{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:06:26Z","timestamp":1793754386176,"version":"4.6.1"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100023003","name":"NITTE University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100023003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.nano.2026.102985","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T15:55:38Z","timestamp":1783007738000},"page":"102985","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Nanostructured lipid carriers of lutein-based dissolving microneedle patch: A promising approach for the management of rheumatoid arthritis"],"prefix":"10.1016","volume":"76","author":[{"given":"Prajna","family":"Shastry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jobin","family":"Jose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kartik Bhairu","family":"Khot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gopika","family":"Gopan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa S.","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinay C.","family":"Sangamesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nano.2026.102985_bb0005","doi-asserted-by":"crossref","first-page":"407","DOI":"10.5114\/reum.2020.102006","article-title":"Baricitinib for the treatment of rheumatoid arthritis","volume":"58","author":"Urits","year":"2021","journal-title":"Reumatologia"},{"key":"10.1016\/j.nano.2026.102985_bb0010","doi-asserted-by":"crossref","first-page":"19","DOI":"10.7812\/TPP\/19.239","article-title":"Concomitant large loculated pleural and pericardial effusions in a patient with rheumatoid arthritis on methotrexate","volume":"24","author":"Whitfield","year":"2020","journal-title":"Perm J"},{"key":"10.1016\/j.nano.2026.102985_bb0015","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.ccm.2019.05.003","article-title":"Thoracic manifestations of rheumatoid arthritis","volume":"40","author":"Esposito","year":"2019","journal-title":"Clin Chest Med"},{"key":"10.1016\/j.nano.2026.102985_bb0020","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1007\/s10067-020-05320-z","article-title":"Rheumatoid arthritis\u2013associated interstitial lung disease: an overview of epidemiology, pathogenesis and management","volume":"40","author":"Dai","year":"2021","journal-title":"Clin Rheumatol"},{"key":"10.1016\/j.nano.2026.102985_bb0025","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/BOR.0000000000000788","article-title":"Glucocorticoid and opioid use in rheumatoid arthritis management","volume":"33","author":"Moore","year":"2021","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.nano.2026.102985_bb0030","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/nature01661","article-title":"Evolving concepts of rheumatoid arthritis","volume":"423","author":"Firestein","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.nano.2026.102985_bb0035","doi-asserted-by":"crossref","unstructured":"Cerhan JR, Saag KG, Merlino LA, Mikuls TR, Criswell LA. Antioxidant micronutrients and risk of rheumatoid arthritis in a cohort of older women. Am J Epidemiol 2003;157:345\u201354. doi:https:\/\/doi.org\/10.1093\/aje\/kwf205.","DOI":"10.1093\/aje\/kwf205"},{"key":"10.1016\/j.nano.2026.102985_bb0040","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1016\/S0140-6736(17)31491-5","article-title":"Novel treatment strategies in rheumatoid arthritis","volume":"389","author":"Burmester","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.nano.2026.102985_bb0045","article-title":"Interleukin-1-interleukin-17 signaling axis induces cartilage destruction and promotes experimental osteoarthritis","volume":"11","author":"Na","year":"2020","journal-title":"Front Immunol"},{"key":"10.1016\/j.nano.2026.102985_bb0050","first-page":"478","article-title":"Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies","volume":"7","author":"Da Fonseca","year":"2018","journal-title":"Bone Res"},{"key":"10.1016\/j.nano.2026.102985_bb0055","doi-asserted-by":"crossref","unstructured":"Singh JA, Saag KG, Bridges SL, Akl EA, Bannuru RR, Sullivan MC, et al. 2015 American College of Rheumatology guideline for the treatment of rheumatoid arthritis. Arthritis Care Res (Hoboken) 2016;68:1\u201325. doi:https:\/\/doi.org\/10.1002\/acr.22783.","DOI":"10.1002\/art.39480"},{"key":"10.1016\/j.nano.2026.102985_bb0060","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.3109\/10717544.2014.986309","article-title":"Microneedles for drug delivery: trends and progress","volume":"23","author":"Cheung","year":"2016","journal-title":"Drug Deliv"},{"key":"10.1016\/j.nano.2026.102985_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2022.991677","article-title":"Non-pharmacological treatment in difficult-to-treat rheumatoid arthritis","volume":"9","author":"Majnik","year":"2022","journal-title":"Front Med"},{"key":"10.1016\/j.nano.2026.102985_bb0070","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1016\/j.biopha.2018.10.078","article-title":"Microneedles: A smart approach and increasing potential for transdermal drug delivery system","volume":"109","author":"Waghule","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.nano.2026.102985_bb0075","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1080\/09205063.2024.2333627","article-title":"Fabrication and mechanical modelling of dissolvable PVA\/PVP composite microneedles with biocompatibility for efficient transdermal delivery of ibuprofen","volume":"35","author":"Xiao","year":"2024","journal-title":"J Biomater Sci Polym Ed"},{"key":"10.1016\/j.nano.2026.102985_bb0080","doi-asserted-by":"crossref","first-page":"S760","DOI":"10.1136\/annrheumdis-2019-216653","article-title":"Safety of synthetic and biological DMARDs: a systematic literature review informing the 2019 update of the EULAR recommendations for the management of rheumatoid arthritis","volume":"79","author":"Sepriano","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.nano.2026.102985_bb0085","doi-asserted-by":"crossref","unstructured":"Alimardani V, Abolmaali SS, Yousefi G, Rahiminezhad Z, Abedi M, Tamaddon A, et al. Microneedle arrays combined with nanomedicine approaches for transdermal delivery of therapeutics. J Clin Med 2021;10:1\u201333. doi:https:\/\/doi.org\/10.3390\/jcm10020181.","DOI":"10.3390\/jcm10020181"},{"key":"10.1016\/j.nano.2026.102985_bb0090","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1038\/s41551-021-00720-1","article-title":"Cryomicroneedles for transdermal cell delivery","volume":"5","author":"Chang","year":"2021","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.nano.2026.102985_bb0095","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.jconrel.2017.11.049","article-title":"Nanoemulsion as pharmaceutical carrier for dermal and transdermal drug delivery: formulation development, stability issues, basic considerations and applications","volume":"270","author":"Rai","year":"2018","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2026.102985_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jconrel.2025.113597","article-title":"Microneedle-mediated hypoxic extracellular vesicle-encapsulated selenium nanoparticles delivery to treat androgenetic alopecia","volume":"381","author":"Jing","year":"2025","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2026.102985_bb0105","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1080\/03639045.2025.2529437","article-title":"Microneedle-based wearable sensors: a new frontier in real-time biomarker monitoring","volume":"51","author":"Patil","year":"2025","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.nano.2026.102985_bb0110","first-page":"224","article-title":"Nanostructured lipid carrier: the second generation of solid lipid nanoparticle","volume":"1","author":"S","year":"2012","journal-title":"Int J Pharm Res Sch"},{"key":"10.1016\/j.nano.2026.102985_bb0115","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1080\/03639045.2021.1916521","article-title":"Development and evaluation of tofacitinib transdermal system for the treatment of rheumatoid arthritis in rats","volume":"47","author":"Li","year":"2021","journal-title":"Drug Dev Ind Pharm"},{"key":"10.1016\/j.nano.2026.102985_bb0120","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1080\/10717544.2022.2157518","article-title":"Dissolving microneedle patch-assisted transdermal delivery of methotrexate improve the therapeutic efficacy of rheumatoid arthritis","volume":"30","author":"Zhao","year":"2023","journal-title":"Drug Deliv"},{"key":"10.1016\/j.nano.2026.102985_bb0125","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.ijpharm.2019.02.011","article-title":"Combination of microneedles and microemulsions to increase celecoxib topical delivery for potential application in chemoprevention of breast cancer","volume":"560","author":"Mojeiko","year":"2019","journal-title":"Int J Pharm"},{"key":"10.1016\/j.nano.2026.102985_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.125374","article-title":"The use of cellulose, chitosan and hyaluronic acid in transdermal therapeutic management of obesity: A review","volume":"244","author":"Gopan","year":"2023","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.nano.2026.102985_bb0135","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.ijpharm.2018.02.031","article-title":"Transdermal delivery of vitamin K using dissolving microneedles for the prevention of vitamin K deficiency bleeding","volume":"541","author":"Hutton","year":"2018","journal-title":"Int J Pharm"},{"key":"10.1016\/j.nano.2026.102985_bb0140","doi-asserted-by":"crossref","DOI":"10.1136\/bmjoq-2017-000209","article-title":"Monitoring long-term oral corticosteroids","volume":"6","author":"Mundell","year":"2017","journal-title":"BMJ Open Qual"},{"key":"10.1016\/j.nano.2026.102985_bb0145","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.biopha.2017.02.099","article-title":"Anti-arthritic effect of berberine on adjuvant-induced rheumatoid arthritis in rats","volume":"89","author":"Wang","year":"2017","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.nano.2026.102985_bb0150","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.clindermatol.2008.01.011","article-title":"Lutein and zeaxanthin in eye and skin health","volume":"27","author":"Roberts","year":"2009","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.nano.2026.102985_bb0155","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.preteyeres.2012.03.002","article-title":"Lutein: more than just a filter for blue light","volume":"31","author":"K","year":"2012","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.nano.2026.102985_bb0160","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1002\/art.22912","article-title":"Antioxidants and other novel cardiovascular risk factors in subjects with rheumatoid arthritis in a large population sample","volume":"57","author":"De Pablo","year":"2007","journal-title":"Arthritis Care Res"},{"key":"10.1016\/j.nano.2026.102985_bb0165","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.colsurfa.2009.11.006","article-title":"Optimization of nanostructured lipid carriers for lutein delivery","volume":"353","author":"Liu","year":"2010","journal-title":"Colloids Surf A Physicochem Eng Asp"},{"key":"10.1016\/j.nano.2026.102985_bb0170","doi-asserted-by":"crossref","unstructured":"Tan F, Cui H, Bai C, Qing C, Xu L, Han J. Preparation, optimization, and transcorneal permeability study of lutein-loaded solid lipid nanoparticles. J Drug Deliv Sci Technol 2021;62:102362. doi:https:\/\/doi.org\/10.1016\/j.jddst.2021.102362.","DOI":"10.1016\/j.jddst.2021.102362"},{"key":"10.1016\/j.nano.2026.102985_bb0175","first-page":"145","article-title":"Development and validation of method for determination of lutein by HPLC","volume":"4","author":"Bhuyian","year":"2015","journal-title":"Artic World J Pharm Res"},{"key":"10.1016\/j.nano.2026.102985_bb0180","doi-asserted-by":"crossref","DOI":"10.3390\/polym14102026","article-title":"A design of experiments (DoE) approach to optimize cryogel manufacturing for tissue engineering applications","volume":"14","author":"Carvalho","year":"2022","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.nano.2026.102985_bb0185","doi-asserted-by":"crossref","unstructured":"Khot KB, D S S, Gopan G, Deshpande N S, Shastry P, Bandiwadekar A, et al. Enhancing selegiline hydrochloride efficacy: box Behnken-optimized liposomal delivery via intranasal route for Parkinson's disease intervention. J Liposome Res 2024;34:575\u201392. doi:https:\/\/doi.org\/10.1080\/08982104.2024.2336549.","DOI":"10.1080\/08982104.2024.2336549"},{"key":"10.1016\/j.nano.2026.102985_bb0190","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1007\/s13346-024-01656-0","article-title":"Transdermal delivery of resveratrol loaded solid lipid nanoparticle as a microneedle patch: a novel approach for the treatment of Parkinson\u2019s disease","volume":"15","author":"Bandiwadekar","year":"2025","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.nano.2026.102985_bb0195","first-page":"13","article-title":"Effect of compositions in nanostructured lipid carriers (NLC) on skin hydration and occlusion","volume":"8","author":"Loo","year":"2013","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2026.102985_bb0200","series-title":"Handb Non-Invasive Drug Deliv Syst","first-page":"59","article-title":"Emulsions and microemulsions for topical and transdermal drug delivery","author":"Lu","year":"2010"},{"key":"10.1016\/j.nano.2026.102985_bb0205","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.colsurfb.2005.08.005","article-title":"Preparation and characterization of stearic acid nanostructured lipid carriers by solvent diffusion method in an aqueous system","volume":"45","author":"Hu","year":"2005","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1016\/j.nano.2026.102985_bb0210","unstructured":"Puchalski M, Da\u0327browski P, Olejniczak W, Krukowski P, Kowalczyk P, Pola\u0144ski K. The study of silver nanoparticles by scanning electron microscopy, energy dispersive X-ray analysis and scanning tunnelling microscopy. Mater Sci Pol 2007;25:473\u20138."},{"key":"10.1016\/j.nano.2026.102985_bb0215","doi-asserted-by":"crossref","first-page":"2675","DOI":"10.1021\/acs.jchemed.0c01231","article-title":"Introducing ATR-FTIR spectroscopy through analysis of acetaminophen drugs: practical lessons for interdisciplinary and progressive learning for undergraduate students","volume":"98","author":"Zapata","year":"2021","journal-title":"J Chem Educ"},{"key":"10.1016\/j.nano.2026.102985_bb0220","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.saa.2011.07.043","article-title":"Experimental IR and Raman spectra and quantum chemical studies of molecular structures, conformers and vibrational characteristics of l-ascorbic acid and its anion and cation","volume":"84","author":"Yadav","year":"2011","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc"},{"key":"10.1016\/j.nano.2026.102985_bb0225","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1007\/s13346-021-01014-4","article-title":"Quality by design (QbD)\u2013based fabrication of atazanavir-loaded nanostructured lipid carriers for lymph targeting: bioavailability enhancement using chylomicron flow block model and toxicity studies","volume":"12","author":"Gurumukhi","year":"2022","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.nano.2026.102985_bb0230","doi-asserted-by":"crossref","unstructured":"Zheng M, Falkeborg M, Zheng Y, Yang T, Xu X. Formulation and characterization of nanostructured lipid carriers containing a mixed lipids core. Colloids Surf A Physicochem Eng Asp 2013;430:76\u201384. doi:https:\/\/doi.org\/10.1016\/j.colsurfa.2013.03.070.","DOI":"10.1016\/j.colsurfa.2013.03.070"},{"key":"10.1016\/j.nano.2026.102985_bb0235","doi-asserted-by":"crossref","unstructured":"Brito Raj S, Chandrasekhar KB, Reddy KB. Formulation, in-vitro and in-vivo pharmacokinetic evaluation of simvastatin nanostructured lipid carrier loaded transdermal drug delivery system. Futur J Pharm Sci 2019;5:9. doi:https:\/\/doi.org\/10.1186\/s43094-019-0008-7.","DOI":"10.1186\/s43094-019-0008-7"},{"key":"10.1016\/j.nano.2026.102985_bb0240","doi-asserted-by":"crossref","DOI":"10.1186\/s43094-022-00418-4","article-title":"Ex vivo permeation parameters and skin deposition of melatonin-loaded microemulsion for treatment of alopecia","volume":"8","author":"Elshall","year":"2022","journal-title":"Futur J Pharm Sci"},{"key":"10.1016\/j.nano.2026.102985_bb0245","first-page":"1687","article-title":"Fabrication of dissolving microneedles with thermal-responsive coating for NIR-triggered transdermal delivery of metformin on diabetic rats","volume":"4","author":"Liu","year":"2018","journal-title":"ACS Biomater Sci Eng"},{"key":"10.1016\/j.nano.2026.102985_bb0250","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.jsps.2023.03.007","article-title":"Formulation and characterization of thiolated chitosan\/polyvinyl acetate based microneedle patch for transdermal delivery of dydrogesterone","volume":"31","author":"Khalid","year":"2023","journal-title":"Saudi Pharm J"},{"key":"10.1016\/j.nano.2026.102985_bb0255","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cbi.2006.05.003","article-title":"Therapeutic effects of Semecarpus anacardium Linn. Nut milk extract on the changes associated with collagen and glycosaminoglycan metabolism in adjuvant arthritic Wistar rats","volume":"162","author":"Ramprasath","year":"2006","journal-title":"Chem Biol Interact"},{"key":"10.1016\/j.nano.2026.102985_bb0260","article-title":"Dissolving microneedles loading TPGS biphasic functionalized PLGA nanoparticles for efficient chemo-photothermal combined therapy of melanoma","volume":"3","author":"Peng","year":"2020","journal-title":"Adv Ther"},{"key":"10.1016\/j.nano.2026.102985_bb0265","doi-asserted-by":"crossref","unstructured":"McGrath MG, Vucen S, Vrdoljak A, Kelly A, O'Mahony C, Crean AM, et al. Production of dissolvable microneedles using an atomised spray process: effect of microneedle composition on skin penetration. Eur J Pharm Biopharm 2014;86:200\u201311. doi:https:\/\/doi.org\/10.1016\/j.ejpb.2013.04.023.","DOI":"10.1016\/j.ejpb.2013.04.023"},{"key":"10.1016\/j.nano.2026.102985_bb0270","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1007\/s11095-006-9165-4","article-title":"Skin irritation in transdermal drug delivery systems: A strategy for its reduction","volume":"24","author":"Kawahara","year":"2007","journal-title":"Pharm Res"},{"key":"10.1016\/j.nano.2026.102985_bb0275","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1208\/s12249-021-02186-5","article-title":"Transdermal delivery of curcumin-loaded solid lipid nanoparticles as microneedle patch: an in vitro and in vivo study","volume":"23","author":"Prabhu","year":"2022","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.nano.2026.102985_bb0280","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1111\/1756-185X.13602","article-title":"Rosmarinic acid attenuates inflammation in experimentally induced arthritis in Wistar rats, using Freund\u2019s complete adjuvant","volume":"22","author":"Gautam","year":"2019","journal-title":"Int J Rheum Dis"},{"key":"10.1016\/j.nano.2026.102985_bb0285","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jtcme.2017.06.003","article-title":"Anti-rheumatoid activity of ethanolic extract of Sesamum indicum seed extract in Freund\u2019s complete adjuvant induced arthritis in Wistar albino rats","volume":"8","author":"Ruckmani","year":"2018","journal-title":"J Tradit Complement Med"},{"key":"10.1016\/j.nano.2026.102985_bb0290","first-page":"57","article-title":"Open-field assessment of spontaneous activity","volume":"42","author":"Pritchett","year":"2003","journal-title":"Contemp Top Lab Anim Sci"},{"key":"10.1016\/j.nano.2026.102985_bb0295","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jep.2014.02.015","article-title":"Therapeutic effects of dichloromethane fraction of Securidaca inappendiculata on adjuvant-induced arthritis in rat","volume":"153","author":"Zuo","year":"2014","journal-title":"J Ethnopharmacol"},{"key":"10.1016\/j.nano.2026.102985_bb0300","unstructured":"Brahn E, Banquerigo ML, Firestein GS, Boyle DL, Salzman AL, Szab\u00f3 C. Collagen induced arthritis: reversal by mercaptoethylguanidine, a novel antiinflammatory agent with a combined mechanism of action. J Rheumatol 1998;25:1785\u201393."},{"key":"10.1016\/j.nano.2026.102985_bb0305","first-page":"213","article-title":"In vivo anti-inflammatory and antiarthritic activities of aqueous extracts from Thymelaea hirsuta","volume":"7","author":"Azza","year":"2015","journal-title":"Pharm Res"},{"key":"10.1016\/j.nano.2026.102985_bb0310","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-2249.2010.04293.x","article-title":"Therapeutic effects of TACI-Ig on rat with adjuvant arthritis","volume":"163","author":"Wang","year":"2011","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.nano.2026.102985_bb0315","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1002\/art.1780340804","article-title":"The latex test revisited. Rheumatoid factor testing in 8,287 rheumatic disease patients","volume":"34","author":"Wolfe","year":"1991","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.nano.2026.102985_bb0320","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/BF01964912","article-title":"An X-ray analysis of adjuvant arthritis in the rat. The effect of prednisolone and indomethacin","volume":"7","author":"Blackham","year":"1977","journal-title":"Agents Actions"},{"key":"10.1016\/j.nano.2026.102985_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114684","article-title":"5-Aminolevulinic acid-loaded dissolving microneedle Array for photodynamic therapy of rheumatoid arthritis on rats","volume":"162","author":"Li","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.nano.2026.102985_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119508","article-title":"Fabrication, characterization and comparison of \u03b1-arbutin loaded dissolving and hydrogel forming microneedles","volume":"586","author":"Aung","year":"2020","journal-title":"Int J Pharm"},{"key":"10.1016\/j.nano.2026.102985_bb0335","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1007\/s13346-016-0332-9","article-title":"Rapidly dissolving polymeric microneedles for minimally invasive intraocular drug delivery","volume":"6","author":"Thakur","year":"2016","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.nano.2026.102985_bb0340","doi-asserted-by":"crossref","DOI":"10.3390\/mi13081304","article-title":"Simvastatin loaded dissolvable microneedle patches with improved pharmacokinetic performance","volume":"13","author":"Zulcaif","year":"2022","journal-title":"Micromachines"},{"key":"10.1016\/j.nano.2026.102985_bb0345","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1208\/s12249-019-1611-9","article-title":"Fabrication and characterization of Thiolated chitosan microneedle patch for transdermal delivery of tacrolimus","volume":"21","author":"Ahmad","year":"2020","journal-title":"AAPS PharmSciTech"},{"key":"10.1016\/j.nano.2026.102985_bb0350","first-page":"230","article-title":"Evaluation of the anti arthritic potential of the genus strobilanthus","volume":"4","author":"S.","year":"2012","journal-title":"Int J Drug Dev Res"},{"key":"10.1016\/j.nano.2026.102985_bb0355","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1111\/cei.12372","article-title":"Emerging role of leptin in rheumatoid arthritis","volume":"177","author":"Tian","year":"2014","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.nano.2026.102985_bb0360","doi-asserted-by":"crossref","first-page":"4015","DOI":"10.1002\/art.23063","article-title":"Collagen-induced arthritis as a model of hyperalgesia: functional and cellular analysis of the analgesic actions of tumor necrosis factor blockade","volume":"56","author":"Inglis","year":"2007","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.nano.2026.102985_bb0365","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0260423","article-title":"Effects of different doses of complete Freund\u2019s adjuvant on nociceptive behaviour and inflammatory parameters in polyarthritic rat model mimicking rheumatoid arthritis","volume":"16","author":"Noh","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.nano.2026.102985_bb0370","first-page":"1541","article-title":"Microneedle-mediated transdermal delivery of nanostructured lipid carriers for alkaloids from Aconitum sinomontanum","volume":"46","author":"Guo","year":"2018","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"10.1016\/j.nano.2026.102985_bb0375","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2022.102021","article-title":"Talaromyces purpurogenus from a marine-polluted environment inhibits pro-inflammatory markers in LPS-stimulated RAW 264.7 cells and in carrageenan-induced paw edema","volume":"34","author":"Teles","year":"2022","journal-title":"J King Saud Univ Sci"},{"key":"10.1016\/j.nano.2026.102985_bb0380","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jtcme.2021.07.006","article-title":"Anti-rheumatoid activity of a hexane-insoluble fraction from Plantago major in female Wistar rats induced by complete Freund\u2019s adjuvant","volume":"12","author":"Triastuti","year":"2022","journal-title":"J Tradit Complement Med"},{"key":"10.1016\/j.nano.2026.102985_bb0385","first-page":"289","article-title":"Nanostructured lipid carrier-loaded hyaluronic acid microneedles for controlled dermal delivery of a lipophilic molecule","volume":"9","author":"Lee","year":"2013","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2026.102985_bb0390","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev.immunol.14.1.397","article-title":"Role of cytokines in rheumatoid arthritis","volume":"14","author":"Feldmann","year":"1996","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.nano.2026.102985_bb0395","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jconrel.2021.07.005","article-title":"Polymeric microneedle-mediated transdermal delivery of melittin for rheumatoid arthritis treatment","volume":"336","author":"Du","year":"2021","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2026.102985_bb0400","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.freeradbiomed.2008.06.019","article-title":"The non-provitamin A carotenoid, lutein, inhibits NF-\u03baB-dependent gene expression through redox-based regulation of the phosphatidylinositol 3-kinase\/PTEN\/Akt and NF-\u03baB-inducing kinase pathways: role of H2O2 in NF-\u03baB activation","volume":"45","author":"Kim","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"10.1016\/j.nano.2026.102985_bb0405","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24108944","article-title":"The role of inflammation in age-associated changes in red blood system","volume":"24","author":"Wacka","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.nano.2026.102985_bb0410","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-016-1500-7","article-title":"Anti-arthritic activity of ethanol extract of Claoxylon indicum on Freund\u2019s complete adjuvant-induced arthritis in mice","volume":"17","author":"Chen","year":"2017","journal-title":"BMC Complement Altern Med"},{"key":"10.1016\/j.nano.2026.102985_bb0415","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.addr.2003.10.023","article-title":"Microneedles for transdermal drug delivery","volume":"56","author":"Prausnitz","year":"2004","journal-title":"Adv Drug Deliv Rev"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963426000869?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963426000869?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T11:12:35Z","timestamp":1788606755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963426000869"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":83,"alternative-id":["S1549963426000869"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2026.102985","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nanostructured lipid carriers of lutein-based dissolving microneedle patch: A promising approach for the management of rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2026.102985","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102985"}}