{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T18:58:59Z","timestamp":1790535539015,"version":"4.1.0"},"reference-count":31,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T00:00:00Z","timestamp":1533081600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1016\/j.nano.2018.06.003","type":"journal-article","created":{"date-parts":[[2018,6,19]],"date-time":"2018-06-19T21:53:22Z","timestamp":1529445202000},"page":"1941-1947","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["CT imaging of myocardial scar burden with CNA35-conjugated gold nanoparticles"],"prefix":"10.1016","volume":"14","author":[{"given":"Patrick H.","family":"Kee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delia","family":"Danila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nano.2018.06.003_bb0005","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.1161\/01.CIR.100.19.1992","article-title":"Relationship of MRI delayed contrast enhancement to irreversible injury, infarct age, and contractile function","volume":"100","author":"Kim","year":"1999","journal-title":"Circulation"},{"key":"10.1016\/j.nano.2018.06.003_bb0010","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ahj.2004.03.007","article-title":"Extent of myocardial scarring on nonstress delayed-contrast-enhancement cardiac magnetic resonance imaging correlates directly with degrees of resting regional dysfunction in chronic ischemic heart disease","volume":"148","author":"Srichai","year":"2004","journal-title":"Am Heart J"},{"key":"10.1016\/j.nano.2018.06.003_bb0015","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jcmg.2008.10.004","article-title":"Can cardiac magnetic resonance myocardial scar features affect treatment decisions for patients with coronary artery disease and heart failure?","volume":"2","author":"Kwong","year":"2009","journal-title":"JACC Cardiovasc Imaging"},{"key":"10.1016\/j.nano.2018.06.003_bb0020","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1093\/ndt\/gfk062","article-title":"Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibrosis?","volume":"21","author":"Grobner","year":"2006","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.nano.2018.06.003_bb0025","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.nano.2013.03.009","article-title":"CT imaging of myocardial scars with collagen-targeting gold nanoparticles","volume":"9","author":"Danila","year":"2013","journal-title":"Nanomedicine"},{"key":"10.1016\/j.nano.2018.06.003_bb0030","doi-asserted-by":"crossref","first-page":"37","DOI":"10.4236\/ami.2013.34006","article-title":"Gold as a potential contrast agent for dual-energy CT","volume":"3","author":"Krissak","year":"2013","journal-title":"Adv Mol Imaging"},{"key":"10.1016\/j.nano.2018.06.003_bb0035","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.2214\/AJR.12.8933","article-title":"Gold nanoparticles provide bright long-lasting vascular contrast for CT imaging","volume":"200","author":"Au","year":"2013","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.nano.2018.06.003_bb0040","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2310\/7290.2007.00021","article-title":"Imaging collagen in intact viable healthy and atherosclerotic arteries using fluorescently labeled CNA35 and two-photon laser scanning microscopy","volume":"6","author":"Megens","year":"2007","journal-title":"Mol Imaging"},{"key":"10.1016\/j.nano.2018.06.003_bb0045","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.jsb.2007.04.008","article-title":"High resolution imaging of collagen organisation and synthesis using a versatile collagen specific probe","volume":"159","author":"Boerboom","year":"2007","journal-title":"J Struct Biol"},{"key":"10.1016\/j.nano.2018.06.003_bb0050","doi-asserted-by":"crossref","DOI":"10.2310\/7290.2014.00036","article-title":"Ex vivo and in vivo Administration of Fluorescent CNA35 specifically marks cardiac fibrosis","volume":"13","author":"de Jong","year":"2014","journal-title":"Mol Imaging"},{"key":"10.1016\/j.nano.2018.06.003_bb0055","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1161\/CIRCIMAGING.112.000119","article-title":"Dual-energy computed tomography imaging of atherosclerotic plaques in a mouse model using a liposomal-iodine nanoparticle contrast agent","volume":"6","author":"Bhavane","year":"2013","journal-title":"Circ Cardiovasc Imaging"},{"key":"10.1016\/j.nano.2018.06.003_bb0060","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S1076-6332(03)80055-7","article-title":"Long-residence-time nano-scale liposomal iohexol for X-ray-based blood pool imaging","volume":"10","author":"Kao","year":"2003","journal-title":"Acad Radiol"},{"key":"10.1016\/j.nano.2018.06.003_bb0065","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2214\/AJR.05.0523","article-title":"A liposomal nanoscale contrast agent for preclinical CT in mice","volume":"186","author":"Mukundan","year":"2006","journal-title":"AJR Am J Roentgenol"},{"key":"10.1016\/j.nano.2018.06.003_bb0070","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1007\/s11307-014-0798-0","article-title":"Noninvasive detection of macrophages in atheroma using a radiocontrast-loaded phosphatidylserine-containing liposomal contrast agent for computed tomography","volume":"17","author":"Kee","year":"2015","journal-title":"Mol Imaging Biol"},{"key":"10.1016\/j.nano.2018.06.003_bb0075","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.acra.2008.09.004","article-title":"Dual-energy CT discrimination of iodine and calcium: experimental results and implications for lower extremity CT angiography","volume":"16","author":"Tran","year":"2009","journal-title":"Acad Radiol"},{"key":"10.1016\/j.nano.2018.06.003_bb0080","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1038\/nm1571","article-title":"Noninvasive detection of macrophages using a nanoparticulate contrast agent for computed tomography","volume":"13","author":"Hyafil","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.nano.2018.06.003_bb0085","doi-asserted-by":"crossref","first-page":"959","DOI":"10.2967\/jnumed.108.060749","article-title":"Quantification of inflammation within rabbit atherosclerotic plaques using the macrophage-specific CT contrast agent N1177: a comparison with 18F-FDG PET\/CT and histology","volume":"50","author":"Hyafil","year":"2009","journal-title":"J Nucl Med"},{"key":"10.1016\/j.nano.2018.06.003_bb0090","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1021\/acs.bioconjchem.7b00194","article-title":"Use of nanoparticle contrast agents for cell tracking with computed tomography","volume":"28","author":"Kim","year":"2017","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.nano.2018.06.003_bb0095","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1038\/nmat1571","article-title":"An X-ray computed tomography imaging agent based on long-circulating bismuth sulphide nanoparticles","volume":"5","author":"Rabin","year":"2006","journal-title":"Nat Mater"},{"key":"10.1016\/j.nano.2018.06.003_bb0100","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1097\/RLI.0b013e318260fc40","article-title":"Biological performance of a size-fractionated core-shell tantalum oxide nanoparticle x-ray contrast agent","volume":"47","author":"Torres","year":"2012","journal-title":"Investig Radiol"},{"key":"10.1016\/j.nano.2018.06.003_bb0105","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1039\/b806051g","article-title":"Gold nanoparticles in nanomedicine: preparations, imaging, diagnostics, therapies and toxicity","volume":"38","author":"Boisselier","year":"2009","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.nano.2018.06.003_bb0110","doi-asserted-by":"crossref","first-page":"321","DOI":"10.2217\/nnm.14.171","article-title":"Gold nanoparticles as contrast agents in x-ray imaging and computed tomography","volume":"10","author":"Cole","year":"2015","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.nano.2018.06.003_bb0115","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1021\/mp3005885","article-title":"Multifunctional gold nanoparticles for diagnosis and therapy of disease","volume":"10","author":"Mieszawska","year":"2013","journal-title":"Mol Pharm"},{"key":"10.1016\/j.nano.2018.06.003_bb0120","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.biomaterials.2016.06.015","article-title":"Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging","volume":"102","author":"Cheheltani","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.nano.2018.06.003_bb0125","doi-asserted-by":"crossref","first-page":"6139","DOI":"10.1158\/1078-0432.CCR-10-0978","article-title":"Phase I and pharmacokinetic studies of CYT-6091, a novel PEGylated colloidal gold-rhTNF nanomedicine","volume":"16","author":"Libutti","year":"2010","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.nano.2018.06.003_bb0130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2015.00256","article-title":"In vivo small animal micro-CT using nanoparticle contrast agents","volume":"6","author":"Ashton","year":"2015","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.nano.2018.06.003_bb0135","doi-asserted-by":"crossref","first-page":"4593","DOI":"10.1021\/nl8029114","article-title":"Targeted gold nanoparticles enable molecular CT imaging of cancer","volume":"8","author":"Popovtzer","year":"2008","journal-title":"Nano Lett"},{"key":"10.1016\/j.nano.2018.06.003_bb0140","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1021\/nn901877h","article-title":"A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer","volume":"4","author":"Kim","year":"2010","journal-title":"ACS Nano"},{"key":"10.1016\/j.nano.2018.06.003_bb0145","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1259\/bjr\/42612922","article-title":"Micro-CT enables microlocalisation and quantification of Her2-targeted gold nanoparticles within tumour regions","volume":"84","author":"Hainfeld","year":"2011","journal-title":"Br J Radiol"},{"key":"10.1016\/j.nano.2018.06.003_bb0150","first-page":"2859","article-title":"Targeted gold nanoparticles enable molecular CT imaging of cancer: an in vivo study","volume":"6","author":"Reuveni","year":"2011","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2018.06.003_bb0155","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1002\/jps.24518","article-title":"Vascular targeting of a gold nanoparticle to breast Cancer metastasis","volume":"104","author":"Peiris","year":"2015","journal-title":"J Pharm Sci"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963418304763?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963418304763?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,7,21]],"date-time":"2018-07-21T11:08:16Z","timestamp":1532171296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963418304763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":31,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["S1549963418304763"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2018.06.003","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2018,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CT imaging of myocardial scar burden with CNA35-conjugated gold nanoparticles","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2018.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}