{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:19:34Z","timestamp":1791404374974,"version":"4.3.3"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81602358"],"award-info":[{"award-number":["81602358"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771964"],"award-info":[{"award-number":["81771964"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81472829"],"award-info":[{"award-number":["81472829"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fudan University Affiliated Jinshan Hospital Excellent Youth Talent Training Program","award":["2015-2"],"award-info":[{"award-number":["2015-2"]}]},{"name":"Shanghai Jinshan District Health Family Planning System Excellent Youth Talent Training Program","award":["JSYQ201605"],"award-info":[{"award-number":["JSYQ201605"]}]},{"name":"Shanghai Jinshan District Health Family Planning System Excellent Youth Talent Training Program","award":["JSYQ201608"],"award-info":[{"award-number":["JSYQ201608"]}]},{"name":"Shanghai Health and Family Planning Commission Research Project","award":["20144Y0191"],"award-info":[{"award-number":["20144Y0191"]}]},{"name":"2017 Shanghai Minhang District Central Hospital Project","award":["2017MHJC01"],"award-info":[{"award-number":["2017MHJC01"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.nano.2018.05.015","type":"journal-article","created":{"date-parts":[[2018,6,10]],"date-time":"2018-06-10T01:26:43Z","timestamp":1528594003000},"page":"2115-2127","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":70,"title":["Targeted salinomycin delivery with EGFR and CD133 aptamers based dual-ligand lipid-polymer nanoparticles to both osteosarcoma cells and cancer stem cells"],"prefix":"10.1016","volume":"14","author":[{"given":"Fangyi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yibin","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Qi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengxin","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinmei","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huaiwen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuochong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nano.2018.05.015_bb0005","first-page":"1123","article-title":"Osteosarcoma: a multidisciplinary approach to diagnosis and treatment","volume":"65","author":"Wittig","year":"2002","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.nano.2018.05.015_bb0010","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1200\/JCO.2014.59.4895","article-title":"Osteosarcoma: current treatment and a collaborative pathway to success","volume":"33","author":"Isakoff","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.nano.2018.05.015_bb0015","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1586\/14737140.8.8.1257","article-title":"Current concepts on the surgical and medical management of osteosarcoma","volume":"8","author":"Siegel","year":"2008","journal-title":"Expert Rev Anticancer Ther"},{"key":"10.1016\/j.nano.2018.05.015_bb0020","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nrc1650","article-title":"Repopulation of cancer cells during therapy: an important cause of treatment failure","volume":"5","author":"Kim","year":"2005","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.nano.2018.05.015_bb0025","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1749-799X-5-78","article-title":"Targeting the osteosarcoma cancer stem cell","volume":"5","author":"Siclari","year":"2010","journal-title":"J Orthop Surg Res"},{"key":"10.1016\/j.nano.2018.05.015_bb0030","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.copbio.2007.10.007","article-title":"Cancer stem cells in solid tumors","volume":"18","author":"Ailles","year":"2007","journal-title":"Curr Opin Biotechnol"},{"key":"10.1016\/j.nano.2018.05.015_bb0035","doi-asserted-by":"crossref","first-page":"7274","DOI":"10.1038\/sj.onc.1207947","article-title":"Self-renewal and solid tumor stem cells","volume":"23","author":"Al-Hajj","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.nano.2018.05.015_bb0040","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1158\/0008-5472.CAN-08-2242","article-title":"Identification of cancer stem cells in Ewing's sarcoma","volume":"69","author":"Suv\u00e0","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.nano.2018.05.015_bb0045","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1096\/fj.10-179036","article-title":"Human primary bone sarcomas contain CD133+ cancer stem cells displaying high tumorigenicity in vivo","volume":"25","author":"Tirino","year":"2011","journal-title":"FASEB J"},{"key":"10.1016\/j.nano.2018.05.015_bb0050","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3892\/mmr.2012.1231","article-title":"CD133 expression in osteosarcoma and derivation of CD133+ cells","volume":"7","author":"Li","year":"2013","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.nano.2018.05.015_bb0055","doi-asserted-by":"crossref","DOI":"10.1177\/1010428317695035","article-title":"Sali: a new paradigm in cancer therapy","volume":"39","author":"Dewangan","year":"2017","journal-title":"Tumor Biol"},{"key":"10.1016\/j.nano.2018.05.015_bb0060","first-page":"2537","article-title":"Poly(lactic-co-glycolic acid) nanoparticles conjugated with CD133 aptamers for targeted sali delivery to CD133+ osteosarcoma cancer stem cells","volume":"10","author":"Ni","year":"2015","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2018.05.015_bb0065","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.canlet.2011.07.016","article-title":"Sali inhibits osteosarcoma by targeting its tumor stem cells","volume":"311","author":"Li","year":"2011","journal-title":"Cancer Lett"},{"key":"10.1016\/j.nano.2018.05.015_bb0070","doi-asserted-by":"crossref","first-page":"7950","DOI":"10.1073\/pnas.1102454108","article-title":"Normal and neoplastic nonstem cells can spontaneously convert to a stem-like state","volume":"108","author":"Chaffer","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nano.2018.05.015_bb0075","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.cell.2011.07.026","article-title":"Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells","volume":"146","author":"Gupta","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.nano.2018.05.015_bb0080","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1073\/pnas.1018898108","article-title":"Inducible formation of breast cancer stem cells and their dynamic equilibrium with non-stem cancer cells via IL6 secretion","volume":"108","author":"Iliopoulos","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nano.2018.05.015_bb0085","doi-asserted-by":"crossref","first-page":"227","DOI":"10.4155\/tde.11.148","article-title":"Cancer stem cell targeting: the next generation of cancer therapy and molecular imaging","volume":"3","author":"Shigdar","year":"2012","journal-title":"Ther Deliv"},{"key":"10.1016\/j.nano.2018.05.015_bb0090","doi-asserted-by":"crossref","first-page":"2565","DOI":"10.2217\/nnm-2016-0137","article-title":"Co-delivery of sali and doxorubicin using nanoliposomes for targeting both liver cancer cells and cancer stem cells","volume":"11","author":"Gong","year":"2016","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.nano.2018.05.015_bb0095","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.2217\/nnm-2016-0125","article-title":"Codelivery of sali and chloroquine by liposomes enables synergistic antitumor activity in vitro","volume":"11","author":"Xie","year":"2016","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.nano.2018.05.015_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/srep37062","article-title":"Noscapine targets EGFRp-Tyr1068to suppress the proliferation and invasion of MG63 cells","volume":"6","author":"He","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.nano.2018.05.015_bb0105","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.3892\/ijo.2013.1764","article-title":"ERK1\/2 activation mediated by the nutlin-3-induced mitochondrial translocation of p53","volume":"42","author":"Lee","year":"2013","journal-title":"Int J Oncol"},{"key":"10.1016\/j.nano.2018.05.015_bb0110","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1002\/pbc.21368","article-title":"Initial testing of dasatinib by the pediatric preclinical testing program","volume":"50","author":"Kolb","year":"2008","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.nano.2018.05.015_bb0115","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/cncr.26339","article-title":"Cell surface receptor expression patterns in osteosarcoma","volume":"118","author":"Hassan","year":"2012","journal-title":"Cancer"},{"key":"10.1016\/j.nano.2018.05.015_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0024071","article-title":"A neutralizing RNA aptamer against EGFR causes selective apoptotic cell death","volume":"6","author":"Esposito","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.nano.2018.05.015_bb0125","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.nano.2013.08.001","article-title":"A novel liposomal formulation of FTY720 (Fingolimod) for promising enhanced targeted delivery","volume":"10","author":"Mao","year":"2014","journal-title":"Nanomedicine"},{"key":"10.1016\/j.nano.2018.05.015_bb0130","doi-asserted-by":"crossref","first-page":"6185","DOI":"10.1016\/j.biomaterials.2013.04.063","article-title":"Targeted drug delivery and cross-linking induced apoptosis with anti-CD37 based dual-ligand immunoliposomes in B chronic lymphocytic leukemia cells","volume":"34","author":"Yu","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.nano.2018.05.015_bb0135","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bbamem.2005.02.007","article-title":"Liposomes targeted via two different antibodies: assay, B-cell binding and cytotoxicity","volume":"1711","author":"Laginha","year":"2005","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.nano.2018.05.015_bb0140","doi-asserted-by":"crossref","first-page":"279","DOI":"10.2217\/nnm.13.20","article-title":"Lipid-polymer hybrid nanoparticles conjugated with anti-EGF receptor antibody for targeted drug delivery to hepatocellular carcinoma","volume":"9","author":"Gao","year":"2014","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.nano.2018.05.015_bb0145","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1021\/nn800275r","article-title":"Self-assembled lipid-polymer hybrid nanoparticles: a robust drug delivery platform","volume":"2","author":"Zhang","year":"2008","journal-title":"ACS Nano"},{"key":"10.1016\/j.nano.2018.05.015_bb0150","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/nnano.2009.242","article-title":"Towards a definition of inorganic nanoparticles from an environmental, health and safety perspective","volume":"4","author":"Auffan","year":"2009","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.nano.2018.05.015_bb0155","doi-asserted-by":"crossref","first-page":"3893","DOI":"10.1021\/cr030027b","article-title":"Recent advances in the liquid-phase syntheses of inorganic nanoparticles","volume":"104","author":"Cushing","year":"2004","journal-title":"Chem Rev"},{"key":"10.1016\/j.nano.2018.05.015_bb0160","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrd1955","article-title":"Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease","volume":"5","author":"Ng","year":"2006","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.nano.2018.05.015_bb0165","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/950658","article-title":"Sali as a drug for targeting human cancer stem cells","volume":"2012","author":"Naujokat","year":"2012","journal-title":"J Biomed Biotechnol"},{"key":"10.1016\/j.nano.2018.05.015_bb0170","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1038\/nrd2137","article-title":"Tumour-initiating cells: challenges and opportunities for anticancer drug discovery","volume":"8","author":"Zhou","year":"2009","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.nano.2018.05.015_bb0175","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1007\/s12185-013-1298-8","article-title":"Hematopoietic stem cell donation","volume":"97","author":"Chen","year":"2013","journal-title":"Int J Hematol"},{"key":"10.1016\/j.nano.2018.05.015_bb0180","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/bmt.2013.227","article-title":"A review of the haematopoietic stem cell donation experience: is there room for improvement?","volume":"49","author":"Billen","year":"2014","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.nano.2018.05.015_bb0185","doi-asserted-by":"crossref","first-page":"6172","DOI":"10.1182\/blood-2008-02-136762","article-title":"Targeting the Notch1 and mTOR pathways in a mouse T-ALL model","volume":"113","author":"Cullion","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.nano.2018.05.015_bb0190","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nrc903","article-title":"Ligand-targeted therapeutics in anticancer therapy","volume":"2","author":"Allen","year":"2002","journal-title":"Nat Rev Cancer"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963418301072?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963418301072?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T19:44:42Z","timestamp":1538768682000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963418301072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S1549963418301072"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2018.05.015","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted salinomycin delivery with EGFR and CD133 aptamers based dual-ligand lipid-polymer nanoparticles to both osteosarcoma cells and cancer stem cells","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2018.05.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}