{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:39:40Z","timestamp":1791848380385,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008386","name":"Marmara \u00dcniversitesi","doi-asserted-by":"publisher","award":["TTU-2021-10326"],"award-info":[{"award-number":["TTU-2021-10326"]}],"id":[{"id":"10.13039\/501100008386","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.mvr.2023.104591","type":"journal-article","created":{"date-parts":[[2023,8,3]],"date-time":"2023-08-03T22:51:09Z","timestamp":1691103069000},"page":"104591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Endothelial dysfunction, thrombophilia, and nailfold capillaroscopic features in livedoid vasculopathy"],"prefix":"10.1016","volume":"150","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6980-8986","authenticated-orcid":false,"given":"O.","family":"Apti Sengun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9935-6298","authenticated-orcid":false,"given":"T.","family":"Ergun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7969-5962","authenticated-orcid":false,"given":"T.","family":"Guctekin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6653-1758","authenticated-orcid":false,"given":"F.","family":"Alibaz Oner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.mvr.2023.104591_bb0005","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/s11239-011-0556-y","article-title":"Enhanced functional stability of plasminogen activator inhibitor-1 in patients with livedoid vasculopathy","volume":"32","author":"Agirbasli","year":"2011","journal-title":"J. Thromb. Thrombolysis"},{"key":"10.1016\/j.mvr.2023.104591_bb0010","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.vph.2018.12.005","article-title":"The endothelial status reflected by circulating endothelial cells, circulating endothelial progenitor cells and soluble thrombomodulin in patients with mild and resistant hypertension","volume":"113","author":"Budzy\u0144","year":"2019","journal-title":"Vasc. Pharmacol."},{"issue":"3","key":"10.1016\/j.mvr.2023.104591_bb0015","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.jaad.2022.06.1188","article-title":"A novel combination (\u201cCHAP\u201d) regimen for management of livedoid vasculopathy in 12 patients","volume":"88","author":"Coromilas","year":"2023","journal-title":"J. Am. Acad. Dermatol."},{"issue":"6","key":"10.1016\/j.mvr.2023.104591_bb0020","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.autrev.2010.11.008","article-title":"Livedoid vasculopathy as a coagulation disorder","volume":"10","author":"Criado","year":"2011","journal-title":"Autoimmun. Rev."},{"issue":"2","key":"10.1016\/j.mvr.2023.104591_bb0025","doi-asserted-by":"crossref","first-page":"e14810","DOI":"10.1111\/dth.14810","article-title":"Livedoid vasculopathy in 75 Brazilian patients in a single-center institution: clinical, histopathological and therapy evaluation","volume":"34","author":"Criado","year":"2021","journal-title":"Dermatol. Ther."},{"issue":"11","key":"10.1016\/j.mvr.2023.104591_bb0030","doi-asserted-by":"crossref","DOI":"10.1001\/archderm.142.11.1466","article-title":"Livedoid vasculopathy associated with plasminogen activator inhibitor-1 promoter homozygosity (4G\/4G) treated successfully with tissue plasminogen activator","volume":"142","author":"Deng","year":"2006","journal-title":"Arch. Dermatol."},{"issue":"11","key":"10.1016\/j.mvr.2023.104591_bb0035","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1111\/jth.15047","article-title":"Guidance from the Scientific and Standardization Committee for lupus anticoagulant\/antiphospholipid antibodies of the International Society on Thrombosis and Haemostasis: update of the guidelines for lupus anticoagulant detection and interpretation","volume":"18","author":"Devreese","year":"2020","journal-title":"J. Thromb. Haemost."},{"issue":"11","key":"10.1016\/j.mvr.2023.104591_bb0040","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1111\/j.1468-3083.2010.03646.x","article-title":"Frequency of thrombophilia determinant factors in patients with livedoid vasculopathy and treatment with anticoagulant drugs - a prospective study: livedoid vasculopathy - thrombophilia and anticoagulation","volume":"24","author":"Di Giacomo","year":"2010","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"10.1016\/j.mvr.2023.104591_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.semarthrit.2023.152228","article-title":"Increased oxidative stress response in circulating blood of systemic sclerosis patients - relation to disease characteristics and inflammatory blood biomarkers","volume":"62","author":"Dziedzic","year":"2023","journal-title":"Semin. Arthritis Rheum."},{"issue":"6","key":"10.1016\/j.mvr.2023.104591_bb0050","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1073\/pnas.92.6.1851","article-title":"Allele-specific increase in basal transcription of the plasminogen-activator inhibitor 1 gene is associated with myocardial infarction","volume":"92","author":"Eriksson","year":"1995","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"12","key":"10.1016\/j.mvr.2023.104591_bb0055","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/cup.13043","article-title":"Analysis of serum levels and cutaneous expression of lipoprotein (a) in 38 patients with livedoid vasculopathy","volume":"44","author":"Espinel","year":"2017","journal-title":"J. Cutan. Pathol."},{"issue":"1","key":"10.1016\/j.mvr.2023.104591_bb0060","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1080\/09546634.2020.1737634","article-title":"Efficacy of an anti-TNF-alpha agent in refractory livedoid vasculopathy: a retrospective analysis","volume":"33","author":"Gao","year":"2022","journal-title":"J. Dermatol. Treat."},{"issue":"3","key":"10.1016\/j.mvr.2023.104591_bb0065","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/01.ATV.18.3.356","article-title":"Vitamin supplementation reduces blood homocysteine levels: a controlled trial in patients with venous thrombosis and healthy volunteers","volume":"18","author":"den Heijer","year":"1998","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.mvr.2023.104591_bb0070","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3389\/fmed.2018.00175","article-title":"Circulating protein biomarkers in systemic sclerosis related pulmonary arterial hypertension: a review of published data","volume":"5","author":"Hickey","year":"2018","journal-title":"Front. Med."},{"issue":"11","key":"10.1016\/j.mvr.2023.104591_bb0075","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1136\/annrheumdis-2013-204424","article-title":"2013 classification criteria for systemic sclerosis: an American college of rheumatology\/European league against rheumatism collaborative initiative","volume":"72","author":"van den Hoogen","year":"2013","journal-title":"Ann. Rheum. Dis."},{"issue":"4","key":"10.1016\/j.mvr.2023.104591_bb0080","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.semarthrit.2007.10.008","article-title":"Feasibility of different capillaroscopic measures for identifying nailfold microvascular alterations","volume":"38","author":"Ingegnoli","year":"2009","journal-title":"Semin. Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.mvr.2023.104591_bb0085","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1684\/ejd.2022.4200","article-title":"Exacerbation of livedoid vasculopathy after coronavirus disease 2019","volume":"32","author":"Kawabe","year":"2022","journal-title":"Eur. J. Dermatol."},{"issue":"5","key":"10.1016\/j.mvr.2023.104591_bb0090","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1177\/12034754211003525","article-title":"Intravenous immunoglobulin therapy in livedoid vasculopathy: retrospective observation of clinical outcome and patient\u2019s activity level","volume":"25","author":"Kofler","year":"2021","journal-title":"Journal of Cutaneous Medicine and Surgery."},{"issue":"42","key":"10.1016\/j.mvr.2023.104591_bb0095","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.1093\/eurheartj\/eht053","article-title":"When should we measure lipoprotein (a)?","volume":"34","author":"Kostner","year":"2013","journal-title":"Eur. Heart J."},{"issue":"4","key":"10.1016\/j.mvr.2023.104591_bb0100","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.jaad.2020.05.158","article-title":"Methylene tetrahydrofolate reductase C677T polymorphism in Korean livedoid vasculopathy patients","volume":"84","author":"Lee","year":"2021","journal-title":"J. Am. Acad. Dermatol."},{"issue":"5","key":"10.1016\/j.mvr.2023.104591_bb0105","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/0003319720903586","article-title":"Novel biomarkers for evaluation of endothelial dysfunction","volume":"71","author":"Leite","year":"2020","journal-title":"Angiology"},{"key":"10.1016\/j.mvr.2023.104591_bb0110","series-title":"StatPearls [Internet]","article-title":"Livedoid vasculopathy. 2022 Aug 8","author":"Majmundar","year":"2023"},{"issue":"3","key":"10.1016\/j.mvr.2023.104591_bb0115","article-title":"Livedoid vasculopathy: an updated review","volume":"7","author":"Micieli","year":"2018","journal-title":"Curr. Dermatol. Rep."},{"issue":"4","key":"10.1016\/j.mvr.2023.104591_bb0120","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1097\/TP.0000000000000571","article-title":"Functional difference between membrane-bound and soluble human thrombomodulin","volume":"99","author":"Miwa","year":"2015","journal-title":"Transplantation"},{"issue":"4","key":"10.1016\/j.mvr.2023.104591_bb0125","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/j.jaad.2014.05.039","article-title":"Efficacy of intravenous immunoglobulins in livedoid vasculopathy: long-term follow-up of 11 patients","volume":"71","author":"Monshi","year":"2014","journal-title":"J. Am. Acad. Dermatol."},{"issue":"6","key":"10.1016\/j.mvr.2023.104591_bb0130","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00005-017-0465-7","article-title":"Evaluation of endothelial function by flow-mediated dilation: a comprehensive review in rheumatic disease","volume":"65","author":"Moroni","year":"2017","journal-title":"Arch. Immunol. Ther. Exp."},{"issue":"7","key":"10.1016\/j.mvr.2023.104591_bb0135","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1742-1241.2005.00477.x","article-title":"Impaired endothelium-dependent flow-mediated dilation in Beh\u00e7et\u2019s disease: more prominent endothelial dysfunction in patients with vascular involvement: endothelial dysfunction in beh\u00e7et\u2019s disease","volume":"59","author":"Oflaz","year":"2005","journal-title":"Int. J. Clin. Pract."},{"issue":"4","key":"10.1016\/j.mvr.2023.104591_bb0140","doi-asserted-by":"crossref","first-page":"495","DOI":"10.5114\/ada.2019.83501","article-title":"Endothelial dysfunction in patients with systemic sclerosis","volume":"37","author":"Pacholczak-Madej","year":"2020","journal-title":"Adv. Dermatol. Allergol."},{"issue":"7","key":"10.1016\/j.mvr.2023.104591_bb0145","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1177\/0003319720987752","article-title":"Endothelial dysfunction and its clinical implications","volume":"72","author":"Poredos","year":"2021","journal-title":"Angiology"},{"issue":"3","key":"10.1016\/j.mvr.2023.104591_bb0150","doi-asserted-by":"crossref","DOI":"10.1111\/micc.12440","article-title":"Microvascular involvement in systemic sclerosis and systemic lupus erythematosus","volume":"26","author":"Saygin","year":"2019","journal-title":"Microcirculation"},{"issue":"1","key":"10.1016\/j.mvr.2023.104591_bb0155","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/cbf.1132","article-title":"Genotype and allele frequencies of the polymorphic methylenetetrahydrofolate reductase gene in Turkey","volume":"23","author":"Sazci","year":"2005","journal-title":"Cell Biochem. Funct."},{"issue":"11","key":"10.1016\/j.mvr.2023.104591_bb0160","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1111\/ddg.14520","article-title":"German S1 guideline: diagnosis and treatment of livedovasculopathy","volume":"19","author":"Schiffmann","year":"2021","journal-title":"JDDG J. Dtsch. Dermatol. Ges."},{"issue":"3","key":"10.1016\/j.mvr.2023.104591_bb0165","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1002\/art.37783","article-title":"Livedoid vasculopathy-a vasculitic mimic","volume":"65","author":"Shankar","year":"2013","journal-title":"Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.mvr.2023.104591_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2020.102458","article-title":"Standardisation of nailfold capillaroscopy for the assessment of patients with Raynaud\u2019s phenomenon and systemic sclerosis","volume":"19","author":"Smith","year":"2020","journal-title":"Autoimmun. Rev."},{"issue":"5","key":"10.1016\/j.mvr.2023.104591_bb0175","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1001\/jamadermatol.2022.0241","article-title":"Treatment of livedoid vasculopathy with baricitinib","volume":"158","author":"Song","year":"2022","journal-title":"JAMA Dermatol."},{"issue":"1","key":"10.1016\/j.mvr.2023.104591_bb0180","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3109\/14397595.2013.854064","article-title":"Clinical correlation of brachial artery flow-mediated dilation in patients with systemic sclerosis","volume":"24","author":"Takahashi","year":"2014","journal-title":"Mod. Rheumatol."},{"issue":"3","key":"10.1016\/j.mvr.2023.104591_bb0185","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jdermsci.2008.12.010","article-title":"Polymorphisms of MTHFR gene associated with livedoid vasculopathy in Taiwanese population","volume":"54","author":"Tsai","year":"2009","journal-title":"J. Dermatol. Sci."},{"issue":"5","key":"10.1016\/j.mvr.2023.104591_bb0190","doi-asserted-by":"crossref","first-page":"478","DOI":"10.4103\/0378-6323.183635","article-title":"Livedoid vasculopathy: a review of pathogenesis and principles of management","volume":"82","author":"Vasudevan","year":"2016","journal-title":"Indian J. Dermatol. Venereol. Leprol."},{"issue":"3","key":"10.1016\/j.mvr.2023.104591_bb0195","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.283","article-title":"Time course of endothelial dysfunction markers and mortality in COVID-19 patients: a pilot study","volume":"11","author":"Vieceli Dalla Sega","year":"2021","journal-title":"Clin. Transl. Med."},{"issue":"4","key":"10.1016\/j.mvr.2023.104591_bb0200","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3233\/CH-180486","article-title":"Correlations of carotid intima-media thickness with endothelial function and atherosclerosis degree in patients with type 2 diabetes mellitus","volume":"72","author":"Wang","year":"2019","journal-title":"Clin. Hemorheol. Microcirc."},{"issue":"2","key":"10.1016\/j.mvr.2023.104591_bb0205","doi-asserted-by":"crossref","first-page":"e72","DOI":"10.1016\/S2352-3026(15)00251-3","article-title":"Anticoagulation with rivaroxaban for livedoid vasculopathy (RILIVA): a multicentre, single-arm, open-label, phase 2a, proof-of-concept trial","volume":"3","author":"Weishaupt","year":"2016","journal-title":"Lancet Haematol."},{"issue":"9","key":"10.1016\/j.mvr.2023.104591_bb0210","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1111\/jdv.15639","article-title":"Characteristics, risk factors and treatment reality in livedoid vasculopathy \u2013 a multicentre analysis","volume":"33","author":"Weishaupt","year":"2019","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"issue":"1","key":"10.1016\/j.mvr.2023.104591_bb0215","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jaad.2011.07.021","article-title":"Association between peripheral vascular endothelial dysfunction and livedoid vasculopathy","volume":"67","author":"Yang","year":"2012","journal-title":"J. Am. Acad. Dermatol."},{"issue":"5","key":"10.1016\/j.mvr.2023.104591_bb0220","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/j.transproceed.2021.03.011","article-title":"Endothelial markers: Thrombomodulin and Von Willebrand factor and risk of kidney thrombosis after transplantation","volume":"53","author":"Zi\u0119tek","year":"2021","journal-title":"Transplant. Proc."}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286223001176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286223001176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T06:02:17Z","timestamp":1758434537000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286223001176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":44,"alternative-id":["S0026286223001176"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2023.104591","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Endothelial dysfunction, thrombophilia, and nailfold capillaroscopic features in livedoid vasculopathy","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2023.104591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"104591"}}