{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T02:20:38Z","timestamp":1794277238753,"version":"4.9.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81770042"],"award-info":[{"award-number":["81770042"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81500033"],"award-info":[{"award-number":["81500033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2019,6]]},"DOI":"10.1016\/j.nano.2019.03.010","type":"journal-article","created":{"date-parts":[[2019,4,11]],"date-time":"2019-04-11T10:46:33Z","timestamp":1554979593000},"page":"259-271","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"special_numbering":"C","title":["Bronchial epithelial cell extracellular vesicles ameliorate epithelial\u2013mesenchymal transition in COPD pathogenesis by alleviating M2 macrophage polarization"],"prefix":"10.1016","volume":"18","author":[{"given":"Shengyang","family":"He","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duanni","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Traini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georges E.","family":"Grau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengpeng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjuan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanzhi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.nano.2019.03.010_bb0005","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.chest.2018.02.023","article-title":"Considerations for the correct diagnosis of COPD and its management with bronchodilators","volume":"154","author":"Anzueto","year":"2018","journal-title":"Chest"},{"key":"10.1016\/j.nano.2019.03.010_bb0010","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01009-2017","article-title":"Aberrant epithelial differentiation by cigarette smoke dysregulates respiratory host defence","volume":"51","author":"Amatngalim","year":"2018","journal-title":"Eur Respir J"},{"key":"10.1016\/j.nano.2019.03.010_bb0015","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.2147\/COPD.S81032","article-title":"Epithelial mesenchymal transition in smokers: large versus small airways and relation to airflow obstruction","volume":"10","author":"Mahmood","year":"2015","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.nano.2019.03.010_bb0020","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.diff.2016.05.008","article-title":"The origin of renal fibroblasts\/myofibroblasts and the signals that trigger fibrosis","volume":"92","author":"Sun","year":"2016","journal-title":"Differentiation"},{"key":"10.1016\/j.nano.2019.03.010_bb0025","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s40169-014-0033-2","article-title":"Clinical significance of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): potential target for prevention of airway fibrosis and lung cancer","volume":"3","author":"Sohal","year":"2014","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.nano.2019.03.010_bb0030","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/BF02147594","article-title":"Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction","volume":"27","author":"Gabbiani","year":"1971","journal-title":"Experientia"},{"key":"10.1016\/j.nano.2019.03.010_bb0035","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.1378\/chest.06-2568","article-title":"Molecular targets in pulmonary fibrosis: the myofibroblast in focus","volume":"132","author":"Scotton","year":"2007","journal-title":"Chest"},{"key":"10.1016\/j.nano.2019.03.010_bb0040","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1097\/ACI.0b013e32834ec6eb","article-title":"Epithelial\u2013mesenchymal transition in the pathophysiology of airway remodelling in asthma","volume":"12","author":"Hackett","year":"2012","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.nano.2019.03.010_bb0045","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0096708","article-title":"Upregulation of gelatinases and epithelial\u2013mesenchymal transition in small airway remodeling associated with chronic exposure to wood smoke","volume":"9","author":"Zou","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.nano.2019.03.010_bb0050","doi-asserted-by":"crossref","first-page":"L525","DOI":"10.1152\/ajplung.00163.2007","article-title":"TGF-beta-induced EMT: mechanisms and implications for fibrotic lung disease","volume":"293","author":"Willis","year":"2007","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.nano.2019.03.010_bb0055","doi-asserted-by":"crossref","first-page":"5","DOI":"10.7603\/s40681-016-0005-5","article-title":"M2 macrophage polarization modulates epithelial\u2013mesenchymal transition in cisplatin-induced tubulointerstitial fibrosis","volume":"6","author":"Yu","year":"2016","journal-title":"Biomedicine (Taipei)"},{"key":"10.1016\/j.nano.2019.03.010_bb0060","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/cbin.10909","article-title":"MCP2 activates NF-kappaB signaling pathway promoting the migration and invasion of ESCC cells","volume":"42","author":"Zhou","year":"2018","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.nano.2019.03.010_bb0065","doi-asserted-by":"crossref","first-page":"e130","DOI":"10.1093\/nar\/gks463","article-title":"Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes","volume":"40","author":"Wahlgren","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.nano.2019.03.010_bb0070","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.smim.2013.12.001","article-title":"Exosomes: an emerging factor in stress-induced immunomodulation","volume":"26","author":"Beninson","year":"2014","journal-title":"Semin Immunol"},{"issue":"16","key":"10.1016\/j.nano.2019.03.010_bb0075","doi-asserted-by":"crossref","first-page":"4586","DOI":"10.1158\/0008-5472.CAN-17-3841","article-title":"Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN\/PI3Kgamma to promote pancreatic cancer metastasis","volume":"78","author":"Wang","year":"2018","journal-title":"Cancer Res"},{"key":"10.1016\/j.nano.2019.03.010_bb0080","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2337\/db17-0356","article-title":"Exosomes from adipose-derived stem cells attenuate adipose inflammation and obesity through polarizing M2 macrophages and beiging in white adipose tissue","volume":"67","author":"Zhao","year":"2018","journal-title":"Diabetes"},{"key":"10.1016\/j.nano.2019.03.010_bb0085","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/1465-9921-11-148","article-title":"MicroRNAs in inflammatory lung disease\u2014master regulators or target practice?","volume":"11","author":"Oglesby","year":"2010","journal-title":"Respir Res"},{"key":"10.1016\/j.nano.2019.03.010_bb0090","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1186\/s12885-018-4631-z","article-title":"Differential expression of hsa-miR-221, hsa-miR-21, hsa-miR-135b, and hsa-miR-29c suggests a field effect in oral cancer","volume":"18","author":"Lopes","year":"2018","journal-title":"BMC Cancer"},{"key":"10.1016\/j.nano.2019.03.010_bb0095","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.1038\/sj.onc.1210083","article-title":"miR-21-mediated tumor growth","volume":"26","author":"Si","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.nano.2019.03.010_bb0100","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/7565076","article-title":"The role of autophagy and related MicroRNAs in inflammatory bowel disease","volume":"2018","author":"Wang","year":"2018","journal-title":"Gastroenterol Res Pract"},{"key":"10.1016\/j.nano.2019.03.010_bb0105","doi-asserted-by":"crossref","first-page":"790","DOI":"10.3389\/fphys.2018.00790","article-title":"miR-21 protects against ischemia\/reperfusion-induced acute kidney injury by preventing epithelial cell apoptosis and inhibiting dendritic cell maturation","volume":"9","author":"Song","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.nano.2019.03.010_bb0110","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1038\/s41419-018-0805-5","article-title":"MicroRNA-21 prevents excessive inflammation and cardiac dysfunction after myocardial infarction through targeting KBTBD7","volume":"9","author":"Yang","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.nano.2019.03.010_bb0115","article-title":"Budesonide and calcitriol synergistically inhibit airway remodeling in asthmatic mice","volume":"2018","author":"Qian","year":"2018","journal-title":"Can Respir J"},{"key":"10.1016\/j.nano.2019.03.010_bb0120","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1177\/0963689718767159","article-title":"MicroRNA-21 mediates the protective effects of mesenchymal stem cells derived from iPSCs to human bronchial epithelial cell injury under hypoxia","volume":"27","author":"Li","year":"2018","journal-title":"Cell Transplant"},{"key":"10.1016\/j.nano.2019.03.010_bb0125","first-page":"1","article-title":"Mutual regulation between miR-21 and the TGFbeta\/Smad signaling pathway in human bronchial fibroblasts promotes airway remodeling","author":"Yu","year":"2018","journal-title":"J Asthma"},{"key":"10.1016\/j.nano.2019.03.010_bb0130","doi-asserted-by":"crossref","first-page":"706","DOI":"10.4161\/rna.8.5.16154","article-title":"Regulation and function of miRNA-21 in health and disease","volume":"8","author":"Kumarswamy","year":"2011","journal-title":"RNA Biol"},{"key":"10.1016\/j.nano.2019.03.010_bb0135","first-page":"2590","article-title":"Role of miRNA-21\/PTEN on the high glucose-induced EMT in human mesothelial peritoneal cells","volume":"10","author":"Yang","year":"2018","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.nano.2019.03.010_bb0140","doi-asserted-by":"crossref","first-page":"7245","DOI":"10.1007\/s13277-015-4604-7","article-title":"MiRNA-21 induces epithelial to mesenchymal transition and gemcitabine resistance via the PTEN\/AKT pathway in breast cancer","volume":"37","author":"Wu","year":"2016","journal-title":"Tumour Biol"},{"key":"10.1016\/j.nano.2019.03.010_bb0145","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1039\/C3MB70564A","article-title":"An increased ratio of serum miR-21 to miR-181a levels is associated with the early pathogenic process of chronic obstructive pulmonary disease in asymptomatic heavy smokers","volume":"10","author":"Xie","year":"2014","journal-title":"Mol Biosyst"},{"key":"10.1016\/j.nano.2019.03.010_bb0150","doi-asserted-by":"crossref","first-page":"503","DOI":"10.3389\/fphys.2018.00503","article-title":"A novel murine chronic obstructive pulmonary disease model and the pathogenic role of MicroRNA-21","volume":"9","author":"He","year":"2018","journal-title":"Front Physiol"},{"key":"10.1016\/j.nano.2019.03.010_bb0155","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.2147\/COPD.S147144","article-title":"Characteristics and potential role of M2 macrophages in COPD","volume":"12","author":"He","year":"2017","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.nano.2019.03.010_bb0160","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/sji.12545","article-title":"PTEN\/PI3k\/AKT regulates macrophage polarization in emphysematous mice","volume":"85","author":"Lu","year":"2017","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.nano.2019.03.010_bb0165","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1164\/rccm.201701-0218PP","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary","volume":"195","author":"Vogelmeier","year":"2017","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.nano.2019.03.010_bb0170","doi-asserted-by":"crossref","first-page":"R281","DOI":"10.1152\/ajpregu.00279.2002","article-title":"Guiding principles for research involving animals and human beings","volume":"283","author":"World Medical","year":"2002","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.nano.2019.03.010_bb0175","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00005-015-0333-2","article-title":"A targeted multiple antigenic peptide vaccine augments the immune response to self TGF-beta1 and suppresses ongoing hepatic fibrosis","volume":"63","author":"Li","year":"2015","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"10.1016\/j.nano.2019.03.010_bb0180","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.freeradbiomed.2017.03.026","article-title":"Cigarette smoke extract induced exosome release is mediated by depletion of exofacial thiols and can be inhibited by thiol-antioxidants","volume":"108","author":"Benedikter","year":"2017","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.nano.2019.03.010_bb0185","doi-asserted-by":"crossref","DOI":"10.3402\/jev.v4.28388","article-title":"Suppression of autophagy by extracellular vesicles promotes myofibroblast differentiation in COPD pathogenesis","volume":"4","author":"Fujita","year":"2015","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.nano.2019.03.010_bb0190","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003484","article-title":"Systemically circulating viral and tumor-derived microRNAs in KSHV-associated malignancies","volume":"9","author":"Chugh","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.nano.2019.03.010_bb0195","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1159\/000485949","article-title":"Exosomes from MiR-126-overexpressing Adscs are therapeutic in relieving acute myocardial ischaemic injury","volume":"44","author":"Luo","year":"2017","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.nano.2019.03.010_bb0200","doi-asserted-by":"crossref","first-page":"3679","DOI":"10.1111\/jcmm.13278","article-title":"MicroRNA-30a ameliorates hepatic fibrosis by inhibiting Beclin1-mediated autophagy","volume":"21","author":"Chen","year":"2017","journal-title":"J Cell Mol Med"},{"key":"10.1016\/j.nano.2019.03.010_bb0205","doi-asserted-by":"crossref","first-page":"169","DOI":"10.7150\/thno.21234","article-title":"Exosomes from human umbilical cord blood accelerate cutaneous wound healing through miR-21-3p-mediated promotion of angiogenesis and fibroblast function","volume":"8","author":"Hu","year":"2018","journal-title":"Theranostics"},{"key":"10.1016\/j.nano.2019.03.010_bb0210","article-title":"Differentiation of THP1 cells into macrophages for Transwell co-culture assay with melanoma cells","volume":"5","author":"Smith","year":"2015","journal-title":"Bio Protoc"},{"key":"10.1016\/j.nano.2019.03.010_bb0215","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-13265-8","article-title":"microRNA profiling in lung tissue and bronchoalveolar lavage of cigarette smoke-exposed mice and in COPD patients: a translational approach","volume":"7","author":"Conickx","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.nano.2019.03.010_bb0220","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.2147\/COPD.S130616","article-title":"Expression profiling of miRNA-145 and miRNA-338 in serum and sputum of patients with COPD, asthma, and asthma-COPD overlap syndrome phenotype","volume":"12","author":"Lacedonia","year":"2017","journal-title":"Int J Chron Obstruct Pulmon Dis"},{"key":"10.1016\/j.nano.2019.03.010_bb0225","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.molmed.2013.10.005","article-title":"Smoking and microRNA dysregulation: a cancerous combination","volume":"20","author":"Momi","year":"2014","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.nano.2019.03.010_bb0230","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/01902148.2018.1439548","article-title":"MicroRNA-21 aggravates chronic obstructive pulmonary disease by promoting autophagy","volume":"44","author":"Zeng","year":"2018","journal-title":"Exp Lung Res"},{"key":"10.1016\/j.nano.2019.03.010_bb0235","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41419-018-0425-0","article-title":"Hypoxia-induced matrix metalloproteinase-13 expression in exosomes from nasopharyngeal carcinoma enhances metastases","volume":"9","author":"Shan","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.nano.2019.03.010_bb0240","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1164\/rccm.201705-0925OC","article-title":"Mesenchymal stromal cell exosomes ameliorate experimental bronchopulmonary dysplasia and restore lung function through macrophage immunomodulation","volume":"197","author":"Willis","year":"2018","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.nano.2019.03.010_bb0245","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.4049\/jimmunol.0900473","article-title":"Smoking-dependent reprogramming of alveolar macrophage polarization: implication for pathogenesis of chronic obstructive pulmonary disease","volume":"183","author":"Shaykhiev","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.nano.2019.03.010_bb0250","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1136\/thoraxjnl-2012-201761","article-title":"Epithelial to mesenchymal transition is increased in patients with COPD and induced by cigarette smoke","volume":"68","author":"Milara","year":"2013","journal-title":"Thorax"},{"key":"10.1016\/j.nano.2019.03.010_bb0255","first-page":"12","article-title":"IL-17A and GDF15 are able to induce epithelial\u2013mesenchymal transition of lung epithelial cells in response to cigarette smoke","volume":"16","author":"Jiang","year":"2018","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.nano.2019.03.010_bb0260","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1183\/09031936.00135814","article-title":"Imprinting of the COPD airway epithelium for dedifferentiation and mesenchymal transition","volume":"45","author":"Gohy","year":"2015","journal-title":"Eur Respir J"},{"key":"10.1016\/j.nano.2019.03.010_bb0265","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/labinvest.2013.69","article-title":"M2-polarized tumor-associated macrophages promoted epithelial\u2013mesenchymal transition in pancreatic cancer cells, partially through TLR4\/IL-10 signaling pathway","volume":"93","author":"Liu","year":"2013","journal-title":"Lab Invest"},{"key":"10.1016\/j.nano.2019.03.010_bb0270","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1007\/s10753-014-9941-y","article-title":"Macrophages regulate renal fibrosis through modulating TGFbeta superfamily signaling","volume":"37","author":"Shen","year":"2014","journal-title":"Inflammation"},{"key":"10.1016\/j.nano.2019.03.010_bb0275","doi-asserted-by":"crossref","first-page":"e284","DOI":"10.1038\/emm.2016.127","article-title":"Adipose stem cell-derived nanovesicles inhibit emphysema primarily via an FGF2-dependent pathway","volume":"49","author":"Kim","year":"2017","journal-title":"Exp Mol Med"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963419300723?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963419300723?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:09:51Z","timestamp":1761548991000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963419300723"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":55,"alternative-id":["S1549963419300723"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2019.03.010","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2019,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bronchial epithelial cell extracellular vesicles ameliorate epithelial\u2013mesenchymal transition in COPD pathogenesis by alleviating M2 macrophage polarization","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2019.03.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}