{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T21:22:15Z","timestamp":1787865735572,"version":"build-2784847793"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001858","name":"Sweden's Innovation Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001729","name":"Swedish Foundation for Strategic Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003945","name":"Link\u00f6ping University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003945","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Microvascular Research"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.mvr.2026.104987","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T06:03:40Z","timestamp":1783922620000},"page":"104987","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cutaneous microvascular reactivity in the foot evaluated by optical multimodal pointwise and imaging techniques and different stimuli"],"prefix":"10.1016","volume":"167","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7299-891X","authenticated-orcid":false,"given":"Tomas","family":"Str\u00f6mberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Berggren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6385-6760","authenticated-orcid":false,"given":"Marcus","family":"Larsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3454-6576","authenticated-orcid":false,"given":"Ingemar","family":"Fredriksson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5912-3281","authenticated-orcid":false,"given":"Martin","family":"Hultman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mvr.2026.104987_bb0005","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1093\/eurjpc\/zwae052","article-title":"Association between cardiovascular risk profile and impaired microvascular function in a Swedish middle-aged cohort (the SCAPIS study)","volume":"31","author":"Bergstrand","year":"2024","journal-title":"Eur. J. Prev. Cardiol."},{"key":"10.1016\/j.mvr.2026.104987_bb0010","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/1523-1747.ep12484917","article-title":"Correlation of laser Doppler wave patterns with underlying microvascular anatomy","volume":"95","author":"Braverman","year":"1990","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.mvr.2026.104987_bb0015","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0026-2862(92)90100-4","article-title":"Topographic mapping of the cutaneous microcirculation using two outputs of laser-Doppler flowmetry: flux and the concentration of moving blood cells","volume":"44","author":"Braverman","year":"1992","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2026.104987_bb0020","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1056-8727(02)00256-8","article-title":"Topical methyl nicotinate-induced skin vasodilation in diabetic neuropathy","volume":"17","author":"Caselli","year":"2003","journal-title":"J. Diabetes Complications"},{"key":"10.1016\/j.mvr.2026.104987_bb0025","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s12933-025-02628-5","article-title":"Impaired microcirculation in the skin and subclinical atherosclerosis in individuals with dysglycaemia in a large population-based cohort","volume":"24","author":"Cederqvist","year":"2025","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.mvr.2026.104987_bb0030","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1152\/japplphysiol.01397.2013","article-title":"New approach to measure cutaneous microvascular function: an improved test of NO-mediated vasodilation by thermal hyperemia","volume":"117","author":"Choi","year":"2014","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.mvr.2026.104987_bb0035","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.ejvs.2019.05.006","article-title":"Global vascular guidelines on the management of chronic limb-threatening ischemia","volume":"58","author":"Conte","year":"2019","journal-title":"Eur. J. Vasc. Endovasc. Surg."},{"key":"10.1016\/j.mvr.2026.104987_bb0040","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.mvr.2019.03.002","article-title":"The microvascular response in the skin to topical application of methyl nicotinate: effect of concentration and variation between skin sites","volume":"124","author":"Elawa","year":"2019","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2026.104987_bb0045","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1111\/srt.12807","article-title":"Skin blood flow response to topically applied methyl nicotinate: possible mechanisms","volume":"26","author":"Elawa","year":"2020","journal-title":"Skin Res. Technol."},{"key":"10.1016\/j.mvr.2026.104987_bb0050","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.jtherbio.2014.09.003","article-title":"Responses in acral and non-acral skin vasomotion and temperature during lowering of ambient temperature","volume":"45","author":"Elstad","year":"2014","journal-title":"J. Therm. Biol."},{"key":"10.1016\/j.mvr.2026.104987_bb0055","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.18.12.127004","article-title":"Inverse Monte Carlo in a multilayered tissue model \u2014 merging diffuse reflectance spectroscopy and laser Doppler flowmetry","volume":"18","author":"Fredriksson","year":"2013","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.mvr.2026.104987_bb0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1117\/1.JBO.24.1.016001","article-title":"Machine learning in multiexposure laser speckle contrast imaging can replace conventional laser Doppler flowmetry","volume":"24","author":"Fredriksson","year":"2019","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.mvr.2026.104987_bb0065","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.25.11.112905","article-title":"Machine learning for direct oxygen saturation and hemoglobin concentration assessment using diffuse reflectance spectroscopy","volume":"25","author":"Fredriksson","year":"2020","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.mvr.2026.104987_bb0070","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1002\/lsm.23225","article-title":"Microcirculatory response to photobiomodulation\u2014why some respond and others do not: a randomized controlled study","volume":"52","author":"Gavish","year":"2020","journal-title":"Lasers Surg. Med."},{"key":"10.1016\/j.mvr.2026.104987_bb0075","first-page":"1","article-title":"Mirror mirror on the wall\u2026 an unobtrusive intelligent multisensory mirror for well-being status self-assessment and visualization","author":"Henriquez","year":"2017","journal-title":"IEEE Trans. Multim."},{"key":"10.1016\/j.mvr.2026.104987_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2022.104317","article-title":"Comprehensive imaging of microcirculatory changes in the foot during endovascular intervention \u2014 a technical feasibility study","volume":"141","author":"Hultman","year":"2022","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2026.104987_bb0085","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.28.3.036007","article-title":"Speed-resolved perfusion imaging using multi-exposure laser speckle contrast imaging and machine learning","volume":"28","author":"Hultman","year":"2023","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.mvr.2026.104987_bb0090","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mvr.2015.08.006","article-title":"Oxygen saturation, red blood cell tissue fraction and speed resolved perfusion \u2014 a new optical method for microcirculatory assessment","volume":"102","author":"Jonasson","year":"2015","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2026.104987_bb0095","doi-asserted-by":"crossref","first-page":"H908","DOI":"10.1152\/ajpheart.00668.2019","article-title":"Normative data and the influence of age and sex on microcirculatory function in a middle-aged cohort: results from the SCAPIS study","volume":"318","author":"Jonasson","year":"2020","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.mvr.2026.104987_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2021.104284","article-title":"Post-ischemic skin peak oxygen saturation is associated with cardiovascular risk factors: a Swedish cohort study","volume":"140","author":"Jonasson","year":"2022","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2026.104987_bb0105","doi-asserted-by":"crossref","first-page":"S33304","DOI":"10.1117\/1.JBO.29.S3.S33304","article-title":"Artificial neural networks trained on simulated multispectral data for real-time imaging of skin microcirculatory blood oxygen saturation","volume":"29","author":"Larsson","year":"2024","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.mvr.2026.104987_bb0110","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/aje\/kwaa023","article-title":"Microvascular phenotyping in the Maastricht Study: design and main findings, 2010\u20132018","volume":"189","author":"Li","year":"2020","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.mvr.2026.104987_bb0115","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1152\/jappl.2001.91.4.1619","article-title":"Nitric oxide and neurally mediated regulation of skin blood flow during local heating","volume":"91","author":"Minson","year":"2001","journal-title":"J. Appl. Physiol."},{"key":"10.1016\/j.mvr.2026.104987_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mvr.2016.03.001","article-title":"Reproducibility of axon reflex-related vasodilation assessed by dynamic thermal imaging in healthy subjects","volume":"106","author":"Nieuwenhoff","year":"2016","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2026.104987_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2025.104819","article-title":"Day-to-day variability in cutaneous microcirculation measured with multi-exposure laser speckle contrast imaging and multispectral imaging","volume":"160","author":"Nilsson","year":"2025","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2026.104987_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.mvr.2025.104783","article-title":"Sex and age-related day-to-day variability in the skin microcirculation during post-occlusive reactive hyperemia","volume":"159","author":"Richter","year":"2025","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.mvr.2026.104987_bb0135","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s12933-021-01290-x","article-title":"Sex differences in the association of prediabetes and type 2 diabetes with microvascular complications and function: the Maastricht Study","volume":"20","author":"de Ritter","year":"2021","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.mvr.2026.104987_bb0140","first-page":"81","article-title":"Spatial and temporal variations in human skin blood flow","volume":"2","author":"Tenland","year":"1983","journal-title":"Int. J. Microcirc. Clin. Exp."},{"key":"10.1016\/j.mvr.2026.104987_bb0145","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1152\/japplphysiol.00254.2003","article-title":"Nitric oxide synthase inhibition does not alter the reactive hyperemic response in the cutaneous circulation","volume":"95","author":"Wong","year":"2003","journal-title":"J. Appl. Physiol."}],"container-title":["Microvascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286226000877?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0026286226000877?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:56:26Z","timestamp":1787864186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0026286226000877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":29,"alternative-id":["S0026286226000877"],"URL":"https:\/\/doi.org\/10.1016\/j.mvr.2026.104987","relation":{},"ISSN":["0026-2862"],"issn-type":[{"value":"0026-2862","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cutaneous microvascular reactivity in the foot evaluated by optical multimodal pointwise and imaging techniques and different stimuli","name":"articletitle","label":"Article Title"},{"value":"Microvascular Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mvr.2026.104987","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"104987"}}