{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:02:46Z","timestamp":1790413366768,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal de Mycologie M\u00e9dicale"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.mycmed.2017.11.002","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T05:12:24Z","timestamp":1512537144000},"page":"137-142","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Histatin-5 induces the reversal of Pdr5p mediated fluconazole resistance in Saccharomyces\u00a0cerevisae"],"prefix":"10.1016","volume":"28","author":[{"given":"J.A.","family":"da Rocha Curvelo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.F.","family":"Reis de S\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.C.","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ferreira-Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.mycmed.2017.11.002_bib0155","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1086\/317550","article-title":"Fungal endocarditis: evidence in the world literature, 1965\u20131995","volume":"32","author":"Ellis","year":"2001","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0160","first-page":"862","article-title":"Infections caused by filamentous fungi in patients with hematologic malignancies. A report of 391 cases by GINEMA infection program","volume":"86","author":"Pagano","year":"2001","journal-title":"Haematologica"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0165","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/1469-0691.12495","article-title":"Antifungal drug resistance mechanisms in pathogenic fungi: from bench to bedside","volume":"20","author":"Cuenca-Estrella","year":"2014","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0170","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1146\/annurev.bi.62.070193.002125","article-title":"Biochemistry of multidrug resistance mediated by the multidrug transporter","volume":"62","author":"Gottesman","year":"1993","journal-title":"Annu Rev Biochem"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0175","first-page":"155","article-title":"Drug resistance in yeasts\u00a0\u2013\u00a0an emerging scenario","author":"Prasad","year":"200246","journal-title":"Adv Microb Physiol"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0180","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1046\/j.1432-1033.2003.03701.x","article-title":"Weak organic acid stress inhibits aromatic amino acid uptake by yeast, causing a strong influence of amino acid auxotrophies on the phenotypes of membrane transporter mutants","volume":"270","author":"Bauer","year":"2003","journal-title":"Eur J Biochem"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0185","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.tplants.2008.02.001","article-title":"Plant ABC proteins\u00a0\u2013\u00a0a unified nomenclature and updated inventory","volume":"13","author":"Verrier","year":"2008","journal-title":"Trends Plant Sci"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0190","article-title":"Novel regulatory mechanisms of pathogenicity and virulence to combat MDR in Candida\u00a0albicans","volume":"2013","author":"Hameed","year":"20131","journal-title":"Int J Microbiol"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0195","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1128\/AAC.48.4.1256-1271.2004","article-title":"Chemosensitization of fluconazole resistance in Saccharomyces\u00a0cerevisiae and pathogenic fungi by a d-octapeptide derivative","volume":"48","author":"Niimi","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0200","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1128\/AAC.01648-07","article-title":"Enhanced susceptibility to antifungal oligopeptides in yeast strains overexpressing ABC multidrug efflux pumps","volume":"52","author":"Wakie\u0107","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0205","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1080\/02713680590968637","article-title":"A review of antimicrobial peptides and their therapeutic potential as anti-infective drugs","volume":"30","author":"Gordon","year":"2005","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0210","first-page":"733","article-title":"Protection of the oral mucosa by salivary Histatin-5 against Candida\u00a0albicans in an ex vivo murine model of oral infection","volume":"34","author":"Peters","year":"2007","journal-title":"Radiology"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0215","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.1399-302X.1998.tb00730.x","article-title":"The relationship between salivary Histatin levels and oral yeast carriage","volume":"13","author":"Jainkittivong","year":"1998","journal-title":"Oral Microb Immunol"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0220","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1007\/BF00352101","article-title":"Molecular cloning and characterization of a novel gene of Candida albicans, CDR1, conferring multiple resistance to drugs and antifungals","volume":"27","author":"Prasad","year":"1995","journal-title":"Curr Genet"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0225","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1099\/00221287-143-2-405","article-title":"Cloning of Candida albicans genes conferring resistance to azole antifungal agents: characterization of CDR2, a new multidrug ABC transporter gene","volume":"143","author":"Sanglard","year":"1997","journal-title":"Microbiology"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0230","unstructured":"NCCLS. M\u00e9todo De Refer\u00eancia Para Testes De Dilui\u00e7\u00e3o Em Caldo Para Determina\u00e7\u00e3o da Sensibilidade de Leveduras \u00e0 Terapia Antif\u00fangica: Norma Aprovada \u2013 Segunda Edi\u00e7\u00e3o. NCCLS document M27-A2 [ISBN 1-56238-469-4]. NCCLS, 940 West Valley Road, Suite 1400, Wayne, Pennsylvania 19087-1898 United States of America, 2002."},{"key":"10.1016\/j.mycmed.2017.11.002_bib0235","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1128\/EC.00091-07","article-title":"Characterization of three classes of membrane proteins involved in fungal azole resistance by functional hyperexpression in Saccharomyces\u00a0cerevisiae","volume":"6","author":"Lamping","year":"2007","journal-title":"Eukaryot Cell"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0240","series-title":"M\u00e9todo de refer\u00eancia para testes de dilui\u00e7\u00e3o em caldo para determina\u00e7\u00e3o da Sensibilidade de leveduras \u00e0 terapia antif\u00fangica: norma aprovada\u00a0\u2013\u00a0segunda edi\u00e7\u00e3o","author":"Pfaller","year":"2012"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0245","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.bbrc.2005.03.009","article-title":"A new function of isonitrile as an inhibitor of the Pdr5p multidrug ABC transporter in Saccharomyces\u00a0cerevisiae","volume":"330","author":"Yamamoto","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0250","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1111\/j.1567-1364.2009.00603.x","article-title":"Inhibitory effects of Gallic Acid Ester derivatives on Saccharomyces\u00a0cerevisiae multidrug resistance protein Pdr5p","volume":"10","author":"Pereira Rangel","year":"2010","journal-title":"FEMS Yeast Res"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0255","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0003-2697(75)90275-4","article-title":"Determination of inorganic phosphate in the presence of detergents or protein","volume":"67","author":"Dulley","year":"1975","journal-title":"Anal Biochem"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0260","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0021-9258(18)84756-1","article-title":"The colorimetric determination of phosphorus","volume":"66","author":"Fiske","year":"1925","journal-title":"J Biol Chem"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0265","doi-asserted-by":"crossref","first-page":"1812","DOI":"10.1128\/AAC.41.8.1812","article-title":"In vitro activities of terbinafine in combination with fluconazole and itraconazole against isolates of Candida\u00a0albicans with reduced susceptibility to azoles","volume":"41","author":"Barchiesi","year":"1997","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0270","first-page":"3","article-title":"Human lactoferrin-derived peptide's antifungal activities against disseminated Candida\u00a0albicans","volume":"196","author":"Lupetti","year":"2007","journal-title":"Infection"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0275","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1128\/CMR.18.1.163-194.2005","article-title":"A combination treatment of invasive fungal infections","volume":"18","author":"Mukherjee","year":"2005","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0280","doi-asserted-by":"crossref","first-page":"5193","DOI":"10.1016\/j.bbagen.2013.07.016","article-title":"Mechanism of action of novel synthetic dodecapeptides against Candida\u00a0albicans","volume":"1830","author":"Maurya","year":"2013","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0285","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1034\/j.1399-302X.2001.160409.x","article-title":"Antifungal activity of Histatin-5 against non-albicans Candida species","volume":"16","author":"Nikawa","year":"2001","journal-title":"Oral Microbiol Immunol"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0290","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1439-0507.2008.01602.x","article-title":"Salivary Histatin-5 and oral fungal colonisation in HIV+ individuals","volume":"52","author":"Torres","year":"2009","journal-title":"Mycoses"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0295","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/jac\/44.1.27","article-title":"Rhodamine 6G efflux for the detection of CDR1-overexpressing azole-resistant Candida\u00a0albicans strains","volume":"44","author":"Maesaki","year":"1999","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2017.11.002_bib0300","doi-asserted-by":"crossref","unstructured":"Monk BC, Niimi K, Lin S, Knight A, Kardos TB, Cannon RD, et al. Surface-active fungicidal d-peptide inhibitors of the plasma membrane proton pump that block azole resistance. Antimicrob Agents Chemother 2005; 49:57-70.","DOI":"10.1128\/AAC.49.1.57-70.2005"}],"container-title":["Journal de Mycologie M\u00e9dicale"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1156523317302664?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1156523317302664?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:17:59Z","timestamp":1761110279000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1156523317302664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S1156523317302664"],"URL":"https:\/\/doi.org\/10.1016\/j.mycmed.2017.11.002","relation":{},"ISSN":["1156-5233"],"issn-type":[{"value":"1156-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Histatin-5 induces the reversal of Pdr5p mediated fluconazole resistance in Saccharomyces\u00a0cerevisae","name":"articletitle","label":"Article Title"},{"value":"Journal de Mycologie M\u00e9dicale","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mycmed.2017.11.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}