{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:49:57Z","timestamp":1792518597768,"version":"4.5.0"},"reference-count":198,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,11,1]],"date-time":"2022-11-01T00:00:00Z","timestamp":1667260800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001230","name":"Macquarie University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001230","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2022,11]]},"DOI":"10.1016\/j.nano.2022.102599","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T14:13:33Z","timestamp":1662387213000},"page":"102599","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Potential nanotechnology-based diagnostic and therapeutic approaches for Meniere's disease"],"prefix":"10.1016","volume":"46","author":[{"given":"Afsaneh","family":"Kashizadeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Pastras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navid","family":"Rabiee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Mohseni-Dargah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payal","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Asadnia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.nano.2022.102599_bb0005","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/j.otc.2010.05.001","article-title":"Current epidemiology of Meniere's syndrome","volume":"43","author":"Alexander","year":"2010","journal-title":"Otolaryngol Clin North Am"},{"key":"10.1016\/j.nano.2022.102599_bb0010","article-title":"Nanocarriers for drug delivery to the inner ear: physicochemical key parameters, biodistribution, safety and efficacy","volume":"120038","author":"Jaudoin","year":"2020","journal-title":"Int J Pharm"},{"issue":"9636","key":"10.1016\/j.nano.2022.102599_bb0015","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0140-6736(08)61161-7","article-title":"Meniere's disease","volume":"372","author":"Sajjadi","year":"2008","journal-title":"The Lancet"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrdp.2016.28","article-title":"Meniere's disease","volume":"2","author":"Nakashima","year":"2016","journal-title":"Nat Rev Dis Primers"},{"issue":"2_suppl","key":"10.1016\/j.nano.2022.102599_bb0025","first-page":"S1","article-title":"Clinical practice guideline: M\u00e9ni\u00e8re\u2019s disease","volume":"162","author":"Basura","year":"2020","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"3","key":"10.1016\/j.nano.2022.102599_bb0030","doi-asserted-by":"crossref","first-page":"e202","DOI":"10.1097\/AUD.0000000000000264","article-title":"The cost of Meniere's disease: a novel multisource approach","volume":"37","author":"Tyrrell","year":"2016","journal-title":"Ear Hear"},{"issue":"10","key":"10.1016\/j.nano.2022.102599_bb0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111039","article-title":"Autoimmunity as a candidate for the etiopathogenesis of Meniere's disease: detection of autoimmune reactions and diagnostic biomarker candidate","volume":"9","author":"Kim","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0040","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1038\/ejhg.2016.154","article-title":"Variable expressivity and genetic heterogeneity involving DPT and SEMA3D genes in autosomal dominant familial Meniere's disease","volume":"25","author":"Mart\u00edn-Sierra","year":"2017","journal-title":"Eur J Hum Genet"},{"key":"10.1016\/j.nano.2022.102599_bb0045","article-title":"Recent advancements in bioelectronic devices to interface with the peripheral vestibular system","volume":"114521","author":"Moshizi","year":"2022","journal-title":"Biosens Bioelectron"},{"key":"10.1016\/j.nano.2022.102599_bb0050","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.heares.2013.05.011","article-title":"Changes in utricular function during artificial endolymph injections in Guinea pigs","volume":"304","author":"Brown","year":"2013","journal-title":"Hear Res"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0055","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.anl.2019.09.005","article-title":"A possible mechanism of the formation of endolymphatic hydrops and its associated inner ear disorders","volume":"47","author":"Takeda","year":"2020","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.nano.2022.102599_bb0060","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.heares.2018.03.006","article-title":"Controlled drug release to the inner ear: concepts, materials, mechanisms, and performance","volume":"368","author":"M\u00e4der","year":"2018","journal-title":"Hear Res"},{"key":"10.1016\/j.nano.2022.102599_bb0065","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.heares.2016.01.010","article-title":"Pathophysiology of the cochlear intrastrial fluid-blood barrier","volume":"338","author":"Shi","year":"2016","journal-title":"Hear Res"},{"issue":"4","key":"10.1016\/j.nano.2022.102599_bb0070","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1002\/etc.3039","article-title":"Nanopharmaceuticals: tiny challenges for the environmental risk assessment of pharmaceuticals","volume":"35","author":"Berkner","year":"2016","journal-title":"Environ Toxicol Chem"},{"key":"10.1016\/j.nano.2022.102599_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ultsonch.2019.104783","article-title":"Scalable fabrication of tunable titanium nanotubes via sonoelectrochemical process for biomedical applications","volume":"64","author":"Mansoorianfar","year":"2020","journal-title":"Ultrason Sonochem"},{"issue":"43","key":"10.1016\/j.nano.2022.102599_bb0080","doi-asserted-by":"crossref","first-page":"38076","DOI":"10.1021\/acsami.7b13618","article-title":"Preparation of iridescent 2D photonic crystals by using a mussel-inspired spatial patterning of ZIF-8 with potential applications in optical switch and chemical sensor","volume":"9","author":"Razmjou","year":"2017","journal-title":"ACS Appl Mater Interfaces"},{"key":"10.1016\/j.nano.2022.102599_bb0085","series-title":"An Easily Fabricated Three-dimensional Threaded Lemniscate-shaped Micromixer for a Wide Range of Flow Rates","first-page":"014108","volume":"11","author":"Rafeie","year":"2017"},{"key":"10.1016\/j.nano.2022.102599_bb0090","series-title":"Preparation of Iridescent 2D Photonic Crystals by Using a Mussel-inspired Spatial Patterning of ZIF-8 With Potential Applications in Optical Switch and Chemical Sensor","first-page":"38076","volume":"9","author":"Razmjou","year":"2017"},{"key":"10.1016\/j.nano.2022.102599_bb0095","series-title":"Development of Ultrasensitive Biomimetic Auditory Hair Cells Based on Piezoresistive Hydrogel Nanocomposites","first-page":"44904","volume":"13","author":"Ahmadi","year":"2021"},{"key":"10.1016\/j.nano.2022.102599_bb0100","series-title":"Heterogeneous Asymmetric Passable Cavities Within Graphene Oxide Nanochannels for Highly Efficient Lithium Sieving","first-page":"115888","volume":"538","author":"Ahmadi","year":"2022"},{"key":"10.1016\/j.nano.2022.102599_bb0105","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/978-1-4939-3615-1_21","article-title":"An overview of nanoparticle based delivery for treatment of inner ear disorders","author":"Pyykk\u00f6","year":"2016","journal-title":"Audit Vestib Res"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0110","doi-asserted-by":"crossref","DOI":"10.1002\/aenm.201701210","article-title":"Recent advances in nanogenerator-driven self-powered implantable biomedical devices","volume":"8","author":"Parvez Mahmud","year":"2018","journal-title":"Advanced Energy Materials"},{"issue":"9","key":"10.1016\/j.nano.2022.102599_bb0115","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1002\/jbm.a.35425","article-title":"I n vitro and in vivo study of hazardous effects of ag nanoparticles and arginine-treated multi walled carbon nanotubes on blood cells: a pplication in hemodialysis membranes","volume":"103","author":"Zare-Zardini","year":"2015","journal-title":"J Biomed Mater Res A"},{"issue":"3","key":"10.1016\/j.nano.2022.102599_bb0120","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1007\/s12010-020-03280-3","article-title":"Cancer therapy and imaging through functionalized carbon nanotubes decorated with magnetite and gold nanoparticles as a multimodal tool","volume":"191","author":"Saghatchi","year":"2020","journal-title":"Appl Biochem Biotechnol"},{"issue":"8","key":"10.1016\/j.nano.2022.102599_bb0125","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2217\/nnm-2018-0342","article-title":"Carbon nanotube-delivered iC9 suicide gene therapy for killing breast cancer cells in vitro","volume":"14","author":"Mohseni-Dargah","year":"2019","journal-title":"Nanomedicine"},{"issue":"13","key":"10.1016\/j.nano.2022.102599_bb0130","doi-asserted-by":"crossref","first-page":"1901864","DOI":"10.1002\/admi.201901864","article-title":"Domino P-\u03bcMB: a new approach for the sequential immobilization of enzymes using Polydopamine\/Polyethyleneimine chemistry and microfabrication","volume":"7","author":"Changani","year":"2020","journal-title":"Adv Mater Interfaces"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-018-0392-8","article-title":"Nano based drug delivery systems: recent developments and future prospects","volume":"16","author":"Patra","year":"2018","journal-title":"J Nanobiotechnol"},{"issue":"5\u20136","key":"10.1016\/j.nano.2022.102599_bb0140","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3109\/00016488409132937","article-title":"Distribution of HRP in the inner ear after injection into the middle ear cavity","volume":"97","author":"Saijo","year":"1984","journal-title":"Acta Otolaryngol"},{"key":"10.1016\/j.nano.2022.102599_bb0145","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.heares.2018.06.017","article-title":"Anatomical basis of drug delivery to the inner ear","volume":"368","author":"Glueckert","year":"2018","journal-title":"Hear Res"},{"issue":"14","key":"10.1016\/j.nano.2022.102599_bb0150","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.2217\/nnm.13.181","article-title":"Pathway and morphological transformation of liposome nanocarriers after release from a novel sustained inner-ear delivery system","volume":"9","author":"Zou","year":"2014","journal-title":"Nanomedicine"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0155","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1177\/000348941212100209","article-title":"Oval window transport of gd-dOTA from rat middle ear to vestibulum and scala vestibuli visualized by in vivo magnetic resonance imaging","volume":"121","author":"Zou","year":"2012","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.nano.2022.102599_bb0160","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejps.2018.02.031","article-title":"Is oval window transport a royal gate for nanoparticle delivery to vestibule in the inner ear?","volume":"126","author":"Ding","year":"2019","journal-title":"Eur J Pharm Sci"},{"issue":"7","key":"10.1016\/j.nano.2022.102599_bb0165","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1002\/jbm.b.33719","article-title":"Efficient penetration of ceric ammonium nitrate oxidant-stabilized gamma-maghemite nanoparticles through the oval and round windows into the rat inner ear as demonstrated by MRI","volume":"105","author":"Zou","year":"2017","journal-title":"J Biomed Mater Res B Appl Biomater"},{"issue":"20","key":"10.1016\/j.nano.2022.102599_bb0170","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.2217\/nnm-2020-0198","article-title":"Development of nanoparticle drug-delivery systems for the inner ear","volume":"15","author":"An","year":"2020","journal-title":"Nanomedicine"},{"issue":"5","key":"10.1016\/j.nano.2022.102599_bb0175","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.3390\/nano11051311","article-title":"Nanoparticles for the treatment of inner ear infections","volume":"11","author":"Gheorghe","year":"2021","journal-title":"Nanomaterials"},{"issue":"44","key":"10.1016\/j.nano.2022.102599_bb0180","doi-asserted-by":"crossref","first-page":"2008701","DOI":"10.1002\/adfm.202008701","article-title":"Drug delivery across barriers to the middle and inner ear","volume":"31","author":"Zhang","year":"2021","journal-title":"Adv Funct Mater"},{"key":"10.1016\/j.nano.2022.102599_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.120038","article-title":"Nanocarriers for drug delivery to the inner ear: physicochemical key parameters, biodistribution, safety and efficacy","volume":"592","author":"Jaudoin","year":"2021","journal-title":"Int J Pharm"},{"issue":"475","key":"10.1016\/j.nano.2022.102599_bb0190","article-title":"Nanocarriers for inner ear disease therapy. Review","volume":"15","author":"Xu","year":"2021","journal-title":"Frontiers in Cellular Neuroscience"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0195","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1080\/21691401.2019.1573182","article-title":"Nanoparticle-based drug delivery in the inner ear: current challenges, limitations and opportunities","volume":"47","author":"Mittal","year":"2019","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"10.1016\/j.nano.2022.102599_bb0200","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2021.700271","article-title":"Advanced imaging of the vestibular endolymphatic space in Meniere's disease","volume":"8","author":"Zanetti","year":"2021","journal-title":"Front Surg"},{"issue":"11","key":"10.1016\/j.nano.2022.102599_bb0205","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40134-020-00365-z","article-title":"State of the art imaging in Meni\u00e8re's disease. Tips and tricks for protocol and interpretation","volume":"8","author":"de Pont","year":"2020","journal-title":"Curr Radiol Rep"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0210","doi-asserted-by":"crossref","first-page":"22","DOI":"10.5319\/wjo.v3.i1.22","article-title":"Endolymphatic hydrops in Meniere's disease secondary to otitis media and visualized by gadolinium-enhanced magnetic resonance imaging","volume":"3","author":"Zou","year":"2013","journal-title":"World J Otorhinolaryngol"},{"key":"10.1016\/j.nano.2022.102599_bb0215","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g6544","article-title":"Meniere\u2019s disease","volume":"349","author":"Harcourt","year":"2014","journal-title":"BMJ"},{"issue":"10","key":"10.1016\/j.nano.2022.102599_bb0220","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1080\/00016489.2020.1776385","article-title":"Current status on researches of Meniere's disease: a review","volume":"140","author":"Liu","year":"2020","journal-title":"Acta Otolaryngol"},{"issue":"2\u20133","key":"10.1016\/j.nano.2022.102599_bb0225","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3233\/VES-180646","article-title":"Systematic review of magnetic resonance imaging for diagnosis of meniere disease","volume":"29","author":"Lopez-Escamez","year":"2019","journal-title":"J Vestib Res"},{"issue":"9","key":"10.1016\/j.nano.2022.102599_bb0230","doi-asserted-by":"crossref","first-page":"879","DOI":"10.3109\/00016489.2016.1169556","article-title":"Endolymphatic space size in patients with Meniere\u2019s disease and healthy controls","volume":"136","author":"Ito","year":"2016","journal-title":"Acta Otolaryngol"},{"issue":"6","key":"10.1016\/j.nano.2022.102599_bb0235","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1002\/lio2.313","article-title":"Endolymphatic volume in patients with meniere's disease and healthy controls: three-dimensional analysis with magnetic resonance imaging","volume":"4","author":"Ito","year":"2019","journal-title":"Laryngoscope Investig Otolaryngol"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0240","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s00330-014-3414-4","article-title":"MR volumetric assessment of endolymphatic hydrops","volume":"25","author":"G\u00fcrkov","year":"2015","journal-title":"Eur Radiol"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0245","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.crad.2017.09.002","article-title":"MRI in otology: applications in cholesteatoma and M\u00e9ni\u00e8re's disease","volume":"73","author":"Lingam","year":"2018","journal-title":"Clin Radiol"},{"issue":"7","key":"10.1016\/j.nano.2022.102599_bb0250","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1097\/MAO.0000000000001458","article-title":"Ultra-high-field (9.4 T) MRI analysis of contrast agent transport across the blood-perilymph barrier and intrastrial fluid-blood barrier in the mouse inner ear","volume":"38","author":"Counter","year":"2017","journal-title":"Otol Neurotol"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0255","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1039\/C8MT00302E","article-title":"The biological fate of gadolinium-based MRI contrast agents: a call to action for bioinorganic chemists","volume":"11","author":"Le Fur","year":"2019","journal-title":"Metallomics"},{"issue":"3","key":"10.1016\/j.nano.2022.102599_bb0260","doi-asserted-by":"crossref","first-page":"e225","DOI":"10.1097\/MAO.0000000000002082","article-title":"Diagnostic value of the magnetic resonance imaging with intratympanic gadolinium administration (IT-gd MRI) versus audio-vestibular tests in Meniere's disease: IT-gd MRI makes the difference","volume":"40","author":"Wesseler","year":"2019","journal-title":"Otol Neurotol"},{"issue":"4","key":"10.1016\/j.nano.2022.102599_bb0265","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1053\/j.ajkd.2020.07.012","article-title":"Risks and options with gadolinium-based contrast agents in patients with CKD: a review","volume":"77","author":"Rudnick","year":"2021","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0270","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.nano.2017.10.004","article-title":"Challenges and opportunities in developing targeted molecular imaging to determine inner ear defects of sensorineural hearing loss","volume":"14","author":"Kayyali","year":"2018","journal-title":"Nanomedicine"},{"issue":"32","key":"10.1016\/j.nano.2022.102599_bb0275","doi-asserted-by":"crossref","first-page":"12624","DOI":"10.1021\/ja203340u","article-title":"Large-scale synthesis of uniform and extremely small-sized iron oxide nanoparticles for high-resolution T 1 magnetic resonance imaging contrast agents","volume":"133","author":"Kim","year":"2011","journal-title":"J Am Chem Soc"},{"issue":"17","key":"10.1016\/j.nano.2022.102599_bb0280","doi-asserted-by":"crossref","first-page":"7664","DOI":"10.1039\/c3nr01616a","article-title":"Multifunctional superparamagnetic iron oxide nanoparticles: design, synthesis and biomedical photonic applications","volume":"5","author":"Zhang","year":"2013","journal-title":"Nanoscale"},{"issue":"4","key":"10.1016\/j.nano.2022.102599_bb0285","doi-asserted-by":"crossref","first-page":"656","DOI":"10.3390\/nano10040656","article-title":"Systemic review of biodegradable nanomaterials in nanomedicine","volume":"10","author":"Su","year":"2020","journal-title":"Nanomaterials"},{"key":"10.1016\/j.nano.2022.102599_bb0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.crgsc.2020.100042","article-title":"A review on synthesis, characterization and potential biological applications of superparamagnetic iron oxide nanoparticles","volume":"4","author":"Samrot","year":"2021","journal-title":"Curr Res Green Sustain Chem"},{"key":"10.1016\/j.nano.2022.102599_bb0295","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.biomaterials.2016.06.015","article-title":"Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging","volume":"102","author":"Cheheltani","year":"2016","journal-title":"Biomaterials"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0300","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/21691401.2019.1709855","article-title":"Toxicity assessment of superparamagnetic iron oxide nanoparticles in different tissues","volume":"48","author":"Vakili-Ghartavol","year":"2020","journal-title":"Artif Cells Nanomed Biotechnol"},{"issue":"6","key":"10.1016\/j.nano.2022.102599_bb0305","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1007\/s12274-014-0697-3","article-title":"How toxic are gold nanoparticles?The state-of-the-art","volume":"8","author":"Fratoddi","year":"2015","journal-title":"Nano Research"},{"key":"10.1016\/j.nano.2022.102599_bb0310","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jmr.2012.11.027","article-title":"Advances in multimodal neuroimaging: hybrid MR\u2013PET and MR\u2013PET\u2013EEG at 3 T and 9.4 T","volume":"229","author":"Shah","year":"2013","journal-title":"J Magn Reson"},{"issue":"4","key":"10.1016\/j.nano.2022.102599_bb0315","article-title":"A novel nano-approach for targeted inner ear imaging","volume":"8","author":"Kayyali","year":"2017","journal-title":"J Nanomed Nanotechnol"},{"issue":"3","key":"10.1016\/j.nano.2022.102599_bb0320","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/00001756-199902250-00006","article-title":"Magnetic resonance imaging of the cochlea, spiral ganglia and eighth nerve of the Guinea pig","volume":"10","author":"Counter","year":"1999","journal-title":"Neuroreport"},{"issue":"5","key":"10.1016\/j.nano.2022.102599_bb0325","doi-asserted-by":"crossref","first-page":"739","DOI":"10.2217\/nnm.10.45","article-title":"MRI manifestation of novel superparamagnetic iron oxide nanoparticles in the rat inner ear","volume":"5","author":"Zou","year":"2010","journal-title":"Nanomedicine"},{"issue":"10","key":"10.1016\/j.nano.2022.102599_bb0330","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1080\/00016480600621722","article-title":"Rupture of Reissner's membrane during acute endolymphatic hydrops in the Guinea pig: a model for Meniere's disease?","volume":"126","author":"Valk","year":"2006","journal-title":"Acta Otolaryngol"},{"issue":"9","key":"10.1016\/j.nano.2022.102599_bb0335","doi-asserted-by":"crossref","first-page":"846","DOI":"10.3109\/1061186X.2013.829075","article-title":"The effect of surface charge of glycerol monooleate-based nanoparticles on the round window membrane permeability and cochlear distribution","volume":"21","author":"Liu","year":"2013","journal-title":"J Drug Target"},{"issue":"12","key":"10.1016\/j.nano.2022.102599_bb0340","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.2967\/jnumed.116.181362","article-title":"Clinically approved nanoparticle imaging agents","volume":"57","author":"Thakor","year":"2016","journal-title":"J Nucl Med"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0345","doi-asserted-by":"crossref","first-page":"796","DOI":"10.7150\/thno.67375","article-title":"Repurposing ferumoxytol: diagnostic and therapeutic applications of an FDA-approved nanoparticle","volume":"12","author":"Huang","year":"2022","journal-title":"Theranostics"},{"issue":"47","key":"10.1016\/j.nano.2022.102599_bb0350","doi-asserted-by":"crossref","first-page":"13400","DOI":"10.3748\/wjg.v21.i47.13400","article-title":"Current status of superparamagnetic iron oxide contrast agents for liver magnetic resonance imaging","volume":"21","author":"Wang","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0355","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/jcbfm.2009.192","article-title":"Superparamagnetic iron oxide nanoparticles: diagnostic magnetic resonance imaging and potential therapeutic applications in neurooncology and central nervous system inflammatory pathologies, a review","volume":"30","author":"Weinstein","year":"2010","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.nano.2022.102599_bb0360","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fsurg.2021.662530","article-title":"A synchrotron and micro-CT study of the human endolymphatic duct system: is Meniere's disease caused by an acute endolymph backflow?","volume":"8","author":"Li","year":"2021","journal-title":"Front Surg"},{"key":"10.1016\/j.nano.2022.102599_bb0365","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1055\/s-0037-1604463","article-title":"Anatomical variations in patients with M\u00e9ni\u00e8re disease: a tomography study","volume":"22","author":"Lucinda","year":"2018","journal-title":"Int Arch Otorhinolaryngol"},{"issue":"5","key":"10.1016\/j.nano.2022.102599_bb0370","doi-asserted-by":"crossref","DOI":"10.1097\/MAO.0000000000002198","article-title":"Vestibular aqueduct morphology correlates with endolymphatic sac pathologies in Meniere's disease\u2014a correlative histology and computed tomography study","volume":"40","author":"B\u00e4chinger","year":"2019","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.nano.2022.102599_bb0375","unstructured":"Hearring Health Foundation. CT imaging as a diagnostic tool for m\u00e9ni\u00e8re\u2019s disease. https:\/\/hearinghealthfoundation.org\/blogs\/ct-imaging-as-a-diagnostic-tool-for-menieres-disease."},{"key":"10.1016\/j.nano.2022.102599_bb0380","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.31635\/ccschem.021.202100807","article-title":"Nanoparticles: untying the gordian knot in conventional computed tomography imaging","author":"Sun","year":"2021","journal-title":"CCS Chemistry"},{"key":"10.1016\/j.nano.2022.102599_bb0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2020.128599","article-title":"Metallic nanoparticles as X-ray computed tomography (CT) contrast agents: a review","volume":"1219","author":"Aslan","year":"2020","journal-title":"J Mol Struct"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0390","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-015-0065-9","article-title":"Micro CT visualization of silver nanoparticles in the middle and inner ear of rat and transportation pathway after transtympanic injection","volume":"13","author":"Zou","year":"2015","journal-title":"J Nanobiotechnol"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0395","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1002\/acm2.13155","article-title":"CT imaging of gold nanoparticles in a human-sized phantom","volume":"22","author":"Oumano","year":"2021","journal-title":"J Appl Clin Med Phys"},{"key":"10.1016\/j.nano.2022.102599_bb0400","doi-asserted-by":"crossref","first-page":"9309","DOI":"10.2147\/IJN.S224805","article-title":"Design and synthesis of gold-gadolinium-core-shell nanoparticles as contrast agent: a smart way to future nanomaterials for nanomedicine applications","volume":"14","author":"Aouidat","year":"2019","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2022.102599_bb0405","doi-asserted-by":"crossref","first-page":"990","DOI":"10.3389\/fbioe.2020.00990","article-title":"Multifunctional gold nanoparticles: a novel nanomaterial for various medical applications and biological activities","volume":"8","author":"Hu","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.nano.2022.102599_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2019.110519","article-title":"Advances in biosynthesis of noble metal nanoparticles mediated by photosynthetic organisms\u2014a review","volume":"184","author":"Bao","year":"2019","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"8","key":"10.1016\/j.nano.2022.102599_bb0415","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.3390\/cancers13081825","article-title":"Recent development of gold nanoparticles as contrast agents for cancer diagnosis","volume":"13","author":"Luo","year":"2021","journal-title":"Cancers"},{"issue":"13","key":"10.1016\/j.nano.2022.102599_bb0420","doi-asserted-by":"crossref","first-page":"4978","DOI":"10.1021\/ja401612x","article-title":"Passive tumor targeting of renal-clearable luminescent gold nanoparticles: long tumor retention and fast normal tissue clearance","volume":"135","author":"Liu","year":"2013","journal-title":"J Am Chem Soc"},{"key":"10.1016\/j.nano.2022.102599_bb0425","article-title":"Engineering and quantification of bismuth nanoparticles as targeted contrast agent for computed tomography imaging in cellular and animal models","volume":"66","author":"Tarighatnia","year":"2021","journal-title":"J Drug Deliv Sci Technol"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0430","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/MAO.0b013e318277a40e","article-title":"Magnetic targeted delivery of dexamethasone acetate across the round window membrane in guinea pigs","volume":"34","author":"Du","year":"2013","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.nano.2022.102599_bb0435","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.ejps.2018.06.011","article-title":"Toxicology study for magnetic injection of prednisolone into the rat cochlea","volume":"126","author":"Shimoji","year":"2019","journal-title":"Eur J Pharm Sci"},{"issue":"6","key":"10.1016\/j.nano.2022.102599_bb0440","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1177\/1553350619867217","article-title":"Superparamagnetic nanoparticle delivery to the cochlea through round window by external magnetic field: feasibility and toxicity","volume":"26","author":"Leterme","year":"2019","journal-title":"Surg Innov"},{"issue":"3","key":"10.1016\/j.nano.2022.102599_bb0445","doi-asserted-by":"crossref","first-page":"358","DOI":"10.3390\/brainsci11030358","article-title":"Use of super paramagnetic iron oxide nanoparticles as drug carriers in brain and ear: state of the art and challenges","volume":"11","author":"Guigou","year":"2021","journal-title":"Brain Sci"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0450","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.ymthe.2021.07.013","article-title":"Local magnetic delivery of adeno-associated virus AAV2 (quad YF)-mediated BDNF gene therapy restores hearing after noise injury","volume":"30","author":"Mukherjee","year":"2022","journal-title":"Molecular Therapy"},{"key":"10.1016\/j.nano.2022.102599_bb0455","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3389\/fncel.2017.00268","article-title":"Magnetic nanoparticle mediated steroid delivery mitigates cisplatin induced hearing loss","volume":"11","author":"Ramaswamy","year":"2017","journal-title":"Front Cell Neurosci"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0460","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/03639045.2017.1373803","article-title":"A novel vehicle for local protein delivery to the inner ear: injectable and biodegradable thermosensitive hydrogel loaded with PLGA nanoparticles","volume":"44","author":"Dai","year":"2018","journal-title":"Drug Dev Ind Pharm"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0465","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/MAO.0000000000000445","article-title":"A novel chitosan-hydrogel-based nanoparticle delivery system for local inner ear application","volume":"36","author":"Lajud","year":"2015","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.nano.2022.102599_bb0470","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neulet.2016.03.012","article-title":"Dexamethasone loaded nanoparticles exert protective effects against Cisplatin-induced hearing loss by systemic administration","volume":"619","author":"Sun","year":"2016","journal-title":"Neurosci Lett"},{"issue":"5","key":"10.1016\/j.nano.2022.102599_bb0475","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1016\/j.ymthe.2018.03.004","article-title":"Regeneration of cochlear hair cells and hearing recovery through Hes1 modulation with siRNA nanoparticles in adult guinea pigs","volume":"26","author":"Du","year":"2018","journal-title":"Mol Ther"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0480","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijpharm.2017.08.084","article-title":"Engineering PLGA nano-based systems through understanding the influence of nanoparticle properties and cell-penetrating peptides for cochlear drug delivery","volume":"532","author":"Cai","year":"2017","journal-title":"Int J Pharm"},{"key":"10.1016\/j.nano.2022.102599_bb0485","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.addr.2016.01.004","article-title":"Advances in nano-based inner ear delivery systems for the treatment of sensorineural hearing loss","volume":"108","author":"Li","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0490","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jconrel.2011.10.005","article-title":"Polymersomes for drug delivery: design, formation and characterization","volume":"161","author":"Lee","year":"2012","journal-title":"J Control Release"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0495","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1007\/s13346-019-00692-5","article-title":"Cochlear protein biomarkers as potential sites for targeted inner ear drug delivery","volume":"10","author":"Naples","year":"2020","journal-title":"Drug Deliv Transl Res"},{"issue":"21","key":"10.1016\/j.nano.2022.102599_bb0500","doi-asserted-by":"crossref","first-page":"4244","DOI":"10.1002\/smll.201401767","article-title":"Mesoporous silica supraparticles for sustained inner-ear drug delivery","volume":"10","author":"Wang","year":"2014","journal-title":"Small"},{"issue":"10","key":"10.1016\/j.nano.2022.102599_bb0505","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0164867","article-title":"Improved auditory nerve survival with nanoengineered supraparticles for neurotrophin delivery into the deafened cochlea","volume":"11","author":"Wise","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.nano.2022.102599_bb0510","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2160854","article-title":"Hollow mesoporous silica@ zeolitic imidazolate framework capsules and their applications for gentamicin delivery","volume":"2018","author":"Xu","year":"2018","journal-title":"Neural Plast"},{"key":"10.1016\/j.nano.2022.102599_bb0515","series-title":"Intracellular Delivery","first-page":"225","article-title":"Poly (alkyl cyanoacrylate) nanosystems","author":"Nicolas","year":"2011"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0520","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00221-020-05970-0","article-title":"Lipid nanoparticles-encapsulated brain-derived neurotrophic factor mRNA delivered through the round window niche in the cochleae of guinea pigs","volume":"239","author":"Miwa","year":"2021","journal-title":"Exp Brain Res"},{"issue":"9","key":"10.1016\/j.nano.2022.102599_bb0525","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.3390\/jcm8091464","article-title":"Solid lipid nanoparticles loaded with glucocorticoids protect auditory cells from cisplatin-induced ototoxicity","volume":"8","author":"Cervantes","year":"2019","journal-title":"J Clin Med"},{"issue":"12","key":"10.1016\/j.nano.2022.102599_bb0530","doi-asserted-by":"crossref","first-page":"7412","DOI":"10.1166\/jnn.2020.18522","article-title":"Use of solid lipid nanoparticles for the treatment of acute acoustic stress-induced cochlea damage","volume":"20","author":"Wang","year":"2020","journal-title":"J Nanosci Nanotechnol"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0535","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ijpharm.2015.08.015","article-title":"Recent advances in local drug delivery to the inner ear","volume":"494","author":"El Kechai","year":"2015","journal-title":"Int J Pharm"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0540","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2019.111755","article-title":"The preparation of dexamethasone sodium phosphate multivesicular liposomes thermosensative hydrogel and its impact on noise-induced hearing loss in the Guinea pigs","volume":"387","author":"Li","year":"2020","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.nano.2022.102599_bb0545","first-page":"5","article-title":"Dietary restriction for the treatment of Meniere's disease","volume":"22","author":"De Luca","year":"2020","journal-title":"Transl Medic UniSa"},{"key":"10.1016\/j.nano.2022.102599_bb0550","article-title":"Restriction of salt, caffeine and alcohol intake for the treatment of M\u00e9ni\u00e8re's disease or syndrome","volume":"12","author":"Hussain","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.nano.2022.102599_bb0555","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2021.108228","article-title":"Inner ear drug delivery through a cochlear implant: pharmacokinetics in a Macaque experimental model","volume":"404","author":"Manrique-Huarte","year":"2021","journal-title":"Hear Res"},{"key":"10.1016\/j.nano.2022.102599_bb0560","first-page":"1","article-title":"Microimaging of a novel intracochlear drug delivery device in combination with cochlear implants in the human inner ear","author":"Lehner","year":"2021","journal-title":"Drug Deliv Transl Res"},{"issue":"3","key":"10.1016\/j.nano.2022.102599_bb0565","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3342\/ceo.2008.1.3.117","article-title":"The role of inflammatory mediators in the pathogenesis of otitis media and sequelae","volume":"1","author":"Juhn","year":"2008","journal-title":"Clin Exp Otorhinolaryngol"},{"issue":"3","key":"10.1016\/j.nano.2022.102599_bb0570","doi-asserted-by":"crossref","first-page":"291","DOI":"10.15537\/smj.2015.3.9940","article-title":"Oral steroid treatment for idiopathic sudden sensorineural hearing loss","volume":"36","author":"Chen","year":"2015","journal-title":"Saudi Med J"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0580","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/mao.0b013e31815dbafc","article-title":"Longitudinal results with intratympanic dexamethasone in the treatment of Meniere's disease","volume":"29","author":"Boleas-Aguirre","year":"2008","journal-title":"Otol Neurotol"},{"issue":"3","key":"10.1016\/j.nano.2022.102599_bb0585","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1177\/014556130308200311","article-title":"Changing trends in the surgical treatment of Meniere's disease: results of a 10-year survey","volume":"82","author":"Silverstein","year":"2003","journal-title":"Ear Nose Throat J"},{"issue":"8","key":"10.1016\/j.nano.2022.102599_bb0590","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1097\/MAO.0b013e31815aee21","article-title":"Intratympanic versus intravenous delivery of methylprednisolone to cochlear perilymph","volume":"28","author":"Bird","year":"2007","journal-title":"Otol Neurotol"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0595","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1745-6215-15-328","article-title":"Intratympanic gentamicin treatment for M\u00e9ni\u00e8re's disease: a randomized, double-blind, placebo-controlled trial on dose efficacy-results of a prematurely ended study","volume":"15","author":"Bremer","year":"2014","journal-title":"Trials"},{"issue":"4","key":"10.1016\/j.nano.2022.102599_bb0600","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/MAO.0b013e318254501b","article-title":"Dexamethasone levels and base to apex concentration gradients in scala tympani perilymph following intracochlear delivery in the guinea pig","volume":"33","author":"Hahn","year":"2012","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.nano.2022.102599_bb0605","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.heares.2018.03.002","article-title":"Pharmacokinetic principles in the inner ear: influence of drug properties on intratympanic applications","volume":"368","author":"Salt","year":"2018","journal-title":"Hear Res"},{"issue":"5","key":"10.1016\/j.nano.2022.102599_bb0610","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/MOO.0b013e32833d30f0","article-title":"Round window perfusion dynamics: implications for intracochlear therapy","volume":"18","author":"Bowe","year":"2010","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0615","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jsps.2017.10.012","article-title":"Applications of nanoparticle systems in drug delivery technology","volume":"26","author":"Rizvi","year":"2018","journal-title":"Saudi Pharm J"},{"key":"10.1016\/j.nano.2022.102599_bb0620","doi-asserted-by":"crossref","first-page":"5591","DOI":"10.2147\/IJN.S72555","article-title":"Enhanced local bioavailability of single or compound drugs delivery to the inner ear through application of PLGA nanoparticles via round window administration","volume":"9","author":"Cai","year":"2014","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2022.102599_bb0625","first-page":"3567","article-title":"A single dose of dexamethasone encapsulated in polyethylene glycol-coated polylactic acid nanoparticles attenuates cisplatin-induced hearing loss following round window membrane administration","volume":"10","author":"Sun","year":"2015","journal-title":"Int J Nanomedicine"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0630","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1080\/10717544.2017.1402220","article-title":"SS-31 peptide enables mitochondrial targeting drug delivery: a promising therapeutic alteration to prevent hair cell damage from aminoglycosides","volume":"24","author":"Kuang","year":"2017","journal-title":"Drug Deliv"},{"issue":"1\u20132","key":"10.1016\/j.nano.2022.102599_bb0635","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ijpharm.2011.12.042","article-title":"Prestin binding peptides as ligands for targeted polymersome mediated drug delivery to outer hair cells in the inner ear","volume":"424","author":"Surovtseva","year":"2012","journal-title":"Int J Pharm"},{"key":"10.1016\/j.nano.2022.102599_bb0640","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.2147\/IJN.S28185","article-title":"Targeted delivery of Tet1 peptide functionalized polymersomes to the rat cochlear nerve","volume":"7","author":"Zhang","year":"2012","journal-title":"Int J Nanomedicine"},{"issue":"30","key":"10.1016\/j.nano.2022.102599_bb0645","doi-asserted-by":"crossref","first-page":"16359","DOI":"10.1039\/D0NR04860G","article-title":"A metal\u2013organic framework based inner ear delivery system for the treatment of noise-induced hearing loss","volume":"12","author":"Xu","year":"2020","journal-title":"Nanoscale"},{"issue":"3","key":"10.1016\/j.nano.2022.102599_bb0650","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0194778","article-title":"Long-term delivery of brain-derived neurotrophic factor (BDNF) from nanoporous silica nanoparticles improves the survival of spiral ganglion neurons in vitro","volume":"13","author":"Schmidt","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.nano.2022.102599_bb0655","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.biomaterials.2018.04.038","article-title":"Optimized phospholipid-based nanoparticles for inner ear drug delivery and therapy","volume":"171","author":"Yang","year":"2018","journal-title":"Biomaterials"},{"key":"10.1016\/j.nano.2022.102599_bb0660","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.jconrel.2016.02.013","article-title":"Hyaluronic acid liposomal gel sustains delivery of a corticoid to the inner ear","volume":"226","author":"El Kechai","year":"2016","journal-title":"J Control Release"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0665","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1080\/10717544.2021.1992041","article-title":"Local drug delivery using poly(lactic-co-glycolic acid) nanoparticles in thermosensitive gels for inner ear disease treatment","volume":"28","author":"Kim","year":"2021","journal-title":"Drug Deliv"},{"key":"10.1016\/j.nano.2022.102599_bb0670","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jconrel.2018.04.028","article-title":"A novel nanoparticle delivery system for targeted therapy of noise-induced hearing loss","volume":"279","author":"Kayyali","year":"2018","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2022.102599_bb0675","doi-asserted-by":"crossref","first-page":"1623","DOI":"10.3389\/fphar.2021.689032","article-title":"Ultrasound microbubble\u2013facilitated inner ear delivery of gold nanoparticles involves transient disruption of the tight junction barrier in the round window membrane","volume":"12","author":"Lin","year":"2021","journal-title":"Front Pharmacol"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0680","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.apsb.2013.02.003","article-title":"Current strategies for drug delivery to the inner ear","volume":"3","author":"Liu","year":"2013","journal-title":"Acta Pharm SinB"},{"key":"10.1016\/j.nano.2022.102599_bb0685","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.ejps.2018.05.020","article-title":"Inner ear drug delivery: Recent advances, challenges, and perspective","volume":"126","author":"Hao","year":"2019","journal-title":"Eur J Pharm Sci"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0690","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41598-020-79946-z","article-title":"Steady streaming as a method for drug delivery to the inner ear","volume":"11","author":"Sumner","year":"2021","journal-title":"Scientific Reports"},{"issue":"3","key":"10.1016\/j.nano.2022.102599_bb0695","doi-asserted-by":"crossref","DOI":"10.1116\/6.0000067","article-title":"Lithium niobate nanoparticles as biofunctional interface material for inner ear devices","volume":"15","author":"Danti","year":"2020","journal-title":"Biointerphases"},{"key":"10.1016\/j.nano.2022.102599_bb0700","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jddst.2017.03.003","article-title":"Nanoparticle drug delivery systems for inner ear therapy: an overview","volume":"39","author":"Valente","year":"2017","journal-title":"J Drug Delivery Sci Technol"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0705","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/lio2.336","article-title":"Inner ear delivery: challenges and opportunities","volume":"5","author":"Szeto","year":"2020","journal-title":"Laryngoscope Investig Otolaryngol"},{"key":"10.1016\/j.nano.2022.102599_bb0710","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2020.100914","article-title":"Stimulus-responsive sequential release systems for drug and gene delivery","volume":"34","author":"Ahmadi","year":"2020","journal-title":"Nano Today"},{"key":"10.1016\/j.nano.2022.102599_bb0715","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3098230","article-title":"Nanomedicine for inner ear diseases: a review of recent in vivo studies","volume":"2017","author":"Kim","year":"2017","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.nano.2022.102599_bb0720","doi-asserted-by":"crossref","first-page":"3926","DOI":"10.33263\/BRIAC93.926933","article-title":"Graphene-based polymeric nano-composites: an introspection into functionalization, processing techniques and biomedical applications","volume":"9","author":"Zindani","year":"2019","journal-title":"Biointerface Res Appl Chem"},{"key":"10.1016\/j.nano.2022.102599_bb0725","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2147\/IJN.S154968","article-title":"Understanding the translocation mechanism of PLGA nanoparticles across round window membrane into the inner ear: a guideline for inner ear drug delivery based on nanomedicine","volume":"13","author":"Zhang","year":"2018","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2022.102599_bb0730","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.msec.2015.11.041","article-title":"New progress and prospects: the application of nanogel in drug delivery","volume":"60","author":"Zhang","year":"2016","journal-title":"Mater Sci Eng C"},{"key":"10.1016\/j.nano.2022.102599_bb0735","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ijbiomac.2020.03.182","article-title":"Dual-crosslinked nanocomposite hydrogels based on quaternized chitosan and clindamycin-loaded hyperbranched nanoparticles for potential antibacterial applications","volume":"155","author":"Wei","year":"2020","journal-title":"Int J Biol Macromol"},{"issue":"3","key":"10.1016\/j.nano.2022.102599_bb0740","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/000348941212100311","article-title":"Distribution of gentamicin in inner ear after local administration via a chitosan glycerophosphate hydrogel delivery system","volume":"121","author":"Luo","year":"2012","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0745","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1515\/secm-2017-0161","article-title":"A review on nanocomposite hydrogels and their biomedical applications","volume":"26","author":"Rafieian","year":"2019","journal-title":"Sci Eng Compos Mater"},{"key":"10.1016\/j.nano.2022.102599_bb0750","doi-asserted-by":"crossref","first-page":"6493","DOI":"10.2147\/IJN.S93750","article-title":"Design and evaluation of an intravesical delivery system for superficial bladder cancer: preparation of gemcitabine HCl-loaded chitosan\u2013thioglycolic acid nanoparticles and comparison of chitosan\/poloxamer gels as carriers","volume":"10","author":"\u015eenyi\u011fit","year":"2015","journal-title":"Int J Nanomedicine"},{"issue":"5","key":"10.1016\/j.nano.2022.102599_bb0755","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2165\/00063030-200822050-00004","article-title":"The impact of PEGylation on biological therapies","volume":"22","author":"Veronese","year":"2008","journal-title":"BioDrugs"},{"issue":"1\u20132","key":"10.1016\/j.nano.2022.102599_bb0760","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.ijpharm.2018.09.019","article-title":"Theranostic polymeric nanoparticles for NIR imaging and photodynamic therapy","volume":"551","author":"Sarcan","year":"2018","journal-title":"Int J Pharm"},{"key":"10.1016\/j.nano.2022.102599_bb0765","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3389\/fbioe.2020.00381","article-title":"PLGA-based drug delivery systems for remotely triggered cancer therapeutic and diagnostic applications","volume":"8","author":"Shen","year":"2020","journal-title":"Front Bioeng Biotechnol"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0770","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3390\/polym12020298","article-title":"The importance of poly (ethylene glycol) alternatives for overcoming PEG immunogenicity in drug delivery and bioconjugation","volume":"12","author":"Hoang Thi","year":"2020","journal-title":"Polymers"},{"issue":"24","key":"10.1016\/j.nano.2022.102599_bb0775","doi-asserted-by":"crossref","first-page":"10748","DOI":"10.1039\/D1NR02065J","article-title":"Effects of polyethylene glycol on the surface of nanoparticles for targeted drug delivery","volume":"13","author":"Shi","year":"2021","journal-title":"Nanoscale"},{"key":"10.1016\/j.nano.2022.102599_bb0780","first-page":"71","article-title":"Polyethyleneimine (PEI) as a polymer-based co-delivery system for breast cancer therapy","volume":"14","author":"Fahira","year":"2022","journal-title":"Breast Cancer"},{"issue":"7","key":"10.1016\/j.nano.2022.102599_bb0785","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1166\/jnn.2020.17896","article-title":"Polyethyleneimine-functionalized magnetic Fe3O4 and nanodiamond particles as a platform for amoxicillin delivery","volume":"20","author":"Rouhani","year":"2020","journal-title":"J Nanosci Nanotechnol"},{"issue":"4","key":"10.1016\/j.nano.2022.102599_bb0790","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.otohns.2007.04.013","article-title":"Distribution of PLGA nanoparticles in chinchilla cochleae","volume":"137","author":"Ge","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"6","key":"10.1016\/j.nano.2022.102599_bb0795","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1007\/s11051-010-9886-5","article-title":"Polymersomes, smaller than you think: ferrocene as a TEM probe to determine core structure","volume":"12","author":"Johnston","year":"2010","journal-title":"J Nanopart Res"},{"key":"10.1016\/j.nano.2022.102599_bb0800","doi-asserted-by":"crossref","first-page":"6744","DOI":"10.33263\/BRIAC106.67446756","article-title":"Immobilization of candida antarctica b (calb) in silica aerogel: Morphological characteristics and stability","volume":"10","author":"Ficanha","year":"2020","journal-title":"Biointerface Res Appl Chem"},{"issue":"24","key":"10.1016\/j.nano.2022.102599_bb0805","doi-asserted-by":"crossref","first-page":"1900669","DOI":"10.1002\/smll.201900669","article-title":"Mesoporous silica-based materials with bactericidal properties","volume":"15","author":"Bernardos","year":"2019","journal-title":"Small"},{"issue":"17","key":"10.1016\/j.nano.2022.102599_bb0810","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.3390\/molecules25173814","article-title":"Mesoporous silica platforms with potential applications in release and adsorption of active agents","volume":"25","author":"Chircov","year":"2020","journal-title":"Molecules"},{"key":"10.1016\/j.nano.2022.102599_bb0815","doi-asserted-by":"crossref","first-page":"602","DOI":"10.3389\/fchem.2020.00602","article-title":"Silica nanoparticles\u2014a versatile tool for the treatment of bacterial infections","volume":"8","author":"Selvarajan","year":"2020","journal-title":"Front Chem"},{"issue":"9","key":"10.1016\/j.nano.2022.102599_bb0820","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1134\/S1063784218090207","article-title":"Porous silicon as a nanomaterial for disperse transport systems of targeted drug delivery to the inner ear","volume":"63","author":"Spivak","year":"2018","journal-title":"Techn Phys"},{"issue":"9","key":"10.1016\/j.nano.2022.102599_bb0825","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1097\/01.mlg.0000167804.82950.9e","article-title":"Diameter of the cochlear nerve in endolymphatic hydrops: implications for the etiology of hearing loss in Meniere's disease","volume":"115","author":"Megerian","year":"2005","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0830","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.anorl.2017.07.002","article-title":"Control of vertigo in Meniere's disease by intratympanic dexamethasone","volume":"135","author":"Weckel","year":"2018","journal-title":"Eur Ann Otorhinolaryngol Head Neck Dis"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0835","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1109\/TMAG.2012.2221456","article-title":"Magnetic injection of nanoparticles into rat inner ears at a human head working distance","volume":"49","author":"Sarwar","year":"2012","journal-title":"IEEE Trans Magnet"},{"issue":"4","key":"10.1016\/j.nano.2022.102599_bb0840","doi-asserted-by":"crossref","first-page":"402","DOI":"10.3109\/00016489.2015.1129069","article-title":"Superparamagnetic nanoparticles as vectors for inner ear treatments: Driving and toxicity evaluation","volume":"136","author":"Nguyen","year":"2016","journal-title":"Acta Otolaryngol"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0845","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/0192623317732028","article-title":"Middle ear histopathology following magnetic delivery to the cochlea of prednisolone-loaded iron oxide nanoparticles in rats","volume":"46","author":"Lafond","year":"2018","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.nano.2022.102599_bb0850","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.biocel.2016.02.008","article-title":"Understanding the nanoparticle\u2013protein corona complexes using computational and experimental methods","volume":"75","author":"Kharazian","year":"2016","journal-title":"Int J Biochem Cell Biol"},{"issue":"19","key":"10.1016\/j.nano.2022.102599_bb0855","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.2217\/nnm-2019-0114","article-title":"Opportunities and challenging issues of nanomaterials in otological fields: an occupational health perspective","volume":"14","author":"Leso","year":"2019","journal-title":"Nanomedicine"},{"issue":"4","key":"10.1016\/j.nano.2022.102599_bb0860","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3390\/pharmaceutics10040191","article-title":"Solid lipid nanoparticles: emerging colloidal nano drug delivery systems","volume":"10","author":"Mishra","year":"2018","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.nano.2022.102599_bb0865","first-page":"982","article-title":"Solid lipid nanoparticles as attractive drug vehicles: Composition, properties and therapeutic strategies","volume":"68","author":"Geszke-Moritz","year":"2016","journal-title":"Korean J Couns Psychother"},{"issue":"10","key":"10.1016\/j.nano.2022.102599_bb0870","doi-asserted-by":"crossref","first-page":"2958","DOI":"10.1002\/anie.201804067","article-title":"Cubosomes: the next generation of smart lipid nanoparticles?","volume":"58","author":"Barriga","year":"2019","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.nano.2022.102599_bb0875","first-page":"6879","article-title":"Enhanced bioavailability of nerve growth factor with phytantriol lipid-based crystalline nanoparticles in cochlea","volume":"10","author":"Bu","year":"2015","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2022.102599_bb0880","doi-asserted-by":"crossref","first-page":"5959","DOI":"10.2147\/IJN.S116867","article-title":"Nanomedicine strategy for optimizing delivery to outer hair cells by surface-modified poly (lactic\/glycolic acid) nanoparticles with hydrophilic molecules","volume":"11","author":"Wen","year":"2016","journal-title":"Int J Nanomedicine"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0885","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1097\/MAO.0000000000002467","article-title":"The physiologic role of corticosteroids in Meniere's disease: an update on glucocorticoid-mediated pathophysiology and corticosteroid inner ear distribution","volume":"41","author":"Froehlich","year":"2020","journal-title":"Otol Neurotol"},{"issue":"7","key":"10.1016\/j.nano.2022.102599_bb0890","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1097\/MAO.0b013e3181eb32d1","article-title":"A controlled and sustained local gentamicin delivery system for inner ear applications","volume":"31","author":"Xu","year":"2010","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.nano.2022.102599_bb0895","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jconrel.2016.12.027","article-title":"pH-sensitive polymeric micelles for targeted delivery to inflamed joints","volume":"246","author":"Li","year":"2017","journal-title":"J Control Release"},{"issue":"8","key":"10.1016\/j.nano.2022.102599_bb0900","doi-asserted-by":"crossref","first-page":"1705137","DOI":"10.1002\/adfm.201705137","article-title":"Stimuli-responsive nucleic acid-based polyacrylamide hydrogel-coated metal\u2013organic framework nanoparticles for controlled drug release","volume":"28","author":"Chen","year":"2018","journal-title":"Adv Funct Mater"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0905","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/adhm.201400235","article-title":"Hydrogel doped with nanoparticles for local sustained release of siRNA in breast cancer","volume":"4","author":"Segovia","year":"2015","journal-title":"Adv Healthc Mater"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0910","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1146\/annurev-pharmtox-032320-110338","article-title":"Nanoparticle toxicology","volume":"61","author":"Yang","year":"2021","journal-title":"Annu Rev Pharmacol Toxicol"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0915","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3390\/polym11020275","article-title":"Nanoparticle-hydrogel composites: from molecular interactions to macroscopic behavior","volume":"11","author":"Dannert","year":"2019","journal-title":"Polymers"},{"issue":"2","key":"10.1016\/j.nano.2022.102599_bb0920","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1021\/acs.nanolett.7b05210","article-title":"Gold nanorods conjugated porous silicon nanoparticles encapsulated in calcium alginate nano hydrogels using microemulsion templates","volume":"18","author":"Zhang","year":"2018","journal-title":"Nano Lett"},{"issue":"3","key":"10.1016\/j.nano.2022.102599_bb0925","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.132880","article-title":"Ultrasound-induced microbubble cavitation via a transcanal or transcranial approach facilitates inner ear drug delivery","volume":"5","author":"Liao","year":"2020","journal-title":"JCI Insight"},{"issue":"8","key":"10.1016\/j.nano.2022.102599_bb0930","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1002\/lary.27713","article-title":"Middle-ear dexamethasone delivery via ultrasound microbubbles attenuates noise-induced hearing loss","volume":"129","author":"Shih","year":"2019","journal-title":"Laryngoscope"},{"key":"10.1016\/j.nano.2022.102599_bb0935","first-page":"350","article-title":"Nanoparticle-based inner ear delivery systems for the treatment of hearing loss","volume":"2","author":"Xu","year":"2021","journal-title":"Smart Mater Med"},{"key":"10.1016\/j.nano.2022.102599_bb0940","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.jconrel.2020.02.016","article-title":"An easy-to-prepare microshotgun for efficient transmembrane delivery by powering nanoparticles","volume":"321","author":"Liang","year":"2020","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2022.102599_bb0945","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.addr.2016.01.004","article-title":"Advances in nano-based inner ear delivery systems for the treatment of sensorineural hearing loss","volume":"108","author":"Li","year":"2017","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.nano.2022.102599_bb0950","first-page":"179","article-title":"Inner ear targeted drug delivery: what does the future hold?","author":"Agrahari","year":"2017","journal-title":"FutureScience"},{"issue":"3","key":"10.1016\/j.nano.2022.102599_bb0955","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1517\/17425247.2015.974548","article-title":"The role of intracochlear drug delivery devices in the management of inner ear disease","volume":"12","author":"Ayoob","year":"2015","journal-title":"Expert Opin Drug Deliv"},{"key":"10.1016\/j.nano.2022.102599_bb0960","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.791573","article-title":"Nanocarriers for inner ear disease therapy","volume":"15","author":"Xu","year":"2021","journal-title":"Front Cell Neurosci"},{"issue":"5","key":"10.1016\/j.nano.2022.102599_bb0965","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00204-011-0773-3","article-title":"Magnetic nanoparticles: an update of application for drug delivery and possible toxic effects","volume":"86","author":"Kim","year":"2012","journal-title":"Arch Toxicol"},{"issue":"4","key":"10.1016\/j.nano.2022.102599_bb0970","first-page":"580","article-title":"A strategy towards the generation of testable adverse outcome pathways for nanomaterials","volume":"38","author":"Murugadoss","year":"2021","journal-title":"Altern Anim Exp"},{"issue":"3","key":"10.1016\/j.nano.2022.102599_bb0975","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.jconrel.2012.12.031","article-title":"A regulated delivery system for inner ear drug application","volume":"166","author":"Lajud","year":"2013","journal-title":"J Control Release"},{"issue":"1\u20132","key":"10.1016\/j.nano.2022.102599_bb0980","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ijpharm.2010.11.006","article-title":"Inner ear biocompatibility of lipid nanocapsules after round window membrane application","volume":"404","author":"Zhang","year":"2011","journal-title":"Int J Pharm"},{"issue":"1","key":"10.1016\/j.nano.2022.102599_bb0985","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12951-014-0052-6","article-title":"Toxicity of silver nanoparticle in rat ear and BALB\/c 3T3 cell line","volume":"12","author":"Zou","year":"2014","journal-title":"J Nanobiotechnol"},{"issue":"6","key":"10.1016\/j.nano.2022.102599_bb0990","doi-asserted-by":"crossref","first-page":"4381","DOI":"10.3892\/mmr.2015.3306","article-title":"Linear polyethylenimine-plasmid DNA nanoparticles are ototoxic to the cultured sensory epithelium of neonatal mice","volume":"11","author":"Zhou","year":"2015","journal-title":"Mol Med Rep"},{"issue":"4","key":"10.1016\/j.nano.2022.102599_bb0995","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.3906\/sag-1912-209","article-title":"Nanotoxicity: a challenge for future medicine","volume":"50","author":"Ak\u00e7an","year":"2020","journal-title":"Turk J Med Sci"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963422000855?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963422000855?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:17:32Z","timestamp":1761549452000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963422000855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11]]},"references-count":198,"alternative-id":["S1549963422000855"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2022.102599","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2022,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Potential nanotechnology-based diagnostic and therapeutic approaches for Meniere's disease","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2022.102599","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102599"}}