{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:27:12Z","timestamp":1792787232570,"version":"4.5.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Research Sector at Kuwait University","award":["MR01\/13"],"award-info":[{"award-number":["MR01\/13"]}],"id":[{"id":"https:\/\/ror.org\/021e5j056","id-type":"ROR","asserted-by":"crossref"}]},{"name":"OMICS Research Unit\/RCF and the General Facility Grant","award":["SRUL02\/13"],"award-info":[{"award-number":["SRUL02\/13"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.nano.2019.02.012","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T17:35:06Z","timestamp":1551720906000},"page":"78-89","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":30,"special_numbering":"C","title":["Chronic administration of nano-sized PAMAM dendrimers in vivo inhibits EGFR-ERK1\/2-ROCK signaling pathway and attenuates diabetes-induced vascular remodeling and dysfunction"],"prefix":"10.1016","volume":"18","author":[{"given":"Saghir","family":"Akhtar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bindu","family":"Chandrasekhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam HM","family":"Yousif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Waleed","family":"Renno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim F.","family":"Benter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Z","family":"El-Hashim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nano.2019.02.012_bb0005","doi-asserted-by":"crossref","DOI":"10.1007\/s12272-018-1008-4","article-title":"Recent progress in dendrimer-based nanomedicine development","author":"Kim","year":"2018","journal-title":"Arch Pharm Res"},{"issue":"2","key":"10.1016\/j.nano.2019.02.012_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph15020338","article-title":"Toxicology of engineered nanoparticles: focus on poly(amidoamine) dendrimers","volume":"15","author":"Naha","year":"2018","journal-title":"Int J Environ Res Public Health"},{"issue":"6","key":"10.1016\/j.nano.2019.02.012_bb0015","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1111\/joim.12280","article-title":"Emerging concepts in dendrimer-based nanomedicine: from design principles to clinical applications","volume":"276","author":"Kannan","year":"2014","journal-title":"J Intern Med"},{"key":"10.1016\/j.nano.2019.02.012_bb0020","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1042\/BST0350061","article-title":"Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging","volume":"35","author":"Tomalia","year":"2007","journal-title":"Biochem Soc Trans"},{"issue":"2","key":"10.1016\/j.nano.2019.02.012_bb0025","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2016.1173773","article-title":"Poly(amido amine) dendrimers in oral delivery","volume":"4","author":"Yellepeddi","year":"2016","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.nano.2019.02.012_bb0030","doi-asserted-by":"crossref","first-page":"907","DOI":"10.4155\/tde.11.55","article-title":"Poly(amidoamine) polymers: soluble linear amphiphilic drug-delivery systems for genes, proteins and oligonucleotides","volume":"2","author":"Pettit","year":"2011","journal-title":"Ther Deliv"},{"key":"10.1016\/j.nano.2019.02.012_bb0035","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1016\/j.addr.2005.09.019","article-title":"Dendrimer biocompatibility and toxicity","volume":"57","author":"Duncan","year":"2005","journal-title":"Adv Drug Deliv"},{"issue":"5","key":"10.1016\/j.nano.2019.02.012_bb0040","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1021\/acs.molpharmaceut.6b00045","article-title":"Naked polyamidoamine polymers intrinsically inhibit angiotensin II-mediated EGFR and ErbB2 transactivation in a dendrimer generation- and surface chemistry-dependent manner","volume":"13","author":"Akhtar","year":"2016","journal-title":"Mol Pharm"},{"issue":"2","key":"10.1016\/j.nano.2019.02.012_bb0045","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.ijpharm.2016.03.039","article-title":"Impact of PAMAM delivery systems on signal transduction pathways in vivo: modulation of ERK1\/2 and p38 MAP kinase signaling in the normal and diabetic kidney","volume":"514","author":"Akhtar","year":"2016","journal-title":"Int J Pharm"},{"key":"10.1016\/j.nano.2019.02.012_bb0050","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1517\/17425255.2010.518611","article-title":"Cationic nanosystems for the delivery of small interfering ribonucleic acid therapeutics: a focus on toxicogenomics","volume":"6","author":"Akhtar","year":"2010","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"9","key":"10.1016\/j.nano.2019.02.012_bb0055","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1038\/sj.gt.3302692","article-title":"Non-viral cancer gene therapy: beyond delivery","volume":"13","author":"Akhtar","year":"2006","journal-title":"Gene Ther"},{"key":"10.1016\/j.nano.2019.02.012_bb0060","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1172\/JCI33494","article-title":"Nonviral delivery of synthetic siRNAs in vivo","volume":"117","author":"Akhtar","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.nano.2019.02.012_bb0065","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1016\/j.addr.2006.09.019","article-title":"Polymer genomics: an insight into pharmacology and toxicology of nanomedicines","volume":"58","author":"Kabanov","year":"2006","journal-title":"Adv Drug Deliv"},{"issue":"1","key":"10.1016\/j.nano.2019.02.012_bb0070","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.ijpharm.2013.03.039","article-title":"On the nanotoxicity of PAMAM dendrimers: Superfect\u00ae stimulates the EGFR-ERK1\/2 signal transduction pathway via an oxidative stress-dependent mechanism in HEK 293 cells","volume":"448","author":"Akhtar","year":"2013","journal-title":"Int J Pharm"},{"issue":"7","key":"10.1016\/j.nano.2019.02.012_bb0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0132215","article-title":"Cationic polyamidoamine dendrimers as modulators of EGFR signaling in vitro and in vivo","volume":"10","author":"Akhtar","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.nano.2019.02.012_bb0080","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.diabres.2017.03.024","article-title":"IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040","volume":"128","author":"Ogurtsova","year":"2017","journal-title":"Diabetes Res Clin Pract"},{"issue":"5","key":"10.1016\/j.nano.2019.02.012_bb0085","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.cjca.2017.12.005","article-title":"Diabetes, hypertension, and cardiovascular disease: clinical insights and vascular mechanisms","volume":"34","author":"Petrie","year":"2018","journal-title":"Can J Cardiol"},{"issue":"6","key":"10.1016\/j.nano.2019.02.012_bb0090","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/sj.bjp.0706238","article-title":"Epidermal growth factor receptor tyrosine kinase-mediated signalling contributes to diabetes-induced vascular dysfunction in the mesenteric bed","volume":"145","author":"Benter","year":"2005","journal-title":"Br J Pharmacol"},{"issue":"4","key":"10.1016\/j.nano.2019.02.012_bb0095","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1159\/000085904","article-title":"Diabetes-induced renal vascular dysfunction is normalized by inhibition of epidermal growth factor receptor tyrosine kinase","volume":"42","author":"Benter","year":"2005","journal-title":"J Vasc Res"},{"issue":"2\u20133","key":"10.1016\/j.nano.2019.02.012_bb0100","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.vph.2009.04.004","article-title":"Global upregulation of gene expression associated with renal dysfunction in DOCA-salt-induced hypertensive rats occurs via signaling cascades involving epidermal growth factor receptor: a microarray analysis","volume":"51","author":"Benter","year":"2009","journal-title":"Vascul Pharmacol"},{"key":"10.1016\/j.nano.2019.02.012_bb0105","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0067813","article-title":"Activation of ErbB2 and downstream signaling via rho kinases and ERK1\/2 contributes to diabetes-induced vascular dysfunction","volume":"8","author":"Akhtar","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.nano.2019.02.012_bb0110","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1111\/j.1476-5381.2011.01613.x","article-title":"Angiotensin-(1-7) inhibits epidermal growth factor receptor transactivation via a mas receptor-dependent pathway","volume":"165","author":"Akhtar","year":"2012","journal-title":"Br J Pharmacol"},{"issue":"6","key":"10.1016\/j.nano.2019.02.012_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039066","article-title":"Activation of EGFR\/ERBB2 via pathways involving ERK1\/2, P38 MAPK, AKT and FOXO enhances recovery of diabetic hearts from ischemia-reperfusion injury","volume":"7","author":"Akhtar","year":"2012","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.nano.2019.02.012_bb0120","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0141657","article-title":"Transactivation of ErbB family of receptor tyrosine kinases is inhibited by angiotensin-(1-7) via its mas receptor","volume":"10","author":"Akhtar","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.nano.2019.02.012_bb0125","doi-asserted-by":"crossref","first-page":"506","DOI":"10.3109\/1061186X.2015.1057150","article-title":"The dual targeting of EGFR and ErbB2 with the inhibitor Lapatinib corrects high glucose-induced apoptosis and vascular dysfunction by opposing multiple diabetes-induced signaling changes","volume":"23","author":"Benter","year":"2015","journal-title":"J Drug Target"},{"key":"10.1016\/j.nano.2019.02.012_bb0130","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1021\/bm9000298","article-title":"Unexpected in vivo anti-inflammatory activity observed for simple, surface functionalized poly(amidoamine) dendrimers","volume":"10","author":"Chauhan","year":"2009","journal-title":"Biomacromolecules"},{"issue":"1\u20132","key":"10.1016\/j.nano.2019.02.012_bb0135","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.ijpharm.2012.03.037","article-title":"Ambiguous effect of dendrimer PAMAM G3 on rat heart respiration in a model of an experimental diabetes \u2014 objective causes of laboratory misfortune or unpredictable G3 activity?","volume":"430","author":"Siewiera","year":"2012","journal-title":"Int J Pharm"},{"issue":"1","key":"10.1016\/j.nano.2019.02.012_bb0140","doi-asserted-by":"crossref","first-page":"9919","DOI":"10.1038\/s41598-017-09349-0","article-title":"Src-dependent EGFR transactivation regulates lung inflammation via downstream signaling involving ERK1\/2, PI3K\u03b4\/Akt and NF\u03baB induction in a murine asthma model","volume":"7","author":"El-Hashim","year":"2017","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.nano.2019.02.012_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18030628","article-title":"PAMAM dendrimers cross the blood\u2013brain barrier when administered through the carotid artery in C57BL\/6J mice","volume":"18","author":"Srinageshwar","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"4","key":"10.1016\/j.nano.2019.02.012_bb0150","doi-asserted-by":"crossref","first-page":"590","DOI":"10.2174\/1567201812666150817123049","article-title":"Efficient siRNA delivery using PEG-conjugated PAMAM dendrimers targeting vascular endothelial growth factor in a CoCl2-induced neovascularization model in retinal endothelial cells","volume":"13","author":"Xu","year":"2016","journal-title":"Curr Drug Deliv"},{"issue":"9","key":"10.1016\/j.nano.2019.02.012_bb0155","doi-asserted-by":"crossref","first-page":"3966","DOI":"10.1073\/pnas.0908401107","article-title":"Systemic antiangiogenic activity of cationic poly-L-lysine dendrimer delays tumor growth","volume":"107","author":"Al-Jamal","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nano.2019.02.012_bb0160","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.addr.2016.11.003","article-title":"Gene delivery nanoparticles to modulate angiogenesis","volume":"119","author":"Kim","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"issue":"1\u20132","key":"10.1016\/j.nano.2019.02.012_bb0165","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.ijpharm.2012.06.033","article-title":"Poly(amido)amine dendrimers generation 4.0 (PAMAM G4) reduce blood hyperglycaemia and restore impaired blood-brain barrier permeability in streptozotocin diabetes in rats","volume":"436","author":"Karolczak","year":"2012","journal-title":"Int J Pharm"},{"issue":"11","key":"10.1016\/j.nano.2019.02.012_bb0170","doi-asserted-by":"crossref","first-page":"13769","DOI":"10.3390\/molecules181113769","article-title":"The Janus face of PAMAM dendrimers used to potentially cure nonenzymatic modifications of biomacromolecules in metabolic disorders\u2014a critical review of the pros and cons","volume":"18","author":"Labieniec-Watala","year":"2013","journal-title":"Molecules"},{"key":"10.1016\/j.nano.2019.02.012_bb0175","doi-asserted-by":"crossref","first-page":"9900","DOI":"10.1021\/nn303472r","article-title":"Cationic PAMAM dendrimers aggressively initiate blood clot formation","volume":"6","author":"Jones","year":"2012","journal-title":"ACS Nano"},{"key":"10.1016\/j.nano.2019.02.012_bb0180","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1021\/acs.molpharmaceut.7b00515","article-title":"Pyrrolidone modification prevents PAMAM dendrimers from activation of pro-inflammatory signaling pathways in human monocytes","volume":"15","author":"Janaszewska","year":"2018","journal-title":"Mol Pharm"},{"key":"10.1016\/j.nano.2019.02.012_bb0185","series-title":"Proceedings of the Royal Society A: Mathematical, Physical and Enegineering Sciences","article-title":"Pre-clinical and behavioural toxicity profile of PAMAM dendrimers in mice","author":"Chauhan","year":"2009"},{"issue":"7","key":"10.1016\/j.nano.2019.02.012_bb0190","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.3390\/ijms19072006","article-title":"Application of nanoparticles for targeting G protein-coupled receptors","volume":"19","author":"Ma","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.nano.2019.02.012_bb0195","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1021\/bc900473v","article-title":"Polyamidoamine (PAMAM) dendrimer conjugates of \"clickable\" agonists of the A3 adenosine receptor and coactivation of the P2Y14 receptor by a tethered nucleotide","volume":"21","author":"Tosh","year":"2010","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.nano.2019.02.012_bb0200","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1021\/mp900303s","article-title":"Evaluating the gene-expression profiles of HeLa cancer cells treated with activated and nonactivated poly(amidoamine) dendrimers, and their DNA complexes","volume":"7","author":"Kuo","year":"2010","journal-title":"Mol Pharm"},{"issue":"1","key":"10.1016\/j.nano.2019.02.012_bb0205","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1021\/nn5061783","article-title":"Next-generation sequencing reveals low-dose effects of cationic dendrimers in primary human bronchial epithelial cells","volume":"9","author":"Feliu","year":"2015","journal-title":"ACS Nano"},{"key":"10.1016\/j.nano.2019.02.012_bb0210","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1080\/10611860601151860","article-title":"Toxicogenomics of drug delivery systems: exploiting delivery system-induced changes in target gene expression to enhance siRNA activity","volume":"15","author":"Hollins","year":"2007","journal-title":"J Drug Target"},{"key":"10.1016\/j.nano.2019.02.012_bb0215","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.addr.2007.03.010","article-title":"Toxicogenomics of non-viral drug delivery systems for RNAi: potential impact on siRNA-mediated gene silencing activity and specificity","volume":"59","author":"Akhtar","year":"2007","journal-title":"Adv Drug Deliv"},{"key":"10.1016\/j.nano.2019.02.012_bb0220","doi-asserted-by":"crossref","first-page":"12938","DOI":"10.1073\/pnas.1204928109","article-title":"Nucleic acid scavengers inhibit thrombosis without increasing bleeding","volume":"109","author":"Jain","year":"2012","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.nano.2019.02.012_bb0225","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.ejmech.2013.08.047","article-title":"PAMAM dendrimer derivatives as a potential drug for antithrombotic therapy","volume":"69","author":"Dur\u00e1n-Lara","year":"2013","journal-title":"Eur J Med Chem"},{"issue":"1","key":"10.1016\/j.nano.2019.02.012_bb0230","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12989-015-0080-x","article-title":"Cationic nanoparticles directly bind angiotensin-converting enzyme 2 and induce acute lung injury in mice","volume":"12","author":"Sun","year":"2015","journal-title":"Part Fibre Toxicol"},{"key":"10.1016\/j.nano.2019.02.012_bb0235","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.toxlet.2009.07.018","article-title":"Nanosized polyamidoamine (PAMAM) dendrimer-induced apoptosis mediated by mitochondrial dysfunction","volume":"190","author":"Lee","year":"2009","journal-title":"Toxicol Lett"},{"key":"10.1016\/j.nano.2019.02.012_bb0240","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/jmcb\/mjp002","article-title":"PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway","volume":"1","author":"Li","year":"2009","journal-title":"J Mol Cell Biol"},{"issue":"3","key":"10.1016\/j.nano.2019.02.012_bb0245","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3109\/17435390.2014.930533","article-title":"Inhibition of autophagy protects against PAMAM dendrimers-induced hepatotoxicity","volume":"9","author":"Li","year":"2015","journal-title":"Nanotoxicology"},{"issue":"12","key":"10.1016\/j.nano.2019.02.012_bb0250","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.7150\/thno.13181","article-title":"Interplay of oxidative stress and autophagy in PAMAM dendrimers-induced neuronal cell death","volume":"5","author":"Li","year":"2015","journal-title":"Theranostics"},{"issue":"26","key":"10.1016\/j.nano.2019.02.012_bb0255","doi-asserted-by":"crossref","first-page":"7588","DOI":"10.1016\/j.biomaterials.2014.05.029","article-title":"The role of autophagy in the neurotoxicity of cationic PAMAM dendrimers","volume":"35","author":"Wang","year":"2014","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.nano.2019.02.012_bb0260","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1021\/bm501390d","article-title":"Protective effects and mechanisms of G5 PAMAM dendrimers against acute pancreatitis induced by caerulein in mice","volume":"16","author":"Tang","year":"2015","journal-title":"Biomacromolecules"},{"issue":"6","key":"10.1016\/j.nano.2019.02.012_bb0265","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1021\/mp2006054","article-title":"Cationic PAMAM dendrimers disrupt key platelet functions","volume":"9","author":"Jones","year":"2012","journal-title":"Mol Pharm"},{"key":"10.1016\/j.nano.2019.02.012_bb0270","first-page":"1150","article-title":"One-pot synthesize of dendritic hyperbranched PAMAM and assessment as a broad spectrum antimicrobial agent and anti-biofilm","volume":"58","author":"Labena","year":"2016","journal-title":"Korean J Couns Psychother"},{"issue":"7","key":"10.1016\/j.nano.2019.02.012_bb0275","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1021\/bm500328v","article-title":"Cationic PAMAM dendrimers as pore-blocking binary toxin inhibitors","volume":"15","author":"F\u00f6rstner","year":"2014","journal-title":"Biomacromolecules"},{"issue":"6","key":"10.1016\/j.nano.2019.02.012_bb0280","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1021\/bm0701088","article-title":"Antibacterial activities of poly(amidoamine) dendrimers terminated with amino and poly(ethylene glycol) groups","volume":"8","author":"Calabretta","year":"2007","journal-title":"Biomacromolecules"},{"issue":"9","key":"10.1016\/j.nano.2019.02.012_bb0285","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1007\/s00011-016-0959-5","article-title":"In vivo proinflammatory activity of generations 0-3 (G0-G3) polyamidoamine (PAMAM) nanoparticles","volume":"65","author":"Durocher","year":"2016","journal-title":"Inflamm Res"},{"issue":"3","key":"10.1016\/j.nano.2019.02.012_bb0290","doi-asserted-by":"crossref","first-page":"2128","DOI":"10.1007\/s11356-015-5022-5","article-title":"PAMAM dendrimers as nano carriers to investigate inflammatory responses induced by pulmonary exposure of PCB metabolites in Sprague-Dawley rats","volume":"23","author":"Wangpradit","year":"2016","journal-title":"Environ Sci Pollut Res Int"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963419300437?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963419300437?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T23:07:59Z","timestamp":1560812879000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963419300437"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":58,"alternative-id":["S1549963419300437"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2019.02.012","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic administration of nano-sized PAMAM dendrimers in vivo inhibits EGFR-ERK1\/2-ROCK signaling pathway and attenuates diabetes-induced vascular remodeling and dysfunction","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2019.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}