{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:38:51Z","timestamp":1793878731067,"version":"4.7.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.nano.2025.102806","type":"journal-article","created":{"date-parts":[[2025,1,22]],"date-time":"2025-01-22T11:18:28Z","timestamp":1737544708000},"page":"102806","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Soluble microneedle acupuncture patches containing melittin liposomes for the percutaneous treatment of rheumatoid arthritis"],"prefix":"10.1016","volume":"64","author":[{"given":"Tong","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Du","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuncheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoyue","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nenggui","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shihui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.nano.2025.102806_bb0005","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s10067-019-04900-y","article-title":"The association between anxiety and disease activity and quality of life in rheumatoid arthritis: a systematic review and meta-analysis","volume":"39","author":"Machin","year":"2020","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.nano.2025.102806_bb0010","doi-asserted-by":"crossref","unstructured":"Myasoedova E, Davis J, Matteson EL, Crowson CS. Is the epidemiology of rheumatoid arthritis changing? Results from a population-based incidence study, 1985-2014. Ann Rheum Dis 2020;79(4):440\u20134. https:\/\/doi.org\/10.1136\/annrheumdis-2019-216694.","DOI":"10.1136\/annrheumdis-2019-216694"},{"issue":"1637","key":"10.1016\/j.nano.2025.102806_bb0015","first-page":"177","volume":"63","author":"Drugs for rheumatoid arthritis","year":"2021","journal-title":"Med Lett Drugs Ther"},{"issue":"6","key":"10.1016\/j.nano.2025.102806_bb0020","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1136\/annrheumdis-2019-216656","article-title":"Efficacy of pharmacological treatment in rheumatoid arthritis: a systematic literature research informing the 2019 update of the EULAR recommendations for management of rheumatoid arthritis","volume":"79","author":"Kerschbaumer","year":"2020","journal-title":"Ann Rheum Dis"},{"issue":"2","key":"10.1016\/j.nano.2025.102806_bb0025","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00296-010-1718-5","article-title":"The outcomes and cost-effectiveness of intraarticular injection of the rheumatoid knee","volume":"32","author":"Chavez-Chiang","year":"2012","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.nano.2025.102806_bb0030","article-title":"The evidence for acupuncture as a treatment for rheumatologic conditions","volume":"26(1):103-+","author":"Berman","year":"2000","journal-title":"Rheum Dis Clin N Am"},{"issue":"6","key":"10.1016\/j.nano.2025.102806_bb0035","volume":"18","author":"Ramos","year":"2018","journal-title":"Acupuncture for rheumatoid arthritis Medwave"},{"issue":"4","key":"10.1016\/j.nano.2025.102806_bb0040","first-page":"251","article-title":"Treatment of rheumatoid arthritis by bee-venom acupuncture","volume":"43","author":"Chen","year":"2018","journal-title":"Zhen Ci Yan Jiu"},{"issue":"2","key":"10.1016\/j.nano.2025.102806_bb0045","first-page":"124","article-title":"Bugs as drugs, part 1: insects. The \u201cnew\u201d alternative medicine for the 21st century?","volume":"15","author":"Cherniack","year":"2010","journal-title":"Altern Med Rev"},{"issue":"4","key":"10.1016\/j.nano.2025.102806_bb0050","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3390\/toxins14040238","article-title":"Incidence rate of bee venom acupuncture related anaphylaxis: a systematic review","volume":"14","author":"Ko","year":"2022","journal-title":"Toxins (Basel)"},{"issue":"3","key":"10.1016\/j.nano.2025.102806_bb0055","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1136\/bmjopen-2021-056545","article-title":"Effectiveness and safety of bee venom pharmacopuncture for rheumatoid arthritis: a systematic review protocol","volume":"12","author":"Sung","year":"2022","journal-title":"BMJ Open"},{"issue":"5","key":"10.1016\/j.nano.2025.102806_bb0060","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3390\/molecules21050616","article-title":"Anti-inflammatory applications of Melittin, a major component of bee venom: detailed mechanism of action and adverse effects","volume":"21","author":"Lee","year":"2016","journal-title":"Molecules"},{"issue":"16","key":"10.1016\/j.nano.2025.102806_bb0065","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/molecules24162997","article-title":"Bee venom: overview of Main compounds and bioactivities for therapeutic interests","volume":"24","author":"Wehbe","year":"2019","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.nano.2025.102806_bb0070","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/toxins13030191","article-title":"Bee venom and its sub-components: characterization, pharmacology, and therapeutics","volume":"13","author":"Kim","year":"2021","journal-title":"Toxins (Basel)"},{"issue":"4","key":"10.1016\/j.nano.2025.102806_bb0075","doi-asserted-by":"crossref","first-page":"379","DOI":"10.2174\/1389203720666191202112429","article-title":"Nano-inspired technologies for peptide delivery","volume":"21","author":"Covarrubias-Zambrano","year":"2020","journal-title":"Curr Protein Pept Sci"},{"key":"10.1016\/j.nano.2025.102806_bb0080","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.actbio.2022.01.054","article-title":"Development of a hyperbranched polymer-based methotrexate nanomedicine for rheumatoid arthritis","volume":"142","author":"Marasini","year":"2022","journal-title":"Acta Biomater"},{"issue":"2","key":"10.1016\/j.nano.2025.102806_bb0085","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3390\/pharmaceutics9020012","article-title":"Liposomal formulations in clinical use: an updated review","volume":"9","author":"Bulbake","year":"2017","journal-title":"Pharmaceutics"},{"issue":"4","key":"10.1016\/j.nano.2025.102806_bb0090","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1529\/biophysj.104.043596","article-title":"Interaction of melittin with membrane cholesterol: a fluorescence approach","volume":"87","author":"Raghuraman","year":"2004","journal-title":"Biophys J"},{"issue":"1","key":"10.1016\/j.nano.2025.102806_bb0095","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ejpb.2011.01.011","article-title":"Skin penetration behaviour of liposomes as a function of their composition","volume":"79","author":"Gillet","year":"2011","journal-title":"Eur J Pharm Biopharm"},{"issue":"1\u20132","key":"10.1016\/j.nano.2025.102806_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2017.10.046","article-title":"Lipid nanocarriers as skin drug delivery systems: properties, mechanisms of skin interactions and medical applications","volume":"535","author":"Sala","year":"2018","journal-title":"Int J Pharm"},{"key":"10.1016\/j.nano.2025.102806_bb0105","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jconrel.2020.09.016","article-title":"Recent trends, challenges and future outlook of transdermal drug delivery systems for rheumatoid arthritis therapy","volume":"327","author":"Qindeel","year":"2020","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2025.102806_bb0110","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ijpharm.2019.03.033","article-title":"Flexible two-layer dissolving and safing microneedle transdermal of neurotoxin: a biocomfortable attempt to treat rheumatoid arthritis","volume":"563","author":"Yao","year":"2019","journal-title":"Int J Pharm"},{"key":"10.1016\/j.nano.2025.102806_bb0115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.lfs.2021.119877","article-title":"Panorama of dissolving microneedles for transdermal drug delivery","volume":"284","author":"Dalvi","year":"2021","journal-title":"Life Sci"},{"issue":"6","key":"10.1016\/j.nano.2025.102806_bb0120","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s11095-020-02844-6","article-title":"Microneedle mediated transdermal delivery of protein, peptide and antibody based therapeutics: current status and future considerations","volume":"37","author":"Kirkby","year":"2020","journal-title":"Pharm Res"},{"key":"10.1016\/j.nano.2025.102806_bb0125","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ijpharm.2021.120749","article-title":"Fabrication, evaluation and applications of dissolving microneedles","volume":"604","author":"Zhang","year":"2021","journal-title":"Int J Pharm"},{"issue":"5","key":"10.1016\/j.nano.2025.102806_bb0130","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/pharmaceutics11050235","article-title":"Microneedle-assisted transdermal delivery of Etanercept for rheumatoid arthritis treatment","volume":"11","author":"Cao","year":"2019","journal-title":"Pharmaceutics"},{"issue":"1\u20132","key":"10.1016\/j.nano.2025.102806_bb0135","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2016.05.006","article-title":"Systemic delivery of artemether by dissolving microneedles","volume":"508","author":"Qiu","year":"2016","journal-title":"Int J Pharm"},{"issue":"6","key":"10.1016\/j.nano.2025.102806_bb0140","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1142\/S0192415X10008457","article-title":"The anti-arthritic effects of synthetic Melittin on the complete Freund\u2019s adjuvant-induced rheumatoid arthritis model in rats","volume":"38","author":"Li","year":"2010","journal-title":"Am J Chin Med"},{"issue":"1\u20132","key":"10.1016\/j.nano.2025.102806_bb0145","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.ijpharm.2010.03.041","article-title":"Transdermal delivery of insulin using microneedle rollers in vivo","volume":"392","author":"Zhou","year":"2010","journal-title":"Int J Pharm"},{"key":"10.1016\/j.nano.2025.102806_bb0150","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ijpharm.2023.122885","article-title":"Quantification methods comparing in vitro and in vivo percutaneous permeation by microneedles and passive diffusion","volume":"638","author":"Iapichino","year":"2023","journal-title":"Int J Pharm"},{"key":"10.1016\/j.nano.2025.102806_bb0155","doi-asserted-by":"crossref","first-page":"3123","DOI":"10.2147\/IJN.S241923","article-title":"Preparation and in vitro and in vivo study of Asiaticoside-loaded Nanoemulsions and Nanoemulsions-based gels for transdermal delivery","volume":"15","author":"Li","year":"2020","journal-title":"Int J Nanomedicine"},{"issue":"11","key":"10.1016\/j.nano.2025.102806_bb0160","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1136\/ard.2010.134684","article-title":"State-of-the-art: rheumatoid arthritis","volume":"69","author":"McInnes","year":"2010","journal-title":"Ann Rheum Dis"},{"issue":"18","key":"10.1016\/j.nano.2025.102806_bb0165","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1097\/MD.0000000000019975","article-title":"Bee venom acupuncture for adhesive capsulitis a protocol for systematic review and meta-analysis","volume":"99","author":"Chen","year":"2020","journal-title":"Medicine (Baltimore)"},{"issue":"11","key":"10.1016\/j.nano.2025.102806_bb0170","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1136\/bmjopen-2014-006140","article-title":"Bee venom acupuncture for rheumatoid arthritis: a systematic review of randomised clinical trials","volume":"4","author":"Lee","year":"2014","journal-title":"BMJ Open"},{"issue":"10","key":"10.1016\/j.nano.2025.102806_bb0175","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1111\/cea.12582","article-title":"Immunological and clinical factors associated with adverse systemic reactions during the build-up phase of honeybee venom immunotherapy","volume":"45","author":"Korosec","year":"2015","journal-title":"Clin Exp Allergy"},{"issue":"5","key":"10.1016\/j.nano.2025.102806_bb0180","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1371\/journal.pone.0126971","article-title":"Risk associated with bee venom therapy: a systematic review and Meta-analysis","volume":"10","author":"Park","year":"2015","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.nano.2025.102806_bb0185","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.pneurobio.2010.06.006","article-title":"The nociceptive and anti-nociceptive effects of bee venom injection and therapy: a double-edged sword","volume":"92","author":"Chen","year":"2010","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.nano.2025.102806_bb0190","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bcp.2021.114769","article-title":"Applications and evolution of melittin, the quintessential membrane active peptide","volume":"193","author":"Guha","year":"2021","journal-title":"Biochem Pharmacol"},{"issue":"1","key":"10.1016\/j.nano.2025.102806_bb0195","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12951-020-00675-6","article-title":"Exosome-based biomimetic nanoparticles targeted to inflamed joints for enhanced treatment of rheumatoid arthritis","volume":"18","author":"Yan","year":"2020","journal-title":"J Nanobiotechnol"},{"key":"10.1016\/j.nano.2025.102806_bb0200","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jpba.2020.113642","article-title":"Analytical characterization of liposomes and other lipid nanoparticles for drug delivery","volume":"192","author":"Fan","year":"2021","journal-title":"J Pharm Biomed Anal"},{"key":"10.1016\/j.nano.2025.102806_bb0205","first-page":"24","article-title":"Solid lipid nanoparticles for drug delivery: pharmacological and biopharmaceutical aspects","volume":"7","author":"Montoto","year":"2020","journal-title":"Front Mol Biosci"},{"issue":"3","key":"10.1016\/j.nano.2025.102806_bb0210","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0939-6411(03)00021-3","article-title":"Liposomes increase skin penetration of entrapped and non-entrapped hydrophilic substances into human skin: a skin penetration and confocal laser scanning microscopy study","volume":"55","author":"Verma","year":"2003","journal-title":"Eur J Pharm Biopharm"},{"issue":"2","key":"10.1016\/j.nano.2025.102806_bb0215","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3390\/pharmaceutics10020057","article-title":"Impact of particle size and polydispersity index on the clinical applications of Lipidic Nanocarrier systems","volume":"10","author":"Danaei","year":"2018","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.nano.2025.102806_bb0220","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/s41598-023-43689-4","article-title":"Application of ensemble machine learning approach to assess the factors affecting size and polydispersity index of liposomal nanoparticles","volume":"13","author":"Hoseini","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.nano.2025.102806_bb0225","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.msec.2016.12.073","article-title":"Stavudine loaded gelatin liposomes for HIV therapy: preparation, characterization and in vitro cytotoxic evaluation","volume":"73","author":"Nayak","year":"2017","journal-title":"Mater Sci Eng C-Mater Biol Appl"},{"key":"10.1016\/j.nano.2025.102806_bb0230","doi-asserted-by":"crossref","first-page":"5977","DOI":"10.2147\/IJN.S259938","article-title":"Preparation, characterization and in vivo study of Borneol-Baicalin-liposomes for treatment of cerebral ischemia-reperfusion injury","volume":"15","author":"Zhang","year":"2020","journal-title":"Int J Nanomedicine"},{"issue":"36","key":"10.1016\/j.nano.2025.102806_bb0235","doi-asserted-by":"crossref","first-page":"7920","DOI":"10.1021\/bi100729m","article-title":"Cell-selective lysis by novel analogues of melittin against human red blood cells and Escherichia coli","volume":"49","author":"Pandey","year":"2010","journal-title":"Biochemistry"},{"issue":"1\u20132","key":"10.1016\/j.nano.2025.102806_bb0240","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.ijpharm.2005.05.005","article-title":"Cholesteryl hemisuccinate as a membrane stabilizer in dipalmitoylphosphatidylcholine liposomes containing saikosaponin-d","volume":"300","author":"Ding","year":"2005","journal-title":"Int J Pharm"},{"issue":"5","key":"10.1016\/j.nano.2025.102806_bb0250","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.ejps.2013.05.005","article-title":"Microneedles for intradermal and transdermal drug delivery","volume":"50","author":"Tuan-Mahmood","year":"2013","journal-title":"Eur J Pharm Sci"},{"issue":"1","key":"10.1016\/j.nano.2025.102806_bb0255","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1080\/1061186X.2016.1200589","article-title":"Considerations in the use of microneedles: pain, convenience, anxiety and safety","volume":"25","author":"Jeong","year":"2017","journal-title":"J Drug Target"},{"issue":"11","key":"10.1016\/j.nano.2025.102806_bb0260","doi-asserted-by":"crossref","first-page":"3504","DOI":"10.1002\/art.20626","article-title":"Antiarthritic effect of bee venom -: inhibition of inflammation mediator generation by suppression of NF-\u03baB through interaction with the p50 subunit","volume":"50","author":"Park","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.nano.2025.102806_bb0265","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s13075-022-02975-8","article-title":"Neuronal CRMP2 phosphorylation inhibition by the flavonoid, naringenin, contributes to the reversal of spinal sensitization and arthritic pain improvement","volume":"24","author":"Jiang","year":"2022","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.nano.2025.102806_bb0270","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.physbeh.2015.06.035","article-title":"Automated assessment of pain in rats using a voluntarily accessed static weight-bearing test","volume":"151","author":"Kim","year":"2015","journal-title":"Physiol Behav"},{"issue":"3","key":"10.1016\/j.nano.2025.102806_bb0275","first-page":"304","article-title":"Bone erosions in rheumatoid arthritis: recent developments in pathogenesis and therapeutic implications","volume":"18","author":"Panagopoulos","year":"2018","journal-title":"J Musculoskelet Neuronal Interact"},{"issue":"1","key":"10.1016\/j.nano.2025.102806_bb0280","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13075-020-02413-7","article-title":"Predictors of radiographic erosion and joint space narrowing progression in patients with early rheumatoid arthritis: a cohort study","volume":"23","author":"Rydell","year":"2021","journal-title":"Arthritis Res Ther"},{"issue":"1","key":"10.1016\/j.nano.2025.102806_bb0285","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41598-020-63155-9","article-title":"Imaging evaluation of the cartilage in rheumatoid arthritis patients with an x-ray phase imaging apparatus based on Talbot-Lau interferometry","volume":"10","author":"Yoshioka","year":"2020","journal-title":"Sci Rep"},{"issue":"11","key":"10.1016\/j.nano.2025.102806_bb0290","doi-asserted-by":"crossref","DOI":"10.3390\/toxins9110351","article-title":"Suppressive effects of bee venom acupuncture on paclitaxel-induced neuropathic pain in rats: mediation by spinal alpha\u2082-adrenergic receptor","volume":"9","author":"Choi","year":"2017","journal-title":"Toxins (Basel)"},{"key":"10.1016\/j.nano.2025.102806_bb0295","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1472-6882-14-431","article-title":"Perineural pretreatment of bee venom attenuated the development of allodynia in the spinal nerve ligation injured neuropathic pain model; an experimental study","volume":"14","author":"Koh","year":"2014","journal-title":"BMC Complement Altern Med"},{"issue":"8","key":"10.1016\/j.nano.2025.102806_bb0300","doi-asserted-by":"crossref","first-page":"19","DOI":"10.3390\/pharmaceutics14081625","article-title":"The finite element analysis research on microneedle design strategy and transdermal drug delivery system","volume":"14","author":"Yan","year":"2022","journal-title":"Pharmaceutics"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154996342500005X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154996342500005X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T02:48:33Z","timestamp":1740624513000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S154996342500005X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":59,"alternative-id":["S154996342500005X"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2025.102806","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Soluble microneedle acupuncture patches containing melittin liposomes for the percutaneous treatment of rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2025.102806","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102806"}}