{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:22:42Z","timestamp":1786994562275,"version":"build-2736575974"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.mvr.2021.104166","type":"journal-article","created":{"date-parts":[[2021,4,9]],"date-time":"2021-04-09T02:16:44Z","timestamp":1617934604000},"page":"104166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["Evaluation of the direct effects on retinal and choroidal microvascularity of systemic scleroderma"],"prefix":"10.1016","volume":"136","author":[{"given":"Mehmet","family":"K\u00f6k","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ay\u015fe","family":"Ayan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"Fatih K\u00fc\u00e7\u00fck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammet Kazim","family":"Erol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00fctfiye","family":"Yaprak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2021.104166_bb0005","doi-asserted-by":"crossref","first-page":"608","DOI":"10.3899\/jrheum.141425","article-title":"Intact calibers of retinal vessels in patients with systemic sclerosis","volume":"42","author":"Aissopou","year":"2015","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.mvr.2021.104166_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrdp.2015.2","article-title":"Systemic sclerosis","volume":"1","author":"Allanore","year":"2015","journal-title":"Nat. Rev. Dis. Primers."},{"key":"10.1016\/j.mvr.2021.104166_bb0015","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/BOR.0000000000000112","article-title":"Endothelial dysfunction in systemic clerosis","volume":"26","author":"Altorok","year":"2014","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.mvr.2021.104166_bb0020","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.semarthrit.2013.05.002","article-title":"Neurologic involvement in scleroderma: a systematic review","volume":"43","author":"Amaral","year":"2013","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.mvr.2021.104166_bb0025","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/cxo.12498","article-title":"Choroidal and central foveal thickness in patients with scleroderma and its systemic associations","volume":"100","author":"Aydin","year":"2017","journal-title":"Clin. Exp. Optom."},{"key":"10.1016\/j.mvr.2021.104166_bb0030","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1152\/physrev.1975.55.3.383","article-title":"Blood circulation and fluid dynamics in the eye","volume":"55","author":"Bill","year":"1975","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.mvr.2021.104166_bb0035","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1053\/sarh.2002.50011","article-title":"Blood coagulation, fibrinolysis, and markers of endothelial dysfunction in systemic sclerosis","volume":"32","author":"Cerinic","year":"2003","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.mvr.2021.104166_bb0040","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/eye.2015.287","article-title":"Evaluation of choroidal thickness in patients with scleroderma","volume":"30","author":"Co\u015fkun","year":"2016","journal-title":"Eye"},{"key":"10.1016\/j.mvr.2021.104166_bb0045","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1080\/1744666X.2019.1614915","article-title":"Pathophysiology of systemic sclerosis: current understanding and new insights","volume":"15","author":"Cutolo","year":"2019","journal-title":"Expert. Rev. Clin. Immunol."},{"key":"10.1016\/j.mvr.2021.104166_bb0050","doi-asserted-by":"crossref","first-page":"iii26","DOI":"10.1093\/rheumatology\/kel295","article-title":"Angiogenesis and vasculogenesis in systemic sclerosis","volume":"45","author":"Distler","year":"2006","journal-title":"Rheumatology"},{"key":"10.1016\/j.mvr.2021.104166_bb0055","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3109\/09273948.2015.1129424","article-title":"Evaluating choroidal characteristics in systemic sclerosis using enhanced depth imaging optical coherence tomography","volume":"25","author":"Esen","year":"2017","journal-title":"Ocul. Immunol. Inflamm."},{"key":"10.1016\/j.mvr.2021.104166_bb0060","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/0002-9394(72)91208-1","article-title":"The choroidopathy of progressive systemic sclerosis (scleroderma)","volume":"74","author":"Farkas","year":"1972","journal-title":"Am J. Ophthalmol."},{"key":"10.1016\/j.mvr.2021.104166_bb0065","first-page":"20","article-title":"The eye","volume":"4","author":"Forrester","year":"2016","journal-title":"Basic Sciences In Practice"},{"key":"10.1016\/j.mvr.2021.104166_bb0070","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1590\/S1807-59322011000300003","article-title":"Ocular findings in patients with systemic sclerosis","volume":"66","author":"Gomes","year":"2011","journal-title":"Clinics"},{"key":"10.1016\/j.mvr.2021.104166_bb0075","article-title":"Involvement of the eye in SLE and scleroderma. A study using fluorescein angiography in addition to clinical ophthalmic assessment","volume":"36:152-156","author":"Grennan","year":"1977","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.mvr.2021.104166_bb0080","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/s41433-019-0591-z","article-title":"Analysis of retinal and choroidal microvasculature in systemic sclerosis: an optical coherence tomography angiography study","volume":"34","author":"Hekimsoy","year":"2020","journal-title":"Eye"},{"key":"10.1016\/j.mvr.2021.104166_bb0085","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.mvr.2014.08.008","article-title":"Choroidal impairment and macular thinning in patients with systemic sclerosis: the acute study","volume":"97","author":"Ingegnoli","year":"2015","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2021.104166_bb0090","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.semarthrit.2018.12.007","article-title":"Ocular involvement in systemic sclerosis: a systematic literature review, it\u2019s not all scleroderma that meets the eye","volume":"49","author":"Kreps","year":"2019","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.mvr.2021.104166_bb0095","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0140-6736(04)16853-0","article-title":"Defective vasculogenesis in systemic sclerosis","volume":"364","author":"Kuwana","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.mvr.2021.104166_bb0100","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.exer.2004.02.012","article-title":"Investigations for retinopathy in an avian model for systemic sclerosis","volume":"79","author":"Peter","year":"2004","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.mvr.2021.104166_bb0105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s11926-011-0219-1","article-title":"Angiogenesis and vasculopathy in systemic sclerosis: evolving concepts","volume":"14","author":"Rabquer","year":"2012","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.mvr.2021.104166_bb0110","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.joco.2018.02.001","article-title":"Impact of correct anatomical slab segmentation on foveal avascular zone measurements by optical coherence tomography angiography in healthy adults","volume":"30","author":"Rommel","year":"2018","journal-title":"Journal of current ophthalmology"},{"key":"10.1016\/j.mvr.2021.104166_bb0115","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1136\/annrheumdis-2018-214541","article-title":"Evaluation of retinal microvascular perfusion in systemic sclerosis: a case\u2013control study","volume":"78","author":"Rothe","year":"2019","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.mvr.2021.104166_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102458","article-title":"Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud\u2019s phenomenon and systemic sclerosis","volume":"19","author":"Smith","year":"2020","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.mvr.2021.104166_bb0125","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1001\/jamaophthalmol.2014.3616","article-title":"Retinal vascular layers imaged by fluorescein angiography and optical coherence tomography angiography","volume":"133","author":"Spaide","year":"2015","journal-title":"JAMA Ophthalmology"},{"key":"10.1016\/j.mvr.2021.104166_bb0130","series-title":"Systemic Sclerosis: Scleroderma","first-page":"221","article-title":"Renal involvement in systemic sclerosis (scleroderma)","author":"Steigerwald","year":"1988"},{"key":"10.1016\/j.mvr.2021.104166_bb0135","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nri1224","article-title":"Ocular immune privilege: therapeutic opportunities from an experiment of nature","volume":"3","author":"Streilein","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.mvr.2021.104166_bb0140","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1136\/ard.62.3.204","article-title":"Retinal findings in systemic sclerosis: a comparison with nailfold capillaroscopic patterns","volume":"62","author":"Ushiyama","year":"2003","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.mvr.2021.104166_bb0145","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/art.38098","article-title":"2013 classification criteria for systemic sclerosis: an American College of Rheumatology\/European League against Rheumatism collaborative initiative","volume":"65","author":"Van Den Hoogen","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.mvr.2021.104166_bb0150","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1001\/archopht.121.4.547","article-title":"Retinal oxygen: fundamental and clinical aspects","volume":"121","author":"Wangsa-Wirawan","year":"2003","journal-title":"Arch. Ophthalmol."},{"key":"10.1016\/j.mvr.2021.104166_bb0155","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1056\/NEJMra032865","article-title":"Hypertensive retinopathy","volume":"351","author":"Wong","year":"2004","journal-title":"N. Engl. J. Med."}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286221000364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286221000364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T05:57:20Z","timestamp":1758434240000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286221000364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":31,"alternative-id":["S0026286221000364"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2021.104166","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluation of the direct effects on retinal and choroidal microvascularity of systemic scleroderma","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2021.104166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104166"}}