{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:37:19Z","timestamp":1776724639808,"version":"3.51.2"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973510"],"award-info":[{"award-number":["81973510"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81374002"],"award-info":[{"award-number":["81374002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.mvr.2021.104309","type":"journal-article","created":{"date-parts":[[2022,1,4]],"date-time":"2022-01-04T11:01:17Z","timestamp":1641294077000},"page":"104309","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["VEGFR2 in vascular smooth muscle cells mediates H2S-induced dilation of the rat cerebral basilar artery"],"prefix":"10.1016","volume":"141","author":[{"given":"Jinhua","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohong","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuo","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qianjun","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyue","family":"Wen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiwu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.mvr.2021.104309_bb0005","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/sj.bjp.0706906","article-title":"Regulation of vascular nitric oxide in vitro and in vivo; a new role for endogenous hydrogen sulphide?","volume":"149","author":"Ali","year":"2006","journal-title":"Br. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.mvr.2021.104309_bb0010","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.yjmcc.2010.12.016","article-title":"SERCA2a controls the mode of agonist-induced intracellular Ca2+ signal, transcription factor NFAT and proliferation in human vascular smooth muscle cells","volume":"50","author":"Bobe","year":"2011","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.mvr.2021.104309_bb0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/ars.2017.7058","article-title":"A review of hydrogen sulfide synthesis, metabolism, and measurement: is modulation of hydrogen sulfide a novel therapeutic for cancer?","volume":"31","author":"Cao","year":"2019","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mvr.2021.104309_bb0025","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.phrs.2015.08.007","article-title":"Blocking the L-type Ca2+ channel (Cav 1.2) is the key mechanism for the vascular relaxing effect of Pterodon spp. and its isolated diterpene methyl-6alpha-acetoxy-7beta-hydroxyvouacapan-17beta-oate","volume":"100","author":"de Fatima Reis","year":"2015","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.mvr.2021.104309_bb0030","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1179\/1743132811Y.0000000049","article-title":"Magnesium increases iberiotoxin-sensitive large conductance calcium activated potassium currents on the basilar artery smooth muscle cells in rabbits","volume":"34","author":"Dhungel","year":"2012","journal-title":"Neurol. Res."},{"issue":"4","key":"10.1016\/j.mvr.2021.104309_bb0035","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.fitote.2011.01.023","article-title":"Cellular mechanisms underlying hyperin-induced relaxation of rat basilar artery","volume":"82","author":"Fan","year":"2011","journal-title":"Fitoterapia"},{"issue":"1","key":"10.1016\/j.mvr.2021.104309_bb0040","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1053\/j.gastro.2006.02.033","article-title":"The emerging roles of hydrogen sulfide in the gastrointestinal tract and liver","volume":"131","author":"Fiorucci","year":"2006","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.mvr.2021.104309_bb0045","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1254\/jphs.12277FP","article-title":"Acetylcholine- and sodium hydrosulfide-induced endothelium-dependent relaxation and hyperpolarization in cerebral vessels of global cerebral ischemia-reperfusion rat","volume":"121","author":"Han","year":"2013","journal-title":"J. Pharmacol. Sci."},{"issue":"3","key":"10.1016\/j.mvr.2021.104309_bb0055","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1002\/jcp.1121","article-title":"Expression of vascular endothelial growth factor receptors in smooth muscle cells","volume":"188","author":"Ishida","year":"2001","journal-title":"J. Cell. Physiol."},{"issue":"11","key":"10.1016\/j.mvr.2021.104309_bb0060","doi-asserted-by":"crossref","first-page":"H1446","DOI":"10.1152\/ajpheart.00506.2012","article-title":"Hydrogen sulfide dilates rat mesenteric arteries by activating endothelial large-conductance Ca(2)(+)-activated K(+) channels and smooth muscle Ca(2)(+) sparks","volume":"304","author":"Jackson-Weaver","year":"2013","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mvr.2021.104309_bb0065","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/bs.mie.2014.11.025","article-title":"Role of hydrogen sulfide in brain synaptic remodeling","volume":"555","author":"Kamat","year":"2015","journal-title":"Methods Enzymol."},{"issue":"5","key":"10.1016\/j.mvr.2021.104309_bb0070","doi-asserted-by":"crossref","first-page":"C537","DOI":"10.1152\/ajpcell.00329.2016","article-title":"Vascular biology of hydrogen sulfide","volume":"312","author":"Kanagy","year":"2017","journal-title":"Am. J. Physiol. Cell Physiol."},{"issue":"14","key":"10.1016\/j.mvr.2021.104309_bb0075","doi-asserted-by":"crossref","DOI":"10.1242\/dev.151019","article-title":"Vascular endothelial growth factor signaling in development and disease","volume":"145","author":"Karaman","year":"2018","journal-title":"Development"},{"issue":"7","key":"10.1016\/j.mvr.2021.104309_bb0080","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a006502","article-title":"Signal transduction by vascular endothelial growth factor receptors","volume":"2","author":"Koch","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"issue":"2","key":"10.1016\/j.mvr.2021.104309_bb0085","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.tips.2007.11.003","article-title":"Putative biological roles of hydrogen sulfide in health and disease: a breath of not so fresh air?","volume":"29","author":"Li","year":"2008","journal-title":"Trends Pharmacol. Sci."},{"issue":"5","key":"10.1016\/j.mvr.2021.104309_bb0090","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1161\/CIRCRESAHA.118.311134","article-title":"Evolution of hydrogen sulfide therapeutics to treat cardiovascular disease","volume":"123","author":"Li","year":"2018","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.mvr.2021.104309_bb0095","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/j.celrep.2014.09.003","article-title":"VEGFR2-mediated vascular dilation as a mechanism of VEGF-induced anemia and bone marrow cell mobilization","volume":"9","author":"Lim","year":"2014","journal-title":"Cell Rep."},{"issue":"3 Pt 2","key":"10.1016\/j.mvr.2021.104309_bb0100","first-page":"H1317","article-title":"Hemodynamic effects of intracoronary VEGF delivery: evidence of tachyphylaxis and NO dependence of response","volume":"273","author":"Lopez","year":"1997","journal-title":"Am. J. Phys."},{"issue":"5","key":"10.1016\/j.mvr.2021.104309_bb0105","doi-asserted-by":"crossref","first-page":"H1157","DOI":"10.1152\/ajpheart.00303.2019","article-title":"Hydrogen sulfide regulation of renal and mesenteric blood flow","volume":"317","author":"Morales-Loredo","year":"2019","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"issue":"4","key":"10.1016\/j.mvr.2021.104309_bb0110","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1161\/CIRCRESAHA.114.300505","article-title":"Emergence of hydrogen sulfide as an endogenous gaseous signaling molecule in cardiovascular disease","volume":"114","author":"Polhemus","year":"2014","journal-title":"Circ. Res."},{"key":"10.1016\/j.mvr.2021.104309_bb0115","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ejphar.2019.02.012","article-title":"alpha1D-adrenoceptor involves the relaxation effect of farrerol in rat aortic vascular smooth muscle cells","volume":"853","author":"Qin","year":"2019","journal-title":"Eur. J. Pharmacol."},{"issue":"7","key":"10.1016\/j.mvr.2021.104309_bb0125","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1167\/iovs.05-1229","article-title":"VEGF expression and receptor activation in the choroid during development and in the adult","volume":"47","author":"Saint-Geniez","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.mvr.2021.104309_bb0130","doi-asserted-by":"crossref","first-page":"1873962","DOI":"10.1155\/2018\/1873962","article-title":"Antioxidant and cell-signaling functions of hydrogen sulfide in the central nervous system","volume":"2018","author":"Shefa","year":"2018","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"11","key":"10.1016\/j.mvr.2021.104309_bb0135","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1038\/aps.2009.145","article-title":"Doxorubicin-induced vasomotion and [Ca(2+)](i) elevation in vascular smooth muscle cells from C57BL\/6 mice","volume":"30","author":"Shen","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"issue":"1","key":"10.1016\/j.mvr.2021.104309_bb0140","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1093\/jb\/mvs136","article-title":"Vascular endothelial growth factor and its receptor system: physiological functions in angiogenesis and pathological roles in various diseases","volume":"153","author":"Shibuya","year":"2013","journal-title":"J. Biochem."},{"issue":"1","key":"10.1016\/j.mvr.2021.104309_bb0145","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1530\/JOE-20-0190","article-title":"Interaction among estrogen, IGF-1, and H2S on smooth muscle cell proliferation","volume":"248","author":"Shuang","year":"2021","journal-title":"J. Endocrinol."},{"issue":"11","key":"10.1016\/j.mvr.2021.104309_bb0150","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/nrd2425","article-title":"Hydrogen sulphide and its therapeutic potential","volume":"6","author":"Szabo","year":"2007","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.mvr.2021.104309_bb0155","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1089\/ars.2012.4565","article-title":"VEGFR2 functions as an H2S-targeting receptor protein kinase with its novel Cys1045-Cys1024 disulfide bond serving as a specific molecular switch for hydrogen sulfide actions in vascular endothelial cells","volume":"19","author":"Tao","year":"2013","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.mvr.2021.104309_bb0160","series-title":"Handb. Exp. Pharmacol","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-3-319-18144-8_6","article-title":"H2S is a promoter of angiogenesis: identification of H2S \"receptors\" and its molecular switches in vascular endothelial cells","volume":"230","author":"Tao","year":"2015"},{"issue":"2","key":"10.1016\/j.mvr.2021.104309_bb0165","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/MNH.0000000000000206","article-title":"Hydrogen sulfide in hypertension","volume":"25","author":"van Goor","year":"2016","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"issue":"5","key":"10.1016\/j.mvr.2021.104309_bb0170","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nrd4433","article-title":"Hydrogen sulfide-based therapeutics: exploiting a unique but ubiquitous gasotransmitter","volume":"14","author":"Wallace","year":"2015","journal-title":"Nat. Rev. Drug Discov."},{"issue":"9","key":"10.1016\/j.mvr.2021.104309_bb0175","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1007\/s10620-017-4681-0","article-title":"Gaseous mediators in gastrointestinal mucosal defense and injury","volume":"62","author":"Wallace","year":"2017","journal-title":"Dig. Dis. Sci."},{"issue":"3\u20134","key":"10.1016\/j.mvr.2021.104309_bb0180","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1159\/000448712","article-title":"Involvement of hydrogen sulfide in endothelium-derived relaxing factor-mediated responses in rat cerebral arteries","volume":"53","author":"Wang","year":"2016","journal-title":"J. Vasc. Res."},{"issue":"5","key":"10.1016\/j.mvr.2021.104309_bb0185","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/00005344-200411000-00016","article-title":"Vascular endothelial growth factor-induced nitric oxide- and PGI2-dependent relaxation in human internal mammary arteries: a comparative study with KDR and Flt-1 selective mutants","volume":"44","author":"Wei","year":"2004","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1016\/j.mvr.2021.104309_bb0190","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3389\/fneur.2018.00779","article-title":"Vascular protection of hydrogen sulfide on cerebral ischemia\/reperfusion injury in rats","volume":"9","author":"Wen","year":"2018","journal-title":"Front. Neurol."},{"issue":"3","key":"10.1016\/j.mvr.2021.104309_bb0195","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1021\/acschemneuro.8b00533","article-title":"Role of CSE-produced H2S on cerebrovascular relaxation via RhoA-ROCK inhibition and cerebral ischemia-reperfusion injury in mice","volume":"10","author":"Wen","year":"2019","journal-title":"ACS Chem. Neurosci."},{"issue":"Pt 9","key":"10.1016\/j.mvr.2021.104309_bb0200","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1242\/jcs.02805","article-title":"Agonist- and depolarization-induced signals for myosin light chain phosphorylation and force generation of cultured vascular smooth muscle cells","volume":"119","author":"Woodsome","year":"2006","journal-title":"J. Cell Sci."},{"issue":"7","key":"10.1016\/j.mvr.2021.104309_bb0205","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/1440-1681.13087","article-title":"Mechanisms of U46619-induced contraction in mouse intrarenal artery","volume":"46","author":"Yan","year":"2019","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"issue":"6","key":"10.1016\/j.mvr.2021.104309_bb0210","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1097\/00005344-199606000-00011","article-title":"Effects of vascular endothelial growth factor on hemodynamics and cardiac performance","volume":"27","author":"Yang","year":"1996","journal-title":"J. Cardiovasc. Pharmacol."},{"issue":"5901","key":"10.1016\/j.mvr.2021.104309_bb0215","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1126\/science.1162667","article-title":"H2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase","volume":"322","author":"Yang","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.mvr.2021.104309_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118831","article-title":"The antihypertension effect of hydrogen sulfide (H2S) is induced by activating VEGFR2 signaling pathway","volume":"267","author":"Zhu","year":"2021","journal-title":"Life Sci."}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286221001795?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286221001795?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T05:59:13Z","timestamp":1758434353000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286221001795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":41,"alternative-id":["S0026286221001795"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2021.104309","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"VEGFR2 in vascular smooth muscle cells mediates H2S-induced dilation of the rat cerebral basilar artery","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2021.104309","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104309"}}