{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:42:53Z","timestamp":1791164573319,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81603051"],"award-info":[{"award-number":["81603051"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81673377"],"award-info":[{"award-number":["81673377"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871477"],"award-info":[{"award-number":["81871477"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20170748"],"award-info":[{"award-number":["BK20170748"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20160760"],"award-info":[{"award-number":["BK20160760"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["2017ZX09101001-004"],"award-info":[{"award-number":["2017ZX09101001-004"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013073","name":"Major Technology Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013073","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2632017PY18"],"award-info":[{"award-number":["2632017PY18"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2016ZPY015"],"award-info":[{"award-number":["2016ZPY015"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.nano.2019.102105","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T02:27:16Z","timestamp":1573784836000},"page":"102105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Desirable PEGylation for improving tumor selectivity of hyaluronic acid-based nanoparticles via low hepatic captured, long circulation times and CD44 receptor-mediated tumor targeting"],"prefix":"10.1016","volume":"24","author":[{"given":"Chao","family":"Teng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuodong","family":"Chai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyue","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianjie","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenshi","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaopeng","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nano.2019.102105_bb0005","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.addr.2017.02.003","article-title":"The battle of \u201cnano\u201d paclitaxel","volume":"122","author":"Sofias","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.nano.2019.102105_bb0010","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1021\/acsnano.6b06040","article-title":"Diverse applications of nanomedicine","volume":"11","author":"Pelaz","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.nano.2019.102105_bb0015","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.addr.2010.04.009","article-title":"The EPR effect: unique features of tumor blood vessels for drug delivery, factors involved, and limitations and augmentation of the effect","volume":"63","author":"Fang","year":"2011","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.nano.2019.102105_bb0020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.addr.2015.01.002","article-title":"Toward a full understanding of the EPR effect in primary and metastatic tumors as well as issues related to its heterogeneity","volume":"91","author":"Maeda","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.nano.2019.102105_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2016.05.050","article-title":"Synergistic active targeting of dually integrin \u03b1v\u03b23\/CD44-targeted nanoparticles to B16F10 tumors located at different sites of mouse bodies","volume":"235","author":"Shi","year":"2016","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2019.102105_bb0030","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.nano.2017.09.003","article-title":"Fab antibody fragment-functionalized liposomes for specific targeting of antigen-positive cells","volume":"14","author":"Ohradanova-Repic","year":"2018","journal-title":"Nanomedicine"},{"key":"10.1016\/j.nano.2019.102105_bb0035","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.molimm.2018.01.010","article-title":"Liposomal nanoparticle armed with bivalent bispecific single-domain antibodies, novel weapon in HER2 positive cancerous cell lines targeting","volume":"96","author":"Nikkhoi","year":"2018","journal-title":"Mol Immunol"},{"key":"10.1016\/j.nano.2019.102105_bb0040","doi-asserted-by":"crossref","first-page":"1704623","DOI":"10.1002\/adfm.201704623","article-title":"Actively targeted deep tissue imaging and photothermal-chemo therapy of breast cancer by antibody-functionalized drug-loaded X-ray-responsive bismuth sulfide@ mesoporous silica core\u2013shell nanoparticles","volume":"28","author":"Li","year":"2018","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.nano.2019.102105_bb0045","doi-asserted-by":"crossref","first-page":"322","DOI":"10.7150\/thno.10257","article-title":"Aptamers: active targeting ligands for cancer diagnosis and therapy","volume":"5","author":"Wu","year":"2015","journal-title":"Theranostics"},{"key":"10.1016\/j.nano.2019.102105_bb0050","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.biomaterials.2016.03.013","article-title":"Multifunctional aptamer-based nanoparticles for targeted drug delivery to circumvent cancer resistance","volume":"91","author":"Liu","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.nano.2019.102105_bb0055","doi-asserted-by":"crossref","DOI":"10.1002\/smll.201803601","article-title":"Quinic acid-conjugated nanoparticles enhance drug delivery to solid tumors via interactions with endothelial Selectins","volume":"14","author":"Xu","year":"2018","journal-title":"Small"},{"key":"10.1016\/j.nano.2019.102105_bb0060","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1021\/acs.molpharmaceut.5b00639","article-title":"Synthesis and characterization of a novel mycophenolic acid\u2013quinic acid conjugate serving as immunosuppressant with decreased toxicity","volume":"12","author":"Peng","year":"2015","journal-title":"Mol Pharm"},{"key":"10.1016\/j.nano.2019.102105_bb0065","doi-asserted-by":"crossref","first-page":"5246","DOI":"10.1002\/ange.201412114","article-title":"Active targeting of tumors through conformational epitope imprinting","volume":"127","author":"Zhang","year":"2015","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.nano.2019.102105_bb0070","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jconrel.2015.09.009","article-title":"A pH-responsive cell-penetrating peptide-modified liposomes with active recognizing of integrin \u03b1v\u03b23 for the treatment of melanoma","volume":"217","author":"Shi","year":"2015","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2019.102105_bb0075","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jconrel.2014.12.032","article-title":"Bioreducible core-crosslinked hyaluronic acid micelle for targeted cancer therapy","volume":"200","author":"Han","year":"2015","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2019.102105_bb0080","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.addr.2015.11.011","article-title":"Hyaluronic acid for anticancer drug and nucleic acid delivery","volume":"97","author":"Dosio","year":"2016","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.nano.2019.102105_bb0085","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.nano.2016.11.012","article-title":"Targeting tumor highly-expressed LAT1 transporter with amino acid-modified nanoparticles: toward a novel active targeting strategy in breast cancer therapy","volume":"13","author":"Li","year":"2017","journal-title":"Nanomedicine"},{"key":"10.1016\/j.nano.2019.102105_bb0090","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.jconrel.2016.10.031","article-title":"Transporter occluded-state conformation-induced endocytosis: amino acid transporter ATB0,+-mediated tumor targeting of liposomes for docetaxel delivery for hepatocarcinoma therapy","volume":"243","author":"Luo","year":"2016","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2019.102105_bb0095","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.biomaterials.2016.01.049","article-title":"Hyaluronic acid-shelled acid-activatable paclitaxel prodrug micelles effectively target and treat CD44-overexpressing human breast tumor xenografts in vivo","volume":"84","author":"Zhong","year":"2016","journal-title":"Biomaterials"},{"key":"10.1016\/j.nano.2019.102105_bb0100","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.nano.2017.12.003","article-title":"PEGylated hyaluronic acid-coated liposome for enhanced in vivo efficacy of sorafenib via active tumor cell targeting and prolonged systemic exposure","volume":"14","author":"Mo","year":"2018","journal-title":"Nanomedicine"},{"key":"10.1016\/j.nano.2019.102105_bb0105","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jconrel.2018.02.024","article-title":"Anti-tumor efficacy of hyaluronan-based nanoparticles for the co-delivery of drugs in lung cancer","volume":"275","author":"Jeannot","year":"2018","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2019.102105_bb0110","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.nano.2015.11.018","article-title":"Targeting CD44 receptor-positive lung tumors using polysaccharide-based nanocarriers: influence of nanoparticle size and administration route","volume":"12","author":"Jeannot","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.nano.2019.102105_bb0115","doi-asserted-by":"crossref","first-page":"5423","DOI":"10.1021\/nn405839n","article-title":"Hyaluronan polymer length, grafting density, and surface poly (ethylene glycol) coating influence in vivo circulation and tumor targeting of hyaluronan-grafted liposomes","volume":"8","author":"Qhattal","year":"2014","journal-title":"ACS Nano"},{"key":"10.1016\/j.nano.2019.102105_bb0120","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jconrel.2014.10.024","article-title":"Stealth CD44-targeted hyaluronic acid supramolecular nanoassemblies for doxorubicin delivery: probing the effect of uncovalent pegylation degree on cellular uptake and blood long circulation","volume":"197","author":"Han","year":"2015","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2019.102105_bb0125","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1016\/j.biomaterials.2010.11.010","article-title":"PEGylation of hyaluronic acid nanoparticles improves tumor targetability in vivo","volume":"32","author":"Choi","year":"2011","journal-title":"Biomaterials"},{"key":"10.1016\/j.nano.2019.102105_bb0130","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.nano.2016.01.013","article-title":"Cellular distribution of injected PLGA-nanoparticles in the liver","volume":"12","author":"Park","year":"2016","journal-title":"Nanomedicine"},{"key":"10.1016\/j.nano.2019.102105_bb0135","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jconrel.2015.11.003","article-title":"Development and characterization of sorafenib-loaded PLGA nanoparticles for the systemic treatment of liver fibrosis","volume":"221","author":"Lin","year":"2016","journal-title":"J Control Release"},{"issue":"11","key":"10.1016\/j.nano.2019.102105_bb0140","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.1073\/pnas.1117560109","article-title":"Inhibition of Stabilin-2 elevates circulating hyaluronic acid levels and prevents tumor metastasis","volume":"109","author":"Hirose","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nano.2019.102105_bb0145","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.foodres.2014.12.045","article-title":"Modified curcumin with hyaluronic acid: combination of pro-drug and nano-micelle strategy to address the curcumin challenge","volume":"69","author":"Li","year":"2015","journal-title":"Food Res Int"},{"key":"10.1016\/j.nano.2019.102105_bb0150","doi-asserted-by":"crossref","first-page":"23595","DOI":"10.1021\/acsami.8b06236","article-title":"Anti-inflammation and joint lubrication dual effects of a novel hyaluronic acid\/curcumin nanomicelle improve the efficacy of rheumatoid arthritis therapy","volume":"10","author":"Fan","year":"2018","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.nano.2019.102105_bb0155","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/adhm.201300091","article-title":"Doxorubicin conjugate of poly (ethylene glycol)-block-polyphosphoester for cancer therapy","volume":"3","author":"Sun","year":"2014","journal-title":"Adv Healthc Mater"},{"key":"10.1016\/j.nano.2019.102105_bb0160","doi-asserted-by":"crossref","first-page":"8591","DOI":"10.1021\/nn202070n","article-title":"Smart nanocarrier based on PEGylated hyaluronic acid for cancer therapy","volume":"5","author":"Choi","year":"2011","journal-title":"ACS Nano"},{"key":"10.1016\/j.nano.2019.102105_bb0165","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.addr.2017.03.001","article-title":"Combination antitumor therapy with targeted dual-nanomedicines","volume":"115","author":"Dai","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.nano.2019.102105_bb0170","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/cbin.10459","article-title":"Effect of the surface modification, size, and shape on cellular uptake of nanoparticles","volume":"39","author":"Salatin","year":"2015","journal-title":"Cell Biol Int"},{"key":"10.1016\/j.nano.2019.102105_bb0175","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jconrel.2016.07.051","article-title":"Role of nanoparticle size, shape and surface chemistry in oral drug delivery","volume":"238","author":"Banerjee","year":"2016","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2019.102105_bb0180","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.actbio.2015.08.029","article-title":"Intracellular delivery and antitumor effects of a redox-responsive polymeric paclitaxel conjugate based on hyaluronic acid","volume":"26","author":"Yin","year":"2015","journal-title":"Acta Biomater"},{"key":"10.1016\/j.nano.2019.102105_bb0185","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.biomaterials.2015.02.089","article-title":"Hyaluronic acid nanoparticles for active targeting atherosclerosis","volume":"53","author":"Lee","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.nano.2019.102105_bb0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/07357907.2016.1247166","article-title":"Anticancer activity of curcumin and its analogues: preclinical and clinical studies","volume":"35","author":"Allegra","year":"2017","journal-title":"Cancer Invest"},{"key":"10.1016\/j.nano.2019.102105_bb0195","doi-asserted-by":"crossref","unstructured":"Wang Y, Wang J, Yang L, Wei W, Sun B, Na K, et al. Redox dual-responsive paclitaxel-doxorubicin heterodimeric prodrug self-delivery nanoaggregates for more effective breast cancer synergistic combination chemotherapy. Nanomedicine 2019; 102066.","DOI":"10.1016\/j.nano.2019.102066"},{"key":"10.1016\/j.nano.2019.102105_bb0200","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/nrd2591","article-title":"Strategies in the design of nanoparticles for therapeutic applications","volume":"9","author":"Petros","year":"2010","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.nano.2019.102105_bb0205","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.colsurfb.2018.02.016","article-title":"The effect of the molecular weight of hyaluronic acid on the physicochemical characterization of hyaluronic acid-curcumin conjugates and in vitro evaluation in glioma cells","volume":"165","author":"Tian","year":"2018","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1016\/j.nano.2019.102105_bb0210","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.biomaterials.2015.05.006","article-title":"Matrix metalloproteinase-sensitive size-shrinkable nanoparticles for deep tumor penetration and pH triggered doxorubicin release","volume":"60","author":"Ruan","year":"2015","journal-title":"Biomaterials"},{"key":"10.1016\/j.nano.2019.102105_bb0215","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1002\/smll.201402865","article-title":"Dual-pH sensitive charge-reversal polypeptide micelles for tumor-triggered targeting uptake and nuclear drug delivery","volume":"11","author":"Han","year":"2015","journal-title":"Small"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963419301893?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963419301893?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T20:32:48Z","timestamp":1778617968000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963419301893"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":43,"alternative-id":["S1549963419301893"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2019.102105","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Desirable PEGylation for improving tumor selectivity of hyaluronic acid-based nanoparticles via low hepatic captured, long circulation times and CD44 receptor-mediated tumor targeting","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2019.102105","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102105"}}