{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:47:47Z","timestamp":1791863267006,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Guangdong Provincial Natural Science Foundation","doi-asserted-by":"publisher","award":["2023A1515011707"],"award-info":[{"award-number":["2023A1515011707"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32100762"],"award-info":[{"award-number":["32100762"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.nano.2026.103018","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T15:07:47Z","timestamp":1788793667000},"page":"103018","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A bibliometric analysis of nanoparticle-based therapeutic strategies for pancreatic cancer (2002\u20132026): Global trends, thematic shifts, and translational frontiers"],"prefix":"10.1016","volume":"77","author":[{"given":"Yunsheng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongde","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fenyong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianlin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinfang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengwei","family":"Kou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.nano.2026.103018_bb0005","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1001\/jama.2021.13027","article-title":"Pancreatic cancer: a review","volume":"326","author":"Park","year":"2021","journal-title":"JAMA"},{"issue":"2","key":"10.1016\/j.nano.2026.103018_bb0010","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1097\/JS9.0000000000003864","article-title":"Asia\u2019s accelerating burden of early-onset pancreatic cancer: a 32-year global comparative analysis using GBD 2021","volume":"112","author":"Ye","year":"2025","journal-title":"Int J Surg"},{"issue":"1","key":"10.1016\/j.nano.2026.103018_bb0015","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1053\/j.gastro.2019.08.032","article-title":"Long-term risk of malignancy in branch-duct intraductal papillary mucinous neoplasms","volume":"158","author":"Oyama","year":"2020","journal-title":"Gastroenterology"},{"issue":"11","key":"10.1016\/j.nano.2026.103018_bb0020","doi-asserted-by":"crossref","first-page":"3643","DOI":"10.1245\/s10434-013-3042-2","article-title":"Incidentally discovered pancreatic intraepithelial neoplasia: what is its clinical significance?","volume":"20","author":"Konstantinidis","year":"2013","journal-title":"Ann Surg Oncol"},{"issue":"7","key":"10.1016\/j.nano.2026.103018_bb0025","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1093\/annonc\/mdr541","article-title":"Cigarette smoking and pancreatic cancer: an analysis from the international pancreatic cancer case-control consortium (Panc4)","volume":"23","author":"Bosetti","year":"2012","journal-title":"Ann Oncol"},{"key":"10.1016\/j.nano.2026.103018_bb0030","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12885-016-2241-1","article-title":"Association between alcohol intake and the risk of pancreatic cancer: a dose-response meta-analysis of cohort studies","volume":"16","author":"Wang","year":"2016","journal-title":"BMC Cancer"},{"issue":"3","key":"10.1016\/j.nano.2026.103018_bb0035","doi-asserted-by":"crossref","first-page":"e137","DOI":"10.1016\/S2468-2667(18)30267-6","article-title":"Emerging cancer trends among young adults in the USA: analysis of a population-based cancer registry","volume":"4","author":"Sung","year":"2019","journal-title":"Lancet Public Health"},{"issue":"3","key":"10.1016\/j.nano.2026.103018_bb0040","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1158\/1055-9965.EPI-08-0880","article-title":"Alcohol intake and pancreatic cancer risk: a pooled analysis of fourteen cohort studies","volume":"18","author":"Genkinger","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"23","key":"10.1016\/j.nano.2026.103018_bb0045","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1001\/jama.2018.6228","article-title":"Association between inherited germline mutations in cancer predisposition genes and risk of pancreatic cancer","volume":"319","author":"Hu","year":"2018","journal-title":"Jama"},{"issue":"19","key":"10.1016\/j.nano.2026.103018_bb0050","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.1056\/NEJMoa1011923","article-title":"FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer","volume":"364","author":"Conroy","year":"2011","journal-title":"N Engl J Med"},{"issue":"2","key":"10.1016\/j.nano.2026.103018_bb0055","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/SLA.0000000000002705","article-title":"Oncological benefits of neoadjuvant chemoradiation with gemcitabine versus upfront surgery in patients with borderline resectable pancreatic cancer: a prospective, randomized, open-label, multicenter phase 2\/3 trial","volume":"268","author":"Jang","year":"2018","journal-title":"Ann Surg"},{"issue":"23","key":"10.1016\/j.nano.2026.103018_bb0060","doi-asserted-by":"crossref","first-page":"21614","DOI":"10.1021\/acsnano.5c04036","article-title":"Virus-like nanoparticles deliver small interfering RNA to pancreatic cancer cells through filopodia-mediated internalization","volume":"19","author":"Yi","year":"2025","journal-title":"ACS Nano"},{"issue":"1","key":"10.1016\/j.nano.2026.103018_bb0065","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1186\/s12885-025-14356-w","article-title":"Enhanced anti-cancer effect of AMTB hydrochloride via chitosan nanoparticles in pancreatic cancer","volume":"25","author":"Liu","year":"2025","journal-title":"BMC Cancer"},{"key":"10.1016\/j.nano.2026.103018_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2025.123255","article-title":"Bioactive polymers as stimulus-responsive anti-metastatic combination agents to treat pancreatic cancer","volume":"320","author":"Panja","year":"2025","journal-title":"Biomaterials"},{"issue":"2","key":"10.1016\/j.nano.2026.103018_bb0075","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/s41573-020-0090-8","article-title":"Engineering precision nanoparticles for drug delivery","volume":"20","author":"Mitchell","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.nano.2026.103018_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2024.125067","article-title":"Gold nanoparticles decorated FOLFIRINOX loaded liposomes for synergistic therapy of pancreatic cancer","volume":"669","author":"Yilmaz","year":"2025","journal-title":"Int J Pharm"},{"issue":"1","key":"10.1016\/j.nano.2026.103018_bb0085","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12943-025-02325-7","article-title":"Advancing pancreatic cancer therapy by mesothelin-specific nanobody conjugation","volume":"24","author":"Yi","year":"2025","journal-title":"Mol Cancer"},{"issue":"6","key":"10.1016\/j.nano.2026.103018_bb0090","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1021\/acsabm.5c00179","article-title":"Expression of a RAS degrader via synthetic nanocarrier-mediated mRNA delivery reduces pancreatic tumors","volume":"8","author":"Escher","year":"2025","journal-title":"ACS Appl Bio Mater"},{"key":"10.1016\/j.nano.2026.103018_bb0095","article-title":"Bibliometric analysis of NMDA receptors: 2015\u20132024","volume":"16","author":"Liu","year":"2025","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.nano.2026.103018_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1692556","article-title":"A bibliometric analysis of vaccine research on Chikungunya virus: contributors, trends, and emerging frontiers","volume":"16","author":"Shao","year":"2025","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.nano.2026.103018_bb0105","article-title":"Therapeutic shifts and scientific influence in treatment-resistant depression research: a data-driven perspective","volume":"6","author":"Liu","year":"2026","journal-title":"Biol Psychiatry Glob Open Sci"},{"issue":"3","key":"10.1016\/j.nano.2026.103018_bb0110","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1007\/s00210-025-04679-7","article-title":"Global hotspots and trends in AMPA receptor research (2000\u20132025): a bibliometric and visualization analysis","volume":"399","author":"Liu","year":"2026","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"issue":"2","key":"10.1016\/j.nano.2026.103018_bb0115","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1007\/s00210-025-04540-x","article-title":"Mapping the evolution of kainate receptor research over five decades: trends, hotspots, and emerging frontiers","volume":"399","author":"Liu","year":"2026","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.nano.2026.103018_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102283","article-title":"Physical activity, sedentary behaviour, and cognitive function among older adults: a bibliometric analysis from 2004 to 2024","volume":"97","author":"Yang","year":"2024","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.nano.2026.103018_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102285","article-title":"Parkinson\u2019s disease diagnosis using deep learning: a bibliometric analysis and literature review","volume":"96","author":"Abumalloh","year":"2024","journal-title":"Ageing Res Rev"},{"issue":"4","key":"10.1016\/j.nano.2026.103018_bb0130","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/j.joi.2017.08.007","article-title":"bibliometrix: an R-tool for comprehensive science mapping analysis","volume":"11","author":"Aria","year":"2017","journal-title":"J Informet"},{"issue":"18","key":"10.1016\/j.nano.2026.103018_bb0135","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.1056\/NEJMoa1304369","article-title":"Increased survival in pancreatic cancer with nab-paclitaxel plus gemcitabine","volume":"369","author":"Von Hoff","year":"2013","journal-title":"N Engl J Med"},{"issue":"10018","key":"10.1016\/j.nano.2026.103018_bb0140","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0140-6736(15)00986-1","article-title":"Nanoliposomal irinotecan with fluorouracil and folinic acid in metastatic pancreatic cancer after previous gemcitabine-based therapy (NAPOLI-1): a global, randomised, open-label, phase 3 trial","volume":"387","author":"Wang-Gillam","year":"2016","journal-title":"Lancet"},{"issue":"7963","key":"10.1016\/j.nano.2026.103018_bb0145","doi-asserted-by":"crossref","first-page":"144+","DOI":"10.1038\/s41586-023-06063-y","article-title":"Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer","volume":"618","author":"Rojas","year":"2023","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.nano.2026.103018_bb0150","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.20517\/evcna.2025.39","article-title":"Tumor-targeted multifunctional extracellular vesicles as drug carriers for lung cancer therapy","volume":"6","author":"Amreddy","year":"2025","journal-title":"Extracell Vesicles Circul Nucl Acids"},{"key":"10.1016\/j.nano.2026.103018_bb0155","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.omto.2018.12.005","article-title":"A phase I\u2013II study using Rexin-G tumor-targeted retrovector encoding a dominant-negative cyclin G1 inhibitor for advanced pancreatic cancer","volume":"12","author":"Chawla","year":"2019","journal-title":"Mol Ther Oncol"},{"issue":"8108","key":"10.1016\/j.nano.2026.103018_bb0160","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1038\/s41586-026-10158-7","article-title":"Pancreatic-targeted lipid nanoparticles based on organ capsule filtration","volume":"652","author":"Lei","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.nano.2026.103018_bb0165","doi-asserted-by":"crossref","DOI":"10.1038\/s41591-026-04538-9","article-title":"KRAS-G12D inhibitor HRS-4642 plus chemotherapy in advanced KRAS(G12D)-mutant pancreatic cancer: a phase 1b\/2 trial","author":"Cui","year":"2026","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.nano.2026.103018_bb0170","doi-asserted-by":"crossref","first-page":"165","DOI":"10.20517\/evcna.2025.161","article-title":"80 years of extracellular vesicles: from discovery to clinical translation","volume":"7","author":"Li","year":"2026","journal-title":"Extracell Vesicles Circul Nucl Acids"},{"issue":"2","key":"10.1016\/j.nano.2026.103018_bb0175","doi-asserted-by":"crossref","first-page":"180","DOI":"10.20517\/evcna.2023.68","article-title":"Potential clinical applications of extracellular vesicles in pancreatic cancer: exploring untapped opportunities from biomarkers to novel therapeutic approaches","volume":"5","author":"Sanchez-Manas","year":"2024","journal-title":"Extracell Vesicles Circul Nucl Acids"},{"issue":"1","key":"10.1016\/j.nano.2026.103018_bb0180","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1186\/s11671-025-04226-6","article-title":"Bibliometric analysis of nanoparticle research for diagnostics and therapeutics in hepatocellular carcinoma","volume":"20","author":"Li","year":"2025","journal-title":"Discov Nano"},{"key":"10.1016\/j.nano.2026.103018_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fbioe.2023.1253048","article-title":"Current perspectives and trends in nanoparticle drug delivery systems in breast cancer: bibliometric analysis and review","volume":"11","author":"Sun","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"key":"10.1016\/j.nano.2026.103018_bb0190","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.995512","article-title":"Bibliometric and visualized analysis of the application of nanotechnology in glioma","volume":"13","author":"Du","year":"2022","journal-title":"Front Pharmacol"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154996342600119X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S154996342600119X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:25:27Z","timestamp":1791861927000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S154996342600119X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":38,"alternative-id":["S154996342600119X"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2026.103018","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A bibliometric analysis of nanoparticle-based therapeutic strategies for pancreatic cancer (2002\u20132026): Global trends, thematic shifts, and translational frontiers","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2026.103018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103018"}}