{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:55:11Z","timestamp":1772121311222,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100009873","name":"Regione Autonoma della Sardegna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007037","name":"Ministeriet Sundhed Forebyggelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011435","name":"Rochester Academy of Science","doi-asserted-by":"publisher","award":["GR-2011-02352816"],"award-info":[{"award-number":["GR-2011-02352816"]}],"id":[{"id":"10.13039\/100011435","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1016\/j.mvr.2020.104038","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T11:14:04Z","timestamp":1593688444000},"page":"104038","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Comprehensive arginine metabolomics and peripheral vasodilatory capacity in rheumatoid arthritis: A monocentric cross-sectional study"],"prefix":"10.1016","volume":"131","author":[{"given":"Gian Luca","family":"Erre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arduino Aleksander","family":"Mangoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Passiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Bassu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Floriana","family":"Castagna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciriaco","family":"Carru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Piga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angelo","family":"Zinellu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Sotgia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2020.104038_bb0005","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1002\/art.27584","article-title":"2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"62","author":"Aletaha","year":"2010","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.mvr.2020.104038_bb0010","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.atherosclerosis.2012.08.033","article-title":"The L-arginine\/asymmetric dimethylarginine ratio is improved by anti-tumor necrosis factor-\u03b1 therapy in inflammatory arthropathies. Associations with aortic stiffness","volume":"225","author":"Angel","year":"2012","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.mvr.2020.104038_bb0015","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.autrev.2019.05.005","article-title":"Rheumatoid arthritis (RA) and cardiovascular disease","volume":"18","author":"Blum","year":"2019","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.mvr.2020.104038_bb0020","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1161\/CIRCULATIONAHA.108.838268","article-title":"Plasma asymmetric dimethylarginine and incidence of cardiovascular disease and death in the community","volume":"119","author":"B\u00f6ger","year":"2009","journal-title":"Circulation"},{"key":"10.1016\/j.mvr.2020.104038_bb0025","doi-asserted-by":"crossref","first-page":"2137","DOI":"10.1016\/j.jacc.2004.08.062","article-title":"Noninvasive identification of patients with early coronary atherosclerosis by assessment of digital reactive hyperemia","volume":"44","author":"Bonetti","year":"2004","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.mvr.2020.104038_bb0030","first-page":"H2087","article-title":"Effects of endothelium-derived nitric oxide on skin and digital blood flow in humans","volume":"267","author":"Coffman","year":"1994","journal-title":"Am. J. Phys."},{"issue":"347268","key":"10.1016\/j.mvr.2020.104038_bb0035","article-title":"Serum levels of asymmetric dimethylarginine and apelin as potential markers of vascular endothelial dysfunction in early rheumatoid arthritis","volume":"2012","author":"Di Franco","year":"2012","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.mvr.2020.104038_bb0040","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3897295","article-title":"Asymmetric dimethyl arginine as a biomarker of atherosclerosis in rheumatoid arthritis","volume":"2018","author":"Di Franco","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.mvr.2020.104038_bb0045","doi-asserted-by":"crossref","first-page":"267","DOI":"10.3109\/03009742.2015.1086433","article-title":"Associations between asymmetric dimethylarginine, homocysteine, and the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism (rs1801133) in rheumatoid arthritis","volume":"45","author":"Dimitroulas","year":"2016","journal-title":"Scand. J. Rheumatol."},{"key":"10.1016\/j.mvr.2020.104038_bb0050","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13075-017-1232-1","article-title":"Endothelial injury in rheumatoid arthritis: a crosstalk between dimethylarginines and systemic inflammation","volume":"19","author":"Dimitroulas","year":"2017","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.mvr.2020.104038_bb0055","doi-asserted-by":"crossref","DOI":"10.1177\/0300060515593255","article-title":"Asymmetric dimethylarginine and arterial stiffness in patients with rheumatoid arthritis: a case\u2013control study","volume":"44","author":"Erre","year":"2016","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.mvr.2020.104038_bb0060","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1007\/s00296-018-4039-8","article-title":"Coronary flow reserve in systemic rheumatic diseases: a systematic review and meta-analysis","volume":"38","author":"Erre","year":"2018","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.mvr.2020.104038_bb0065","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/6548715","article-title":"Prevalence and determinants of peripheral microvascular endothelial dysfunction in rheumatoid arthritis patients: a multicenter cross-sectional study","volume":"2018","author":"Erre","year":"2018","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.mvr.2020.104038_bb0070","doi-asserted-by":"crossref","first-page":"5426","DOI":"10.1038\/s41598-019-41994-5","article-title":"Meta-analysis of asymmetric dimethylarginine concentrations in rheumatic diseases","volume":"9","author":"Erre","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mvr.2020.104038_bb0075","doi-asserted-by":"crossref","DOI":"10.1186\/ar2668","article-title":"Inflammation predicts accelerated brachial arterial wall changes in patients with recent-onset rheumatoid arthritis","volume":"11","author":"Hannawi","year":"2009","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.mvr.2020.104038_bb0080","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1136\/annrheumdis-2016-211066","article-title":"Acute coronary syndrome in new-onset rheumatoid arthritis: a population-based nationwide cohort study of time trends in risks and excess risks","volume":"76","author":"Holmqvist","year":"2017","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.mvr.2020.104038_bb0085","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jchromb.2006.09.023","article-title":"An overview of plasma concentrations of asymmetric dimethylarginine (ADMA) in health and disease and in clinical studies: methodological considerations","volume":"851","author":"Horowitz","year":"2007","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.mvr.2020.104038_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1440-1681.2006.04316.x","article-title":"Amino acids, arginase and nitric oxide in vascular health","volume":"33","author":"Huynh","year":"2006","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.mvr.2020.104038_bb0095","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1161\/01.CIR.99.24.3092","article-title":"Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase","volume":"99","author":"Ito","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.mvr.2020.104038_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20184592","article-title":"The second life of methylarginines as cardiovascular targets","volume":"20","author":"Jarzebska","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mvr.2020.104038_bb0105","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.ijcard.2014.07.296","article-title":"Plasma homoarginine (hArg) and asymmetric dimethylarginine (ADMA) in patients with rheumatoid arthritis: is homoarginine a cardiovascular corrective in rheumatoid arthritis, an anti-ADMA?","volume":"176","author":"Kayacelebi","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.mvr.2020.104038_bb0110","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nm1543","article-title":"Disruption of methylarginine metabolism impairs vascular homeostasis","volume":"13","author":"Leiper","year":"2007","journal-title":"Nat. Med."},{"key":"10.1016\/j.mvr.2020.104038_bb0115","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1161\/CIRCULATIONAHA.109.908988","article-title":"Homoarginine, cardiovascular risk, and mortality","volume":"122","author":"M\u00e4rz","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.mvr.2020.104038_bb0120","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.jacc.2009.10.073","article-title":"Digital assessment of endothelial function and ischemic heart disease in women","volume":"55","author":"Matsuzawa","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.mvr.2020.104038_bb0125","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.113.000426","article-title":"Peripheral endothelial function and cardiovascular events in high-risk patients","volume":"2","author":"Matsuzawa","year":"2013","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.mvr.2020.104038_bb0130","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.002270","article-title":"Prognostic value of flow-mediated vasodilation in brachial artery and fingertip artery for cardiovascular events: a systematic review and meta-analysis","volume":"4","author":"Matsuzawa","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.mvr.2020.104038_bb0135","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1152\/japplphysiol.01285.2005","article-title":"Role of nitric oxide in the regulation of digital pulse volume amplitude in humans","volume":"101","author":"Nohria","year":"2006","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.mvr.2020.104038_bb0140","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.atherosclerosis.2017.10.004","article-title":"Opposing effects of rheumatoid arthritis and low dose prednisolone on arginine metabolomics","volume":"266","author":"Radhakutty","year":"2017","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.mvr.2020.104038_bb0145","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.clinbiochem.2012.07.092","article-title":"Clinical remission following treatment with tumour necrosis factor-alpha antagonists is not accompanied by changes in asymmetric dimethylarginine in patients with rheumatoid arthritis","volume":"45","author":"Sandoo","year":"2012","journal-title":"Clin. Biochem."},{"key":"10.1016\/j.mvr.2020.104038_bb0150","first-page":"388","article-title":"Lack of association between asymmetric dimethylarginine and in vivo microvascular and macrovascular endothelial function in patients with rheumatoid arthritis","volume":"30","author":"Sandoo","year":"2012","journal-title":"Clin. Exp. Rheumatol."},{"issue":"1145\u20131152","key":"10.1016\/j.mvr.2020.104038_bb0155","article-title":"Cumulative inflammation associates with asymmetric dimethylarginine in rheumatoid arthritis: a 6 year follow-up study","volume":"54","author":"Sandoo","year":"2015","journal-title":"Rheumatol. (United Kingdom)"},{"key":"10.1016\/j.mvr.2020.104038_bb0160","doi-asserted-by":"crossref","first-page":"106","DOI":"10.5152\/eurjrheum.2016.15096","article-title":"Relationship between asymmetric dimethylarginine and endothelial dysfunction in patients with rheumatoid arthritis","volume":"3","author":"Senturk","year":"2016","journal-title":"Eur. J. Rheumatol."},{"key":"10.1016\/j.mvr.2020.104038_bb0165","doi-asserted-by":"crossref","first-page":"18001","DOI":"10.1038\/nrdp.2018.1","article-title":"Rheumatoid arthritis","volume":"4","author":"Smolen","year":"2018","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.mvr.2020.104038_bb0170","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.cca.2019.02.004","article-title":"A diethylpyrocarbonate-based derivatization method for the LC-MS\/MS measurement of plasma arginine and its chemically related metabolites and analogs","volume":"492","author":"Sotgia","year":"2019","journal-title":"Clin. Chim. Acta"},{"issue":"537539","key":"10.1016\/j.mvr.2020.104038_bb0175","article-title":"Effect of therapeutic inhibition of TNF on circulating endothelial progenitor cells in patients with rheumatoid arthritis","volume":"2013","author":"Spinelli","year":"2013","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.mvr.2020.104038_bb0180","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1002\/art.22424","article-title":"Elevated plasma asymmetric dimethyl-L-arginine levels are linked to endothelial progenitor cell depletion and carotid atherosclerosis in rheumatoid arthritis","volume":"56","author":"Surdacki","year":"2007","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.mvr.2020.104038_bb0185","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jchromb.2006.07.024","article-title":"HPLC analysis of ADMA and other methylated L-arginine analogs in biological fluids","volume":"851","author":"Teerlink","year":"2007","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.mvr.2020.104038_bb0190","doi-asserted-by":"crossref","first-page":"3697","DOI":"10.1038\/s41598-018-22099-x","article-title":"Homoarginine and inhibition of human arginase activity: kinetic characterization and biological relevance","volume":"8","author":"Tommasi","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.mvr.2020.104038_bb0195","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1111\/j.1755-5922.2009.00119.x","article-title":"Effects of long-term disease-modifying antirheumatic drugs on endothelial function in patients with early rheumatoid arthritis","volume":"28","author":"Turiel","year":"2010","journal-title":"Cardiovasc. Ther."},{"key":"10.1016\/j.mvr.2020.104038_bb0200","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/S0140-6736(01)07184-7","article-title":"Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine","volume":"358","author":"Valkonen","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.mvr.2020.104038_bb0205","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1136\/ard.2003.007740","article-title":"Endothelial dysfunction in young patients with rheumatoid arthritis and low disease activity","volume":"63","author":"Vaudo","year":"2004","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.mvr.2020.104038_bb0210","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.115.001833","article-title":"Asymmetric dimethylarginine and cardiovascular risk: systematic review and meta-analysis of 22 prospective studies","volume":"4","author":"Willeit","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.mvr.2020.104038_bb0215","doi-asserted-by":"crossref","DOI":"10.1111\/eci.12960","article-title":"Homoarginine and all-cause mortality: a systematic review and meta-analysis","volume":"48","author":"Zinellu","year":"2018","journal-title":"Eur. J. Clin. Investig."},{"key":"10.1016\/j.mvr.2020.104038_bb0220","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1016\/S0140-6736(01)07217-8","article-title":"Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: a prospective study","volume":"358","author":"Zoccali","year":"2001","journal-title":"Lancet"}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286220300984?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286220300984?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T05:58:42Z","timestamp":1758434322000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286220300984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9]]},"references-count":44,"alternative-id":["S0026286220300984"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2020.104038","relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.2.21955\/v1","asserted-by":"object"}]},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2020,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comprehensive arginine metabolomics and peripheral vasodilatory capacity in rheumatoid arthritis: A monocentric cross-sectional study","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2020.104038","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104038"}}