{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T14:34:53Z","timestamp":1770906893843,"version":"3.50.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.nano.2022.102577","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T12:24:27Z","timestamp":1655295867000},"page":"102577","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Development of a SERS based cancer diagnosis approach employing cryosectioned thyroid tissue samples on PDMS"],"prefix":"10.1016","volume":"44","author":[{"given":"Sevda","family":"Mert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seda","family":"Sancak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hasan","family":"Ayd\u0131n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe Tuba","family":"Fersaho\u011flu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adnan","family":"Somay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferda","family":"\u00d6zkan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"\u00c7ulha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nano.2022.102577_bb0005","series-title":"Management of Thyroid Cancer And Related Nodular Disease","author":"McDougall","year":"2006"},{"key":"10.1016\/j.nano.2022.102577_bb0010","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1089\/thy.2009.0110","article-title":"American Thyroid Association (ATA) guidelines taskforce on thyroid nodules and differentiated thyroid cancer. Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer","volume":"19","author":"Cooper","year":"2009","journal-title":"Thyroid"},{"issue":"5","key":"10.1016\/j.nano.2022.102577_bb0015","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF03346587","article-title":"American Association of Clinical Endocrinologists, Associazione Medici Endocrinologi, and European Thyroid Association medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations","volume":"33","author":"Gharib","year":"2010","journal-title":"J Endocrinol Invest"},{"key":"10.1016\/j.nano.2022.102577_bb0020","first-page":"1","article-title":"The current management of thyroid cancer","volume":"33","author":"Udelsman","year":"1999","journal-title":"Adv Surg"},{"issue":"4","key":"10.1016\/j.nano.2022.102577_bb0025","first-page":"341","article-title":"Anaplastic thyroid cancer: prevalence, diagnosis and treatment","volume":"33","author":"Chiacchio","year":"2008","journal-title":"Minerva Endocrinol"},{"issue":"1","key":"10.1016\/j.nano.2022.102577_bb0030","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-018-20233-3","article-title":"A new method using Raman spectroscopy for in vivo targeted brain cancer tissue biopsy","volume":"8","author":"Desroches","year":"2018","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.nano.2022.102577_bb0035","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1089\/pho.2011.3191","article-title":"Discrimination of basal cell carcinoma and melanoma from normal skin biopsies in vitro through Raman spectroscopy and principal component analysis","volume":"30","author":"Bodanese","year":"2012","journal-title":"Photomed Laser Surg"},{"issue":"3","key":"10.1016\/j.nano.2022.102577_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.201800396","article-title":"Development and first in-human use of a Raman spectroscopy guidance system integrated with a brain biopsy needle","volume":"12","author":"Desroches","year":"2019","journal-title":"J Biophotonics"},{"issue":"22","key":"10.1016\/j.nano.2022.102577_bb0045","doi-asserted-by":"crossref","first-page":"36012","DOI":"10.18632\/oncotarget.16419","article-title":"Renal mass biopsy using Raman spectroscopy identifies malignant and benign renal tumors: potential for pre-operative diagnosis","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"issue":"12","key":"10.1016\/j.nano.2022.102577_bb0050","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.tibtech.2009.09.001","article-title":"FTIR microspectroscopy for improved prostate cancer diagnosis","volume":"27","author":"Mackanos","year":"2009","journal-title":"Trends Biotechnol"},{"issue":"11","key":"10.1016\/j.nano.2022.102577_bb0055","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1038\/sj.bjc.6604753","article-title":"FTIR-based spectroscopic analysis in the identification of clinically aggressive prostate cancer","volume":"99","author":"Baker","year":"2008","journal-title":"Br J Cancer"},{"issue":"4","key":"10.1016\/j.nano.2022.102577_bb0060","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3390\/mi11040356","article-title":"Recent progress in optical sensors for biomedical diagnostics","volume":"11","author":"Pirzada","year":"2020","journal-title":"Micromachines"},{"issue":"4","key":"10.1016\/j.nano.2022.102577_bb0065","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.20.4.047002","article-title":"Kidney tumor staging using surface-enhanced Raman scattering","volume":"20","author":"Mert","year":"2015","journal-title":"J Biomed Opt"},{"issue":"4","key":"10.1016\/j.nano.2022.102577_bb0070","doi-asserted-by":"crossref","DOI":"10.1063\/1.4789996","article-title":"Esophageal cancer detection based on tissue surface-enhanced Raman spectroscopy and multivariate analysis","volume":"102","author":"Feng","year":"2013","journal-title":"Appl Phys Lett"},{"issue":"4","key":"10.1016\/j.nano.2022.102577_bb0075","article-title":"Surface-enhanced Raman spectroscopy for differentiation between benign and malignant thyroid tissues","volume":"11","author":"Li","year":"2014","journal-title":"Laser PhysLett"},{"key":"10.1016\/j.nano.2022.102577_bb0080","article-title":"Raman spectroscopy and surface-enhanced Raman spectroscopy (SERS) spectra of salivary glands carcinoma, tumor and healthy tissues and their homogenates analyzed by chemometry: towards development of the novel tool for clinical diagnosis","volume":"338784","author":"Czaplicka","year":"2021","journal-title":"Anal Chim Acta"},{"issue":"10","key":"10.1016\/j.nano.2022.102577_bb0085","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1366\/000370209789553219","article-title":"Differentiation of healthy brain tissue and tumors using surface-enhanced Raman scattering","volume":"63","author":"Aydin","year":"2009","journal-title":"Appl Spectrosc"},{"issue":"1","key":"10.1016\/j.nano.2022.102577_bb0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2407-9-42","article-title":"Coherent anti-stokes Raman scattering imaging of lipids in cancer metastasis","volume":"9","author":"Le","year":"2009","journal-title":"BMC Cancer"},{"key":"10.1016\/j.nano.2022.102577_bb0095","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.compmedimag.2015.02.010","article-title":"Texture analysis and classification in coherent anti-stokes Raman scattering (CARS) microscopy images for automated detection of skin cancer","volume":"43","author":"Legesse","year":"2015","journal-title":"Comput Med Imaging Graph"},{"issue":"15","key":"10.1016\/j.nano.2022.102577_bb0100","doi-asserted-by":"crossref","first-page":"6223","DOI":"10.1021\/acs.analchem.1c00522","article-title":"Microcalcification-based tumor malignancy evaluation in fresh breast biopsies with hyperspectral stimulated Raman scattering","volume":"93","author":"Yang","year":"2021","journal-title":"Anal Chem"},{"issue":"2","key":"10.1016\/j.nano.2022.102577_bb0105","first-page":"1","article-title":"Rapid intraoperative histology of unprocessed surgical specimens via fibre-laser-based stimulated Raman scattering microscopy","volume":"1","author":"Orringer","year":"2017","journal-title":"NatBiomedEng"},{"issue":"2","key":"10.1016\/j.nano.2022.102577_bb0110","first-page":"163","article-title":"Raman spectra of pyridine adsorbed at a silver electrode","volume":"26","author":"Fleischmann","year":"1974","journal-title":"ChemPhysLett"},{"issue":"1","key":"10.1016\/j.nano.2022.102577_bb0115","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0022-0728(77)80224-6","article-title":"Surface Raman spectroelectrochemistry: part I. Heterocyclic, aromatic, and aliphatic amines adsorbed on the anodized silver electrode","volume":"84","author":"Jeanmaire","year":"1977","journal-title":"J Electroanal Chem Interfacial Electrochem"},{"issue":"15","key":"10.1016\/j.nano.2022.102577_bb0120","first-page":"2555","article-title":"Biological targeting of plasmonic nanoparticles improves cellular imaging via the enhanced scattering in the aggregates formed","volume":"5","author":"Aioub","year":"2014","journal-title":"JPhysChemLett"},{"issue":"10","key":"10.1016\/j.nano.2022.102577_bb0125","doi-asserted-by":"crossref","first-page":"4946","DOI":"10.1021\/acs.chemrev.7b00668","article-title":"Surface-enhanced Raman spectroscopy for bioanalysis: reliability and challenges","volume":"118","author":"Zong","year":"2018","journal-title":"Chem Rev"},{"issue":"13","key":"10.1016\/j.nano.2022.102577_bb0130","doi-asserted-by":"crossref","first-page":"3945","DOI":"10.1039\/C7CS00172J","article-title":"Recent progress in surface-enhanced Raman spectroscopy for biological and biomedical applications: from cells to clinics","volume":"46","author":"Cialla-May","year":"2017","journal-title":"Chem Soc Rev"},{"issue":"24","key":"10.1016\/j.nano.2022.102577_bb0135","doi-asserted-by":"crossref","first-page":"5723","DOI":"10.1021\/jp027460u","article-title":"A new method for fast preparation of highly surface-enhanced Raman scattering (SERS) active silver colloids at room temperature by reduction of silver nitrate with hydroxylamine hydrochloride","volume":"107","author":"Leopold","year":"2003","journal-title":"J Phys Chem B"},{"key":"10.1016\/j.nano.2022.102577_bb0140","series-title":"Development of SERS Based Methods for Early Cancer Detection","author":"Mert","year":"2018"},{"issue":"1","key":"10.1016\/j.nano.2022.102577_bb0145","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1177\/096228029200100105","article-title":"Principal component analysis and exploratory factor analysis","volume":"1","author":"Joliffe","year":"1992","journal-title":"Stat Methods Med Res"},{"issue":"3","key":"10.1016\/j.nano.2022.102577_bb0150","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1067\/mge.2003.105","article-title":"Diagnostic potential of near-infrared Raman spectroscopy in the colon: differentiating adenomatous from hyperplastic polyps","volume":"57","author":"Molckovsky","year":"2003","journal-title":"Gastrointest Endosc"},{"issue":"19","key":"10.1016\/j.nano.2022.102577_bb0155","doi-asserted-by":"crossref","first-page":"4855","DOI":"10.1039\/C4AN00978A","article-title":"A rapid method to estimate the concentration of citrate capped silver nanoparticles from UV-visible light spectra","volume":"139","author":"Paramelle","year":"2014","journal-title":"Analyst"},{"issue":"39","key":"10.1016\/j.nano.2022.102577_bb0160","doi-asserted-by":"crossref","first-page":"17829","DOI":"10.1039\/c3ra42838a","article-title":"Influence of droplet drying configuration on surface-enhanced Raman scattering performance","volume":"3","author":"Avci","year":"2013","journal-title":"RSC Adv"},{"issue":"11","key":"10.1016\/j.nano.2022.102577_bb0165","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1039\/c2an16296b","article-title":"Label-free detection of proteins from dried-suspended droplets using surface enhanced Raman scattering","volume":"137","author":"Keskin","year":"2012","journal-title":"Analyst"},{"issue":"16","key":"10.1016\/j.nano.2022.102577_bb0170","doi-asserted-by":"crossref","first-page":"5269","DOI":"10.1021\/jp912190v","article-title":"Minimal size of coffee ring structure","volume":"114","author":"Shen","year":"2010","journal-title":"J Phys Chem B"},{"issue":"7","key":"10.1016\/j.nano.2022.102577_bb0175","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.1016\/j.bios.2010.12.020","article-title":"Gastric cancer detection based on blood plasma surface-enhanced Raman spectroscopy excited by polarized laser light","volume":"26","author":"Feng","year":"2011","journal-title":"BiosensorsBioelectron"},{"issue":"2","key":"10.1016\/j.nano.2022.102577_bb0180","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1021\/mp400300m","article-title":"Folic acid-conjugated, SERS-labeled silver nanotriangles for multimodal detection and targeted photothermal treatment on human ovarian cancer cells","volume":"11","author":"Boca-Farcau","year":"2014","journal-title":"Mol Pharm"},{"issue":"2","key":"10.1016\/j.nano.2022.102577_bb0185","first-page":"386","article-title":"Fabrication of silver ordered nanoarrays SERS-active substrates and their applications in bladder cancer cells detection","volume":"32","author":"Liu","year":"2012","journal-title":"<sb:contribution><sb:title>Spectrosc Spectr<\/sb:title> <\/sb:contribution><sb:host><sb:issue><sb:series><sb:title>Anal<\/sb:title><\/sb:series><\/sb:issue><\/sb:host>"},{"issue":"2","key":"10.1016\/j.nano.2022.102577_bb0190","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/jrs.5289","article-title":"Discrimination between oral cancer and healthy cells based on the adenine signature detected by using Raman spectroscopy","volume":"49","author":"Dai","year":"2018","journal-title":"JRaman Spectrosc"},{"issue":"9","key":"10.1016\/j.nano.2022.102577_bb0195","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/jrs.1734","article-title":"Reference database of Raman spectra of biological molecules","volume":"38","author":"De Gelder","year":"2007","journal-title":"JRaman Spectrosc"},{"issue":"5","key":"10.1016\/j.nano.2022.102577_bb0200","first-page":"493","article-title":"Raman spectroscopy of biological tissues","volume":"42","author":"Movasaghi","year":"2007","journal-title":"ApplSpectroscRev"},{"key":"10.1016\/j.nano.2022.102577_bb0205","series-title":"Vibrational Spectroscopy for Tissue Analysis","author":"Rehman","year":"2019"},{"issue":"1","key":"10.1016\/j.nano.2022.102577_bb0210","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0021-9150(98)00119-1","article-title":"Quantitative analysis of cholesterol and cholesteryl esters in human atherosclerotic plaques using near-infrared Raman spectroscopy","volume":"140","author":"Weinmann","year":"1998","journal-title":"Atherosclerosis"},{"issue":"6","key":"10.1016\/j.nano.2022.102577_bb0215","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.surg.2007.08.012","article-title":"The incidence of cancer and rate of false-negative cytology in thyroid nodules greater than or equal to 4 cm in size","volume":"142","author":"McCoy","year":"2007","journal-title":"Surgery"},{"issue":"3","key":"10.1016\/j.nano.2022.102577_bb0220","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00268-008-9721-7","article-title":"Distinguishing molecular markers in thyroid tumors: a tribute to Dr.Orlo Clark","volume":"33","author":"Zeiger","year":"2009","journal-title":"World J Surg"},{"issue":"3","key":"10.1016\/j.nano.2022.102577_bb0225","first-page":"144","article-title":"Cervical tissue collection methods for RNA preservation: comparison of snap-frozen, ethanol-fixed, and RNAlater-fixation","volume":"15","author":"Wang","year":"2006","journal-title":"DiagnMolPathol"},{"issue":"2","key":"10.1016\/j.nano.2022.102577_bb0230","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/labinvest.3700372","article-title":"Biobanking of fresh frozen tissue: RNA is stable in nonfixed surgical specimens","volume":"86","author":"Micke","year":"2006","journal-title":"Lab Invest"},{"issue":"82","key":"10.1016\/j.nano.2022.102577_bb0235","doi-asserted-by":"crossref","first-page":"11298","DOI":"10.1039\/C7CC05420C","article-title":"In situ synthesis of Au-shelled Ag nanoparticles on PDMS for flexible, long-life, and broad spectrum-sensitive SERS substrates","volume":"53","author":"Fortuni","year":"2017","journal-title":"Chem Commun"},{"key":"10.1016\/j.nano.2022.102577_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.matlet.2019.126557","article-title":"Fabrication of patterned small blocks of nanogold-loaded PDMS and its potential as reproducible SERS substrate","volume":"255","author":"Paschoal","year":"2019","journal-title":"Mater Lett"},{"issue":"9","key":"10.1016\/j.nano.2022.102577_bb0245","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1007\/s00216-014-7622-1","article-title":"Surface-enhanced Raman spectroscopy of blood plasma and serum using Ag and Au nanoparticles: a systematic study","volume":"406","author":"Bonifacio","year":"2014","journal-title":"Anal Bioanal Chem"},{"issue":"2","key":"10.1016\/j.nano.2022.102577_bb0250","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1002\/jrs.3038","article-title":"SERS activity and stability of the most frequently used silver colloids","volume":"43","author":"Larmour","year":"2012","journal-title":"JRaman Spectrosc"},{"issue":"7","key":"10.1016\/j.nano.2022.102577_bb0255","first-page":"2332","article-title":"Moving window principal component analysis for detecting positional fluctuation of spectral changes","volume":"32","author":"Ryu","year":"2011","journal-title":"BullKorChemSoc"},{"issue":"14","key":"10.1016\/j.nano.2022.102577_bb0260","doi-asserted-by":"crossref","first-page":"13565","DOI":"10.1364\/OE.19.013565","article-title":"Colorectal cancer detection by gold nanoparticle based surface-enhanced Raman spectroscopy of blood serum and statistical analysis","volume":"19","author":"Lin","year":"2011","journal-title":"Opt Express"},{"issue":"1","key":"10.1016\/j.nano.2022.102577_bb0265","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2011.123","article-title":"Cancer metabolism: current perspectives and future directions","volume":"3","author":"Mu\u00f1oz-Pinedo","year":"2012","journal-title":"Cell Death Dis"},{"issue":"17","key":"10.1016\/j.nano.2022.102577_bb0270","doi-asserted-by":"crossref","first-page":"3430","DOI":"10.7150\/jca.21125","article-title":"The glycolytic switch in tumors: how many players are involved?","volume":"8","author":"Yu","year":"2017","journal-title":"J Cancer"},{"key":"10.1016\/j.nano.2022.102577_bb0275","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1749-6632.1986.tb46578.x","article-title":"Membrane cholesterol and tumor bioenergetics","volume":"488","author":"Coleman","year":"1986","journal-title":"Ann N Y Acad Sci"},{"issue":"3","key":"10.1016\/j.nano.2022.102577_bb0280","first-page":"178","article-title":"Proteomics, and metabolomics: magnetic resonance spectroscopy for the presurgical screening of thyroid nodules","volume":"15","author":"Minuto","year":"2014","journal-title":"CurrGenomics"},{"issue":"1","key":"10.1016\/j.nano.2022.102577_bb0285","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep14869","article-title":"Integrative metabonomics as potential method for diagnosis of thyroid malignancy","volume":"5","author":"Tian","year":"2015","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.nano.2022.102577_bb0290","article-title":"Thyroid cancer metabolism: a review","volume":"5","author":"Gill","year":"2016","journal-title":"JThyroid DisordTher"},{"issue":"1","key":"10.1016\/j.nano.2022.102577_bb0295","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1165\/rcmb.2007-0071OC","article-title":"Collagen I promotes epithelial-to-mesenchymal transition in lung cancer cells via transforming growth factor\u2013\u03b2 signaling","volume":"38","author":"Shintani","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"9","key":"10.1016\/j.nano.2022.102577_bb0300","first-page":"2497","article-title":"Role of extracellular matrix assembly in interstitial transport in solid tumors","volume":"60","author":"Netti","year":"2000","journal-title":"Cancer Res"},{"issue":"1","key":"10.1016\/j.nano.2022.102577_bb0305","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/ng1060","article-title":"A molecular signature of metastasis in primary solid tumors","volume":"33","author":"Ramaswamy","year":"2003","journal-title":"Nat Genet"},{"issue":"21","key":"10.1016\/j.nano.2022.102577_bb0310","doi-asserted-by":"crossref","first-page":"7427","DOI":"10.1158\/1078-0432.CCR-03-0825","article-title":"Type I collagen promotes the malignant phenotype of pancreatic ductal adenocarcinoma","volume":"10","author":"Armstrong","year":"2004","journal-title":"Clin Cancer Res"},{"issue":"11\u201312","key":"10.1016\/j.nano.2022.102577_bb0315","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/j.crci.2015.02.008","article-title":"Chemical diversity of calcifications in thyroid and hypothetical link to disease","volume":"19","author":"Mathonnet","year":"2016","journal-title":"C R Chim"},{"issue":"3","key":"10.1016\/j.nano.2022.102577_bb0320","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0002-9440(10)64045-X","article-title":"\u03b2-Catenin dysregulation in thyroid neoplasms: down-regulation, aberrant nuclear expression, and CTNNB1 exon 3 mutations are markers for aggressive tumor phenotypes and poor prognosis","volume":"158","author":"Garcia-Rostan","year":"2001","journal-title":"Am J Pathol"},{"issue":"5","key":"10.1016\/j.nano.2022.102577_bb0325","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1148\/91.5.971","article-title":"Hamartoma: on occasion a rapidly growing tumor of the lung","volume":"91","author":"Sagel","year":"1968","journal-title":"Radiology"},{"issue":"4","key":"10.1016\/j.nano.2022.102577_bb0330","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1038\/bjc.1991.375","article-title":"Tumour progression and the nature of cancer","volume":"64","author":"Clark","year":"1991","journal-title":"Br J Cancer"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963422000636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963422000636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:17:14Z","timestamp":1761549434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963422000636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":66,"alternative-id":["S1549963422000636"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2022.102577","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development of a SERS based cancer diagnosis approach employing cryosectioned thyroid tissue samples on PDMS","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2022.102577","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"102577"}}