{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T15:41:58Z","timestamp":1786117318707,"version":"build-2736575974"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.nano.2026.102986","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T07:07:59Z","timestamp":1782976079000},"page":"102986","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Surface-charge-engineered magnetic silk fibroin nanocarriers for pH-responsive 5-fluorouracil delivery and in vitro magnetic localization"],"prefix":"10.1016","volume":"75","author":[{"given":"Yixin","family":"Luo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zifan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qitai","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiannan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianmei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nano.2026.102986_bb0005","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.colsurfb.2014.12.041","article-title":"Nanotechnological carriers for cancer chemotherapy: the state of the art","volume":"126","author":"Estanqueiro","year":"2015","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"11","key":"10.1016\/j.nano.2026.102986_bb0010","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/nmat3776","article-title":"Stimuli-responsive nanocarriers for drug delivery","volume":"12","author":"Mura","year":"2013","journal-title":"Nat Mater"},{"issue":"5","key":"10.1016\/j.nano.2026.102986_bb0015","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13050755","article-title":"Bio- and hemo-compatible silk fibroin PEGylated nanocarriers for 5-fluorouracil chemotherapy in colorectal cancer: in vitro studies","volume":"13","author":"Hudita","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.nano.2026.102986_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2025.125931","article-title":"Breaking barriers with pH-responsive nanocarriers: a new frontier in precision oncology","volume":"682","author":"Tapponi","year":"2025","journal-title":"Int J Pharm"},{"key":"10.1016\/j.nano.2026.102986_bb0025","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.ijpharm.2018.11.030","article-title":"Magnetic-silk\/polyethyleneimine core-shell nanoparticles for targeted gene delivery into human breast cancer cells","volume":"555","author":"Song","year":"2019","journal-title":"Int J Pharm"},{"issue":"2","key":"10.1016\/j.nano.2026.102986_bb0030","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.jconrel.2010.11.007","article-title":"Silk fibroin as a vehicle for drug delivery applications","volume":"150","author":"Wenk","year":"2011","journal-title":"J Control Release"},{"key":"10.1016\/j.nano.2026.102986_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.124494","article-title":"Advancements in silk fibroin and silk sericin-based biomaterial applications for cancer therapy and wound dressing formulation: a comprehensive review","volume":"662","author":"Hassan","year":"2024","journal-title":"Int J Pharm"},{"issue":"12","key":"10.1016\/j.nano.2026.102986_bb0040","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1002\/adhm.201300034","article-title":"pH-dependent anticancer drug release from silk nanoparticles","volume":"2","author":"Seib","year":"2013","journal-title":"Adv Healthc Mater"},{"issue":"5","key":"10.1016\/j.nano.2026.102986_bb0045","doi-asserted-by":"crossref","DOI":"10.3390\/biomimetics9050295","article-title":"The emerging role of silk fibroin for the development of novel drug delivery systems","volume":"9","author":"Pollini","year":"2024","journal-title":"Biomimetics"},{"issue":"1","key":"10.1016\/j.nano.2026.102986_bb0050","doi-asserted-by":"crossref","DOI":"10.1080\/15440478.2022.2163028","article-title":"Silk fibroin\/silk braiding fabric composite grafts via layer-by-layer self-assembly: water permeability and cytocompatibility","volume":"20","author":"Yu","year":"2023","journal-title":"J Nat Fibers"},{"issue":"2","key":"10.1016\/j.nano.2026.102986_bb0055","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1080\/17435889.2025.2585164","article-title":"Silk fibroin-based nanocarriers for anticancer drug delivery: advances, mechanisms, and future perspectives","volume":"21","author":"He","year":"2026","journal-title":"Nanomedicine"},{"key":"10.1016\/j.nano.2026.102986_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2024.137121","article-title":"Silk fibroin nanoparticles for locoregional cancer therapy: Preliminary biodistribution in a murine model and microfluidic GMP-like production","volume":"282","author":"Ferrera","year":"2024","journal-title":"Int J Biol Macromol"},{"issue":"6","key":"10.1016\/j.nano.2026.102986_bb0065","doi-asserted-by":"crossref","DOI":"10.1088\/1748-605X\/ad8850","article-title":"Silk fibroin microspheres with photothermal nanocarrier encapsulation for anticancer drug delivery","volume":"19","author":"Lu","year":"2024","journal-title":"Biomed Mater"},{"key":"10.1016\/j.nano.2026.102986_bb0070","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.matlet.2017.03.064","article-title":"A novel preparation method for surface coated superparamagnetic Fe3O4 nanoparticles with vitamin C and sucrose","volume":"196","author":"Aghazadeh","year":"2017","journal-title":"Mater Lett"},{"issue":"2","key":"10.1016\/j.nano.2026.102986_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2023.108710","article-title":"Functional nanoemulsions: controllable low-energy nanoemulsification and advanced biomedical application","volume":"35","author":"Zhang","year":"2024","journal-title":"Chin Chem Lett"},{"key":"10.1016\/j.nano.2026.102986_bb0080","doi-asserted-by":"crossref","first-page":"8437","DOI":"10.2147\/IJN.S477652","article-title":"Surface engineering of magnetic iron oxide nanoparticles for breast cancer diagnostics and drug delivery","volume":"19","author":"Xie","year":"2024","journal-title":"Int J Nanomedicine"},{"issue":"11","key":"10.1016\/j.nano.2026.102986_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/jfb15110340","article-title":"Synthesis, functionalization, and biomedical applications of iron oxide nanoparticles (IONPs)","volume":"15","author":"Salehirozveh","year":"2024","journal-title":"J Function Biomater"},{"issue":"6","key":"10.1016\/j.nano.2026.102986_bb0090","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1021\/acsbiomaterials.7b00153","article-title":"Magnetic-silk core-shell nanoparticles as potential carriers for targeted delivery of curcumin into human breast cancer cells","volume":"3","author":"Song","year":"2017","journal-title":"ACS Biomater Sci Eng"},{"issue":"1","key":"10.1016\/j.nano.2026.102986_bb0095","doi-asserted-by":"crossref","DOI":"10.1007\/s10544-024-00698-y","article-title":"SPIONs: Superparamagnetic iron oxide-based nanoparticles for the delivery of microRNAi-therapeutics in cancer","volume":"26","author":"Kara","year":"2024","journal-title":"Biomed Microdevices"},{"issue":"8","key":"10.1016\/j.nano.2026.102986_bb0100","doi-asserted-by":"crossref","DOI":"10.3390\/jfb15080227","article-title":"Multifunctional iron oxide nanoparticles as promising magnetic biomaterials in drug delivery: a review","volume":"15","author":"Vasic","year":"2024","journal-title":"J Function Biomater"},{"key":"10.1016\/j.nano.2026.102986_bb0105","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2024.1382085","article-title":"Development of high-efficiency superparamagnetic drug delivery system with MPI imaging capability","volume":"12","author":"Bai","year":"2024","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.nano.2026.102986_bb0110","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.jcis.2021.03.086","article-title":"Stiffness-tuneable nanocarriers for controlled delivery of ASC-J9 into colorectal cancer cells","volume":"594","author":"Tomeh","year":"2021","journal-title":"J Colloid Interface Sci"},{"key":"10.1016\/j.nano.2026.102986_bb0115","doi-asserted-by":"crossref","first-page":"6253","DOI":"10.2147\/IJN.S459710","article-title":"Smart nanoplatforms responding to the tumor microenvironment for precise drug delivery in cancer therapy","volume":"19","author":"Wang","year":"2024","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2026.102986_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112549","article-title":"Peptide-functionalised magnetic silk nanoparticles produced by a swirl mixer for enhanced anticancer activity of ASC-J9","volume":"216","author":"Tomeh","year":"2022","journal-title":"Colloid Surf B"},{"issue":"10","key":"10.1016\/j.nano.2026.102986_bb0125","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11100494","article-title":"Silk fibroin as a functional biomaterial for drug and gene delivery","volume":"11","author":"Tomeh","year":"2019","journal-title":"Pharmaceutics"},{"issue":"7","key":"10.1016\/j.nano.2026.102986_bb0130","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics15071811","article-title":"Microfluidic-assisted ZIF-silk-polydopamine nanoparticles as promising drug carriers for breast cancer therapy","volume":"15","author":"Gao","year":"2023","journal-title":"Pharmaceutics"},{"issue":"3","key":"10.1016\/j.nano.2026.102986_bb0135","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1021\/acsbiomaterials.4c02389","article-title":"Dimethylcurcumin and copper sulfate-loaded silk nanoparticles for synergistic therapy against breast cancer","volume":"11","author":"Zhang","year":"2025","journal-title":"ACS Biomater Sci Eng"},{"issue":"1","key":"10.1016\/j.nano.2026.102986_bb0140","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics17010095","article-title":"Efficient and rapid microfluidics production of bio-inspired nanoparticles derived from silkworm for enhanced breast cancer treatment","volume":"17","author":"Mansor","year":"2025","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.nano.2026.102986_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2022.121762","article-title":"Optimization of large-scale manufacturing of biopolymeric and lipid nanoparticles using microfluidic swirl mixers","volume":"620","author":"Tomeh","year":"2022","journal-title":"Int J Pharm"},{"issue":"4","key":"10.1016\/j.nano.2026.102986_bb0150","doi-asserted-by":"crossref","DOI":"10.3390\/nano15040285","article-title":"Magnetic nanoparticles and drug delivery systems for anti-cancer applications: a review","volume":"15","author":"Graham","year":"2025","journal-title":"Nanomaterials (Basel)"},{"issue":"2","key":"10.1016\/j.nano.2026.102986_bb0155","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/j.actbio.2013.09.026","article-title":"Woven silk fabric-reinforced silk nanofibrous scaffolds for regenerating load-bearing soft tissues","volume":"10","author":"Han","year":"2014","journal-title":"Acta Biomater"},{"issue":"2","key":"10.1016\/j.nano.2026.102986_bb0160","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.jmmm.2010.09.009","article-title":"Development of citrate-stabilized Fe3O4 nanoparticles: conjugation and release of doxorubicin for therapeutic applications","volume":"323","author":"Nigam","year":"2011","journal-title":"J Magn Magn Mater"},{"key":"10.1016\/j.nano.2026.102986_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmmm.2022.169140","article-title":"Improvement of the saturation magnetization of PEG coated superparamagnetic iron oxide nanoparticles","volume":"551","author":"Karaagac","year":"2022","journal-title":"J Magn Magn Mater"},{"key":"10.1016\/j.nano.2026.102986_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmmm.2022.169903","article-title":"Synthesis of Fe3O4 at different reaction temperatures and investigation of its magnetic properties on giant magnetoresistance (GMR) sensors for bio-detection applications","volume":"563","author":"Antarnusa","year":"2022","journal-title":"J Magn Magn Mater"},{"key":"10.1016\/j.nano.2026.102986_bb0175","article-title":"CD44-targeted and pH-degradable hollow mesoporous silica nanocarriers for cancer therapy","volume":"117","author":"Tsai","year":"2026","journal-title":"J Drug Deliv Sci Technol"},{"issue":"40","key":"10.1016\/j.nano.2026.102986_bb0180","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202513567","article-title":"Tumor microenvironment-responsive nanomedicines for potentiating cancer immunotherapy","volume":"12","author":"Huang","year":"2025","journal-title":"Adv Sci"},{"key":"10.1016\/j.nano.2026.102986_bb0185","doi-asserted-by":"crossref","first-page":"705","DOI":"10.2147\/IJN.S504629","article-title":"Design of pH-responsive nanomaterials based on the tumor microenvironment","volume":"20","author":"Liu","year":"2025","journal-title":"Int J Nanomedicine"},{"issue":"11","key":"10.1016\/j.nano.2026.102986_bb0190","doi-asserted-by":"crossref","DOI":"10.1007\/s11051-023-05860-w","article-title":"Quantification of the efficiency of magnetic targeting of nanoparticles using finite element analysis","volume":"25","author":"Casallas","year":"2023","journal-title":"J Nanopart Res"},{"issue":"3","key":"10.1016\/j.nano.2026.102986_bb0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms27031262","article-title":"Hemocompatibility evaluation of PEGylated bovine hemoglobin","volume":"27","author":"Wang","year":"2026","journal-title":"Int J Mol Sci"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963426000870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963426000870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:31:50Z","timestamp":1786023110000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963426000870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":39,"alternative-id":["S1549963426000870"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2026.102986","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Surface-charge-engineered magnetic silk fibroin nanocarriers for pH-responsive 5-fluorouracil delivery and in vitro magnetic localization","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2026.102986","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"102986"}}