{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T02:43:33Z","timestamp":1788317013035,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.nano.2019.04.009","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T11:43:58Z","timestamp":1556883838000},"page":"102006","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"special_numbering":"C","title":["Therapeutic potential of andrographolide-loaded nanoparticles on a murine asthma model"],"prefix":"10.1016","volume":"20","author":[{"given":"Shreyasi","family":"Chakraborty","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Ehsan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswajit","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laboni","family":"Mondal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saheli","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishna Das","family":"Saha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brahamacharry","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mita Chatterjee","family":"Debnath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanmoy","family":"Bera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nano.2019.04.009_bb0005","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1038\/nature07204","article-title":"The development of allergic inflammation","volume":"454","author":"Galli","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.nano.2019.04.009_bb0010","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1152\/jappl.1998.85.2.379","article-title":"Recent advances in pulmonary drug delivery using large, porous inhaled particles","volume":"84","author":"Edwards","year":"1998","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.nano.2019.04.009_bb0015","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1146\/annurev.immunol.26.021607.090312","article-title":"T cell trafficking in allergic asthma:the ins and outs","volume":"26","author":"Medoff","year":"2008","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.nano.2019.04.009_bb0020","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/nri1128","article-title":"Regulation of IL4 gene expression by T cells and therapeutic perspectives","volume":"3","author":"Li-Weber","year":"2003","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.nano.2019.04.009_bb0025","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1038\/nri2327","article-title":"Immunomodulatory mast cells:negative, as well as positive, regulators of immunity","volume":"8","author":"Galli","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.nano.2019.04.009_bb0030","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.jaci.2006.07.012","article-title":"Mechanisms of airway hyperresponsiveness","volume":"118","author":"Cockcroft","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.nano.2019.04.009_bb0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pharmthera.2008.09.003","article-title":"Targeting the NF-kappaB pathway in asthma and chronic obstructive pulmonary disease","volume":"121","author":"Edwards","year":"2009","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.nano.2019.04.009_bb0040","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.ijpharm.2010.07.030","article-title":"In vivo efficacy of dendrimer-methylprednisolone conjugate formulation for the treatment of lung inflammation","volume":"399","author":"Inapagolla","year":"2010","journal-title":"Int J Pharm"},{"key":"10.1016\/j.nano.2019.04.009_bb0045","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2223\/JPED.1929","article-title":"Long-term management of children with neuromuscular disorders","volume":"85","author":"Strehle","year":"2009","journal-title":"J Pediatr"},{"issue":"1","key":"10.1016\/j.nano.2019.04.009_bb0050","first-page":"1","article-title":"Nanocarriers as pulmonary drug delivery systems to treat and to diagnose respiratory and non respiratory diseases","volume":"3","author":"Smola","year":"2008","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2019.04.009_bb0055","first-page":"481","article-title":"Inhalation of nanoparticle-based drug for lung cancer treatment: advantages and challenges","volume":"10","author":"Lee","year":"2015","journal-title":"Asian J Pharm Sci"},{"issue":"12","key":"10.1016\/j.nano.2019.04.009_bb0060","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1164\/rccm.200504-613PP","article-title":"The potential advantages of nanoparticle drug delivery systems in chemotherapy of tuberculosis","volume":"172","author":"Gelperina","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"1","key":"10.1016\/j.nano.2019.04.009_bb0065","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1590\/S0001-37652013005000018","article-title":"Nanoparticle-based therapy for respiratory diseases","volume":"85","author":"Da Silva","year":"2013","journal-title":"An Acad Bras Cienc"},{"key":"10.1016\/j.nano.2019.04.009_bb0070","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1021\/acs.molpharmaceut.5b00064","article-title":"Pulmonary delivery of voriconazole loaded nanoparticles providing a prolonged drug level in lungs\u2014a promise for treating fungal infection","volume":"12","author":"Das","year":"2015","journal-title":"Mol Pharm"},{"key":"10.1016\/j.nano.2019.04.009_bb0075","first-page":"621","article-title":"Development of biodegradable polymer based tamoxifen citrate loaded nanoparticles and effect of some manufacturing process parameters on them: a physicochemical and in-vitro evaluation","volume":"5","author":"Sahana","year":"2010","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2019.04.009_bb0080","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.yexmp.2008.12.004","article-title":"Nanoparticle-based targeted drug delivery","volume":"86","author":"Singh","year":"2009","journal-title":"Exp Mol Pathol"},{"key":"10.1016\/j.nano.2019.04.009_bb0085","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1208\/s12249-016-0539-6","article-title":"Early stage HIV management and reduction of stavudine-induced hepatotoxicity in rats by experimentally developed biodegradable nanoparticles","volume":"18","author":"Ghosh","year":"2017","journal-title":"AAPS PharmSciTech"},{"issue":"2","key":"10.1016\/j.nano.2019.04.009_bb0090","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.jconrel.2012.01.043","article-title":"PLGA-based nanoparticles: an overview of biomedical applications","volume":"161","author":"Danhier","year":"2012","journal-title":"J Control Release"},{"issue":"4","key":"10.1016\/j.nano.2019.04.009_bb0095","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1586\/erm.09.15","article-title":"Current advances in research and clinical applications of PLGA-based nanotechnology","volume":"9","author":"L\u00fc","year":"2009","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1016\/j.nano.2019.04.009_bb0100","doi-asserted-by":"crossref","first-page":"2317","DOI":"10.1016\/j.phytochem.2004.05.008","article-title":"Flavonoids and andrographolides from Andrographis paniculata","volume":"65","author":"Rao","year":"2004","journal-title":"Phytochemistry"},{"key":"10.1016\/j.nano.2019.04.009_bb0105","doi-asserted-by":"crossref","first-page":"4207","DOI":"10.4049\/jimmunol.173.6.4207","article-title":"Andrographolide attenuates inflammation by inhibition of NF-kB activation through covalent modification of reduced cysteine 62 of p50","volume":"173","author":"Xia","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.nano.2019.04.009_bb0110","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1164\/rccm.200809-1516OC","article-title":"A novel anti-inflammatory role for andrographolide in asthma via inhibition of the nuclear factor-\u03baB pathway","volume":"179","author":"Bao","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.nano.2019.04.009_bb0115","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cmi.2009.49","article-title":"Inhibition of NF-\u03baB expression and allergen-induced airway inflammation in a mouse allergic asthma model by andrographolide","volume":"6","author":"Li","year":"2009","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.nano.2019.04.009_bb0120","doi-asserted-by":"crossref","first-page":"80262","DOI":"10.18632\/oncotarget.12918","article-title":"Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-\u03baB signaling and NLRP3 inflammasome activation","volume":"7","author":"Peng","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.nano.2019.04.009_bb0125","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1023\/A:1021223407297","article-title":"Study of the supramolecular inclusion of \u03b2-cyclodextrin with andrographolide","volume":"43","author":"Zhao","year":"2002","journal-title":"J Incl Phenom Macrocycl Chem"},{"key":"10.1016\/j.nano.2019.04.009_bb0130","first-page":"266","article-title":"Distribution and excretion of [35S] NaHSO3\u2013andrographolide by autoradiography","volume":"2","author":"Zhu","year":"1981","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.nano.2019.04.009_bb0135","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00280-009-1035-4","article-title":"Effect of antisense oligomer in controlling c-raf.1 overexpression during diethylnitrosamine-induced hepatocarcinogenesis in rats","volume":"65","author":"Das","year":"2010","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.nano.2019.04.009_bb0140","first-page":"3107","article-title":"Preparation and characterization of tamoxifen citrate loaded nanoparticles for breast cancer therapy","volume":"9","author":"Maji","year":"2014","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2019.04.009_bb0145","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2217\/nnm-2017-0291","article-title":"Chitosan-coated nanoparticles enhanced lung pharmacokinetic profile of voriconazole upon pulmonary delivery in mice","volume":"13","author":"Paul","year":"2018","journal-title":"Nanomedicine (Lond)"},{"key":"10.1016\/j.nano.2019.04.009_bb0150","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jconrel.2010.02.006","article-title":"Formulation, characterization and pulmonary deposition of nebulized celecoxib encapsulated nanostructured lipid carriers","volume":"144","author":"Patlolla","year":"2010","journal-title":"J Control Release"},{"issue":"9","key":"10.1016\/j.nano.2019.04.009_bb0155","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.intimp.2008.04.010","article-title":"Tea catechins have dual effect on mast cell degranulation induced by compound 48\/80","volume":"8","author":"Nishikawa","year":"2008","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.nano.2019.04.009_bb0160","doi-asserted-by":"crossref","first-page":"4849","DOI":"10.2147\/IJN.S132114","article-title":"Inhibitory effect of a new orally active cedrol-loaded nanostructured lipid carrier on compound 48\/80-induced mast cell degranulation and anaphylactic shock in mice","volume":"12","author":"Chakraborty","year":"2017","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2019.04.009_bb0165","first-page":"1","article-title":"Garcinol loaded vitamin E TPGS emulsified PLGA nanoparticles: preparation, physicochemical characterization, in vitro and in vivo studies","volume":"7","author":"Gaonkar","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.nano.2019.04.009_bb0170","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.cellimm.2009.07.004","article-title":"Effect of betamethasone phosphate loaded polymeric nanoparticles on a murine asthma model","volume":"260","author":"Matsuo","year":"2009","journal-title":"Cell Immunol"},{"key":"10.1016\/j.nano.2019.04.009_bb0175","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jconrel.2010.11.001","article-title":"Preparation of budesonide-loaded porous PLGA microparticles and their therapeutic efficacy in a murine asthma model","volume":"150","author":"Oh","year":"2011","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2019.04.009_bb0180","doi-asserted-by":"crossref","first-page":"31411","DOI":"10.1021\/acsami.7b07343","article-title":"Covalent organic framework material bearing phloroglucinol building units as a potent anticancer agent","volume":"9","author":"Bhanja","year":"2017","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.nano.2019.04.009_bb0185","first-page":"77","article-title":"Review: in-vitro drug release characterization models","volume":"2","author":"Singhvi","year":"2011","journal-title":"Int J Pharm Stud Res"},{"key":"10.1016\/j.nano.2019.04.009_bb0190","first-page":"811","article-title":"Doxorubicin-loaded phosphatidylethanolamine-conjugated nanoliposomes: in vitro characterization and their accumulation in liver, kidneys, and lungs in rats","volume":"5","author":"Rudra","year":"2010","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2019.04.009_bb0195","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/2008-2231-22-44","article-title":"Preparation, characterization and in vitro efficacy of magnetic nanoliposomes containing the artemisinin and transferrin","volume":"22","author":"Gharib","year":"2014","journal-title":"Daru"},{"key":"10.1016\/j.nano.2019.04.009_bb0200","series-title":"Good cascade impactor practices, AIM and EDA for orally inhaled products","first-page":"15","article-title":"Roberts DL. Current approaches to APSD measurements of OIPs based on inertial impaction","author":"Mitchell","year":"2013"},{"key":"10.1016\/j.nano.2019.04.009_bb0205","first-page":"94","article-title":"Poly-lactide-co-glycolide nanoparticles containing voriconazole for pulmonary delivery: in vitro and in vivo study, nanomedicine: nanotechnology","volume":"9","author":"Sinha","year":"2013","journal-title":"Biol Med"},{"issue":"6","key":"10.1016\/j.nano.2019.04.009_bb0210","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/aps.2017.34","article-title":"Pulmonary delivery of nanoparticle chemotherapy for the treatment of lung cancers: challenges and opportunities","volume":"38","author":"Mangal","year":"2017","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.nano.2019.04.009_bb0215","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.coi.2008.04.001","article-title":"IL-5 and eosinophilia","volume":"20","author":"Takatsu","year":"2008","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.nano.2019.04.009_bb0220","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1365-2222.2008.02958.x","article-title":"Eosinophils: biological properties and role in health and disease","volume":"38","author":"Hogan","year":"2008","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.nano.2019.04.009_bb0225","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.mcp.0000198064.27586.37","article-title":"Mucus and MUC in asthma","volume":"12","author":"Morcillo","year":"2006","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.nano.2019.04.009_bb0230","doi-asserted-by":"crossref","first-page":"L1066","DOI":"10.1152\/ajplung.00195.2001","article-title":"CD4(1) T cell-dependent airway mucus production occurs in response to IL-5 expression in lung","volume":"282","author":"Justice","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.nano.2019.04.009_bb0235","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.imbio.2006.07.001","article-title":"Inflammatory signal transduction from Fc\u03f5RI to NF-\u03baB","volume":"211","author":"Klemm","year":"2006","journal-title":"Immunobiology"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963419300905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963419300905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:09:42Z","timestamp":1761548982000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963419300905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":47,"alternative-id":["S1549963419300905"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2019.04.009","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic potential of andrographolide-loaded nanoparticles on a murine asthma model","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2019.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102006"}}