{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T05:00:49Z","timestamp":1780203649850,"version":"3.54.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T00:00:00Z","timestamp":1762387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004775","name":"Gansu Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["23JRRA1217"],"award-info":[{"award-number":["23JRRA1217"]}],"id":[{"id":"10.13039\/501100004775","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374279"],"award-info":[{"award-number":["82374279"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82360926"],"award-info":[{"award-number":["82360926"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.mvr.2025.104883","type":"journal-article","created":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T16:51:04Z","timestamp":1762361464000},"page":"104883","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Mechanistic investigation of quercetin (an active component of RAS-RH) in modulating radiation-induced coronary microvascular dysfunction via the TCs-ECs crosstalk pathway"],"prefix":"10.1016","volume":"163","author":[{"given":"Jiang","family":"Hugang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Ai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo","family":"Zeao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren","family":"Chunzhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Wenyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Kai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Xinke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yingdong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2025.104883_bb0005","doi-asserted-by":"crossref","first-page":"4465","DOI":"10.2147\/OTT.S105368","article-title":"Mast cells positive to tryptase, endothelial cells positive to protease-activated receptor-2, and microvascular density correlate among themselves in hepatocellular carcinoma patients who have undergone surgery","volume":"9","author":"Ammendola","year":"2016","journal-title":"Onco. Targets. Ther."},{"issue":"3","key":"10.1016\/j.mvr.2025.104883_bb0010","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.jaccao.2021.06.007","article-title":"Past, present, and future of radiation-induced cardiotoxicity: refinements in targeting, surveillance, and risk stratification","volume":"3","author":"Bergom","year":"2021","journal-title":"JACC. CardioOncol."},{"key":"10.1016\/j.mvr.2025.104883_bb0015","series-title":"Methods in Molecular Biology (Clifton, N.J.)","doi-asserted-by":"crossref","DOI":"10.1007\/7651_2024_549","article-title":"Telocytes: detection, visualization, tissue dissociation, and tamoxifen-induction of transgenic mice","author":"Canella","year":"2024"},{"issue":"14","key":"10.1016\/j.mvr.2025.104883_bb0020","doi-asserted-by":"crossref","first-page":"6766","DOI":"10.7150\/thno.60143","article-title":"Coronary microvascular injury in myocardial infarction: perception and knowledge for mitochondrial quality control","volume":"11","author":"Chang","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.mvr.2025.104883_bb0025","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/5580828","article-title":"Ultrafiltration extract of Radix angelica sinensis and Radix hedysari attenuates risk of low-dose X-ray radiation-induced myocardial fibrosis in vitro","volume":"2021","author":"Chang","year":"2021","journal-title":"Evidence-based Complement. Altern. Med.: eCAM"},{"issue":"6","key":"10.1016\/j.mvr.2025.104883_bb0030","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.438","article-title":"Chinese expert consensus on the diagnosis and treatment of coronary microvascular diseases (2023 edition)","volume":"4","author":"Chen","year":"2023","journal-title":"MedComm"},{"key":"10.1016\/j.mvr.2025.104883_bb0035","article-title":"Effect of sodium-glucose Co-transporter 2 inhibitors on coronary microcirculation","volume":"16","author":"Chen","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.mvr.2025.104883_bb0040","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12576-023-00868-2","article-title":"Telocytes response to cardiac growth induced by resistance exercise training and endurance exercise training in adult male rats","volume":"73","author":"Choobineh","year":"2023","journal-title":"J. Physiol. Sci."},{"issue":"18","key":"10.1016\/j.mvr.2025.104883_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810314","article-title":"Cell-based and selected cell-free therapies for myocardial infarction: how do they compare to the current treatment options?","volume":"23","author":"Cs\u00f6b\u00f6nyeiov\u00e1","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.mvr.2025.104883_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23105769","article-title":"Dynamic involvement of telocytes in modulating multiple signaling pathways in cardiac cytoarchitecture","volume":"23","author":"Cucu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.mvr.2025.104883_bb0055","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.ijrobp.2021.02.007","article-title":"Radiation-induced myocardial fibrosis in long-term esophageal cancer survivors","volume":"110","author":"de Groot","year":"2021","journal-title":"Int. J. Radiat. Oncol. Biol. Phys."},{"key":"10.1016\/j.mvr.2025.104883_bb0060","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1280734","article-title":"Inflammation and coronary microvascular disease: relationship, mechanism and treatment","volume":"11","author":"Guo","year":"2024","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.mvr.2025.104883_bb0065","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.3389\/fphar.2019.01531","article-title":"Doxorubicin induces endotheliotoxicity and mitochondrial dysfunction via ROS\/eNOS\/NO pathway","volume":"10","author":"He","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.mvr.2025.104883_bb0070","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.aanat.2018.02.008","article-title":"Cardiac telocytes. From basic science to cardiac diseases. II. Acute myocardial infarction","volume":"218","author":"Hostiuc","year":"2018","journal-title":"Ann. Anat. = Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft"},{"issue":"5","key":"10.1016\/j.mvr.2025.104883_bb0075","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1080\/09553002.2017.1286048","article-title":"New insight into mitochondrial changes in vascular endothelial cells irradiated by gamma ray","volume":"93","author":"Hu","year":"2017","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.mvr.2025.104883_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2025.104856","article-title":"RAS-RH up-regulates the level of miR-126 and inhibits the opening of mPTP in a rat model of coronary microvascular disease","volume":"162","author":"Jiang","year":"2025","journal-title":"Microvasc. Res."},{"issue":"1","key":"10.1016\/j.mvr.2025.104883_bb0085","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/mc.22484","article-title":"Mango polyphenolics reduce inflammation in intestinal colitis-involvement of the miR-126\/PI3K\/AKT\/mTOR axis in vitro and in vivo","volume":"56","author":"Kim","year":"2017","journal-title":"Mol. Carcinog."},{"key":"10.1016\/j.mvr.2025.104883_bb0090","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yjmcc.2025.04.006","article-title":"METTL3-mediated N6-methyladenosine modification contributes to vascular calcification","volume":"203","author":"Li","year":"2025","journal-title":"J. Mol. Cell. Cardiol."},{"issue":"1","key":"10.1016\/j.mvr.2025.104883_bb0095","doi-asserted-by":"crossref","first-page":"268","DOI":"10.7150\/thno.47021","article-title":"Cardiac telocytes inhibit cardiac microvascular endothelial cell apoptosis through exosomal miRNA-21-5p-targeted cdip1 silencing to improve angiogenesis following myocardial infarction","volume":"11","author":"Liao","year":"2021","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.mvr.2025.104883_bb0100","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1186\/s12967-025-06973-7","article-title":"Quercetin promotes angiogenesis and protects the blood-spinal cord barrier structure after spinal cord injury by targeting the PI3K\/Akt signaling pathway","volume":"23","author":"Liu","year":"2025","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.mvr.2025.104883_bb0105","article-title":"The effects of Radix angelica sinensis and Radix hedysari ultrafiltration extract on X-irradiation-induced myocardial fibrosis in rats","volume":"112","author":"Ma","year":"2019","journal-title":"Biomed. Pharmacother. = Biomedecine & Pharmacotherapie"},{"key":"10.1016\/j.mvr.2025.104883_bb0110","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/4675851","article-title":"Radix angelica sinensis and Radix hedysari ultrafiltration extract protects against X-irradiation-induced cardiac fibrosis in rats","volume":"2020","author":"Ma","year":"2020","journal-title":"Evidence-based Complement. Altern. Med.: eCAM"},{"issue":"11","key":"10.1016\/j.mvr.2025.104883_bb0115","doi-asserted-by":"crossref","first-page":"2284","DOI":"10.1111\/j.1582-4934.2011.01449.x","article-title":"Experimental acute myocardial infarction: telocytes involvement in neo-angiogenesis","volume":"15","author":"Manole","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.mvr.2025.104883_bb0120","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3389\/fphar.2017.00275","article-title":"High sensitivity of SIRT3 deficient hearts to ischemia-reperfusion is associated with mitochondrial abnormalities","volume":"8","author":"Parodi-Rull\u00e1n","year":"2017","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.mvr.2025.104883_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11010146","article-title":"Radiation-induced heart disease","volume":"11","author":"Quintero-Martinez","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.mvr.2025.104883_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2024.1444156","article-title":"Telocytes of the male reproductive system: dynamic tissue organizers","volume":"12","author":"Sanches","year":"2024","journal-title":"Front. Cell Dev. Biol."},{"issue":"6","key":"10.1016\/j.mvr.2025.104883_bb0135","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13061289","article-title":"Coronary microvascular disease early after myocardial infarction: diagnostic approach and prognostic value\u2014a narrative review","volume":"13","author":"Sokratous","year":"2025","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.mvr.2025.104883_bb0140","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s11936-018-0627-x","article-title":"Radiation-induced cardiovascular toxicity: mechanisms, prevention, and treatment","volume":"20","author":"Spetz","year":"2018","journal-title":"Curr. Treat. Options Cardiovasc. Med."},{"issue":"3","key":"10.1016\/j.mvr.2025.104883_bb0145","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s10456-022-09835-8","article-title":"Molecular mechanisms of coronary microvascular endothelial dysfunction in diabetes mellitus: focus on mitochondrial quality surveillance","volume":"25","author":"Sun","year":"2022","journal-title":"Angiogenesis"},{"issue":"7","key":"10.1016\/j.mvr.2025.104883_bb0150","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/j.jacc.2013.03.065","article-title":"Coronary microvascular dysfunction and diastolic load correlate with cardiac troponin T release measured by a highly sensitive assay in patients with nonischemic heart failure","volume":"62","author":"Takashio","year":"2013","journal-title":"J. Am. Coll. Cardiol."},{"issue":"5","key":"10.1016\/j.mvr.2025.104883_bb0155","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2174\/1574888X10666150113113420","article-title":"Cardiac telocytes","volume":"11","author":"Tao","year":"2016","journal-title":"Curr. Stem Cell Res. Ther."},{"issue":"1","key":"10.1016\/j.mvr.2025.104883_bb0160","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/s40119-021-00250-6","volume":"11","author":"Thakker","year":"2022","journal-title":"Coron. Microvasc. Dis. Cardiol. Ther."},{"issue":"3","key":"10.1016\/j.mvr.2025.104883_bb0165","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1007\/s00066-017-1220-z","article-title":"Heart irradiation reduces microvascular density and accumulation of HSPA1 in mice","volume":"194","author":"Walaszczyk","year":"2018","journal-title":"Strahlentherapie und Onkologie: Organ der Deutschen Rontgengesellschaft ... [et al]"},{"issue":"10","key":"10.1016\/j.mvr.2025.104883_bb0170","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1016\/j.apsb.2020.03.004","article-title":"Mitochondrial quality control mechanisms as molecular targets in cardiac ischemia-reperfusion injury","volume":"10","author":"Wang","year":"2020","journal-title":"Acta Pharm. Sin. B"},{"issue":"3","key":"10.1016\/j.mvr.2025.104883_bb0175","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10456-020-09720-2","article-title":"New insights into the role of mitochondria in cardiac microvascular ischemia\/reperfusion injury","volume":"23","author":"Wang","year":"2020","journal-title":"Angiogenesis"},{"key":"10.1016\/j.mvr.2025.104883_bb0180","article-title":"Quercetin downregulates cyclooxygenase-2 expression and HIF-1\u03b1\/VEGF signaling-related angiogenesis in a mouse model of abdominal aortic aneurysm","volume":"2020","author":"Wang","year":"2020","journal-title":"Biomed. Res. Int."},{"issue":"3","key":"10.1016\/j.mvr.2025.104883_bb0185","doi-asserted-by":"crossref","first-page":"125","DOI":"10.31083\/ph.2022.1227","article-title":"Traditional use and safety evaluation of combination Traditional Chinese Medicine in European registration: with XiaoYao Tablets as an example","volume":"77","author":"Wang","year":"2022","journal-title":"Pharmazie"},{"issue":"1","key":"10.1016\/j.mvr.2025.104883_bb0190","doi-asserted-by":"crossref","DOI":"10.1111\/ahe.13008","article-title":"Ultrastructural characteristics and morphological relationships of cardiomyocytes and telocytes in the myocardium of the bullfrog (Rana catesbeiana)","volume":"53","author":"Wang","year":"2024","journal-title":"Anat. Histol. Embryol."},{"key":"10.1016\/j.mvr.2025.104883_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2025.104821","article-title":"Interfering with AQP1 alleviates ferroptosis, improves mitochondrial function and energy metabolic disorder in hypoxia\/reoxygenation-induced H9c2 cardiomyocytes via Wnt\/\u03b2-catenin pathway","volume":"160","author":"Xiang","year":"2025","journal-title":"Microvasc. Res."},{"issue":"1","key":"10.1016\/j.mvr.2025.104883_bb0200","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s00404-022-06634-w","article-title":"Telocytes and endometriosis","volume":"307","author":"Xu","year":"2023","journal-title":"Arch. Gynecol. Obstet."},{"issue":"5","key":"10.1016\/j.mvr.2025.104883_bb0205","doi-asserted-by":"crossref","first-page":"5650","DOI":"10.3390\/molecules19055650","article-title":"Chemical profile analysis and comparison of two versions of the classic TCM formula Danggui Buxue Tang by HPLC-DAD-ESI-IT-TOF-MSn","volume":"19","author":"Zhang","year":"2014","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"12","key":"10.1016\/j.mvr.2025.104883_bb0210","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1111\/1440-1681.13823","article-title":"Telocytes protect against lung tissue fibrosis through hexokinase 2-dependent pathway by secreting hepatocyte growth factor","volume":"50","author":"Zhang","year":"2023","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.mvr.2025.104883_bb0215","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/978-981-10-1061-3_15","article-title":"Cardiac telocytes in regeneration of myocardium after myocardial infarction","volume":"913","author":"Zhaofu","year":"2016","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.mvr.2025.104883_bb0220","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1186\/s12933-022-01532-6","article-title":"Empagliflozin attenuates cardiac microvascular ischemia\/reperfusion injury through improving mitochondrial homeostasis","volume":"21","author":"Zou","year":"2022","journal-title":"Cardiovasc. Diabetol."}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286225001025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286225001025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,31]],"date-time":"2026-05-31T04:25:15Z","timestamp":1780201515000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286225001025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":44,"alternative-id":["S0026286225001025"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2025.104883","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanistic investigation of quercetin (an active component of RAS-RH) in modulating radiation-induced coronary microvascular dysfunction via the TCs-ECs crosstalk pathway","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2025.104883","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104883"}}