{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T03:52:07Z","timestamp":1789617127137,"version":"build-2803163510"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007579","name":"Auburn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2023,1]]},"DOI":"10.1016\/j.nano.2022.102620","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T04:41:19Z","timestamp":1666068079000},"page":"102620","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"special_numbering":"C","title":["Diethyldithiocarbamate copper nanoparticle overcomes resistance in cancer therapy without inhibiting P-glycoprotein"],"prefix":"10.1016","volume":"47","author":[{"given":"Xuejia","family":"Kang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Hui","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fajar Setyo","family":"Wibowo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajesh","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nano.2022.102620_bb0005","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/bju.14152","article-title":"Taxane chemotherapy vs antiandrogen agents as first-line therapy for metastatic castration-resistant prostate cancer","volume":"121","author":"Sonpavde","year":"2018","journal-title":"BJU Int."},{"key":"10.1016\/j.nano.2022.102620_bb0010","doi-asserted-by":"crossref","first-page":"2017","DOI":"10.1007\/s40265-015-0484-9","article-title":"Albumin-bound paclitaxel: a review in non-small cell lung cancer","volume":"75","author":"Blair","year":"2015","journal-title":"Drugs"},{"key":"10.1016\/j.nano.2022.102620_bb0015","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.3892\/ijo.2016.3396","article-title":"Downregulation of cytokeratin 18 is associated with paclitaxel-resistance and tumor aggressiveness in prostate cancer","volume":"48","author":"Yin","year":"2016","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.nano.2022.102620_bb0020","doi-asserted-by":"crossref","first-page":"2539","DOI":"10.1021\/mp500099g","article-title":"MicroRNAs and drug resistance in prostate cancers","volume":"11","author":"Li","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.nano.2022.102620_bb0025","first-page":"16185","volume":"9","author":"Machioka","year":"2018","journal-title":"Establishment and characterization of two cabazitaxel-resistant prostate cancer cell lines."},{"key":"10.1016\/j.nano.2022.102620_bb0030","first-page":"100","article-title":"Liang X-J J C j o c","volume":"31","author":"Xue","year":"2012","journal-title":"Overcoming drug efflux-based multidrug resistance in cancer with nanotechnology."},{"key":"10.1016\/j.nano.2022.102620_bb0035","first-page":"10","article-title":"Clinical perspective of FDA approved drugs with P-glycoprotein inhibition activities for potential cancer therapeutics. Frontiers","author":"Lai","year":"2020","journal-title":"Oncology"},{"key":"10.1016\/j.nano.2022.102620_bb0040","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1021\/mp400687w","article-title":"Doxorubicin and lapatinib combination nanomedicine for treating resistant breast cancer","volume":"11","author":"Wang","year":"2014","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.nano.2022.102620_bb0045","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s13346-011-0042-2","article-title":"Paclitaxel- and lapatinib-loaded lipopolymer micelles overcome multidrug resistance in prostate cancer","volume":"1","author":"Li","year":"2011","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.nano.2022.102620_bb0050","first-page":"173","article-title":"Chapter 10 - nanotechnology-based targeted drug delivery systems and drug resistance in colorectal cancer","volume":"Vol. 8","author":"Zhao","year":"2020"},{"key":"10.1016\/j.nano.2022.102620_bb0055","doi-asserted-by":"crossref","first-page":"1900102","DOI":"10.1002\/adtp.201900102","article-title":"Soft and condensed nanoparticles and nanoformulations for cancer drug delivery and repurpose","volume":"3","author":"Yang","year":"2020","journal-title":"Advanced Therapeutics"},{"key":"10.1016\/j.nano.2022.102620_bb0060","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jconrel.2009.12.028","article-title":"Synthesis, formulation and in vitro evaluation of a novel microtubule destabilizer, SMART-100","volume":"143","author":"Li","year":"2010","journal-title":"J. Control. Release"},{"key":"10.1016\/j.nano.2022.102620_bb0065","doi-asserted-by":"crossref","first-page":"230","DOI":"10.4103\/0976-500X.119704","article-title":"Cabazitaxel: a novel taxane for metastatic castration-resistant prostate cancer-current implications and future prospects","volume":"4","author":"Abidi","year":"2013","journal-title":"J. Pharmacol. Pharmacother"},{"key":"10.1016\/j.nano.2022.102620_bb0070","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jconrel.2020.01.001","article-title":"Old wine in new bottles: advanced drug delivery systems for disulfiram-based cancer therapy","volume":"319","author":"McMahon","year":"2020","journal-title":"J. Control. Release"},{"key":"10.1016\/j.nano.2022.102620_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2021.120972","article-title":"Near-infrared light triggered activation of pro-drug combination cancer therapy and induction of immunogenic cell death","volume":"607","author":"Kang","year":"2021","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.nano.2022.102620_bb0080","doi-asserted-by":"crossref","first-page":"1700403","DOI":"10.1002\/adfm.201700403","article-title":"Dual-targeting to cancer cells and M2 macrophages via biomimetic delivery of mannosylated albumin nanoparticles for drug-resistant cancer therapy","volume":"27","author":"Zhao","year":"2017","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.nano.2022.102620_bb0085","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.2147\/IJN.S137347","article-title":"Development and optimization of an injectable formulation of copper diethyldithiocarbamate, an active anticancer agent","volume":"12","author":"Wehbe","year":"2017","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.nano.2022.102620_bb0090","doi-asserted-by":"crossref","first-page":"11531","DOI":"10.1021\/jacs.9b03503","article-title":"Enhanced tumor-specific disulfiram chemotherapy by in situ Cu2+ chelation-initiated nontoxicity-to-toxicity transition","volume":"141","author":"Wu","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.nano.2022.102620_bb0095","series-title":"Polymers in Therapeutic Delivery","first-page":"79","article-title":"Metal-organic nanomaterials for drug delivery","author":"Huang","year":"2020"},{"key":"10.1016\/j.nano.2022.102620_bb0100","first-page":"41118","article-title":"Li F J a a m, interfaces","volume":"10","author":"Chen","year":"2018","journal-title":"Disulfiram copper nanoparticles prepared with a stabilized metal ion ligand complex method for treating drug-resistant prostate cancers."},{"key":"10.1016\/j.nano.2022.102620_bb0105","article-title":"Biomimetic metal-organic nanoparticles prepared with a 3D-printed microfluidic device as a novel formulation for disulfiram-based therapy against breast cancer","volume":"18","author":"Chang","year":"2020","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.nano.2022.102620_bb0110","doi-asserted-by":"crossref","first-page":"2610","DOI":"10.1021\/bm100561v","article-title":"Synthesis and characterization of amphiphilic lipopolymers for micellar drug delivery","volume":"11","author":"Li","year":"2010","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.nano.2022.102620_bb0115","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1002\/jps.22467","article-title":"Poly(ethylene glycol)-block-Poly(2-methyl-2-benzoxycarbonyl-propylene Carbonate) micelles for rapamycin delivery. In vitro characterization and biodistribution","volume":"100","author":"Lu","year":"2011","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.nano.2022.102620_bb0120","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1002\/pros.20581","article-title":"The establishment of two paclitaxel-resistant prostate cancer cell lines and the mechanisms of paclitaxel resistance with two cell lines","volume":"67","author":"Takeda","year":"2007","journal-title":"Prostate"},{"key":"10.1016\/j.nano.2022.102620_bb0125","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.canlet.2020.09.004","article-title":"Orally available tubulin inhibitor VERU-111 enhances antitumor efficacy in paclitaxel-resistant lung cancer","volume":"495","author":"Mahmud","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.nano.2022.102620_bb0130","first-page":"54338","article-title":"Preparation and characterization of lipophilic doxorubicin pro-drug micelles","author":"Li","year":"2016","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.nano.2022.102620_bb0135","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1021\/acssensors.1c01101","article-title":"Nanoplasmonic Sandwich immunoassay for tumor-derived exosome detection and exosomal PD-L1 profiling","volume":"6","author":"Wang","year":"2021","journal-title":"ACS Sensors"},{"key":"10.1016\/j.nano.2022.102620_bb0140","series-title":"Measuring survival of adherent cells with the colony-forming assay","author":"Crowley","year":"2016"},{"key":"10.1016\/j.nano.2022.102620_bb0145","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.actbio.2021.05.018","article-title":"Nanoparticles for co-delivery of osimertinib and selumetinib to overcome osimertinib-acquired resistance in non-small cell lung cancer","volume":"129","author":"Chen","year":"2021","journal-title":"Acta. Biomater"},{"key":"10.1016\/j.nano.2022.102620_bb0150","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1007\/s13346-011-0042-2","article-title":"Paclitaxel-and lapatinib-loaded lipopolymer micelles overcome multidrug resistance in prostate cancer","volume":"1","author":"Li","year":"2011","journal-title":"Drug Deliv. Transl. Res."},{"key":"10.1016\/j.nano.2022.102620_bb0155","doi-asserted-by":"crossref","first-page":"1769","DOI":"10.1093\/jnci\/djh322","article-title":"Death receptor regulation and celecoxib-induced apoptosis in human lung cancer cells","volume":"96","author":"Liu","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.nano.2022.102620_bb0160","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1021\/mp700145f","article-title":"iNOS gene silencing prevents inflammatory cytokine-induced \u03b2-cell apoptosis","volume":"5","author":"Li","year":"2008","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.nano.2022.102620_bb0165","first-page":"365","volume":"81","author":"Zaja","year":"2007","journal-title":"At, Detection and functional characterization of Pgp1 (ABCB1) and MRP3 (ABCC3) efflux transporters in the PLHC-1 fish hepatoma cell line."},{"key":"10.1016\/j.nano.2022.102620_bb0170","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000071510","article-title":"Multidrug resistance in prostate cancer","volume":"26","author":"van Brussel","year":"2003","journal-title":"Oncol. Res. Treat."},{"key":"10.1016\/j.nano.2022.102620_bb0175","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1146\/annurev.pharmtox.39.1.361","article-title":"Biochemical, cellular, and pharmacological aspects of the multidrug transporter","volume":"39","author":"Ambudkar","year":"1999","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.nano.2022.102620_bb0180","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.2174\/138955712802762068","article-title":"Diethyldithiocarbamate complex with copper: the mechanism of action in cancer cells","volume":"12","author":"Skrott","year":"2012","journal-title":"Mini. Rev. Med. Chem."},{"key":"10.1016\/j.nano.2022.102620_bb0185","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.yexcr.2017.11.004","article-title":"Targeting ALDH2 with disulfiram\/copper reverses the resistance of cancer cells to microtubule inhibitors","volume":"362","author":"Wang","year":"2018","journal-title":"Exp. Cell. Res."},{"key":"10.1016\/j.nano.2022.102620_bb0190","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1039\/C5MT00149H","article-title":"Targeting copper in cancer therapy: 'Copper that Cancer'","volume":"7","author":"Denoyer","year":"2015","journal-title":"Metallomics"},{"key":"10.1016\/j.nano.2022.102620_bb0195","doi-asserted-by":"crossref","first-page":"6711","DOI":"10.1038\/s41388-019-0915-2","article-title":"Disulfiram\u2019s anti-cancer activity reflects targeting NPL4, not inhibition of aldehyde dehydrogenase","volume":"38","author":"Skrott","year":"2019","journal-title":"Oncogene"},{"key":"10.1016\/j.nano.2022.102620_bb0200","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1002\/sca.21332","article-title":"Disulfiram chelated with copper promotes apoptosis in human breast cancer cells by impairing the mitochondria functions","volume":"38","author":"Yang","year":"2016","journal-title":"Scanning"},{"key":"10.1016\/j.nano.2022.102620_bb0205","first-page":"194","volume":"552","author":"Skrott","year":"2017","journal-title":"Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4."},{"key":"10.1016\/j.nano.2022.102620_bb0210","doi-asserted-by":"crossref","first-page":"246","DOI":"10.3390\/ijms22010246","article-title":"New evidence for P-gp-mediated export of amyloid-\u03b2 PEPTIDES in molecular, blood-brain barrier and neuronal models","volume":"22","author":"Chai","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.nano.2022.102620_bb0215","doi-asserted-by":"crossref","first-page":"212","DOI":"10.20892\/j.issn.2095-3941.2017.0054","article-title":"Nanotechnology-based combination therapy for overcoming multidrug-resistant cancer","volume":"14","author":"Zhang","year":"2017","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.nano.2022.102620_bb0220","doi-asserted-by":"crossref","first-page":"12661","DOI":"10.1021\/acsami.6b03064","article-title":"MMP2-sensitive PEG-lipid copolymers: a new type of tumor-targeted P-glycoprotein inhibitor","volume":"8","author":"Dai","year":"2016","journal-title":"Acs. Appl. Mater. Inter."},{"key":"10.1016\/j.nano.2022.102620_bb0225","doi-asserted-by":"crossref","first-page":"597","DOI":"10.2217\/nnm.10.35","article-title":"Nanomedicinal strategies to treat multidrug-resistant tumors: current progress","volume":"5","author":"Dong","year":"2010","journal-title":"Nanomedicine"},{"key":"10.1016\/j.nano.2022.102620_bb0230","doi-asserted-by":"crossref","first-page":"13990","DOI":"10.1021\/acsami.1c00852","article-title":"Sequential release of pooled siRNAs and paclitaxel by aptamer-functionalized Shell-Core nanoparticles to overcome paclitaxel resistance of prostate cancer","volume":"13","author":"Guo","year":"2021","journal-title":"Acs. Appl. Mater. Inter."},{"key":"10.1016\/j.nano.2022.102620_bb0235","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s40880-017-0203-x","article-title":"Down-regulation of E-cadherin enhances prostate cancer chemoresistance via notch signaling","volume":"36","author":"Wang","year":"2017","journal-title":"Chin. J. Cancer."},{"key":"10.1016\/j.nano.2022.102620_bb0240","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1146\/annurev-pathol-020117-043854","article-title":"Epithelial mesenchymal transition in tumor metastasis","volume":"13","author":"Mittal","year":"2018","journal-title":"Annu. Rev. Pathol."},{"key":"10.1016\/j.nano.2022.102620_bb0245","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/nrclinonc.2017.44","article-title":"EMT, CSCs, and drug resistance: the mechanistic link and clinical implications","volume":"14","author":"Shibue","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154996342200106X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154996342200106X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T07:18:10Z","timestamp":1761549490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S154996342200106X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1]]},"references-count":49,"alternative-id":["S154996342200106X"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2022.102620","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2023,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diethyldithiocarbamate copper nanoparticle overcomes resistance in cancer therapy without inhibiting P-glycoprotein","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2022.102620","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102620"}}