{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:51:52Z","timestamp":1785711112339,"version":"3.56.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC112-2314-B-075-075"],"award-info":[{"award-number":["NSTC112-2314-B-075-075"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC114-2314-B-038-164-MY2"],"award-info":[{"award-number":["NSTC114-2314-B-038-164-MY2"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC112-2314-B-075-021-MY3"],"award-info":[{"award-number":["NSTC112-2314-B-075-021-MY3"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC113-2320-B-400-016"],"award-info":[{"award-number":["NSTC113-2320-B-400-016"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["CA-110-PP-23"],"award-info":[{"award-number":["CA-110-PP-23"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["CA-112-PP-23"],"award-info":[{"award-number":["CA-112-PP-23"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["BN-110-PP-23"],"award-info":[{"award-number":["BN-110-PP-23"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004737","name":"National Health Research Institutes","doi-asserted-by":"publisher","award":["BN-112-PP-23"],"award-info":[{"award-number":["BN-112-PP-23"]}],"id":[{"id":"10.13039\/501100004737","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031316","name":"Melissa Lee Cancer Foundation","doi-asserted-by":"publisher","award":["MLCF_V114_B11406"],"award-info":[{"award-number":["MLCF_V114_B11406"]}],"id":[{"id":"10.13039\/100031316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004700","name":"Taipei Medical University","doi-asserted-by":"publisher","award":["TMU113-AE1-B23"],"award-info":[{"award-number":["TMU113-AE1-B23"]}],"id":[{"id":"10.13039\/501100004700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["VGHUST114-G1-8-2"],"award-info":[{"award-number":["VGHUST114-G1-8-2"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V114C-125"],"award-info":[{"award-number":["V114C-125"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"publisher","award":["V115C-098"],"award-info":[{"award-number":["V115C-098"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.nano.2026.102957","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T12:09:05Z","timestamp":1778760545000},"page":"102957","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Nanotechnology-based reformulation of AUY922 mitigates retinal toxicity and retains potent anti-tumor activity"],"prefix":"10.1016","volume":"74","author":[{"given":"Chi-Che","family":"Hsieh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nai-Jung","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sin-Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Tzong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung-Shi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1309-6190","authenticated-orcid":false,"given":"Che-Hung","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nano.2026.102957_bb0005","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/pcmr.12472","article-title":"2-phenylethynesulphonamide (PFT-mu) enhances the anticancer effect of the novel hsp90 inhibitor NVP-AUY922 in melanoma, by reducing GSH levels","volume":"29","author":"Yeramian","year":"2016","journal-title":"Pigment Cell Melanoma Res"},{"issue":"206\u2013220","key":"10.1016\/j.nano.2026.102957_bb0010","article-title":"Phospholipid remodeling and cholesterol availability regulate intestinal Stemness and tumorigenesis","volume":"22","author":"Wang","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.nano.2026.102957_bb0015","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cellsig.2014.11.013","article-title":"HSP90 inhibitor NVP-AUY922 enhances TRAIL-induced apoptosis by suppressing the JAK2-STAT3-Mcl-1 signal transduction pathway in colorectal cancer cells","volume":"27","author":"Lee","year":"2015","journal-title":"Cell Signal"},{"key":"10.1016\/j.nano.2026.102957_bb0020","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/SLA.0000000000001467","article-title":"Preclinical study of AUY922, a novel Hsp90 inhibitor, in the treatment of esophageal adenocarcinoma","volume":"264","author":"Kosovec","year":"2016","journal-title":"Ann Surg"},{"key":"10.1016\/j.nano.2026.102957_bb0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3892\/or.2012.2074","article-title":"Antiproliferative effect of the HSP90 inhibitor NVP-AUY922 is determined by the expression of PTEN in esophageal cancer","volume":"29","author":"Bao","year":"2013","journal-title":"Oncol Rep"},{"key":"10.1016\/j.nano.2026.102957_bb0030","doi-asserted-by":"crossref","first-page":"11723","DOI":"10.18632\/oncotarget.2607","article-title":"MTOR inhibition enhances NVP-AUY922-induced autophagy-mediated KIT degradation and cytotoxicity in imatinib-resistant gastrointestinal stromal tumors","volume":"5","author":"Hsueh","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.nano.2026.102957_bb0035","doi-asserted-by":"crossref","first-page":"289","DOI":"10.2174\/1568009611313030007","article-title":"Novel HSP90 inhibitor NVP-AUY922 enhances the anti-tumor effect of temsirolimus against oral squamous cell carcinoma","volume":"13","author":"Okui","year":"2013","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1016\/j.nano.2026.102957_bb0040","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1158\/1535-7163.MCT-15-0778","article-title":"Inhibition of HSP90 by AUY922 preferentially kills mutant KRAS colon cancer cells by activating Bim through ER stress","volume":"15","author":"Wang","year":"2016","journal-title":"Mol Cancer Ther"},{"key":"10.1016\/j.nano.2026.102957_bb0045","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.jtho.2017.11.131","article-title":"Phase 2 study of the HSP-90 inhibitor AUY922 in previously treated and molecularly defined patients with advanced non-small cell lung cancer","volume":"13","author":"Felip","year":"2018","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.nano.2026.102957_bb0050","doi-asserted-by":"crossref","first-page":"37680","DOI":"10.18632\/oncotarget.8974","article-title":"Phase 1B\/2 study of the HSP90 inhibitor AUY922 plus trastuzumab in metastatic HER2-positive breast cancer patients who have progressed on trastuzumab-based regimen","volume":"7","author":"Kong","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.nano.2026.102957_bb0055","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s00280-016-3102-y","article-title":"A phase II study of the HSP90 inhibitor AUY922 in chemotherapy refractory advanced pancreatic cancer","volume":"78","author":"Renouf","year":"2016","journal-title":"Cancer Chemother Pharmacol"},{"key":"10.1016\/j.nano.2026.102957_bb0060","doi-asserted-by":"crossref","first-page":"1666","DOI":"10.1200\/JCO.2014.59.7328","article-title":"Phase I\/II study of HSP90 inhibitor AUY922 and Erlotinib for EGFR-mutant lung cancer with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors","volume":"33","author":"Johnson","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.nano.2026.102957_bb0065","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1200\/jco.2016.34.4_suppl.134","article-title":"Results of phase II trial of AUY922, a novel heat shock protein inhibitor in patients with metastatic gastrointestinal stromal tumor (GIST) and imatinib and sunitinib therapy","volume":"34","author":"Chiang","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.nano.2026.102957_bb0070","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.jsps.2017.10.012","article-title":"Applications of nanoparticle systems in drug delivery technology","volume":"26","author":"Rizvi","year":"2018","journal-title":"Saudi Pharm J"},{"key":"10.1016\/j.nano.2026.102957_bb0075","first-page":"742","article-title":"Progress in nanomedicine: approved and investigational nanodrugs","volume":"42","author":"Ventola","year":"2017","journal-title":"P T"},{"key":"10.1016\/j.nano.2026.102957_bb0080","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1126\/science.1095833","article-title":"Drug delivery systems: entering the mainstream","volume":"303","author":"Allen","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.nano.2026.102957_bb0085","doi-asserted-by":"crossref","DOI":"10.1088\/0957-4484\/22\/18\/185601","article-title":"Ultrafine PEG-coated poly(lactic-co-glycolic acid) nanoparticles formulated by hydrophobic surfactant-assisted one-pot synthesis for biomedical applications","volume":"22","author":"Chu","year":"2011","journal-title":"Nanotechnology"},{"key":"10.1016\/j.nano.2026.102957_bb0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1186\/s12929-021-00751-5","article-title":"AUY922 induces retinal toxicity through attenuating TRPM1","volume":"28","author":"Shen","year":"2021","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.nano.2026.102957_bb0095","doi-asserted-by":"crossref","first-page":"801","DOI":"10.2147\/OPTH.S3967","article-title":"Glial and endothelial blood-retinal barrier responses to amyloid-beta in the neural retina of the rat","volume":"2","author":"Anderson","year":"2008","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.nano.2026.102957_bb0100","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1167\/iovs.09-4191","article-title":"The effect of hyperglycemia on hypoperfusion-induced injury","volume":"51","author":"Holman","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.nano.2026.102957_bb0105","doi-asserted-by":"crossref","first-page":"R33","DOI":"10.1186\/bcr1996","article-title":"NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models","volume":"10","author":"Jensen","year":"2008","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.nano.2026.102957_bb0110","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1158\/0008-5472.CAN-07-5256","article-title":"NVP-AUY922: a novel heat shock protein 90 inhibitor active against xenograft tumor growth, angiogenesis, and metastasis","volume":"68","author":"Eccles","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.nano.2026.102957_bb0115","series-title":"Transforming Learning with Meaningful Technologies","first-page":"396","article-title":"Identifying critical features for formative essay feedback with artificial neural networks and backward elimination","author":"Abbas","year":"2019"},{"key":"10.1016\/j.nano.2026.102957_bb0120","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s43094-023-00551-8","article-title":"Process development and quality attributes for the freeze-drying process in pharmaceuticals, biopharmaceuticals and nanomedicine delivery: a state-of-the-art review","volume":"9","author":"Pardeshi","year":"2023","journal-title":"Future J Pharm Sci"},{"key":"10.1016\/j.nano.2026.102957_bb0125","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.preteyeres.2006.05.003","article-title":"Muller cells in the healthy and diseased retina","volume":"25","author":"Bringmann","year":"2006","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.nano.2026.102957_bb0130","first-page":"546","article-title":"Specific binding of peanut lectin to a class of retinal photoreceptor cells. A species comparison","volume":"25","author":"Blanks","year":"1984","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.nano.2026.102957_bb0135","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/j.stemcr.2018.01.017","article-title":"Quantified F-actin morphology is predictive of phagocytic capacity of stem cell-derived retinal pigment epithelium","volume":"10","author":"Muller","year":"2018","journal-title":"Stem Cell Reports"},{"key":"10.1016\/j.nano.2026.102957_bb0140","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/3813","article-title":"Rpe65 is necessary for production of 11-cis-vitamin a in the retinal visual cycle","volume":"20","author":"Redmond","year":"1998","journal-title":"Nat Genet"},{"key":"10.1016\/j.nano.2026.102957_bb0145","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1038\/nmat4718","article-title":"Mechanism of hard-nanomaterial clearance by the liver","volume":"15","author":"Tsoi","year":"2016","journal-title":"Nat Mater"},{"key":"10.1016\/j.nano.2026.102957_bb0150","doi-asserted-by":"crossref","first-page":"6136","DOI":"10.1038\/s41467-024-50568-7","article-title":"Kupffer cells determine intrahepatic traffic of PEGylated liposomal doxorubicin","volume":"15","author":"Jiang","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.nano.2026.102957_bb0155","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/s41467-017-00600-w","article-title":"Mechanistic understanding of in vivo protein corona formation on polymeric nanoparticles and impact on pharmacokinetics","volume":"8","author":"Bertrand","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.nano.2026.102957_bb0160","doi-asserted-by":"crossref","first-page":"8522","DOI":"10.1021\/acs.biomac.5c01369","article-title":"PEGylation-driven remodeling of the protein corona on PLGA nanoparticles: implications for macrophage recognition","volume":"26","author":"Spinelli","year":"2025","journal-title":"Biomacromolecules"},{"key":"10.1016\/j.nano.2026.102957_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2025.117567","article-title":"Nanoparticle-based drug carriers in transdermal and topical delivery: an in vivo review of anti-inflammatory efficacy","volume":"244","author":"Athinodorou","year":"2026","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.nano.2026.102957_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.onano.2025.100266","article-title":"Nanodiagnostics and nanotoxicology: a systematic review and meta-analysis on nanoparticle applications and safety in metabolic organs","volume":"27","author":"Murali","year":"2026","journal-title":"OpenNano"},{"key":"10.1016\/j.nano.2026.102957_bb0175","first-page":"270","article-title":"Nanoparticles in cancer therapy: strategies to penetrate and modulate the tumor microenvironment \u2013 a review","volume":"6","author":"Minh Hoang","year":"2025","journal-title":"Smart Mater Med"},{"key":"10.1016\/j.nano.2026.102957_bb0180","article-title":"Advances in nanoparticles in targeted drug delivery\u2013a review","volume":"19","author":"Islam","year":"2025","journal-title":"Results Surf Interfaces"},{"key":"10.1016\/j.nano.2026.102957_bb0185","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.nano.2018.09.018","article-title":"Smart nanoparticles assembled by endogenous molecules for siRNA delivery and cancer therapy via CD44 and EGFR dual-targeting","volume":"15","author":"Liang","year":"2019","journal-title":"Nanomedicine"},{"key":"10.1016\/j.nano.2026.102957_bb0190","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bmt.2023.09.001","article-title":"Review of the efficacy of nanoparticle-based drug delivery systems for cancer treatment","volume":"5","author":"Elumalai","year":"2024","journal-title":"Biomed Tech"},{"key":"10.1016\/j.nano.2026.102957_bb0195","article-title":"Deformable nanocarriers for enhanced drug delivery and cancer therapy","volume":"4","author":"Cao","year":"2024","journal-title":"Exploration Beijing"},{"key":"10.1016\/j.nano.2026.102957_bb0200","article-title":"Targeting the tumor microbiota in Cancer therapy basing on nanomaterials","volume":"5","author":"Niu","year":"2025","journal-title":"Exploration Beijing"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963426000584?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963426000584?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T22:27:25Z","timestamp":1785709645000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963426000584"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":40,"alternative-id":["S1549963426000584"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2026.102957","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanotechnology-based reformulation of AUY922 mitigates retinal toxicity and retains potent anti-tumor activity","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2026.102957","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102957"}}