{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:06:44Z","timestamp":1776182804095,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.mvr.2021.104269","type":"journal-article","created":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T07:47:55Z","timestamp":1635148075000},"page":"104269","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Kawasaki disease and increased cardiovascular risk: Is there a link to circulating glycocalyx biomarkers?"],"prefix":"10.1016","volume":"140","author":[{"given":"Andr\u00e9","family":"Jakob","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Bohlig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"K\u00f6nig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Nussbaum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Dalla-Pozza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mathias","family":"Hermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus A.","family":"Haas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bel\u00e9n","family":"Pastor-Villaescusa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2021.104269_bb0005","doi-asserted-by":"crossref","first-page":"H647","DOI":"10.1152\/ajpheart.00090.2018","article-title":"Role of matrix metalloproteinases and histone deacetylase in oxidative stress-induced degradation of the endothelial glycocalyx","volume":"316","author":"Ali","year":"2019","journal-title":"Am. J. Physiol. - Hear. Circ. Physiol."},{"key":"10.1016\/j.mvr.2021.104269_bb0010","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1111\/bcp.12629","article-title":"Degradation of the endothelial glycocalyx in clinical settings: searching for the sheddases","volume":"80","author":"Becker","year":"2015","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.mvr.2021.104269_bb0015","doi-asserted-by":"crossref","DOI":"10.1146\/annurev.biochem.68.1.729","article-title":"Functions of cell surface heparan sulfate proteoglycans","author":"Bernfield","year":"1999","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.mvr.2021.104269_bb0020","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8071619","article-title":"On-the-scene hyaluronan and syndecan-1 serum concentrations and outcome after cardiac arrest and resuscitation","volume":"2019","author":"Bogner-Flatz","year":"2019","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.mvr.2021.104269_bb0025","doi-asserted-by":"crossref","DOI":"10.1097\/MOL.0b013e328321b587","article-title":"Endothelial glycocalyx as potential diagnostic and therapeutic target in cardiovascular disease","author":"Broekhuizen","year":"2009","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.mvr.2021.104269_bb0030","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.bpj.2013.09.060","article-title":"Structure and response to flow of the glycocalyx layer","volume":"106","author":"Cruz-Chu","year":"2014","journal-title":"Biophys. J."},{"key":"10.1016\/j.mvr.2021.104269_bb0035","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.echo.2010.10.004","article-title":"New equations and a critical appraisal of coronary artery Z scores in healthy children","volume":"24","author":"Dallaire","year":"2011","journal-title":"J. Am. Soc. Echocardiogr."},{"key":"10.1016\/j.mvr.2021.104269_bb0040","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.116.309326","article-title":"Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis","author":"F\u00f6rstermann","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.mvr.2021.104269_bb0045","doi-asserted-by":"crossref","DOI":"10.1089\/ars.2011.3999","article-title":"Superoxide dismutases: role in redox signaling, vascular function, and diseases","author":"Fukai","year":"2011","journal-title":"Antioxid. Redox Signal"},{"key":"10.1016\/j.mvr.2021.104269_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2009.12.004","article-title":"Kawasaki disease: aetiopathogenesis and therapeutic utility of intravenous immunoglobulin","author":"Galeotti","year":"2010","journal-title":"Autoimmun. Rev."},{"key":"10.1016\/j.mvr.2021.104269_bb0055","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.mvr.2010.06.005","article-title":"Composition of the endothelial glycocalyx and its relation to its thickness and diffusion of small solutes","volume":"80","author":"Gao","year":"2010","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2021.104269_bb0060","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.jamcollsurg.2017.05.012","article-title":"Syndecan-1: a quantitative marker for the endotheliopathy of trauma","volume":"225","author":"Gonzalez Rodriguez","year":"2017","journal-title":"J. Am. Coll. Surg."},{"key":"10.1016\/j.mvr.2021.104269_bb0065","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S2352-4642(20)30177-2","article-title":"COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study","volume":"4","author":"G\u00f6tzinger","year":"2020","journal-title":"Lancet Child Adolesc. Health"},{"key":"10.1016\/j.mvr.2021.104269_bb0070","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.resuscitation.2012.01.028","article-title":"Perturbation of the endothelial glycocalyx in post cardiac arrest syndrome","volume":"83","author":"Grundmann","year":"2012","journal-title":"Resuscitation"},{"key":"10.1016\/j.mvr.2021.104269_bb0075","first-page":"183","article-title":"Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome","volume":"1","author":"Hadi","year":"2005","journal-title":"Vasc. Health Risk Manag."},{"key":"10.1016\/j.mvr.2021.104269_bb0080","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3233\/CH-180444","article-title":"Biomarkers of endothelial injury in plasma are dependent on kidney function","volume":"72","author":"Hahn","year":"2019","journal-title":"Clin. Hemorheol. Microcirc."},{"key":"10.1016\/j.mvr.2021.104269_bb0085","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1100\/tsw.2010.88","article-title":"Sepsis-induced degradation of endothelial glycocalix","volume":"10","author":"Henrich","year":"2010","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.mvr.2021.104269_bb0090","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/heart.83.3.307","article-title":"Long term consequences of regressed coronary aneurysms after Kawasaki disease: vascular wall morphology and function","volume":"83","author":"Iemura","year":"2000","journal-title":"Heart"},{"key":"10.1016\/j.mvr.2021.104269_bb0095","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s00431-019-03513-6","article-title":"Von Willebrand factor parameters as potential biomarkers for disease activity and coronary artery lesion in patients with Kawasaki disease","volume":"179","author":"Jakob","year":"2020","journal-title":"Eur. J. Pediatr."},{"key":"10.1016\/j.mvr.2021.104269_bb0100","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1097\/INF.0000000000001923","article-title":"Failure to predict high-risk Kawasaki disease patients in a population-based study cohort in Germany","volume":"37","author":"Jakob","year":"2018","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.mvr.2021.104269_bb0105","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/INF.0000000000000953","article-title":"Kawasaki disease in Germany: a prospective, population-based study adjusted for underreporting","volume":"35","author":"Jakob","year":"2016","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.mvr.2021.104269_bb0110","doi-asserted-by":"crossref","first-page":"H104","DOI":"10.1152\/ajpheart.00794.2018","article-title":"Microvascular ion transport through endothelial glycocalyx layer: new mechanism and improved starling principle","volume":"317","author":"Jiang","year":"2019","journal-title":"Am. J. Physiol. - Heart Circ. Physiol."},{"key":"10.1016\/j.mvr.2021.104269_bb0115","doi-asserted-by":"crossref","DOI":"10.1007\/s11897-017-0320-5","article-title":"Endothelial glycocalyx as biomarker for cardiovascular diseases: mechanistic and clinical implications","author":"Kim","year":"2017","journal-title":"Curr. Heart Fail. Rep."},{"key":"10.1016\/j.mvr.2021.104269_bb0120","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.preghy.2019.08.165","article-title":"Levels of syndecan-1 and hyaluronan in early- and late-onset preeclampsia","volume":"18","author":"Kornacki","year":"2019","journal-title":"Pregnancy Hypertens."},{"key":"10.1016\/j.mvr.2021.104269_bb0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0154943","article-title":"Genome-wide association study identifies novel susceptibility genes associated with coronary artery aneurysm formation in Kawasaki disease","volume":"11","author":"Kuo","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.mvr.2021.104269_bb0130","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/INF.0000000000002047","article-title":"Serum levels of syndecan-1 in patients with Kawasaki disease","volume":"38","author":"Luo","year":"2019","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.mvr.2021.104269_bb0135","doi-asserted-by":"crossref","first-page":"e927","DOI":"10.1161\/CIR.0000000000000484","article-title":"Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association","volume":"135","author":"McCrindle","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.mvr.2021.104269_bb0140","doi-asserted-by":"crossref","first-page":"e927","DOI":"10.1161\/CIR.0000000000000484","article-title":"Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American Heart Association","volume":"135","author":"McCrindle","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.mvr.2021.104269_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22083850","article-title":"Endothelial dysfunction, inflammation and coronary artery disease: potential biomarkers and promising therapeutical approaches","author":"Medina-Leyte","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.mvr.2021.104269_bb0150","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.atherosclerosis.2016.02.023","article-title":"Evaluation of the endothelial glycocalyx damage in patients with acute coronary syndrome","volume":"247","author":"Miranda","year":"2016","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.mvr.2021.104269_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacc.2015.12.073","article-title":"Kawasaki disease","author":"Newburger","year":"2016","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.mvr.2021.104269_bb0160","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2004-2182","article-title":"Diagnosis, treatment, and long-term management of Kawasaki disease: a statement for health professionals from the committee on rheumatic fever, endocarditis, and Kawasaki disease, council on cardiovascular disease in the young, American Heart Association","author":"Newburger","year":"2004","journal-title":"Pediatrics"},{"key":"10.1016\/j.mvr.2021.104269_bb0165","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ijcard.2019.05.045","article-title":"Circulating endothelial glycocalyx components as a predictive marker of coronary artery lesions in Kawasaki disease","volume":"292","author":"Ohnishi","year":"2019","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.mvr.2021.104269_bb0170","article-title":"Vascular endothelial injury exacerbates coronavirus disease 2019: the role of endothelial glycocalyx protection","author":"Okada","year":"2020","journal-title":"Microcirculation"},{"key":"10.1016\/j.mvr.2021.104269_bb0175","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1161\/CIRCULATIONAHA.106.684852","article-title":"Shedding of the endothelial glycocalyx in patients undergoing major vascular surgery with global and regional ischemia","volume":"116","author":"Rehm","year":"2007","journal-title":"Circulation"},{"key":"10.1016\/j.mvr.2021.104269_bb0180","doi-asserted-by":"crossref","DOI":"10.1007\/s00424-007-0212-8","article-title":"The endothelial glycocalyx: composition, functions, and visualization","author":"Reitsma","year":"2007","journal-title":"Pflugers arch. EurJ. Physiol."},{"key":"10.1016\/j.mvr.2021.104269_bb0185","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s10456-020-09753-7","article-title":"Microvascular dysfunction in COVID-19: the MYSTIC study","volume":"24","author":"Rovas","year":"2021","journal-title":"Angiogenesis"},{"key":"10.1016\/j.mvr.2021.104269_bb0190","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00796.2005","article-title":"Reactive oxygen species mediate modification of glycocalyx during ischemia-reperfusion injury","volume":"290","author":"Rubio-Gayosso","year":"2006","journal-title":"Am. J. Physiol. - Heart Circ. Physiol."},{"key":"10.1016\/j.mvr.2021.104269_bb0195","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1136\/heartjnl-2015-307734","article-title":"Cardiovascular status after Kawasaki disease in the UK","volume":"101","author":"Shah","year":"2015","journal-title":"Heart"},{"key":"10.1016\/j.mvr.2021.104269_bb0200","article-title":"Reactive oxygen species modulate the barrier function of the human glomerular endothelial glycocalyx","volume":"8","author":"Singh","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.mvr.2021.104269_bb0205","doi-asserted-by":"crossref","DOI":"10.1136\/archdischild-2014-307536","article-title":"The epidemiology of Kawasaki disease: a global update","author":"Singh","year":"2015","journal-title":"Arch. Dis. Child."},{"key":"10.1016\/j.mvr.2021.104269_bb0210","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.2174\/138161209787846702","article-title":"Platelet activation by extracellular matrix proteins in haemostasis and thrombosis","volume":"15","author":"Watson","year":"2009","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.mvr.2021.104269_bb0215","first-page":"1","article-title":"Association of MnSOD gene polymorphism with susceptibility to Kawasaki disease in Chinese children","volume":"31","author":"Wu","year":"2020","journal-title":"Cardiol. Young"}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286221001394?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286221001394?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T05:58:45Z","timestamp":1758434325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286221001394"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":43,"alternative-id":["S0026286221001394"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2021.104269","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Kawasaki disease and increased cardiovascular risk: Is there a link to circulating glycocalyx biomarkers?","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2021.104269","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104269"}}