{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T10:36:22Z","timestamp":1789209382232,"version":"build-2803163510"},"reference-count":53,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,13]],"date-time":"2015-03-13T00:00:00Z","timestamp":1426204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","nanomedjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.nano.2015.02.012","type":"journal-article","created":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T16:04:42Z","timestamp":1426694682000},"page":"1217-1226","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Nebulised amphotericin B-polymethacrylic acid nanoparticle prophylaxis prevents invasive aspergillosis"],"prefix":"10.1016","volume":"11","author":[{"given":"Khojasteh","family":"Shirkhani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Teo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darius","family":"Armstrong-James","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil","family":"Shaunak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nano.2015.02.012_bb0005","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.addr.2003.10.039","article-title":"Membrane-destabilizing polyanions: interaction with lipid bilayers and endosomal escape of biomacromolecules","volume":"56","author":"Yessine","year":"2004","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.nano.2015.02.012_bb0010","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1208\/s12249-009-9348-5","article-title":"Sustained release tablets containing soluble polymethacrylates: comparison with tableted polymethacrylate IPEC polymers","volume":"11","author":"Obeidat","year":"2010","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.nano.2015.02.012_bb0015","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1002\/smll.201000765","article-title":"Polymethacrylic acid polymer hydrogel capsules: drug carriers, sub-compartmentalized microreactors, artificial organelles","volume":"6","author":"Zelikin","year":"2010","journal-title":"Small"},{"key":"10.1016\/j.nano.2015.02.012_bb0020","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1016\/j.addr.2009.09.006","article-title":"Self-assembled hydrogels are also being developed that can encapsulate hydrophobic drugs for sustained drug delivery","volume":"61","author":"Maher","year":"2009","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.nano.2015.02.012_bb0025","doi-asserted-by":"crossref","first-page":"249ra110","DOI":"10.1126\/scitranslmed.3008778","article-title":"A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft","volume":"6","author":"Gajanayake","year":"2014","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.nano.2015.02.012_bb0030","doi-asserted-by":"crossref","first-page":"8029","DOI":"10.1016\/j.biomaterials.2011.07.021","article-title":"Accelerated healing of cutaneous leishmaniasis in non-healing BALB\/c mice using water soluble amphotericin B-polymethacrylic acid","volume":"32","author":"Corware","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.nano.2015.02.012_bb0035","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0168-3659(99)00150-9","article-title":"Uptake and release of budesonide from mucoadhesive pH-sensitive copolymers and their application to nasal delivery","volume":"61","author":"Nakamura","year":"1999","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2015.02.012_bb0040","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1111\/j.1600-6143.2010.03094.x","article-title":"Rapidly curative exogenous interferon-\u03b3 immuno-therapy for invasive fungal infections in renal transplant patients","volume":"10","author":"Armstrong-James","year":"2010","journal-title":"Am J Transplant"},{"key":"10.1016\/j.nano.2015.02.012_bb0045","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1111\/j.1600-6143.2012.04254.x","article-title":"Renal allograft recipients fail to increase interferon-\u03b3 during invasive fungal diseases","volume":"12","author":"Armstrong-James","year":"2012","journal-title":"Am J Transplant"},{"key":"10.1016\/j.nano.2015.02.012_bb0050","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1086\/513943","article-title":"Invasive aspergillosis","volume":"26","author":"Denning","year":"1988","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.nano.2015.02.012_bb0055","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1128\/CMR.12.2.310","article-title":"Aspergillus fumigatus and aspergillosis","volume":"12","author":"Latge","year":"1999","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.nano.2015.02.012_bb0060","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1086\/652768","article-title":"Factors associated with mortality in transplant patients with invasive aspergillosis","volume":"50","author":"Baddley","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.nano.2015.02.012_bb0065","doi-asserted-by":"crossref","first-page":"S261","DOI":"10.1080\/13693780802247702","article-title":"Differences in pathogenicity and clinical syndromes due to Aspergillus fumigatus and Aspergillus flavus","volume":"47","author":"Pasqualotto","year":"2009","journal-title":"Med Mycol"},{"key":"10.1016\/j.nano.2015.02.012_bb0070","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1128\/JCM.00872-06","article-title":"Global surveillance of in vitro activity of micafungin against Candida: a comparison with caspofungin by CLSI-recommended methods","volume":"44","author":"Pfaller","year":"2006","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.nano.2015.02.012_bb0075","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1086\/499949","article-title":"The evolution and evaluation of a whole blood PCR assay for the detection of invasive aspergillosis in haematology patients in a routine clinical setting","volume":"42","author":"White","year":"2006","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.nano.2015.02.012_bb0080","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1002\/emmm.201201290","article-title":"Preventing acute gut wall damage in infectious diarrhoeas with glycosylated dendrimers","volume":"4","author":"Teo","year":"2012","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.nano.2015.02.012_bb0085","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1242\/dmm.010330","article-title":"A new and clinically relevant murine model of solid-organ transplant aspergillosis","volume":"6","author":"Herbst","year":"2013","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.nano.2015.02.012_bb0090","doi-asserted-by":"crossref","first-page":"240","DOI":"10.15252\/emmm.201404556","article-title":"Phagocytosis-dependent activation of the TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus","volume":"7","author":"Herbst","year":"2015","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.nano.2015.02.012_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0026768","article-title":"Nebulisation of receptor-targeted nanocomplexes for gene delivery to the airway epithelium","volume":"6","author":"Manunta","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nano.2015.02.012_bb0100","doi-asserted-by":"crossref","first-page":"2467","DOI":"10.1128\/AAC.42.10.2467","article-title":"Granulocyte colony-stimulating factor and azole antifungal therapy in murine aspergillosis: role of immune suppression","volume":"42","author":"Graybill","year":"1998","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.nano.2015.02.012_bb0105","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1039\/C3PY01051A","article-title":"Poly(methacrylic acid) complexation of amphotericin B to treat neglected diseases","volume":"5","author":"Les","year":"2014","journal-title":"Polym Chem"},{"key":"10.1016\/j.nano.2015.02.012_bb0110","first-page":"57","article-title":"An ultrastructural study of alveolar macrophages after phagocytosis of A. flavus spores in vivo","volume":"62","author":"Merkow","year":"1971","journal-title":"Am J Pathol"},{"key":"10.1016\/j.nano.2015.02.012_bb0115","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1093\/infdis\/jis185","article-title":"Aspergillus terreus: how inoculum size and host characteristics affect its virulence","volume":"205","author":"Lass-Fl\u00f6rl","year":"2012","journal-title":"J Infect Dis"},{"key":"10.1016\/j.nano.2015.02.012_bb0120","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1021\/j100862a600","article-title":"The conformational transition of polymethacrylic acid in solution","volume":"71","author":"Mandel","year":"1967","journal-title":"J Phys Chem"},{"key":"10.1016\/j.nano.2015.02.012_bb0125","first-page":"1505","article-title":"Interpolymer complex between polyethylene oxide and polycarboxylic acid","volume":"13","author":"Ikawa","year":"1975","journal-title":"J Polym Sci"},{"key":"10.1016\/j.nano.2015.02.012_bb0130","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ijpharm.2007.01.037","article-title":"Hydrogen bonded interpolymer complexes as materials for pharmaceutical applications","volume":"334","author":"Khutoryanskiy","year":"2007","journal-title":"Int J Pharm"},{"key":"10.1016\/j.nano.2015.02.012_bb0135","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1128\/AAC.32.11.1676","article-title":"Aerosol amphotericin B is effective for prophylaxis and therapy in a rat model of pulmonary aspergillosis","volume":"32","author":"Schmitt","year":"1988","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.nano.2015.02.012_bb0140","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1128\/IAI.42.3.1109-1115.1983","article-title":"Killing of Aspergillus spores depends on the anatomical source of the macrophage","volume":"42","author":"Schaffner","year":"1983","journal-title":"Infect Immun"},{"key":"10.1016\/j.nano.2015.02.012_bb0145","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/0042-6822(68)90215-8","article-title":"Interferon stimulating and in vivo antiviral effects of various synthetic anionic polymers","volume":"35","author":"Merigan","year":"1968","journal-title":"Virology"},{"key":"10.1016\/j.nano.2015.02.012_bb0150","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/00002371-199108000-00007","article-title":"Induction of cytokine production from human monocytes stimulated with alginate","volume":"10","author":"Otterlei","year":"1991","journal-title":"J Immunother"},{"key":"10.1016\/j.nano.2015.02.012_bb0155","doi-asserted-by":"crossref","first-page":"35489","DOI":"10.1074\/jbc.M201366200","article-title":"Involvement of TLR2 and TLR4 in cell activation by mannuronic acid polymers","volume":"277","author":"Flo","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.nano.2015.02.012_bb0170","doi-asserted-by":"crossref","first-page":"4833","DOI":"10.4049\/jimmunol.170.9.4833","article-title":"Inhibition of IFN-\u03b3 signaling by glucocorticoids","volume":"170","author":"Hu","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.nano.2015.02.012_bb0175","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.4049\/jimmunol.163.3.1529","article-title":"IL-12 is dysregulated in macrophages from IRF-1 and IRF-2 knockout mice","volume":"163","author":"Sallowski","year":"1999","journal-title":"J Immunol"},{"key":"10.1016\/j.nano.2015.02.012_bb0180","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.4049\/jimmunol.181.7.4461","article-title":"IFN-\u03b3 induced TNF-\u03b1 expression is regulated by interferon regulatory factors 1 and 8 in mouse macrophages","volume":"181","author":"Vila-del Sol","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.nano.2015.02.012_bb0185","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1086\/605931","article-title":"Impaired interferon-\u03b3 responses, increased interleukin-17 expression, and a TNF-\u03b1 transcriptional program in invasive aspergillosis","volume":"200","author":"Armstrong-James","year":"2009","journal-title":"J Infect Dis"},{"key":"10.1016\/j.nano.2015.02.012_bb0190","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1093\/infdis\/172.6.1554","article-title":"Interferon-\u03b3 and TNF-\u03b1 protect mice from invasive aspergillosis","volume":"172","author":"Nagai","year":"1995","journal-title":"J Infect Dis"},{"key":"10.1016\/j.nano.2015.02.012_bb0195","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1186\/1471-2334-14-166","article-title":"Interferon-\u03b3 as adjunctive immuno-therapy for invasive fungal infections: a case series","volume":"14","author":"Delsing","year":"2014","journal-title":"BMC Infect Dis"},{"key":"10.1016\/j.nano.2015.02.012_bb0200","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1086\/314425","article-title":"Kinetic study of host defense and inflammatory response to Aspergillus fumigatus in steroid induced immunosuppressed mice","volume":"178","author":"Duong","year":"1998","journal-title":"J Infect Dis"},{"key":"10.1016\/j.nano.2015.02.012_bb0210","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1080\/00362177785190071","article-title":"Germination of Aspergillus fumigatus conidia in the lungs of normal cortisone-treated mice","volume":"15","author":"White","year":"1977","journal-title":"Sabouraudia"},{"key":"10.1016\/j.nano.2015.02.012_bb0215","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1093\/infdis\/150.5.752","article-title":"In-vivo bronchoalveolar macrophage defense against Rhizopus oryzae and Aspergillus fumigatus","volume":"150","author":"Waldorf","year":"1984","journal-title":"J Infect Dis"},{"key":"10.1016\/j.nano.2015.02.012_bb0220","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1093\/infdis\/jis193","article-title":"Murine infection models for Aspergillus terreus pulmonary aspergillosis reveal long-term persistence of conidia and liver degeneration","volume":"205","author":"Slesiona","year":"2012","journal-title":"J Infect Dis"},{"key":"10.1016\/j.nano.2015.02.012_bb0225","doi-asserted-by":"crossref","first-page":"1960","DOI":"10.1128\/AAC.46.6.1960-1965.2002","article-title":"Method for measuring postantifungal effect in Aspergillus species","volume":"46","author":"Vitale","year":"2002","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.nano.2015.02.012_bb0230","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1093\/jac\/dkg285","article-title":"Evaluation of the post-antifungal effect of amphotericin B and nystatin against 30 zygomycetes using two different media","volume":"52","author":"Vitale","year":"2003","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.nano.2015.02.012_bb0235","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1093\/jac\/34.6.1001","article-title":"Prophylactic efficacy of aerosolized liposomal (AmBisome) and non-liposomal (Fungizone) amphotericin B in murine pulmonary aspergillosis","volume":"34","author":"Allen","year":"1994","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.nano.2015.02.012_bb0240","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1111\/j.1600-6143.2006.01529.x","article-title":"Aerosol deposition of lipid complex amphotericin-B (Abelcet) in lung transplant recipients","volume":"6","author":"Corcoran","year":"2006","journal-title":"Am J Transplant"},{"key":"10.1016\/j.nano.2015.02.012_bb0245","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1089\/jamp.2008.0715","article-title":"A review on the clinical use of inhaled amphotericin B","volume":"22","author":"Kuiper","year":"2009","journal-title":"J Aerosol Med Pulm Drug Deliv"},{"key":"10.1016\/j.nano.2015.02.012_bb0250","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/petr.12263","article-title":"Antifungal prophylaxis in pediatric lung transplantation: an international multicentre survey","volume":"18","author":"Mead","year":"2014","journal-title":"Pediatr Transplant"},{"key":"10.1016\/j.nano.2015.02.012_bb0255","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1016\/S0924-8579(08)70019-0","article-title":"Invasive fungal infections in lung transplantation: role of aerosolised amphotericin B","volume":"32","author":"Sol\u00e9","year":"2008","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.nano.2015.02.012_bb0260","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-6143.2010.03375.x","article-title":"Antifungal prophylaxis in lung transplantation: a world-wide survey","volume":"11","author":"Neoh","year":"2001","journal-title":"Am J Transplant"},{"key":"10.1016\/j.nano.2015.02.012_bb0265","article-title":"Efficacy and safety of nebulised amphotericin B in severe asthma with fungal sensitization and allergic bronchopulmonary aspergillosis","author":"Chishimba","year":"2014","journal-title":"J Asthma"},{"key":"10.1016\/j.nano.2015.02.012_bb0270","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/jac\/48.1.89","article-title":"Efficacy of aerosolized amphotericin B deoxycholate and liposomal amphotericin B in the treatment of invasive pulmonary aspergillosis in severely immunocompromised rats","volume":"48","author":"Ruijgrok","year":"2001","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.nano.2015.02.012_bb0275","first-page":"1559","article-title":"Infections due to Aspergillus terreus: a multicenter retrospective analysis of 83 cases","volume":"50","author":"Steinbach","year":"2010","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.nano.2015.02.012_bb0280","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.celrep.2013.10.033","article-title":"Amphotericin B increased influenza A virus infection by preventing IFITM3-mediated restriction","volume":"5","author":"Lin","year":"2013","journal-title":"Cell Rep"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963415000623?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963415000623?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T21:34:32Z","timestamp":1691530472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963415000623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":53,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S1549963415000623"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2015.02.012","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nebulised amphotericin B-polymethacrylic acid nanoparticle prophylaxis prevents invasive aspergillosis","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2015.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}