{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:51:46Z","timestamp":1785711106971,"version":"3.56.0"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,3,30]],"date-time":"2027-03-30T00:00:00Z","timestamp":1806364800000},"content-version":"am","delay-in-days":302,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["1R01CA270783-03"],"award-info":[{"award-number":["1R01CA270783-03"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004191","name":"Novo Nordisk AS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004191","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["R01HL146736-06"],"award-info":[{"award-number":["R01HL146736-06"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.nano.2026.102933","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:58:11Z","timestamp":1774425491000},"page":"102933","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A clinically relevant retrograde intraductal injection (RIDI) for lipid nanoparticles-mediated base editing in the pancreas"],"prefix":"10.1016","volume":"74","author":[{"given":"Deepak","family":"Sahel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amita","family":"Tiyaboonchai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Wakefield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas","family":"Renner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony","family":"Jozic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Dorrell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kseniia","family":"Vlasova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namratha","family":"Turuvekere Vittala Murthy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus","family":"Grompe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Sahay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"27","key":"10.1016\/j.nano.2026.102933_bb0005","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.3748\/wjg.v27.i27.4298","article-title":"Pancreatic cancer: a review of epidemiology, trend, and risk factors","volume":"27","author":"Hu","year":"2021","journal-title":"World J Gastroenterol"},{"issue":"20","key":"10.1016\/j.nano.2026.102933_bb0010","doi-asserted-by":"crossref","first-page":"2521","DOI":"10.2217\/fon-2021-1367","article-title":"First-line gemcitabine plus nab-paclitaxel versus FOLFIRINOX for metastatic pancreatic cancer in a real-world population","volume":"18","author":"Hatashima","year":"2022","journal-title":"Future Oncol"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0015","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/s41392-024-02035-4","article-title":"Nucleic acid drugs: recent progress and future perspectives","volume":"9","author":"Sun","year":"2024","journal-title":"Signal Transduct Target Ther"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0020","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/s43586-022-00104-y","article-title":"Nanodelivery of nucleic acids","volume":"2","author":"Mendes","year":"2022","journal-title":"Nat Rev Methods Primers"},{"issue":"2","key":"10.1016\/j.nano.2026.102933_bb0025","doi-asserted-by":"crossref","first-page":"58","DOI":"10.3390\/pharmacy12020058","article-title":"A comparison of currently approved small interfering RNA (siRNA) medications to alternative treatments by costs, indications, and medicaid coverage","volume":"12","author":"Sehgal","year":"2024","journal-title":"Pharmacy"},{"issue":"7","key":"10.1016\/j.nano.2026.102933_bb0030","first-page":"487","article-title":"FDA approves mRNA-based RSV vaccine","volume":"23","author":"Mullard","year":"2024","journal-title":"Nat Rev Drug Discov"},{"issue":"6","key":"10.1016\/j.nano.2026.102933_bb0035","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1056\/NEJMoa2107454","article-title":"CRISPR-Cas9 in vivo gene editing for transthyretin amyloidosis","volume":"385","author":"Gillmore","year":"2021","journal-title":"New Engl J Med"},{"issue":"5","key":"10.1016\/j.nano.2026.102933_bb0040","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1056\/NEJMoa2309149","article-title":"CRISPR-Cas9 in vivo gene editing of KLKB1 for hereditary angioedema","volume":"390","author":"Longhurst","year":"2024","journal-title":"New Engl J Med"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.omtm.2025.101436","article-title":"Why do lipid nanoparticles target the liver? Understanding of biodistribution and liver-specific tropism","volume":"33","author":"Hosseini-Kharat","year":"2025","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"4","key":"10.1016\/j.nano.2026.102933_bb0050","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41565-020-0669-6","article-title":"Selective organ targeting (SORT) nanoparticles for tissue-specific mRNA delivery and CRISPR\u2013Cas gene editing","volume":"15","author":"Cheng","year":"2020","journal-title":"Nat Nanotechnol"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0055","doi-asserted-by":"crossref","first-page":"4021","DOI":"10.1038\/s41467-025-59136-z","article-title":"Synthesis of ionizable lipopolymers using split-Ugi reaction for pulmonary delivery of various size RNAs and gene editing","volume":"16","author":"Vlasova","year":"2025","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.nano.2026.102933_bb0060","doi-asserted-by":"crossref","first-page":"eade1444","DOI":"10.1126\/sciadv.ade1444","article-title":"Ionizable lipid nanoparticles deliver mRNA to pancreatic \u03b2 cells via macrophage-mediated gene transfer","volume":"9","author":"Melamed","year":"2023","journal-title":"Sci Adv"},{"issue":"3","key":"10.1016\/j.nano.2026.102933_bb0065","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1258\/002367707781282802","article-title":"Implications of experimental technique for analysis and interpretation of data from animal experiments: outliers and increased variability resulting from failure of intraperitoneal injection procedures","volume":"41","author":"Gaines Das","year":"2007","journal-title":"Lab Anim"},{"issue":"4","key":"10.1016\/j.nano.2026.102933_bb0070","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1089\/104303404322959551","article-title":"Comparison of adenoviral and adeno-associated viral vectors for pancreatic gene delivery in vivo","volume":"15","author":"Wang","year":"2004","journal-title":"Hum Gene Ther"},{"issue":"5","key":"10.1016\/j.nano.2026.102933_bb0075","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s11373-007-9159-1","article-title":"Efficient and persistent transduction of exocrine and endocrine pancreas by adeno-associated virus type 8","volume":"14","author":"Cheng","year":"2007","journal-title":"J Biomed Sci"},{"issue":"4","key":"10.1016\/j.nano.2026.102933_bb0080","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/MPA.0b013e31815d349b","article-title":"Pancreatic acinar and islet cell infection by low-dose SV40 administration","volume":"36","author":"Shimony","year":"2008","journal-title":"Pancreas"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0085","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.ymthe.2006.03.014","article-title":"Robust systemic transduction with AAV9 vectors in mice: efficient global cardiac gene transfer superior to that of AAV8","volume":"14","author":"Inagaki","year":"2006","journal-title":"Mol Ther"},{"issue":"2","key":"10.1016\/j.nano.2026.102933_bb0090","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/gt.2013.62","article-title":"A novel gene delivery method transduces porcine pancreatic duct epithelial cells","volume":"21","author":"Griffin","year":"2014","journal-title":"Gene Ther"},{"issue":"14","key":"10.1016\/j.nano.2026.102933_bb0095","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1101\/gad.264861.115","article-title":"Pancreatic cancer modeling using retrograde viral vector delivery and in vivo CRISPR\/Cas9-mediated somatic genome editing","volume":"29","author":"Chiou","year":"2015","journal-title":"Genes Dev"},{"issue":"4","key":"10.1016\/j.nano.2026.102933_bb0100","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1097\/00006676-199605000-00013","article-title":"Adenovirus-mediated in vivo gene transfer and expression in normal rat pancreas","volume":"12","author":"Raper","year":"1996","journal-title":"Pancreas"},{"key":"10.1016\/j.nano.2026.102933_bb0105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.omtm.2017.09.006","article-title":"Safety and efficacy of AAV retrograde pancreatic ductal gene delivery in normal and pancreatic cancer mice","volume":"8","author":"Quirin","year":"2018","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0110","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1021\/acs.accounts.1c00544","article-title":"Chemistry of lipid nanoparticles for RNA delivery","volume":"55","author":"Eygeris","year":"2021","journal-title":"Acc Chem Res"},{"issue":"9","key":"10.1016\/j.nano.2026.102933_bb0115","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/dvg.20335","article-title":"A global double-fluorescent Cre reporter mouse","volume":"45","author":"Muzumdar","year":"2007","journal-title":"Genesis"},{"issue":"12","key":"10.1016\/j.nano.2026.102933_bb0120","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/s41576-018-0059-1","article-title":"Base editing: precision chemistry on the genome and transcriptome of living cells","volume":"19","author":"Rees","year":"2018","journal-title":"Nat Rev Genet"},{"issue":"4","key":"10.1016\/j.nano.2026.102933_bb0125","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1016\/j.ymthe.2023.02.009","article-title":"A luciferase reporter mouse model to optimize in vivo gene editing validated by lipid nanoparticle delivery of adenine base editors","volume":"31","author":"Yu","year":"2023","journal-title":"Mol Ther"},{"issue":"17","key":"10.1016\/j.nano.2026.102933_bb0130","doi-asserted-by":"crossref","first-page":"6240","DOI":"10.3390\/ijms21176240","article-title":"CRISPR-Cas9 DNA base-editing and prime-editing","volume":"21","author":"Kantor","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0135","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1186\/s12967-024-05957-3","article-title":"From bench to bedside: cutting-edge applications of base editing and prime editing in precision medicine","volume":"22","author":"Xu","year":"2024","journal-title":"J Transl Med"},{"issue":"17","key":"10.1016\/j.nano.2026.102933_bb0140","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1158\/0008-5472.CAN-21-2519","article-title":"Efficient correction of oncogenic KRAS and TP53 mutations through CRISPR base editing","volume":"82","author":"Sayed","year":"2022","journal-title":"Cancer Res"},{"key":"10.1016\/j.nano.2026.102933_bb0145","doi-asserted-by":"crossref","first-page":"101400","DOI":"10.1016\/j.mam.2025.101400","article-title":"Viral and non-viral vectors for gene therapy in the treatment of bone-related disorders: molecular insights and clinical perspectives","volume":"105","author":"Ge","year":"2025","journal-title":"Mol Aspects Med"},{"issue":"5","key":"10.1016\/j.nano.2026.102933_bb0150","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.2337\/db05-1367","article-title":"2-(8-hydroxy-6-methoxy-1-oxo-1h-2-benzopyran-3-yl) propionic acid, an inhibitor of angiogenesis, ameliorates renal alterations in obese type 2 diabetic mice","volume":"55","author":"Ichinose","year":"2006","journal-title":"Diabetes"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0155","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/1743-422X-6-61","article-title":"Transduction of rat pancreatic islets with pseudotyped adeno-associated virus vectors","volume":"6","author":"Craig","year":"2009","journal-title":"Virol J"},{"issue":"3","key":"10.1016\/j.nano.2026.102933_bb0160","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.ymthe.2005.04.017","article-title":"Localized gene expression following administration of adeno-associated viral vectors via pancreatic ducts","volume":"12","author":"Loiler","year":"2005","journal-title":"Mol Ther"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0165","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11095-022-03166-5","article-title":"Biodistribution and non-linear gene expression of mRNA LNPs affected by delivery route and particle size","volume":"39","author":"Di","year":"2022","journal-title":"Pharm Res"},{"key":"10.1016\/j.nano.2026.102933_bb0170","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.jconrel.2015.08.007","article-title":"Expression kinetics of nucleoside-modified mRNA delivered in lipid nanoparticles to mice by various routes","volume":"217","author":"Pardi","year":"2015","journal-title":"J Control Release"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0175","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1038\/s42003-021-02441-2","article-title":"Ionization and structural properties of mRNA lipid nanoparticles influence expression in intramuscular and intravascular administration","volume":"4","author":"Carrasco","year":"2021","journal-title":"Commun Biol"},{"issue":"5","key":"10.1016\/j.nano.2026.102933_bb0180","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1016\/j.xphs.2022.12.026","article-title":"Effect of cholesterol content of lipid composition in mRNA-LNPs on the protein expression in the injected site and liver after local administration in mice","volume":"112","author":"Kawaguchi","year":"2023","journal-title":"J Pharm Sci"},{"issue":"2","key":"10.1016\/j.nano.2026.102933_bb0185","first-page":"187","article-title":"Improved localized mRNA delivery using lipid nanoparticles with a novel synthetic cholesterol derivative","volume":"3","author":"Sahel","year":"2025","journal-title":"RSC Pharm"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0190","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/s41467-020-14527-2","article-title":"Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA","volume":"11","author":"Patel","year":"2020","journal-title":"Nat Commun"},{"issue":"4","key":"10.1016\/j.nano.2026.102933_bb0195","doi-asserted-by":"crossref","first-page":"6709","DOI":"10.1021\/acsnano.0c10064","article-title":"Apolipoprotein E binding drives structural and compositional rearrangement of mRNA-containing lipid nanoparticles","volume":"15","author":"Sebastiani","year":"2021","journal-title":"ACS Nano"},{"issue":"24","key":"10.1016\/j.nano.2026.102933_bb0200","doi-asserted-by":"crossref","first-page":"10025","DOI":"10.1021\/acs.nanolett.2c03741","article-title":"The extent to which lipid nanoparticles require apolipoprotein E and low-density lipoprotein receptor for delivery changes with ionizable lipid structure","volume":"22","author":"Paunovska","year":"2022","journal-title":"Nano Lett"},{"issue":"6701","key":"10.1016\/j.nano.2026.102933_bb0205","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1126\/science.adk9428","article-title":"In vivo editing of lung stem cells for durable gene correction in mice","volume":"384","author":"Sun","year":"2024","journal-title":"Science"},{"issue":"40","key":"10.1016\/j.nano.2026.102933_bb0210","doi-asserted-by":"crossref","first-page":"2507657","DOI":"10.1002\/adma.202507657","article-title":"Reengineering endogenous targeting lipid nanoparticles (ENDO) for systemic delivery of mRNA to pancreas","volume":"37","author":"Isaac","year":"2025","journal-title":"Adv Mater"},{"key":"10.1016\/j.nano.2026.102933_bb0215","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2024.11.073","article-title":"Corosolic acid derivative-based lipid nanoparticles for efficient RNA delivery","volume":"378","author":"Liu","year":"2025","journal-title":"J Control Release"},{"issue":"11","key":"10.1016\/j.nano.2026.102933_bb0220","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines12112627","article-title":"Pancreatic morphology, immunology, and the pathogenesis of acute pancreatitis","volume":"12","author":"Mihoc","year":"2024","journal-title":"Biomedicines"},{"issue":"13","key":"10.1016\/j.nano.2026.102933_bb0225","doi-asserted-by":"crossref","first-page":"2547","DOI":"10.1113\/JP275879","article-title":"Intracellular rupture, exocytosis and actin interaction of endocytic vacuoles in pancreatic acinar cells: initiating events in acute pancreatitis","volume":"596","author":"Chvanov","year":"2018","journal-title":"J Physiol"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3727\/096368909788237195","article-title":"Extracellular matrix in pancreatic islets: relevance to scaffold design and transplantation","volume":"18","author":"Stendahl","year":"2009","journal-title":"Cell Transplant"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0235","doi-asserted-by":"crossref","first-page":"13457","DOI":"10.1038\/s41598-024-63898-9","article-title":"ACLS4 could be a potential therapeutic target for severe acute pancreatitis","volume":"14","author":"Guo","year":"2024","journal-title":"Sci Rep"},{"issue":"31","key":"10.1016\/j.nano.2026.102933_bb0240","doi-asserted-by":"crossref","first-page":"7046","DOI":"10.3748\/wjg.v22.i31.7046","article-title":"Therapeutic potential of targeting acinar cell reprogramming in pancreatic cancer","volume":"22","author":"Wong","year":"2016","journal-title":"World J Gastroenterol"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0245","first-page":"e202304","article-title":"Lessons from the first-in-human in vivo CRISPR\/Cas9 editing of the TTR gene by NTLA-2001 trial in patients with transthyretin amyloidosis with cardiomyopathy","volume":"2023","author":"Kotit","year":"2023","journal-title":"Glob Cardiol Sci Pract"},{"key":"10.1016\/j.nano.2026.102933_bb0250","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.omtm.2023.02.003","article-title":"Specific reprogramming of alpha cells to insulin-producing cells by short glucagon promoter-driven Pdx1 and MafA","volume":"28","author":"Guo","year":"2023","journal-title":"Mol Ther Methods Clin Dev"},{"issue":"6","key":"10.1016\/j.nano.2026.102933_bb0255","doi-asserted-by":"crossref","first-page":"216","DOI":"10.5306\/wjco.v6.i6.216","article-title":"Direct therapeutic intervention for advanced pancreatic cancer","volume":"6","author":"Takakura","year":"2015","journal-title":"World J Clin Oncol"},{"issue":"7843","key":"10.1016\/j.nano.2026.102933_bb0260","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1038\/s41586-020-03086-7","article-title":"In vivo base editing rescues Hutchinson\u2013Gilford progeria syndrome in mice","volume":"589","author":"Koblan","year":"2021","journal-title":"Nature"},{"issue":"7866","key":"10.1016\/j.nano.2026.102933_bb0265","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41586-021-03609-w","article-title":"Base editing of haematopoietic stem cells rescues sickle cell disease in mice","volume":"595","author":"Newby","year":"2021","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0270","doi-asserted-by":"crossref","first-page":"9729","DOI":"10.1038\/s41467-024-54108-1","article-title":"Base-editing corrects metabolic abnormalities in a humanized mouse model for glycogen storage disease type-Ia","volume":"15","author":"Arnaoutova","year":"2024","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.nano.2026.102933_bb0275","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41467-024-55086-0","article-title":"Gene-editing in patient and humanized-mice primary muscle stem cells rescues dysferlin expression in dysferlin-deficient muscular dystrophy","volume":"16","author":"Escobar","year":"2025","journal-title":"Nat Commun"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963426000341?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963426000341?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:27:11Z","timestamp":1785709631000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963426000341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":55,"alternative-id":["S1549963426000341"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2026.102933","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A clinically relevant retrograde intraductal injection (RIDI) for lipid nanoparticles-mediated base editing in the pancreas","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2026.102933","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102933"}}