{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T11:45:22Z","timestamp":1773920722182,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","em-consulte.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal de Mycologie M\u00e9dicale"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.mycmed.2017.11.008","type":"journal-article","created":{"date-parts":[[2017,12,19]],"date-time":"2017-12-19T09:07:46Z","timestamp":1513674466000},"page":"106-111","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Modulatory effect of voriconazole on the production of proinflammatory cytokines in experimental cryptococcosis in mice with severe combined immunodeficiency"],"prefix":"10.1016","volume":"28","author":[{"given":"E.","family":"Gon\u00e7alves Silva","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Marilia de Souza Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Rodrigues Paula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"da Silva Ruiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Latercia Tranches Dias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.mycmed.2017.11.008_bib0005","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1590\/S0036-46652006000200003","article-title":"Cryptococcus Neoformans strains isolated from church towers in Rio De Janeiro city, RJ, Brazil","volume":"48","author":"Baroni","year":"2006","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0010","series-title":"Cryptococcus neoformans","author":"Casadevall","year":"1998"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0015","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/02681219680000561","article-title":"Experimental systemic cryptococcosis in scid mice","volume":"34","author":"Clemons","year":"1996","journal-title":"J Med Vet Mycol"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0020","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1080\/13693780600810040","article-title":"Experimental systemic infection with Cryptococcus neoformans Var. Grubii and Cryptococcus gattii in normal and immunodeficient mice","volume":"44","author":"Capilla","year":"2006","journal-title":"Med Mycol"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0025","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1128\/iai.62.5.1975-1981.1994","article-title":"Production of tumor necrosis factor alpha in human leukocytes stimulated by Cryptococcus neoformans","volume":"62","author":"Levitz","year":"1994","journal-title":"Infect Immun"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0030","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1165\/ajrcmb.18.1.2911","article-title":"Role of Interleukin-10 in the lung response to silica in mice","volume":"18","author":"Huaux","year":"1998","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0035","doi-asserted-by":"crossref","first-page":"5302","DOI":"10.1128\/IAI.00661-06","article-title":"Role of capsule and Interleukin-6 in long-term immune control of Cryptococcus neoformans infection by specifically activated human peripheral blood mononuclear cells","volume":"74","author":"Siddiqui","year":"2006","journal-title":"Infect Immun"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0040","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1086\/313757","article-title":"Practice guidelines for the management of cryptococcal disease","volume":"30","author":"Saag","year":"2000","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0045","first-page":"481","article-title":"Amphotericin B nephrotoxicity","volume":"13","author":"Bagnis","year":"2002","journal-title":"Saudi J Kidney Dis Transpl"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0050","first-page":"119","article-title":"[Nephrotoxicity of Amphotericin B]","volume":"23","author":"Deray","year":"2002","journal-title":"Nephrology"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0055","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s11908-000-0015-y","article-title":"Cryptococcal meningitis in HIV-infected patients","volume":"2","author":"Powderly","year":"2000","journal-title":"Curr Infect Dis Rep"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0060","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1128\/AAC.45.11.3065-3069.2001","article-title":"Trends in antifungal drug susceptibility of Cryptococcus neoformans isolates in the United States: 1992 to 1994 and 1996 to 1998","volume":"45","author":"Brandt","year":"2001","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0065","doi-asserted-by":"crossref","first-page":"129","DOI":"10.2147\/tcrm.2006.2.2.129","article-title":"Voriconazole in the management of nosocomial invasive fungal infections","volume":"2","author":"Pem\u00e1n","year":"2006","journal-title":"Ther Clin Risk Manag"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0070","doi-asserted-by":"crossref","first-page":"2009","DOI":"10.1128\/AAC.00163-06","article-title":"In vitro activities of posaconazole, fluconazole, itraconazole, voriconazole, and amphotericin B against a large collection of clinically important molds and yeasts","volume":"50","author":"Sabatelli","year":"2006","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0075","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s11046-011-9499-2","article-title":"Voriconazole, combined with amphotericin B, in the treatment for pulmonary cryptococcosis caused by C. neoformans (Serotype A) in mice with severe combined immunodeficiency (Scid)","volume":"173","author":"Silva","year":"2012","journal-title":"Mycopathologia"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0080","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1128\/AAC.44.9.2435-2441.2000","article-title":"Interactions between triazoles and amphotericin B against Cryptococcus neoformans","volume":"44","author":"Barchiesi","year":"2000","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0085","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11046-010-9375-5","article-title":"Combination efficacy of voriconazole and amphotericin B in the experimental disease in immunodeficient mice caused by fluconazole-resistant Cryptococcus neoformans","volume":"171","author":"Silva","year":"2011","journal-title":"Mycopathologia"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0090","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1093\/jac\/dkh361","article-title":"Increasing in vitro resistance to fluconazole in Cryptococcus neoformans Cambodian isolates: April 2000 to March 2002","volume":"54","author":"Sar","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0095","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1128\/IAI.73.1.39-49.2005","article-title":"Transient neutralization of tumor necrosis factor alpha can produce a chronic fungal infection in an immunocompetent host: potential role of immature dendritic cells","volume":"73","author":"Herring","year":"2005","journal-title":"Infect Immun"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0100","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1128\/IAI.70.3.1571-1580.2002","article-title":"Antibody-mediated protection in murine Cryptococcus neoformans infection is associated with pleotrophic effects on cytokine and leukocyte responses","volume":"70","author":"Feldmesser","year":"2002","journal-title":"Infect Immun"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0105","doi-asserted-by":"crossref","first-page":"1726","DOI":"10.1086\/314495","article-title":"Amphotericin B activation of human genes encoding for cytokines","volume":"178","author":"Rogers","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0110","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1086\/315835","article-title":"Amphotericin B induces expression of genes encoding chemokines and cell adhesion molecules in the human monocytic cell line Thp-1","volume":"182","author":"Rogers","year":"2000","journal-title":"J Infect Dis"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0115","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.1128\/AAC.01095-06","article-title":"Expression of immunomodulatory genes in human monocytes induced by voriconazole in the presence of Aspergillus fumigatus","volume":"51","author":"Simitsopoulou","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0120","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/jac\/dkn036","article-title":"Amphotericin B formulations variably enhance antifungal activity of human neutrophils and monocytes against Fusarium solani: comparison with Aspergillus fumigatus","volume":"61","author":"Dotis","year":"2008","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0125","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1128\/AAC.01018-07","article-title":"Immunomodulatory effects of voriconazole on monocytes challenged with Aspergillus fumigatus: differential role of Toll-like receptors","volume":"52","author":"Simitsopoulou","year":"2008","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0130","doi-asserted-by":"crossref","first-page":"6445","DOI":"10.1128\/IAI.69.10.6445-6455.2001","article-title":"Both Th1 And Th2 cytokines affect the ability of monoclonal antibodies to protect mice against Cryptococcus neoformans","volume":"69","author":"Beenhouwer","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0135","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S1471-4906(02)00013-3","article-title":"Il-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation","volume":"24","author":"Kaplanski","year":"2003","journal-title":"Trends Immunol"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0140","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/path.2277","article-title":"Cellular and molecular mechanisms of fibrosis","volume":"214","author":"Wynn","year":"2008","journal-title":"J Pathol"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0145","doi-asserted-by":"crossref","first-page":"5771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"Il-10: the master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.mycmed.2017.11.008_bib0150","doi-asserted-by":"crossref","first-page":"G829","DOI":"10.1152\/ajpgi.2000.278.6.G829","article-title":"Lessons from genetically engineered animal models. Xii. Il-10-Deficient (Il-10(-\/-) mice and intestinal inflammation","volume":"278","author":"Rennick","year":"2000","journal-title":"Am J Physiol Gastrointest Liver Physiol"}],"container-title":["Journal de Mycologie M\u00e9dicale"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1156523317303372?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1156523317303372?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T05:18:53Z","timestamp":1761110333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1156523317303372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":30,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S1156523317303372"],"URL":"https:\/\/doi.org\/10.1016\/j.mycmed.2017.11.008","relation":{},"ISSN":["1156-5233"],"issn-type":[{"value":"1156-5233","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulatory effect of voriconazole on the production of proinflammatory cytokines in experimental cryptococcosis in mice with severe combined immunodeficiency","name":"articletitle","label":"Article Title"},{"value":"Journal de Mycologie M\u00e9dicale","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.mycmed.2017.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}