types associated with age-related macular degeneration","volume":"10","author":"Menon","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.mvr.2020.104031_bb0185","first-page":"224","article-title":"Macular and peripheral distribution of ICAM-1 in the human choriocapillaris and retina","volume":"12","author":"Mullins","year":"2006","journal-title":"Mol. Vis."},{"key":"10.1016\/j.mvr.2020.104031_bb0190","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/gm315","article-title":"Systems-level analysis of age-related macular degeneration reveals global biomarkers and phenotype-specific functional networks","volume":"4","author":"Newman","year":"2012","journal-title":"Genome Med"},{"key":"10.1016\/j.mvr.2020.104031_bb0195","doi-asserted-by":"crossref","unstructured":"Nork, T.M.; Kim, C.B.; Shanmuganayagam, D.; Van Lysel, M.S.; Ver Hoeve, J.N.; Folts, J.D. Measurement of regional choroidal blood flow in rabbits and monkeys using fluorescent microspheres. Archives of ophthalmology (Chicago, Ill. : 1960) 2006, 124, 860\u2013868, doi:https:\/\/doi.org\/10.1001\/archopht.124.6.860.","DOI":"10.1001\/archopht.124.6.860"},{"key":"10.1016\/j.mvr.2020.104031_bb0200","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1161\/CIRCULATIONAHA.112.000826","article-title":"Deletion of the activated protein-1 transcription factor JunD induces oxidative stress and accelerates age-related endothelial dysfunction","volume":"127","author":"Paneni","year":"2013","journal-title":"Circulation"},{"key":"10.1016\/j.mvr.2020.104031_bb0205","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.exer.2007.05.006","article-title":"Disease susceptibility of the human macula: differential gene transcription in the retinal pigmented epithelium\/choroid","volume":"85","author":"Radeke","year":"2007","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mvr.2020.104031_bb0210","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.mvr.2020.104031_bb0215","doi-asserted-by":"crossref","unstructured":"Rohlenova, K.; Goveia, J.; Garc\u00eda-Caballero, M.; Subramanian, A.; Kalucka, J.; Treps, L.; Falkenberg, K.D.; de Rooij, L.; Zheng, Y.; Lin, L., et al. Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis. Cell Metab 2020, 31, 862\u2013877.e814, doi:https:\/\/doi.org\/10.1016\/j.cmet.2020.03.009.","DOI":"10.1016\/j.cmet.2020.03.009"},{"key":"10.1016\/j.mvr.2020.104031_bb0220","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1084\/jem.20031132","article-title":"KLF2 is a novel transcriptional regulator of endothelial proinflammatory activation","volume":"199","author":"SenBanerjee","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.mvr.2020.104031_bb0225","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1167\/iovs.07-1072","article-title":"Complement-associated deposits in the human retina","volume":"49","author":"Seth","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mvr.2020.104031_bb0230","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1073\/pnas.012582799","article-title":"Profile of the genes expressed in the human peripheral retina, macula, and retinal pigment epithelium determined through serial analysis of gene expression (SAGE)","volume":"99","author":"Sharon","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mvr.2020.104031_bb0240","doi-asserted-by":"crossref","unstructured":"Sohn, E.H.; Flamme-Wiese, M.J.; Whitmore, S.S.; Wang, K.; Tucker, B.A.; Mullins, R.F. Loss of CD34 expression in aging human choriocapillaris endothelial cells. PLoS One 2014a, 9, e86538, doi:https:\/\/doi.org\/10.1371\/journal.pone.0086538.","DOI":"10.1371\/journal.pone.0086538"},{"key":"10.1016\/j.mvr.2020.104031_bb0245","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1167\/iovs.13-13754","article-title":"Structural and biochemical analyses of choroidal thickness in human donor eyes","volume":"55","author":"Sohn","year":"2014","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mvr.2020.104031_bb0250","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1016\/j.ajpath.2019.04.005","article-title":"Choriocapillaris degeneration in geographic atrophy","volume":"189","author":"Sohn","year":"2019","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.mvr.2020.104031_bb0255","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1002\/sctm.16-0399","article-title":"Connective tissue growth factor promotes efficient generation of human induced pluripotent stem cell-derived choroidal endothelium","volume":"6","author":"Songstad","year":"2017","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.mvr.2020.104031_bb0260","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/10428199809050926","article-title":"CD34 molecule epitope distribution on cells of haematopoietic origin","volume":"30","author":"Steen","year":"1998","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.mvr.2020.104031_bb0265","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1093\/hmg\/ddq129","article-title":"Transcriptome analysis and molecular signature of human retinal pigment epithelium","volume":"19","author":"Strunnikova","year":"2010","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.mvr.2020.104031_bb0235","first-page":"1608","article-title":"Comparison of human retinal pigment epithelium gene expression in macula and periphery highlights potential topographic differences in Bruch\u2019s membrane","volume":"13","author":"van Soest","year":"2007","journal-title":"Mol. Vis."},{"key":"10.1016\/j.mvr.2020.104031_bb0270","doi-asserted-by":"crossref","first-page":"24100","DOI":"10.1073\/pnas.1914143116","article-title":"Single-cell transcriptomics of the human retinal pigment epithelium and choroid in health and macular degeneration","volume":"116","author":"Voigt","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.mvr.2020.104031_bb0275","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.exer.2019.05.001","article-title":"Molecular characterization of foveal versus peripheral human retina by single-cell RNA sequencing","volume":"184","author":"Voigt","year":"2019","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mvr.2020.104031_bb0280","doi-asserted-by":"crossref","unstructured":"Wakatsuki, Y.; Shinojima, A.; Kawamura, A.; Yuzawa, M. Correlation of aging and segmental choroidal thickness measurement using swept source optical coherence tomography in healthy eyes. PLoS One 2015, 10, e0144156, doi:https:\/\/doi.org\/10.1371\/journal.pone.0144156.","DOI":"10.1371\/journal.pone.0144156"},{"key":"10.1016\/j.mvr.2020.104031_bb0285","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.exer.2014.11.001","article-title":"Transcriptomic analysis across nasal, temporal, and macular regions of human neural retina and RPE\/choroid by RNA-Seq","volume":"129","author":"Whitmore","year":"2014","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mvr.2020.104031_bb0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2014.11.005","article-title":"Complement activation and choriocapillaris loss in early AMD: implications for pathophysiology and therapy","volume":"45","author":"Whitmore","year":"2015","journal-title":"Prog. Retin. Eye Res."},{"key":"10.1016\/j.mvr.2020.104031_bb0295","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1161\/CIRCRESAHA.108.192286","article-title":"The orphan nuclear receptor Nur77 suppresses endothelial cell activation through induction of IkappaBalpha expression","volume":"104","author":"You","year":"2009","journal-title":"Circ. Res."},{"key":"10.1016\/j.mvr.2020.104031_bb0300","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1161\/CIRCRESAHA.110.222083","article-title":"Deficiency of the NR4A orphan nuclear receptor NOR1 decreases monocyte adhesion and atherosclerosis","volume":"107","author":"Zhao","year":"2010","journal-title":"Circ. Res."}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286220300911?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286220300911?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T05:58:10Z","timestamp":1758434290000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286220300911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":60,"alternative-id":["S0026286220300911"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2020.104031","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bulk and single-cell gene expression analyses reveal aging human choriocapillaris has pro-inflammatory phenotype","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2020.104031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104031"}}