{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:50:50Z","timestamp":1785711050061,"version":"3.56.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013058","name":"Jiangsu Provincial Key Research and Development Program","doi-asserted-by":"publisher","award":["BE2017763"],"award-info":[{"award-number":["BE2017763"]}],"id":[{"id":"10.13039\/501100013058","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.nano.2026.102950","type":"journal-article","created":{"date-parts":[[2026,4,26]],"date-time":"2026-04-26T22:26:12Z","timestamp":1777242372000},"page":"102950","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Magnetic nanoparticle carrying verbascoside suppresses oral squamous cell carcinoma progression by targeting ICAM1 via IL-6\/STAT3 axis"],"prefix":"10.1016","volume":"74","author":[{"given":"Mifang","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heming","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongming","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Shu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.nano.2026.102950_bb0005","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.carj.2018.08.001","article-title":"Essentials on oncological imaging: postoperative computed tomography and magnetic resonance imaging of oral tongue cancer","volume":"69","author":"Baba","year":"2018","journal-title":"Can Assoc Radiol J"},{"issue":"6","key":"10.1016\/j.nano.2026.102950_bb0010","first-page":"647","article-title":"Chronic mechanical irritation and oral squamous cell carcinoma: a systematic review and meta-analysis","volume":"21","author":"Gupta","year":"2021","journal-title":"Bosn J Basic Med Sci"},{"issue":"8","key":"10.1016\/j.nano.2026.102950_bb0015","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.21037\/tcr-23-1150","article-title":"Risk factors for the occurrence of infection in patients with oral squamous cell carcinoma after restorative reconstruction and its impact on recurrence and quality of life: a retrospective cohort study","volume":"12","author":"Shen","year":"2023","journal-title":"Transl Cancer Res"},{"issue":"1","key":"10.1016\/j.nano.2026.102950_bb0020","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41572-020-00224-3","article-title":"Head and neck squamous cell carcinoma","volume":"6","author":"Johnson","year":"2020","journal-title":"Nat Rev Dis Primers"},{"issue":"4","key":"10.1016\/j.nano.2026.102950_bb0025","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.gendis.2022.02.007","article-title":"Cancer chemotherapy and beyond: current status, drug candidates, associated risks and progress in targeted therapeutics","volume":"10","author":"Anand","year":"2023","journal-title":"Genes Dis"},{"issue":"43","key":"10.1016\/j.nano.2026.102950_bb0030","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000022955","article-title":"Traditional Chinese medicine for oral squamous cell carcinoma: a Bayesian network meta-analysis protocol","volume":"99","author":"Wang","year":"2020","journal-title":"Medicine"},{"issue":"5","key":"10.1016\/j.nano.2026.102950_bb0035","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/chromsci\/bmt048","article-title":"Separation of phenylpropanoid glycosides from a Chinese herb by HSCCC","volume":"52","author":"Chen","year":"2014","journal-title":"J Chromatogr Sci"},{"issue":"2","key":"10.1016\/j.nano.2026.102950_bb0040","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1007\/s00268-015-3356-2","article-title":"The global burden of esophageal cancer: a disability-adjusted life-year approach","volume":"40","author":"Di Pardo","year":"2016","journal-title":"World J Surg"},{"issue":"1","key":"10.1016\/j.nano.2026.102950_bb0045","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/1403494817715400","article-title":"The global cancer burden and human development: a review","volume":"46","author":"Fidler","year":"2018","journal-title":"Scand J Public Health"},{"key":"10.1016\/j.nano.2026.102950_bb0050","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fonc.2020.00171","article-title":"Global trends in incidence rates of primary adult liver cancers: a systematic review and Meta-analysis","volume":"10","author":"Dasgupta","year":"2020","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.nano.2026.102950_bb0055","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jsps.2017.10.012","article-title":"Applications of nanoparticle systems in drug delivery technology","volume":"26","author":"Rizvi","year":"2018","journal-title":"Saudi Pharm J"},{"issue":"8","key":"10.1016\/j.nano.2026.102950_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/jpm11080771","article-title":"The enhanced permeability and retention (EPR) effect: the significance of the concept and methods to enhance its application","volume":"11","author":"Wu","year":"2021","journal-title":"J Pers Med"},{"issue":"3","key":"10.1016\/j.nano.2026.102950_bb0065","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3390\/molecules21030342","article-title":"Nanotechnology-based drug delivery Systems for Photodynamic Therapy of Cancer: a review","volume":"21","author":"Calixto","year":"2016","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.nano.2026.102950_bb0070","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s13167-010-0001-x","article-title":"Drug delivery systems: advanced technologies potentially applicable in personalized treatments","volume":"1","author":"Coelho","year":"2010","journal-title":"EPMA J"},{"issue":"11","key":"10.1016\/j.nano.2026.102950_bb0075","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1039\/D3NA00988B","article-title":"Tackling breast cancer with gold nanoparticles: twinning synthesis and particle engineering with efficacy","volume":"6","author":"Mal","year":"2024","journal-title":"Nanoscale Adv"},{"issue":"12","key":"10.1016\/j.nano.2026.102950_bb0080","doi-asserted-by":"crossref","first-page":"3638","DOI":"10.1166\/jbn.2014.2052","article-title":"Anti-tumor activity of verbascoside loaded gold nanoparticles","volume":"10","author":"Zhang","year":"2014","journal-title":"J Biomed Nanotechnol"},{"issue":"2","key":"10.1016\/j.nano.2026.102950_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/ma15020503","article-title":"Multifunctional iron oxide magnetic nanoparticles for biomedical applications: a review","volume":"15","author":"Tran","year":"2022","journal-title":"Materials"},{"issue":"10","key":"10.1016\/j.nano.2026.102950_bb0090","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1080\/15548627.2018.1489946","article-title":"Rocaglamide enhances NK cell-mediated killing of non-small cell lung cancer cells by inhibiting autophagy","volume":"14","author":"Yao","year":"2018","journal-title":"Autophagy"},{"issue":"2","key":"10.1016\/j.nano.2026.102950_bb0095","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.1021\/acsnano.0c09122","article-title":"Highly tumor-specific and long-acting Iodine-131 microbeads for enhanced treatment of hepatocellular carcinoma with low-dose radio-chemoembolization","volume":"15","author":"Qian","year":"2021","journal-title":"ACS Nano"},{"issue":"7","key":"10.1016\/j.nano.2026.102950_bb0100","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1038\/s41565-022-01125-0","article-title":"A pyroptosis nanotuner for cancer therapy","volume":"17","author":"Chen","year":"2022","journal-title":"Nat Nanotechnol"},{"issue":"4","key":"10.1016\/j.nano.2026.102950_bb0105","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.cmet.2017.03.007","article-title":"Farnesoid X receptor regulation of the NLRP3 inflammasome underlies cholestasis-associated sepsis","volume":"25","author":"Hao","year":"2017","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.nano.2026.102950_bb0110","article-title":"Ratiometric afterglow luminescent nanoplatform enables reliable quantification and molecular imaging","volume":"13","author":"Liu","year":"2022","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.nano.2026.102950_bb0115","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.cmet.2018.11.006","article-title":"The circadian protein Period2 suppresses mTORC1 activity via recruiting Tsc1 to mTORC1 complex","volume":"29","author":"Wu","year":"2019","journal-title":"Cell Metab"},{"issue":"3","key":"10.1016\/j.nano.2026.102950_bb0120","doi-asserted-by":"crossref","first-page":"160","DOI":"10.4103\/1947-2714.128482","article-title":"Western blot: technique, theory and trouble shooting","volume":"6","author":"Liu","year":"2014","journal-title":"N Am J Med Sci"},{"issue":"1","key":"10.1016\/j.nano.2026.102950_bb0125","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1186\/s12935-021-02344-6","article-title":"E-cadherin on epithelial-mesenchymal transition in thyroid cancer","volume":"21","author":"Zhu","year":"2021","journal-title":"Cancer Cell Int"},{"issue":"1","key":"10.1016\/j.nano.2026.102950_bb0130","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF00202069","article-title":"Intercellular adhesion molecule-1","volume":"74","author":"van de Stolpe","year":"1996","journal-title":"J Mol Med (Berl)"},{"issue":"6","key":"10.1016\/j.nano.2026.102950_bb0135","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/j.biotechadv.2014.07.001","article-title":"Verbascoside--a review of its occurrence, (bio)synthesis and pharmacological significance","volume":"32","author":"Alipieva","year":"2014","journal-title":"Biotechnol Adv"},{"issue":"23","key":"10.1016\/j.nano.2026.102950_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25235609","article-title":"Production of verbascoside, isoverbascoside and phenolic acids in callus, suspension, and bioreactor cultures of Verbena officinalis and biological properties of biomass extracts","volume":"25","author":"Kubica","year":"2020","journal-title":"Molecules"},{"issue":"29","key":"10.1016\/j.nano.2026.102950_bb0145","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202502315","article-title":"Nanoparticle therapeutics in clinical perspective: classification, marketed products, and regulatory landscape","volume":"21","author":"Desai","year":"2025","journal-title":"Small"},{"issue":"3","key":"10.1016\/j.nano.2026.102950_bb0150","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1002\/JLB.2MR0220-549R","article-title":"ICAM-1: a master regulator of cellular responses in inflammation, injury resolution, and tumorigenesis","volume":"108","author":"Bui","year":"2020","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.nano.2026.102950_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.704224","article-title":"Molecular characterization and expression analysis of intercellular adhesion Molecule-1 (ICAM-1) genes in rainbow trout (Oncorhynchus mykiss) in response to viral, bacterial and parasitic challenge","volume":"12","author":"Zhai","year":"2021","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.nano.2026.102950_bb0160","doi-asserted-by":"crossref","first-page":"4867","DOI":"10.1038\/s41467-021-25189-z","article-title":"ICAM1 initiates CTC cluster formation and trans-endothelial migration in lung metastasis of breast cancer","volume":"12","author":"Taftaf","year":"2021","journal-title":"Nat Commun"},{"issue":"22","key":"10.1016\/j.nano.2026.102950_bb0165","doi-asserted-by":"crossref","first-page":"6028","DOI":"10.1158\/1078-0432.CCR-20-0400","article-title":"Potent activity of an anti-ICAM1 antibody-drug conjugate against multiple myeloma","volume":"26","author":"Sherbenou","year":"2020","journal-title":"Clin Cancer Res"},{"issue":"10","key":"10.1016\/j.nano.2026.102950_bb0170","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a016295","article-title":"IL-6 in inflammation, immunity, and disease","volume":"6","author":"Tanaka","year":"2014","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.nano.2026.102950_bb0175","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1023177","article-title":"The role of IL-6\/JAK2\/STAT3 signaling pathway in cancers","volume":"12","author":"Huang","year":"2022","journal-title":"Front Oncol"},{"key":"10.1016\/j.nano.2026.102950_bb0180","doi-asserted-by":"crossref","first-page":"177","DOI":"10.3389\/fphar.2013.00177","article-title":"The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety","volume":"4","author":"Ekor","year":"2014","journal-title":"Front Pharmacol"},{"issue":"suppl 4","key":"10.1016\/j.nano.2026.102950_bb0185","doi-asserted-by":"crossref","first-page":"S2855","DOI":"10.4103\/jpbs.jpbs_1320_25","article-title":"Treatment strategies for oral cavity and oropharyngeal squamous cell carcinoma: a systematic review of neoadjuvant chemotherapy and transoral robotic surgery","volume":"17","author":"Naik","year":"2025","journal-title":"J Pharm Bioallied Sci"},{"key":"10.1016\/j.nano.2026.102950_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2025.110880","article-title":"Post-operative radiotherapy for oral cavity squamous cell carcinoma: review of the data guiding the selection and the delineation of post-operative target volumes","volume":"207","author":"Evans","year":"2025","journal-title":"Radiother Oncol"},{"issue":"22","key":"10.1016\/j.nano.2026.102950_bb0195","doi-asserted-by":"crossref","first-page":"17255","DOI":"10.1039\/D5RA01910A","article-title":"NIR-responsive cisplatin nanoparticles for synergistic chemo-photothermal therapy of oral squamous cell carcinoma","volume":"15","author":"Liu","year":"2025","journal-title":"RSC Adv"},{"issue":"7","key":"10.1016\/j.nano.2026.102950_bb0200","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics14070697","article-title":"Multifaceted biological properties of verbascoside\/acteoside: antimicrobial, cytotoxic, anti-inflammatory, and immunomodulatory effects","volume":"14","author":"Marcetic","year":"2025","journal-title":"Antibiotics"},{"issue":"4","key":"10.1016\/j.nano.2026.102950_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28041784","article-title":"Synthesis of multi-stimuli responsive Fe(3)O(4) coated with diamonds nanocomposite for magnetic assisted chemo-Photothermal therapy","volume":"28","author":"Li","year":"2023","journal-title":"Molecules"},{"issue":"5","key":"10.1016\/j.nano.2026.102950_bb0210","doi-asserted-by":"crossref","first-page":"256","DOI":"10.23736\/S2724-6329.23.04835-0","article-title":"MicroRNA-34a-3p and its target tumor necrosis factor-alpha in the regulation of South Indian oral squamous cell carcinoma population","volume":"73","author":"Varshan","year":"2024","journal-title":"Minerva Dent Oral Sci"},{"key":"10.1016\/j.nano.2026.102950_bb0215","article-title":"OIP5-AS1 expression profiles in different stages of oral squamous cell carcinoma","volume":"180","author":"K","year":"2025","journal-title":"Arch Oral Biol"},{"issue":"1","key":"10.1016\/j.nano.2026.102950_bb0220","doi-asserted-by":"crossref","first-page":"37","DOI":"10.23736\/S2724-6329.23.04840-4","article-title":"Expression profiling of signal transducer and activator of transcription3 in oral squamous cell carcinoma in south Indian population","volume":"73","author":"Thomas","year":"2024","journal-title":"Minerva Dent Oral Sci"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963426000511?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963426000511?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:25:34Z","timestamp":1785709534000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963426000511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":44,"alternative-id":["S1549963426000511"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2026.102950","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Magnetic nanoparticle carrying verbascoside suppresses oral squamous cell carcinoma progression by targeting ICAM1 via IL-6\/STAT3 axis","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2026.102950","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102950"}}