{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T11:52:48Z","timestamp":1768737168747,"version":"3.49.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,3,1]],"date-time":"2016-03-01T00:00:00Z","timestamp":1456790400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal de Mycologie M\u00e9dicale"],"published-print":{"date-parts":[[2016,3]]},"DOI":"10.1016\/j.mycmed.2015.10.007","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T09:00:26Z","timestamp":1448442026000},"page":"35-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Mechanisms of resistance to fluconazole in Candida albicans clinical isolates from Iranian HIV-infected patients with oropharyngeal candidiasis"],"prefix":"10.1016","volume":"26","author":[{"given":"S.","family":"Salari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.R.","family":"Khosravi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.A.A.","family":"Mousavi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.H.","family":"Nikbakht-Brojeni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mycmed.2015.10.007_bib0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2199-10-54","article-title":"Reference genes for QRT-PCR tested under various stress conditions in Folsomia candida and Orchesella cincta (Insecta, Collembola)","volume":"10","author":"de Boer","year":"2009","journal-title":"BMC Mol Biol"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0290","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1111\/j.1439-0507.2008.01550.x","article-title":"The expression of genes involved in the ergosterol biosynthesis pathway in Candida albicans and Candida dubliniensis biofilms exposed to fluconazole","volume":"52","author":"Boreck\u00e1-Melkusova","year":"2008","journal-title":"Mycoses"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0200","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1677\/jme.0.0250169","article-title":"Absolute quantification of mRNA using real-time reverse transcription polymerase chain reaction assays","volume":"25","author":"Bustin","year":"2000","journal-title":"J Mol Endocrinol"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0205","first-page":"69","article-title":"Fluconazole resistance in Candida albicans: a review of mechanisms","volume":"8","author":"Casalinuovo","year":"2004","journal-title":"Eur Rev Med Pharmacol Sci"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0210","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1128\/AAC.48.6.2124-2131.2004","article-title":"Application of real-time quantitative PCR to molecular analysis of Candida albicans strains exhibiting reduced susceptibilityto azoles","volume":"48","author":"Chau","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0215","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1177\/147323001003800216","article-title":"Overexpression of CDR1 and CDR2 genes plays an important role in fluconazole resistance in Candida albicans with G487T and T916C mutations","volume":"38","author":"Chen","year":"2010","journal-title":"J Int Med Res"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0220","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1128\/JCM.42.5.2085-2093.2004","article-title":"Rapid quantification of drug resistance gene expression in Candida albicans by reverse transcriptase lightcycler PCR and fluorescent probe hybridization","volume":"42","author":"Frade","year":"2004","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0225","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1101\/gr.6.10.995","article-title":"A novel method for real-time quantitative RT-PCR","volume":"6","author":"Gibson","year":"1996","journal-title":"Genome Res"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0230","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.diagmicrobio.2004.04.009","article-title":"Evaluation of fluconazole resistance mechanisms in Candida albicans clinical isolates from HIV-infected patients in Brazil","volume":"50","author":"Goldman","year":"2004","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0235","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1128\/AAC.50.4.1365-1371.2006","article-title":"Journal of medical mycology over expression of the MDR1 gene is sufficient to confer increased resistance to toxic compounds in Candida albicans","volume":"50","author":"Hiller","year":"2006","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0240","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1128\/AAC.00463-08","article-title":"ABC transporter Cdr1p contributes more than Cdr2p does to fluconazole efflux in fluconazole-resistant Candida albicans clinical isolates","volume":"52","author":"Holmes","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0245","series-title":"Reference method for broth dilution antifungal susceptibility testing of yeasts; approved standard","author":"Institute CaLS","year":"2008"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0250","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.bbrc.2008.06.093","article-title":"RTA2, a novel gene involved in azole resistance in Candida albicans","volume":"373","author":"Jia","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/496219","article-title":"Novel molecular beacon probe-based Real-Time RT-PCR assay for diagnosis of crimean-congo hemorrhagic fever encountered in India","volume":"2014","author":"Kamboj","year":"2014","journal-title":"BioMed Res Int"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0260","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.mimet.2006.07.011","article-title":"Development of a new real-time TaqMan PCR assay for quantitative analyses of Candida albicans resistance genes expression","volume":"61","author":"Kofla","year":"2007","journal-title":"J Microbiol Methods"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0265","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1093\/jac\/dkh040","article-title":"Drug resistance genes and trailing growth in Candida albicans isolates","volume":"53","author":"Lee","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0270","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0275","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1128\/AAC.43.7.1621","article-title":"Multiple resistant phenotypes of Candida albicans coexist during episodes of oropharyngeal candidiasis in human immunodeficiency virus-infected patients","volume":"43","author":"Lopez-Ribot","year":"1999","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0280","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/jac\/47.5.527","article-title":"Mechanisms of fluconazole resistance in Candida albicans isolates from Japanese AIDS patients","volume":"47","author":"Maebashia","year":"2001","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0285","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/j.1439-0507.2009.01766.x","article-title":"Investigation of mutations in Erg11 gene of \ufb02uconazole resistant Candida albicans isolates from Turkish hospitals Erg11 gene of fluconazole resistant Candida albicans isolates from Turkish hospitals","volume":"54","author":"Manast\u0131r","year":"2011","journal-title":"Mycoses"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0295","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0925-4439(02)00087-X","article-title":"The genetic basis of fluconazole resistance development in Candida albicans","volume":"1587","author":"Morschh\u00e4user","year":"2002","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0300","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1371\/journal.ppat.0030164","article-title":"The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans","volume":"3","author":"Morschh\u00e4user","year":"2007","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0305","doi-asserted-by":"crossref","first-page":"3366","DOI":"10.1128\/AAC.45.12.3366-3374.2001","article-title":"Functional expression of Candida albicans drug efflux pump Cdr1p in a Saccharomyces cerevisiae strain deficient in membrane transporters","volume":"45","author":"Nakamura","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0310","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1093\/jac\/dkh456","article-title":"Regulated overexpression of CDR1 in Candida albicans confers multidrug resistance","volume":"54","author":"Niimi","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0315","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.clinbiochem.2009.04.016","article-title":"Validation and comparison of two quantitative real-time PCR assays for direct detection of DMD\/BMD carriers","volume":"42","author":"Nosaeida","year":"2009","journal-title":"Clin Biochem"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0320","first-page":"77","article-title":"Detection of ERG11-2 gene in Candida spp. wich resistant to some antifungal agents by Real Time\u2013PCR","volume":"4","author":"Obied","year":"2014","journal-title":"J Nat Sci Res"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0325","first-page":"84","article-title":"Fluconazole susceptibility and ERG11 gene expression in vaginal candida species isolated from lagos Nigeria","volume":"3","author":"Pam","year":"2012","journal-title":"Int J Molecular Epidemiol Genet"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0330","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1089\/mdr.2005.11.232","article-title":"Establishing surrogate markers for fluconazole resistance in Candida albicans","volume":"11","author":"Park","year":"2005","journal-title":"Microb Drug Resist"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0335","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1128\/JCM.38.4.1563-1568.2000","article-title":"Emergence of resistance of Candida albicans to clotrimazole in human immunodeficiency virus-infected children: in vitro and clinical correlations","volume":"38","author":"Pelletier","year":"2000","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0340","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1128\/AAC.45.10.2676-2684.2001","article-title":"Prevalence of molecular mechanisms of resistance to azole antifungal agents in Candida albicans strains displaying high-level fluconazole resistance isolated from human immunodeficiency virus-infected patients","volume":"45","author":"Perea","year":"2001","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0345","doi-asserted-by":"crossref","first-page":"3412","DOI":"10.1128\/AAC.46.11.3412-3417.2002","article-title":"Evaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis","volume":"46","author":"Rogers","year":"2002","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0355","doi-asserted-by":"crossref","first-page":"2378","DOI":"10.1128\/AAC.39.11.2378","article-title":"Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters","volume":"39","author":"Sanglard","year":"1995","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0350","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1128\/AAC.40.10.2300","article-title":"Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors","volume":"40","author":"Sanglard","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0360","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.jviromet.2012.02.002","article-title":"TaqMan hydrolysis probe based real time PCR for detection and quantitation of camelpox virus in skin scabs","volume":"181","author":"Venkatesan","year":"2012","journal-title":"J Virol Methods"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2180-9-167","article-title":"Rapid detection of ERG11 gene mutations in clinical Candida albicans isolates with reduced susceptibility to fluconazole by rolling circle amplification and DNA sequencing","volume":"9","author":"Wang","year":"2009","journal-title":"BMC Microbiol"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0370","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1128\/AAC.41.7.1488","article-title":"The presence of an R467K amino acid substitution and loss of allelic variation correlate with an azole-resistant lanosterol 14a demethylase in Candida albicans","volume":"41","author":"White","year":"1997","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0375","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1128\/AAC.41.7.1482","article-title":"Increased mRNA levels of ERG16, CDR, and MDR1 correlate with increases in azole resistance in Candida albicans isolates from a patient infected with human immunode\ufb01ciency virus","volume":"41","author":"White","year":"1997","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2015.10.007_bib0380","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1128\/AAC.46.6.1704-1713.2002","article-title":"Resistance mechanisms in clinical isolates of Candida albicans","volume":"46","author":"White","year":"2002","journal-title":"J Antimicrob Chemother"}],"container-title":["Journal de Mycologie M\u00e9dicale"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1156523315002085?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1156523315002085?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:16:28Z","timestamp":1761110188000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1156523315002085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,3]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["S1156523315002085"],"URL":"https:\/\/doi.org\/10.1016\/j.mycmed.2015.10.007","relation":{},"ISSN":["1156-5233"],"issn-type":[{"value":"1156-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2016,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mechanisms of resistance to fluconazole in Candida albicans clinical isolates from Iranian HIV-infected patients with oropharyngeal candidiasis","name":"articletitle","label":"Article Title"},{"value":"Journal de Mycologie M\u00e9dicale","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mycmed.2015.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}