{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T19:17:03Z","timestamp":1793906223089,"version":"4.8.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SRG\/2022\/000961"],"award-info":[{"award-number":["SRG\/2022\/000961"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.nano.2024.102752","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T20:17:00Z","timestamp":1715458620000},"page":"102752","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Fisetin-loaded chitosan nanoparticles ameliorate pilocarpine-induced temporal lobe epilepsy and associated neurobehavioral alterations in mice: Role of ROS\/TNF-\u03b1-NLRP3 inflammasomes pathway"],"prefix":"10.1016","volume":"59","author":[{"given":"Sagar","family":"Mahawar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debarati","family":"Rakshit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inklisan","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati Kailas","family":"Gore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srijita","family":"Sen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Om Prakash","family":"Ranjan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7863-5581","authenticated-orcid":false,"given":"Awanish","family":"Mishra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.nano.2024.102752_bb0005","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1093\/brain\/awab162","article-title":"Early childhood epilepsies: epidemiology, classification, aetiology, and socio-economic determinants","volume":"144","author":"Symonds","year":"2021","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.nano.2024.102752_bb0010","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.4102\/phcfm.v12i1.2162","article-title":"General side effects and challenges associated with anti-epilepsy medication: a review of related literature","volume":"12","author":"Mutanana","year":"2020","journal-title":"Afr J Prim Health Care Fam Med"},{"issue":"3","key":"10.1016\/j.nano.2024.102752_bb0015","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4103\/0972-2327.160093","article-title":"Epilepsy in India I: epidemiology and public health","volume":"18","author":"Amudhan","year":"2015","journal-title":"Ann Indian Acad Neurol"},{"issue":"4","key":"10.1016\/j.nano.2024.102752_bb0020","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.yebeh.2007.12.019","article-title":"The global burden and stigma of epilepsy","volume":"12","author":"de Boer","year":"2008","journal-title":"Epilepsy Behav"},{"issue":"13","key":"10.1016\/j.nano.2024.102752_bb0025","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.2174\/1568026620666200416085330","article-title":"Role of flavonoids in neurodegenerative diseases: limitations and future perspectives","volume":"20","author":"Maan","year":"2020","journal-title":"Curr Top Med Chem"},{"issue":"11","key":"10.1016\/j.nano.2024.102752_bb0030","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.2174\/138945011798109509","article-title":"Modulation of GABA(A) receptors by natural products and the development of novel synthetic ligands for the benzodiazepine binding site","volume":"12","author":"Nilsson","year":"2011","journal-title":"Curr Drug Targets"},{"issue":"1","key":"10.1016\/j.nano.2024.102752_bb0035","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/epi.12463","article-title":"Medicinal compounds with antiepileptic\/anticonvulsant activities","volume":"55","author":"Zhu","year":"2014","journal-title":"Epilepsia"},{"key":"10.1016\/j.nano.2024.102752_bb0040","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neuro.2023.06.006","article-title":"Fisetin attenuates arsenic and fluoride subacute co-exposure induced neurotoxicity via regulating TNF-\u03b1 mediated activation of NLRP3 inflammasome","volume":"97","author":"Gopnar","year":"2023","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.nano.2024.102752_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175583","article-title":"Fisetin provides neuroprotection in pentylenetetrazole-induced cognition impairment by upregulating CREB\/BDNF","volume":"944","author":"Khatoon","year":"2023","journal-title":"Eur J Pharmacol"},{"issue":"2","key":"10.1016\/j.nano.2024.102752_bb0050","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/cns.13765","article-title":"Fisetin ameliorates cognitive impairment by activating mitophagy and suppressing neuroinflammation in rats with sepsis-associated encephalopathy","volume":"28","author":"Ding","year":"2022","journal-title":"CNS Neurosci Ther"},{"issue":"2","key":"10.1016\/j.nano.2024.102752_bb0055","doi-asserted-by":"crossref","first-page":"196","DOI":"10.5114\/fn.2023.126893","article-title":"Protective effects of fisetin in an A\u03b21-42-induced rat model of Alzheimer\u2019s disease","volume":"61","author":"Wang","year":"2023","journal-title":"Folia Neuropathol"},{"key":"10.1016\/j.nano.2024.102752_bb0060","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.neuint.2018.05.011","article-title":"Fisetin alleviates oxidative stress after traumatic brain injury via the Nrf2-ARE pathway","volume":"118","author":"Zhang","year":"2018","journal-title":"Neurochem Int"},{"key":"10.1016\/j.nano.2024.102752_bb0065","doi-asserted-by":"crossref","DOI":"10.1177\/1076029619871359","article-title":"Fisetin prolongs therapy window of brain ischemic stroke using tissue plasminogen activator: a double-blind randomized placebo-controlled clinical trial","volume":"25","author":"Wang","year":"2019","journal-title":"Clin Appl Thromb Hemost"},{"key":"10.1016\/j.nano.2024.102752_bb0070","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.phrs.2015.10.007","article-title":"Antinociceptive effects of fisetin against diabetic neuropathic pain in mice: engagement of antioxidant mechanisms and spinal GABAA receptors","volume":"102","author":"Zhao","year":"2015","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.nano.2024.102752_bb0075","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bionut.2012.04.005","article-title":"Anticonvulsant effect of fisetin by modulation of endogenous biomarkers","volume":"2","author":"Raygude","year":"2012","journal-title":"Biomed Prev Nutr"},{"issue":"18","key":"10.1016\/j.nano.2024.102752_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241814158","article-title":"Fisetin-in search of better bioavailability-from macro to nano modifications: a review","volume":"24","author":"Szymczak","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.nano.2024.102752_bb0085","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1517\/17425247.2013.860131","article-title":"Fisetin-loaded nanocochleates: formulation, characterisation, in vitro anticancer testing, bioavailability and biodistribution study","volume":"11","author":"Bothiraja","year":"2014","journal-title":"Expert Opin Drug Deliv"},{"issue":"10","key":"10.1016\/j.nano.2024.102752_bb0090","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.3390\/molecules26103031","article-title":"Nanoformulation development to improve the biopharmaceutical properties of fisetin using design of experiment approach","volume":"26","author":"Liu","year":"2021","journal-title":"Molecules"},{"issue":"1\u20132","key":"10.1016\/j.nano.2024.102752_bb0095","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.ijpharm.2009.11.002","article-title":"Preparation and evaluation of anti-neuroexcitation peptide (ANEP) loaded N-trimethyl chitosan chloride nanoparticles for brain-targeting","volume":"386","author":"Wang","year":"2010","journal-title":"Int J Pharm"},{"key":"10.1016\/j.nano.2024.102752_bb0100","doi-asserted-by":"crossref","DOI":"10.1038\/srep10048","article-title":"Chitosan encapsulation modulates the effect of capsaicin on the tight junctions of MDCK cells","volume":"5","author":"Kaiser","year":"2015","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.nano.2024.102752_bb0105","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1021\/bm201790s","article-title":"In vitro assessment of alkylglyceryl-functionalized chitosan nanoparticles as permeating vectors for the blood-brain barrier","volume":"13","author":"Lien","year":"2012","journal-title":"Biomacromolecules"},{"issue":"8","key":"10.1016\/j.nano.2024.102752_bb0110","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1080\/03639045.2019.1619759","article-title":"Formulation and biopharmaceutical evaluation of risperidone-loaded chitosan nanoparticles for intranasal delivery","volume":"45","author":"Rukmangathen","year":"2019","journal-title":"Drug Dev Ind Pharm"},{"issue":"2","key":"10.1016\/j.nano.2024.102752_bb0115","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.carbpol.2010.02.026","article-title":"Bioadhesive chitosan nanoparticles: preparation and characterization","volume":"81","author":"Dudhani","year":"2010","journal-title":"Carbohydr Polym"},{"issue":"1","key":"10.1016\/j.nano.2024.102752_bb0120","first-page":"333","article-title":"Activation of the phagocyte NADPH oxidase\/NOX2 and myeloperoxidase in the mouse brain during pilocarpine-induced temporal lobe epilepsy and inhibition by ketamine. Inflammopharmacology. 2020;28(2):487\u2013497","volume":"29","author":"Tannich","year":"2021","journal-title":"Erratum in: Inflammopharmacology"},{"key":"10.1016\/j.nano.2024.102752_bb0125","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2021.689069","article-title":"Neuroprotective effect of fisetin through suppression of IL-1R\/TLR axis and apoptosis in pentylenetetrazole-induced kindling in mice","volume":"12","author":"Khatoon","year":"2021","journal-title":"Front Neurol"},{"issue":"4","key":"10.1016\/j.nano.2024.102752_bb0130","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/1028415X.2016.1183342","article-title":"Antiepileptic effect of fisetin in iron-induced experimental model of traumatic epilepsy in rats in the light of electrophysiological, biochemical, and behavioral observations","volume":"20","author":"Das","year":"2017","journal-title":"Nutr Neurosci"},{"key":"10.1016\/j.nano.2024.102752_bb0135","article-title":"Curcumin loaded nanoparticles reversed monocrotophos induced motor impairment and memory deficit: role of oxidative stress and intracellular calcium level","volume":"56","author":"Mandal","year":"2020","journal-title":"J Drug Deliv Sci Technol"},{"issue":"1","key":"10.1016\/j.nano.2024.102752_bb0140","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-00402-7","article-title":"Apparatus design and behavioural testing protocol for the evaluation of spatial working memory in mice through the spontaneous alternation T-maze","volume":"11","author":"d\u2019Isa","year":"2021","journal-title":"Sci Rep"},{"issue":"7","key":"10.1016\/j.nano.2024.102752_bb0145","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1007\/s11011-021-00806-4","article-title":"Neuroinflammation in neurological disorders: pharmacotherapeutic targets from bench to bedside","volume":"36","author":"Mishra","year":"2021","journal-title":"Metab Brain Dis"},{"issue":"3","key":"10.1016\/j.nano.2024.102752_bb0150","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1007\/s12035-016-9795-4","article-title":"Neuroprotective effect of fisetin against amyloid-beta-induced cognitive\/synaptic dysfunction, neuroinflammation, and neurodegeneration in adult mice","volume":"54","author":"Ahmad","year":"2017","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.nano.2024.102752_bb0155","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s12017-012-8210-1","article-title":"Fisetin enhances behavioral performances and attenuates reactive gliosis and inflammation during aluminum chloride-induced neurotoxicity","volume":"15","author":"Prakash","year":"2013","journal-title":"Neuromolecular Med"},{"issue":"12","key":"10.1016\/j.nano.2024.102752_bb0160","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.jnutbio.2015.07.017","article-title":"Dietary flavonoid fisetin regulates aluminium chloride-induced neuronal apoptosis in cortex and hippocampus of mice brain","volume":"26","author":"Prakash","year":"2015","journal-title":"J Nutr Biochem"},{"issue":"6","key":"10.1016\/j.nano.2024.102752_bb0165","doi-asserted-by":"crossref","first-page":"850","DOI":"10.3390\/jcm8060850","article-title":"Phytomedicine-based potent antioxidant, fisetin protects CNS-insult LPS-induced oxidative stress-mediated neurodegeneration and memory impairment","volume":"8","author":"Ahmad","year":"2019","journal-title":"J Clin Med"},{"issue":"4","key":"10.1016\/j.nano.2024.102752_bb0170","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s11011-015-9650-8","article-title":"Comparative behavioral and neurochemical analysis of phenytoin and valproate treatment on epilepsy induced learning and memory deficit: search for add on therapy","volume":"30","author":"Mishra","year":"2015","journal-title":"Metab Brain Dis"},{"key":"10.1016\/j.nano.2024.102752_bb0175","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.neuroscience.2016.10.010","article-title":"Chronic 5-HT3 receptor antagonism ameliorates seizures and associated memory deficit in pentylenetetrazole-kindled mice","volume":"339","author":"Mishra","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.nano.2024.102752_bb0180","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.549037","article-title":"Fisetin regulates gut microbiota and exerts neuroprotective effect on mouse model of Parkinson\u2019s disease","volume":"14","author":"Chen","year":"2020","journal-title":"Front Neurosci"},{"key":"10.1016\/j.nano.2024.102752_bb0185","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.bbi.2019.07.014","article-title":"Anti-inflammatory treatment with a soluble epoxide hydrolase inhibitor attenuates seizures and epilepsy-associated depression in the LiCl-pilocarpine post-status epilepticus rat model","volume":"81","author":"Shen","year":"2019","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.nano.2024.102752_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.yebeh.2024.109659","article-title":"Elevated phase amplitude coupling as a depression biomarker in epilepsy","volume":"152","author":"Young","year":"2024","journal-title":"Epilepsy Behav"},{"issue":"18","key":"10.1016\/j.nano.2024.102752_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231810414","article-title":"Elevated serum cortisol levels in patients with focal epilepsy, depression, and comorbid epilepsy and depression","volume":"23","author":"Druzhkova","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.nano.2024.102752_bb0200","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s00213-018-5105-3","article-title":"Ameliorative effect of fisetin against lipopolysaccharide and restraint stress-induced behavioral deficits via modulation of NF-\u03baB and IDO-1","volume":"236","author":"Choubey","year":"2019","journal-title":"Psychopharmacology (Berl)"},{"issue":"5","key":"10.1016\/j.nano.2024.102752_bb0205","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1007\/s11011-016-9839-5","article-title":"The effects of fisetin on lipopolysaccharide-induced depressive-like behavior in mice","volume":"31","author":"Yu","year":"2016","journal-title":"Metab Brain Dis"},{"issue":"2","key":"10.1016\/j.nano.2024.102752_bb0210","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.bbr.2011.12.017","article-title":"The antidepressant-like effect of fisetin involves the serotonergic and noradrenergic system","volume":"228","author":"Zhen","year":"2012","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.nano.2024.102752_bb0215","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1007\/s12035-023-03659-3","article-title":"A ketogenic diet may improve cognitive function in rats with temporal lobe epilepsy by regulating endoplasmic reticulum stress and synaptic plasticity","volume":"61","author":"Qiao","year":"2024","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.nano.2024.102752_bb0220","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.612078","article-title":"Fisetin rescues the mice brains against D-galactose-induced oxidative stress, neuroinflammation and memory impairment","volume":"12","author":"Ahmad","year":"2021","journal-title":"Front Pharmacol"},{"issue":"44","key":"10.1016\/j.nano.2024.102752_bb0225","doi-asserted-by":"crossref","first-page":"16568","DOI":"10.1073\/pnas.0607822103","article-title":"Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory","volume":"103","author":"Maher","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.nano.2024.102752_bb0230","article-title":"Ursolic acid protects neurons in temporal lobe epilepsy and cognitive impairment by repressing inflammation and oxidation","volume":"13","author":"Liu","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.nano.2024.102752_bb0235","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1016\/j.bcp.2018.09.004","article-title":"Rifampicin ameliorates lithium-pilocarpine-induced seizures, consequent hippocampal damage and memory deficit in rats: impact on oxidative, inflammatory and apoptotic machineries","volume":"156","author":"Ali","year":"2018","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.nano.2024.102752_bb0240","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-023-03826-6","article-title":"Gestational fisetin exerts neuroprotection by regulating mitochondria-directed canonical Wnt signaling, BBB integrity, and apoptosis in prenatal VPA-induced rodent model of autism","author":"Mehra","year":"2023","journal-title":"Mol Neurobiol"},{"issue":"6","key":"10.1016\/j.nano.2024.102752_bb0245","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.3390\/biomedicines10061448","article-title":"Discovering the effects of fisetin on NF-\u03baB\/NLRP-3\/NRF-2 molecular pathways in a mouse model of vascular dementia induced by repeated bilateral carotid occlusion","volume":"10","author":"Cordaro","year":"2022","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.nano.2024.102752_bb0250","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1007\/s10753-021-01434-x","article-title":"Neuroprotective effect of fisetin against the cerebral ischemia-reperfusion damage via suppression of oxidative stress and inflammatory parameters","volume":"44","author":"Zhang","year":"2021","journal-title":"Inflammation"},{"issue":"2","key":"10.1016\/j.nano.2024.102752_bb0255","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s43188-020-00049-y","article-title":"Protective effect of fisetin against subchronic chlorpyrifos-induced toxicity on oxidative stress biomarkers and neurobehavioral parameters in adult male albino mice","volume":"37","author":"Akpa","year":"2020","journal-title":"Toxicol Res"},{"issue":"1","key":"10.1016\/j.nano.2024.102752_bb0260","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1159\/000534833","article-title":"Inhibition of galectin-3 in a rat model of epilepsy and kainate-activated BV2 cells limits microglial activation through the NLRP3\/pyroptosis pathway","volume":"30","author":"Sun","year":"2023","journal-title":"Neuroimmunomodulation"},{"issue":"8","key":"10.1016\/j.nano.2024.102752_bb0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0271995","article-title":"Characterisation of NLRP3 pathway-related neuroinflammation in temporal lobe epilepsy","volume":"17","author":"Pohlentz","year":"2022","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.nano.2024.102752_bb0270","doi-asserted-by":"crossref","first-page":"5076","DOI":"10.3390\/ijms24065076","article-title":"Fisetin, a natural polyphenol, ameliorates endometriosis modulating mast cells derived NLRP-3 Inflammasome pathway and oxidative stress","volume":"24","author":"Arangia","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.nano.2024.102752_bb0275","article-title":"Fisetin attenuates diabetic nephropathy-induced podocyte injury by inhibiting NLRP3 inflammasome","volume":"13","author":"Dong","year":"2022","journal-title":"Front Pharmacol"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963424000212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963424000212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,17]],"date-time":"2024-06-17T03:21:50Z","timestamp":1718594510000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963424000212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":55,"alternative-id":["S1549963424000212"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2024.102752","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fisetin-loaded chitosan nanoparticles ameliorate pilocarpine-induced temporal lobe epilepsy and associated neurobehavioral alterations in mice: Role of ROS\/TNF-\u03b1-NLRP3 inflammasomes pathway","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2024.102752","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102752"}}