{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T20:17:54Z","timestamp":1793650674904,"version":"4.5.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal de Mycologie M\u00e9dicale"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.mycmed.2016.04.004","type":"journal-article","created":{"date-parts":[[2016,8,23]],"date-time":"2016-08-23T03:17:24Z","timestamp":1471922244000},"page":"244-254","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":86,"title":["Anti-Candida activity of geraniol involves disruption of cell membrane integrity and function"],"prefix":"10.1016","volume":"26","author":[{"given":"Y.","family":"Sharma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Manzoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mycmed.2016.04.004_bib0005","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.micpath.2009.10.001","article-title":"Evolution of ergosterol biosynthesis inhibitors as fungicidal against Candida","volume":"48","author":"Ahmad","year":"2010","journal-title":"Microb Pathog"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0010","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1016\/j.fitote.2010.07.020","article-title":"Proton translocating ATPase mediated fungicidal activity of eugenol and thymol","volume":"81","author":"Ahmad","year":"2010","journal-title":"Fitoterapia"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0015","first-page":"B4698","article-title":"Candida and Candida emia. Susceptibility and epidemiology","volume":"60","author":"Arendrup","year":"2013","journal-title":"Dan Med J"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0020","doi-asserted-by":"crossref","first-page":"3332","DOI":"10.1128\/JCM.37.10.3332-3337.1999","article-title":"Quantification of ergosterol content: novel method for determination of fluconazole susceptibility of Candida albicans","volume":"37","author":"Arthington-Skaggs","year":"1999","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0025","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.fct.2007.09.106","article-title":"Biological effects of essential oils a review","volume":"46","author":"Bakkali","year":"2008","journal-title":"Food Chem Toxicol"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0030","first-page":"81","article-title":"Antifungal activity of essential oils from Indian medicinal plants against human pathogenic Aspergillus fumigates and A. niger","volume":"3","author":"Bansod","year":"2008","journal-title":"World J Med Sci"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0035","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1603\/0022-2585-41.4.726","article-title":"Laboratory evaluation of mosquito repellents against Aedes albopictus, Culex nigripalpus, and Ochlerotatus triseriatus (Diptera: Culicidae)","volume":"41","author":"Barnard","year":"2004","journal-title":"J Med Entomol"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0040","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/10412905.2005.9698856","article-title":"Ninde oil (Aeollanthus myrianthusTaylor) revisited: analysis of historical oil","volume":"17","author":"Ba\u015fer","year":"2005","journal-title":"J Essent Oil Res"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0045","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.indcrop.2004.04.004","article-title":"The effects of harvest date, fermentation duration and Tween 20 treatment on essential oil content and composition of industrial oil rose (Rosa damascene Mill)","volume":"21","author":"Baydar","year":"2005","journal-title":"Ind Crops Prod"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0050","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/cmi.12091","article-title":"Two unlike cousins: Candida albicans and C.\u00a0glabrata infection strategies","volume":"15","author":"Brunke","year":"2013","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0055","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijfoodmicro.2004.03.022","article-title":"Essential oils: their antibacterial properties and potential applications in foods \u2013\u00a0a review","volume":"94","author":"Burt","year":"2004","journal-title":"Int J Food Microbiol"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0060","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1111\/j.1365-2672.2006.02862.x","article-title":"Antifungal activity of Juniperus essential oils against dermatophyte Aspergillus and Candida strains","volume":"100","author":"Cavaleiro","year":"2006","journal-title":"J Appl Microbiol"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0065","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1080\/00365540902777105","article-title":"Recent experience with fungaemia: change in species distribution and azole resistance","volume":"41","author":"Chakrabarti","year":"2009","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0070","series-title":"Reference method for broth dilution antifungal susceptibility testing of yeast. Approved Standard M27-A3","author":"Clinical Laboratory Standards Institute","year":"2008"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0075","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1128\/CMR.12.4.564","article-title":"Plant products as antimicrobial agents","volume":"12","author":"Cowan","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0080","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0031-9422(01)00122-4","article-title":"Biotransformation of geranyl acetate to geraniol during palmarosa (Cymbopogon martinii, Roxb. wats. var. motia) inflorescence development","volume":"57","author":"Dubey","year":"2001","journal-title":"Phytochemistry"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0085","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.4315\/0362-028X-65.10.1545","article-title":"Bactericidal activities of plant essential oils and some of their isolated constituents against Campylobacter jejuni, Escherichia coli, Listeria monocytogenes and Salmonella enterica","volume":"10","author":"Friedman","year":"2002","journal-title":"J Food Prot"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0090","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s00436-011-2668-x","article-title":"Comparative efficacy of new commercial pediculicides against adults and eggs of Pediculus humanus capitis (head lice)","volume":"110","author":"Gallardo","year":"2012","journal-title":"Parasitol Res"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0095","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1007\/s002530100822","article-title":"Antifungal antibiotics","volume":"58","author":"Gupte","year":"2002","journal-title":"Appl Microbiol Biotechnol"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0100","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.phymed.2005.05.001","article-title":"In vivo larvicidal activity of monoterpenic derivatives from aromatic plants against L3 larvae of Anisakis simplex s.l","volume":"13","author":"Hierro","year":"2006","journal-title":"Phytomedicine"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0105","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/jac\/47.5.565","article-title":"Antibacterial activity of essential oils and their major constituents against respiratory tract pathogens by gaseous contact","volume":"47","author":"Inouye","year":"2001","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0110","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1016\/S0041-1345(02)02910-X","article-title":"K. Monoterpene geraniol prevents acute allograft rejection","volume":"34","author":"Ji","year":"2002","journal-title":"Transplant Proc"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0115","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1006\/bbrc.1995.1272","article-title":"Mode of action and resistance to azole antifungal associated with the formation of 14a-methylergosta-8, 24 (28)-dien-3b, 6a-diol","volume":"207","author":"Kelly","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0120","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.resmic.2010.09.008","article-title":"Ocimum sanctum essential oil and its active principles exert their antifungal activity by disrupting ergosterol biosynthesis and membrane integrity","volume":"161","author":"Khan","year":"2010","journal-title":"Res Microbiol"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0125","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1099\/jmm.0.013227-0","article-title":"Candida tropicalis: its prevalence, pathogenicity and increasing resistance to fluconazole","volume":"59","author":"Kothavade","year":"2010","journal-title":"J Med Microbiol"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0130","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/mmy\/myu078","article-title":"Investigating the antifungal activity and mechanisms of geraniol against Candida albicans strains","volume":"53","author":"Leite","year":"2015","journal-title":"Med Mycol"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0135","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S1471-4914(02)02280-3","article-title":"Molecular basis of resistance to azole antifungals","volume":"8","author":"Lupetti","year":"2002","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0140","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.1186\/1475-2875-10-S1-S11","article-title":"Plant-based insect repellents: a review of their efficacy, development and testing","volume":"10","author":"Maia","year":"2011","journal-title":"Malar J"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0145","first-page":"785","article-title":"Effect of phosphocreatine on H+ extrusion, pHi and dimorphism in Candida albicans","volume":"40","author":"Manzoor","year":"2002","journal-title":"Indian J Exp Biol"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0150","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF03263194","article-title":"Inhibition of H+ extrusion by phosphocreatine in Candida albicans","volume":"13","author":"Manzoor","year":"2004","journal-title":"J Plant Biochem Biotechnol"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0155","doi-asserted-by":"crossref","first-page":"228","DOI":"10.3109\/13880209.2014.913299","article-title":"Antifungal activity of geraniol and citronellol, two monoterpenes alcohols, against Trichophyton rubrum involves inhibition of ergosterol biosynthesis","volume":"53","author":"Pereira","year":"2015","journal-title":"Pharm Biol"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0160","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1749-6632.1997.tb52330.x","article-title":"The plasma membrane H+ ATPase of fungi. A Candida te drug target?","volume":"834","author":"Perlin","year":"2006","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0165","doi-asserted-by":"crossref","first-page":"4419","DOI":"10.1128\/JCM.42.10.4419-4431.2004","article-title":"Rare and emerging opportunistic fungal pathogens: concern for resistance beyond Candida albicans and Aspergillus fumigatus","volume":"42","author":"Pfaller","year":"2004","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0170","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/ffj.1313","article-title":"Yellowing and crinkling disease and its impact on the yield and composition of the essential oil of Citronella (Cymbopogon winterianus Jowitt.)","volume":"19","author":"Rajeswara Rao","year":"2004","journal-title":"Flavour Fragr J"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0175","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.phymed.2012.09.029","article-title":"\u03b2-Asarone, an active principle of Acorus calamus rhizome inhibits morphogenesis, biofilm formation and ergosterol biosynthesis in Candida albicans","volume":"20","author":"Rajput","year":"2013","journal-title":"Phytomedicine"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0180","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.3109\/13880209.2014.989623","article-title":"Synergistic anti-Candida l activity and mode of action of Mentha piperita essential oil and its major components","volume":"53","author":"Samber","year":"2015","journal-title":"Pharm Biol"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0185","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1128\/AAC.47.8.2404-2412.2003","article-title":"Candida albicans mutations in the ergosterol biosynthetic pathway and resistance to several antifungal agents","volume":"47","author":"Sanglard","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0190","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0014-5793(83)80237-3","article-title":"In vivo glucose activation of the yeast plasma membrane ATPase","volume":"156","author":"Serrano","year":"1983","journal-title":"FEBS Lett"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0195","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0005-2736(97)00028-X","article-title":"Exploring an antifungal target in the plasma membrane H+ ATPase of fungi","volume":"1326","author":"Seto-Young","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0200","first-page":"211","article-title":"Predisposing factors endorsing Candida infections","volume":"23","author":"Singh","year":"2015","journal-title":"Infez Med"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0205","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1111\/j.1742-4658.2012.08564.x","article-title":"Significant differences in the cell-wall mannans from three Candida glabrata strains correlate with antifungal drug sensitivity","volume":"279","author":"Takahashi","year":"2012","journal-title":"FEBS J"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0210","series-title":"Plant drug analysis \u2013\u00a0a thin-layer chromatography atlas","year":"1996"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0215","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.bbabio.2008.12.019","article-title":"P-type ATPase as drug targets: tools for medicine and science","volume":"1787","author":"Yatime","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.mycmed.2016.04.004_bib0220","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1016\/j.phymed.2011.03.008","article-title":"Terpenoids inhibit Candida albicans growth by affecting membrane integrity and arrest of cell cycle","volume":"18","author":"Zore","year":"2011","journal-title":"Phytomedicine"}],"container-title":["Journal de Mycologie M\u00e9dicale"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1156523316300075?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1156523316300075?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:17:36Z","timestamp":1761110256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1156523316300075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["S1156523316300075"],"URL":"https:\/\/doi.org\/10.1016\/j.mycmed.2016.04.004","relation":{},"ISSN":["1156-5233"],"issn-type":[{"value":"1156-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anti-Candida activity of geraniol involves disruption of cell membrane integrity and function","name":"articletitle","label":"Article Title"},{"value":"Journal de Mycologie M\u00e9dicale","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mycmed.2016.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}