{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:22:51Z","timestamp":1786994571579,"version":"build-2736575974"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.nano.2021.102502","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T02:16:50Z","timestamp":1637893010000},"page":"102502","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":22,"special_numbering":"C","title":["NIR irradiation enhances the apoptotic potentiality of quinacrine-gold hybrid nanoparticles by modulation of HSP-70 in oral cancer stem cells"],"prefix":"10.1016","volume":"40","author":[{"given":"Somya Ranjan","family":"Dash","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhajit","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saptarshi","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswajit","family":"Das","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subarno","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajalaxmi","family":"Pradhan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chinmayee","family":"Sethy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rupayana","family":"Panda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasaswini","family":"Tripathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chanakya Nath","family":"Kundu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nano.2021.102502_bb0005","series-title":"Mayo Clinic Proceedings","first-page":"386","article-title":"Head and neck squamous cell carcinoma: update on epidemiology, diagnosis, and treatment","author":"Marur","year":"2016"},{"issue":"22","key":"10.1016\/j.nano.2021.102502_bb0010","doi-asserted-by":"crossref","first-page":"7856","DOI":"10.1039\/D0CS00379D","article-title":"Cancer stem cell-targeted bio-imaging and chemotherapeutic perspective","volume":"49","author":"Han","year":"2020","journal-title":"Chem Soc Rev"},{"issue":"7","key":"10.1016\/j.nano.2021.102502_bb0015","doi-asserted-by":"crossref","first-page":"3011","DOI":"10.1021\/acs.molpharmaceut.9b00242","article-title":"Comparative and mechanistic study on the anticancer activity of quinacrine-based silver and gold hybrid nanoparticles in head and neck cancer","volume":"16","author":"Hembram","year":"2019","journal-title":"Mol Pharm"},{"issue":"7","key":"10.1016\/j.nano.2021.102502_bb0020","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1021\/acs.molpharmaceut.0c00197","article-title":"Quinacrine based gold hybrid nanoparticles caused apoptosis through modulating replication fork in oral cancer stem cells","volume":"17","author":"Hembram","year":"2020","journal-title":"Mol Pharm"},{"key":"10.1016\/j.nano.2021.102502_bb0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pmatsci.2018.07.005","article-title":"Nanomaterials as photothermal therapeutic agents","volume":"99","author":"Chen","year":"2019","journal-title":"Prog Mater Sci"},{"issue":"3","key":"10.1016\/j.nano.2021.102502_bb0030","first-page":"305","article-title":"Advances in nanomaterial-mediated photothermal cancer therapies: toward clinical applications","volume":"9","author":"Han","year":"2021","journal-title":"Biomedicine"},{"issue":"4","key":"10.1016\/j.nano.2021.102502_bb0035","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3390\/cells9040892","article-title":"Molecular chaperones in cancer stem cells: determinants of stemness and potential targets for antitumor therapy","volume":"9","author":"Kabakov","year":"2020","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.nano.2021.102502_bb0040","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12192-016-0676-6","article-title":"The human HSP70 family of chaperones: where do we stand?","volume":"21","author":"Radons","year":"2016","journal-title":"Cell Stress Chaperones"},{"issue":"3 (33)","key":"10.1016\/j.nano.2021.102502_bb0045","article-title":"Death receptors: new opportunities in cancer therapy","volume":"9","author":"Ukrainskaya","year":"2017","journal-title":"Acta Naturae \u0410\u043d\u0433\u043b\u043e\u044f\u0437\u044b\u0447\u043d\u0430\u044f \u0412\u0435\u0440\u0441\u0438\u044f"},{"key":"10.1016\/j.nano.2021.102502_bb0050","article-title":"Metabolic adaptations in cancer stem cells. Front","volume":"10","author":"Yadav","year":"2020","journal-title":"Oncologia"},{"key":"10.1016\/j.nano.2021.102502_bb0055","doi-asserted-by":"crossref","first-page":"416","DOI":"10.2174\/1871520620666200721123046","article-title":"Anti-cancer stem cells potentiality of an anti-malarial agent quinacrine: an old wine in a new bottle","volume":"21","author":"Das","year":"2020","journal-title":"Anti Cancer Agents Med Chem"},{"issue":"23","key":"10.1016\/j.nano.2021.102502_bb0060","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.4161\/cc.8.23.10179","article-title":"Anti-malaria drug blocks proteotoxic stress response: anti-cancer implications","volume":"8","author":"Neznanov","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.nano.2021.102502_bb0065","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3389\/fchem.2019.00167","article-title":"Gold nanoparticles for photothermal cancer therapy","volume":"7","author":"Vines","year":"2019","journal-title":"Front Chem"},{"issue":"3","key":"10.1016\/j.nano.2021.102502_bb0070","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.nano.2018.01.007","article-title":"Metallic gold and bioactive quinacrine hybrid nanoparticles inhibit oral cancer stem cell and angiogenesis by deregulating inflammatory cytokines in p53 dependent manner","volume":"14","author":"Satapathy","year":"2018","journal-title":"Nanomedicine Nanotechnol Biol Med"},{"key":"10.1016\/j.nano.2021.102502_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173308","article-title":"Nanoformulated quinacrine regulates NECTIN-4 domain specific functions in cervical cancer stem cells","volume":"883","author":"Chatterjee","year":"2020","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.nano.2021.102502_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2020.109902","article-title":"PARP inhibitor Veliparib (ABT-888) enhances the anti-angiogenic potentiality of curcumin through deregulation of NECTIN-4 in oral cancer: role of nitric oxide (NO)","volume":"80","author":"Chatterjee","year":"2021","journal-title":"Cell Signal"},{"key":"10.1016\/j.nano.2021.102502_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2019.105682","article-title":"Quinacrine and curcumin synergistically increased the breast cancer stem cells death by inhibiting ABCG2 and modulating DNA damage repair pathway","volume":"119","author":"Nayak","year":"2020","journal-title":"Int J Biochem Cell Biol"},{"issue":"2","key":"10.1016\/j.nano.2021.102502_bb0090","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s12253-014-9835-1","article-title":"The apoptotic effect of plant based nanosilver in colon cancer cells is a p53 dependent process involving ROS and JNK cascade","volume":"21","author":"Satapathy","year":"2015","journal-title":"Pathol Oncol Res"},{"key":"10.1016\/j.nano.2021.102502_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2021.108624","article-title":"Nano formulated resveratrol inhibits metastasis and angiogenesis by reducing inflammatory cytokines in oral cancer cells by targeting tumor associated macrophages","volume":"92","author":"Pradhan","year":"2021","journal-title":"J Nutr Biochem"},{"key":"10.1016\/j.nano.2021.102502_bb0100","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.biopha.2017.12.082","article-title":"TNF-related apoptosis-inducing ligand (TRAIL) as the potential therapeutic target in hematological malignancies","volume":"98","author":"Naimi","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"2","key":"10.1016\/j.nano.2021.102502_bb0105","doi-asserted-by":"crossref","first-page":"206","DOI":"10.18632\/oncotarget.813","article-title":"TRAIL induces apoptosis in oral squamous carcinoma cells: a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5","volume":"4","author":"Chen","year":"2013","journal-title":"Oncotarget"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963421001453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963421001453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:17:37Z","timestamp":1761549457000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963421001453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":21,"alternative-id":["S1549963421001453"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2021.102502","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NIR irradiation enhances the apoptotic potentiality of quinacrine-gold hybrid nanoparticles by modulation of HSP-70 in oral cancer stem cells","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2021.102502","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102502"}}