{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T05:57:00Z","timestamp":1751608620114,"version":"3.38.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013061","name":"Jilin Scientific and Technological Development Program","doi-asserted-by":"publisher","award":["YDZJ202201ZYTS670"],"award-info":[{"award-number":["YDZJ202201ZYTS670"]}],"id":[{"id":"10.13039\/501100013061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Jilin Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["201215146"],"award-info":[{"award-number":["201215146"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.nano.2025.102802","type":"journal-article","created":{"date-parts":[[2025,1,7]],"date-time":"2025-01-07T16:37:16Z","timestamp":1736267836000},"page":"102802","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Glutathione-responsive polypeptide nanogel encapsulates Shikonin for breast cancer therapy"],"prefix":"10.1016","volume":"64","author":[{"given":"Siqi","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingshuang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhilin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiahe","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuai","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changshun","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianhui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangru","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nano.2025.102802_bb0005","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jconrel.2021.05.042","article-title":"Magnetic nanoparticles for cancer theranostics: advances and prospects","volume":"335","author":"Li","year":"2021","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2025.102802_bb0010","doi-asserted-by":"crossref","first-page":"4681","DOI":"10.1039\/D2BM00776B","article-title":"A chemical biology toolbox to overcome the hypoxic tumor microenvironment for photodynamic therapy: a review","volume":"10","author":"Zheng","year":"2022","journal-title":"Biomater Sci"},{"key":"10.1016\/j.nano.2025.102802_bb0015","doi-asserted-by":"crossref","first-page":"1269224","DOI":"10.3389\/fphar.2023.1269224","article-title":"Engineered nanomaterials enhance drug delivery strategies for the treatment of osteosarcoma","volume":"14","author":"Zhang","year":"2023","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.nano.2025.102802_bb0020","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.jiec.2022.03.042","article-title":"Tumor intracellular microenvironment-responsive nanoparticles for magnetically targeted chemotherapy","volume":"111","author":"Noh","year":"2022","journal-title":"J Ind Eng Chem"},{"key":"10.1016\/j.nano.2025.102802_bb0025","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1039\/D3NH00388D","article-title":"Tumor microenvironment-responsive degradable silica nanoparticles: design principles and precision theranostic applications","volume":"9","author":"Zhang","year":"2024","journal-title":"Nanoscale Horiz"},{"key":"10.1016\/j.nano.2025.102802_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.matdes.2021.109465","article-title":"Immunogenic cell death-inducing chemotherapeutic nanoformulations potentiate combination chemoimmunotherapy","volume":"202","author":"Liu","year":"2021","journal-title":"Mater Des"},{"key":"10.1016\/j.nano.2025.102802_bb0035","doi-asserted-by":"crossref","first-page":"5209","DOI":"10.2147\/IJN.S388075","article-title":"Nanoparticles for chemoimmunotherapy against triple-negative breast cancer","volume":"17","author":"Liu","year":"2022","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2025.102802_bb0040","first-page":"2300545","article-title":"Transformable neuropeptide prodrug with tumor microenvironment responsiveness for tumor growth and metastasis inhibition of triple-negative breast cancer","volume":"10","author":"Cao","year":"2023","journal-title":"Adv Sci (Weinheim Ger)"},{"key":"10.1016\/j.nano.2025.102802_bb0045","doi-asserted-by":"crossref","first-page":"2200498","DOI":"10.1002\/mabi.202200498","article-title":"Oxidation responsive PEGylated polyamino acid bearing thioether pendants for enhanced anticancer drug delivery","volume":"23","author":"Sun","year":"2023","journal-title":"Macromol Biosci"},{"key":"10.1016\/j.nano.2025.102802_bb0050","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3390\/polym16020206","article-title":"Degradable polymeric bio(nano)materials and their biomedical applications: a comprehensive overview and recent updates","volume":"16","author":"Kuperkar","year":"2024","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.nano.2025.102802_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2023.113232","article-title":"Construction of poly(amino acid)s nano-delivery system and sustained release with redox-responsive","volume":"224","author":"Hu","year":"2023","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1016\/j.nano.2025.102802_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2022.109431","article-title":"Design of pH-responsive polymeric nanocarrier for targeted delivery of pyrogallol with enhanced antitumor potential in colon cancer","volume":"731","author":"Mahmoud","year":"2022","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.nano.2025.102802_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioadv.2022.212842","article-title":"A hybrid thermoresponsive plasmonic nanogel designed for NIR-mediated chemotherapy","volume":"137","author":"Bergueiro","year":"2022","journal-title":"Biomater Adv"},{"key":"10.1016\/j.nano.2025.102802_bb0070","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.jconrel.2020.08.033","article-title":"Doxorubicin-loaded composite nanogels for cancer treatment","volume":"328","author":"Mohammadi","year":"2020","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2025.102802_bb0075","doi-asserted-by":"crossref","first-page":"2198","DOI":"10.7150\/ijbs.79651","article-title":"Crosstalk between N6-methyladenosine (m6A) modification and noncoding RNA in tumor microenvironment","volume":"19","author":"Wang","year":"2023","journal-title":"Int J Biol Sci"},{"key":"10.1016\/j.nano.2025.102802_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.101838","article-title":"Microenvironment-responsive nanocarriers for targeted bone disease therapy","volume":"50","author":"Li","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.nano.2025.102802_bb0085","doi-asserted-by":"crossref","first-page":"2303580","DOI":"10.1002\/advs.202303580","article-title":"Tumor microenvironment-activated nanocomposite for self-amplifying chemodynamic\/starvation therapy enhanced IDO-blockade tumor immunotherapy","volume":"10","author":"Bian","year":"2023","journal-title":"Adv Sci"},{"key":"10.1016\/j.nano.2025.102802_bb0090","doi-asserted-by":"crossref","first-page":"2100243","DOI":"10.1002\/adhm.202100243","article-title":"Stimuli-responsive nanotheranostics","volume":"10","author":"Hou","year":"2021","journal-title":"Adv Healthcare Mater"},{"key":"10.1016\/j.nano.2025.102802_bb0095","doi-asserted-by":"crossref","first-page":"11612","DOI":"10.1039\/D3TB01731A","article-title":"A glutathione-responsive PEGylated nanogel with doxorubicin-conjugation for cancer therapy","volume":"11","author":"Li","year":"2023","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.nano.2025.102802_bb0100","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jconrel.2023.08.019","article-title":"Polysaccharide-based tumor microenvironment-responsive drug delivery systems for cancer therapy","volume":"362","author":"Wu","year":"2023","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2025.102802_bb0105","doi-asserted-by":"crossref","first-page":"8367","DOI":"10.1039\/C8CC01795F","article-title":"Redox-responsive cisplatin nanogels for anticancer drug delivery","volume":"54","author":"Zhang","year":"2018","journal-title":"Chem Commun"},{"key":"10.1016\/j.nano.2025.102802_bb0110","doi-asserted-by":"crossref","first-page":"3897","DOI":"10.1039\/D3PY00210A","article-title":"Redox-responsive nanogels for drug-delivery: thiol\u2013maleimide and thiol\u2013disulfide exchange chemistry as orthogonal tools for fabrication and degradation","volume":"14","author":"Altinbasak","year":"2023","journal-title":"Polym Chem"},{"key":"10.1016\/j.nano.2025.102802_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.addr.2021.114075","article-title":"Responsive nanomedicines enhanced by or enhancing physical modalities to treat solid cancer tumors: preclinical and clinical evidence of safety and efficacy","volume":"181","author":"Papaioannou","year":"2022","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.nano.2025.102802_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.semcancer.2016.08.006","article-title":"Bioactive natural products in cancer prevention and therapy: progress and promise","volume":"40-41","author":"Bishayee","year":"2016","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.nano.2025.102802_bb0125","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1016\/j.lfs.2004.05.015","article-title":"Anticancer activity and mechanism of Scutellaria barbata extract on human lung cancer cell line A549","volume":"75","author":"Yin","year":"2004","journal-title":"Life Sci"},{"key":"10.1016\/j.nano.2025.102802_bb0130","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1021\/mp900243b","article-title":"Cancer therapies utilizing the camptothecins: a review of the in vivo literature","volume":"7","author":"Venditto","year":"2010","journal-title":"Mol Pharm"},{"key":"10.1016\/j.nano.2025.102802_bb0135","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1097\/00001813-199112000-00002","article-title":"Taxol: a new and effective anticancer drug","volume":"2","author":"DD. SWV","year":"1991","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.nano.2025.102802_bb0140","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1021\/bc0700842","article-title":"Development of albumin-binding camptothecin prodrugs using a peptide positional scanning library","volume":"18","author":"Bj\u00f6rn Schmid","year":"2007","journal-title":"Bioconjug Chem"},{"key":"10.1016\/j.nano.2025.102802_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104463","article-title":"Pharmacological properties and derivatives of shikonin\u2014a review in recent years","volume":"149","author":"Guo","year":"2019","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.nano.2025.102802_bb0150","doi-asserted-by":"crossref","first-page":"2083","DOI":"10.2147\/DDDT.S364441","article-title":"Shikonin could be used to treat tubal pregnancy via enhancing ferroptosis sensitivity","volume":"16","author":"Lai","year":"2022","journal-title":"Drug Des Dev Ther"},{"key":"10.1016\/j.nano.2025.102802_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154596","article-title":"Shikonin triggers GSDME-mediated pyroptosis in tumours by regulating autophagy via the ROS-MAPK14\/p38\u03b1 axis","volume":"109","author":"Ju","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.nano.2025.102802_bb0160","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.2147\/IJN.S374895","article-title":"Combined Shikonin-loaded MPEG-PCL micelles inhibits effective transition of endothelial-to-mesenchymal cells","volume":"17","author":"Li","year":"2022","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2025.102802_bb0165","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.2147\/IJN.S401570","article-title":"Promising nanomedicines of Shikonin for cancer therapy","volume":"18","author":"Yan","year":"2023","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2025.102802_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154701","article-title":"Shikonin and cisplatin synergistically overcome cisplatin resistance of ovarian cancer by inducing ferroptosis via upregulation of HMOX1 to promote Fe2+ accumulation","volume":"112","author":"Ni","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.nano.2025.102802_bb0175","article-title":"Macrophage-targeted shikonin-loaded nanogels for modulation of inflammasome activation","volume":"42","author":"Cardoso","year":"2022","journal-title":"Nanomedicine"},{"key":"10.1016\/j.nano.2025.102802_bb0180","doi-asserted-by":"crossref","first-page":"2857","DOI":"10.1039\/c1py00360g","article-title":"One-step preparation of reduction-responsive poly(ethylene glycol)-poly(amino acid)s nanogels as efficient intracellular drug delivery platforms","volume":"2","author":"Ding","year":"2011","journal-title":"Polym Chem"},{"key":"10.1016\/j.nano.2025.102802_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2024.148618","article-title":"Tumor microenvironment-responsive multifunctional nanoplatform with selective toxicity for MRI-guided photothermal\/photodynamic\/nitric oxide combined cancer therapy","volume":"481","author":"Zhou","year":"2024","journal-title":"Chem Eng J"},{"key":"10.1016\/j.nano.2025.102802_bb0190","doi-asserted-by":"crossref","first-page":"3291","DOI":"10.1021\/acs.biomac.7b00950","article-title":"Reduction-responsive polypeptide micelles for intracellular delivery of antineoplastic agent","volume":"18","author":"Xu","year":"2017","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.nano.2025.102802_bb0195","doi-asserted-by":"crossref","first-page":"1199343","DOI":"10.3389\/fbioe.2023.1199343","article-title":"PLGA-based drug delivery systems in treating bone tumors","volume":"11","author":"Qiu","year":"2023","journal-title":"Front Bioeng Biotechnol"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963425000012?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963425000012?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T02:48:27Z","timestamp":1740624507000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963425000012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":39,"alternative-id":["S1549963425000012"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2025.102802","relation":{},"ISSN":["1549-9634"],"issn-type":[{"type":"print","value":"1549-9634"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Glutathione-responsive polypeptide nanogel encapsulates Shikonin for breast cancer therapy","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2025.102802","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102802"}}