{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:47:48Z","timestamp":1791863268746,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012411","name":"Alborz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.nano.2026.103019","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:47:45Z","timestamp":1788882465000},"page":"103019","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Naringenin and collagen encapsulated alginate containing niosomes: A novel drug delivery system for wound healing"],"prefix":"10.1016","volume":"77","author":[{"given":"Amir","family":"Baghaei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faeze","family":"Khalaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedram","family":"Ebrahimnejad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaynab","family":"Sadeghi Ghadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.nano.2026.103019_bb0005","doi-asserted-by":"crossref","first-page":"566","DOI":"10.4103\/1735-5362.272565","article-title":"Naringenin potentiated \u03b2-sitosterol healing effect on the scratch wound assay","volume":"14","author":"Abbas","year":"2019","journal-title":"Res Pharm Sci"},{"key":"10.1016\/j.nano.2026.103019_bb0010","article-title":"Anatomy, Skin (Integument), Epidermis, in StatPearls. 2025, StatPearls Publishing Copyright \u00a9","author":"Yousef","year":"2025"},{"issue":"2","key":"10.1016\/j.nano.2026.103019_bb0015","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.jcma.2017.11.002","article-title":"Wound healing","volume":"81","author":"Wang","year":"2018","journal-title":"J Chin Med Assoc"},{"issue":"5","key":"10.1016\/j.nano.2026.103019_bb0020","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1590\/abd1806-4841.20164741","article-title":"Wound healing - a literature review","volume":"91","author":"Gonzalez","year":"2016","journal-title":"An Bras Dermatol"},{"key":"10.1016\/j.nano.2026.103019_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2024.106586","article-title":"Improved wound care via novel dextran and boric acid loaded wound healing gel in excision mice wound model","volume":"105","author":"Maqbool","year":"2025","journal-title":"J Drug Delivery Sci Technol"},{"key":"10.1016\/j.nano.2026.103019_bb0030","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3389\/fbioe.2019.00329","article-title":"The correlation between quality of life and acceptability of disability in patients with facial burn scars","volume":"7","author":"Zhang","year":"2019","journal-title":"Front Bioeng Biotechnol"},{"issue":"4","key":"10.1016\/j.nano.2026.103019_bb0035","article-title":"Daily quality-of-life impact of scars: an interview-based foundational study of patient-reported themes","volume":"9","author":"Hsieh","year":"2021","journal-title":"Plast Reconstr Surg Glob Open"},{"issue":"1","key":"10.1016\/j.nano.2026.103019_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/ph12010011","article-title":"The therapeutic potential of Naringenin: a review of clinical trials","volume":"12","author":"Salehi","year":"2019","journal-title":"Pharmaceuticals (Basel)"},{"key":"10.1016\/j.nano.2026.103019_bb0045","series-title":"Naringenin: Present status and its future prospective","author":"Kumar","year":"2015"},{"key":"10.1016\/j.nano.2026.103019_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.crphar.2021.100019","article-title":"Tocotrienols-rich naringenin nanoemulgel for the management of diabetic wound: fabrication, characterization and comparative in vitro evaluations","volume":"2","author":"Yeo","year":"2021","journal-title":"Current Research in Pharmacology and Drug Discovery"},{"issue":"2","key":"10.1016\/j.nano.2026.103019_bb0055","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1177\/0300060517692483","article-title":"Naringenin improves the healing process of thermally-induced skin damage in rats","volume":"45","author":"Al-Roujayee","year":"2017","journal-title":"J Int Med Res"},{"issue":"1","key":"10.1016\/j.nano.2026.103019_bb0060","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s13346-020-00731-6","article-title":"Accelerating healing of excisional wound with alginate hydrogel containing naringenin in rat model","volume":"11","author":"Salehi","year":"2021","journal-title":"Drug Deliv Transl Res"},{"issue":"4","key":"10.1016\/j.nano.2026.103019_bb0065","doi-asserted-by":"crossref","DOI":"10.3390\/gels11040271","article-title":"Collagen-based wound dressings: innovations, mechanisms, and clinical applications","volume":"11","author":"Alberts","year":"2025","journal-title":"Gels"},{"issue":"5","key":"10.1016\/j.nano.2026.103019_bb0070","article-title":"Collagen in wound healing","volume":"8","author":"Mathew-Steiner","year":"2021","journal-title":"Bioengineering (Basel)"},{"issue":"1","key":"10.1016\/j.nano.2026.103019_bb0075","article-title":"Collagen structure-function mapping informs applications for regenerative medicine","volume":"8","author":"San Antonio","year":"2020","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.nano.2026.103019_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2024.106579","article-title":"Advanced wound healing: the synergy of nature and nanotechnology","volume":"105","author":"Ali","year":"2025","journal-title":"J Drug Delivery Sci Technol"},{"issue":"3","key":"10.1016\/j.nano.2026.103019_bb0085","doi-asserted-by":"crossref","first-page":"369","DOI":"10.2174\/1567201818666210726160956","article-title":"Preparation and optimization of controlled release nanoparticles containing Cefixime using central composite design: an attempt to enrich its antimicrobial activity","volume":"19","author":"Mahjoub","year":"2022","journal-title":"Curr Drug Deliv"},{"key":"10.1016\/j.nano.2026.103019_bb0090","series-title":"Niosomes: A Novel Targeted Drug Delivery System","author":"Akbarzadeh","year":"2021"},{"key":"10.1016\/j.nano.2026.103019_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2025.106869","article-title":"Curcumin loaded hyaluronan modified niosomes: preparation, characterization and anti-cancer activity on triple-negative breast cancer cells","volume":"108","author":"Abasi","year":"2025","journal-title":"J Drug Delivery Sci Technol"},{"key":"10.1016\/j.nano.2026.103019_bb0100","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ejps.2019.01.035","article-title":"Preparation, characterization and in vivo evaluation of novel hyaluronan containing niosomes tailored by box-Behnken design to co-encapsulate curcumin and quercetin","volume":"130","author":"Sadeghi Ghadi","year":"2019","journal-title":"Eur J Pharm Sci"},{"issue":"2","key":"10.1016\/j.nano.2026.103019_bb0105","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/02652048.2019.1617360","article-title":"Curcumin entrapped hyaluronan containing niosomes: preparation, characterisation and in vitro\/in vivo evaluation","volume":"36","author":"Sadeghi Ghadi","year":"2019","journal-title":"J Microencapsul"},{"issue":"2","key":"10.1016\/j.nano.2026.103019_bb0110","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/1061186X.2020.1830408","article-title":"Improved oral delivery of quercetin with hyaluronic acid containing niosomes as a promising formulation","volume":"29","author":"Sadeghi-Ghadi","year":"2021","journal-title":"J Drug Target"},{"issue":"2","key":"10.1016\/j.nano.2026.103019_bb0115","first-page":"263","article-title":"Promising potent in vitro activity of curcumin and quercetin nano-niosomes against trichomonas vaginalis","volume":"68","author":"Hezarjaribi","year":"2022","journal-title":"Annals of parasitology"},{"issue":"1","key":"10.1016\/j.nano.2026.103019_bb0120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s13036-024-00406-7","article-title":"Enhancing osteogenic differentiation of dental pulp stem cells through rosuvastatin loaded niosomes optimized by box-Behnken design and modified by hyaluronan: a novel strategy for improved efficiency","volume":"18","author":"Sadeghi Ghadi","year":"2024","journal-title":"J Biol Eng"},{"key":"10.1016\/j.nano.2026.103019_bb0125","first-page":"171","article-title":"Formulation and evaluation of a topical niosomal gel containing a combination of benzoyl peroxide and tretinoin for antiacne activity","volume":"10","author":"Gupta","year":"2015","journal-title":"Int J Nanomedicine"},{"key":"10.1016\/j.nano.2026.103019_bb0130","series-title":"Non-Ionic Surfactant Vesicles (Niosomes) as New Drug Delivery Systems","author":"Pardakhty","year":"2017"},{"issue":"2","key":"10.1016\/j.nano.2026.103019_bb0135","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.xphs.2023.10.033","article-title":"Development and evaluation of tacrolimus loaded Nano-Transferosomes for skin targeting and dermatitis treatment","volume":"113","author":"Ren","year":"2024","journal-title":"J Pharm Sci"},{"issue":"Suppl2","key":"10.1016\/j.nano.2026.103019_bb0140","first-page":"1","article-title":"Effect of surfactant type, cholesterol content and various downsizing methods on the particle size of Niosomes","volume":"17","author":"Nowroozi","year":"2018","journal-title":"Iran J Pharm Res"},{"key":"10.1016\/j.nano.2026.103019_bb0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2023.104182","article-title":"Characterization and evaluation of antibacterial and wound healing activity of naringenin-loaded polyethylene glycol\/polycaprolactone electrospun nanofibers","volume":"81","author":"Farzaei","year":"2023","journal-title":"J Drug Delivery Sci Technol"},{"issue":"12","key":"10.1016\/j.nano.2026.103019_bb0150","first-page":"16319","article-title":"Collagen hydrogel dressing for wound healing and angiogenesis in diabetic rat models","volume":"10","author":"Lei","year":"2017","journal-title":"Int J Clin Exp Med"},{"key":"10.1016\/j.nano.2026.103019_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.jddst.2021.102885","article-title":"Development of alendronate niosomal delivery system for gastrointestinal permeability improvement","volume":"67","author":"Saeting","year":"2022","journal-title":"J Drug Delivery Sci Technol"},{"key":"10.1016\/j.nano.2026.103019_bb0170","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ymeth.2021.05.004","article-title":"Methods for preparation of niosomes: a focus on thin-film hydration method","volume":"199","author":"Thabet","year":"2022","journal-title":"Methods"},{"issue":"1","key":"10.1016\/j.nano.2026.103019_bb0175","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.xphs.2016.07.007","article-title":"Maximizing the therapeutic efficacy of Imatinib Mesylate-loaded Niosomes on human Colon adenocarcinoma using box-Behnken design","volume":"106","author":"Kassem","year":"2017","journal-title":"J Pharm Sci"},{"key":"10.1016\/j.nano.2026.103019_bb0180","series-title":"Test No. 404: Acute Dermal Irritation\/Corrosion","author":"OECD","year":"2002"},{"issue":"1","key":"10.1016\/j.nano.2026.103019_bb0185","doi-asserted-by":"crossref","first-page":"31","DOI":"10.15171\/apb.2016.06","article-title":"The effect of particle size on the deposition of solid lipid nanoparticles in different skin layers: a histological study","volume":"6","author":"Mardhiah Adib","year":"2016","journal-title":"Adv Pharm Bull"},{"issue":"4","key":"10.1016\/j.nano.2026.103019_bb0190","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics14040726","article-title":"Niosomal Nanocarriers for enhanced dermal delivery of epigallocatechin Gallate for protection against oxidative stress of the skin","volume":"14","author":"Li","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.nano.2026.103019_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2020.105434","article-title":"Investigating the skin penetration and wound healing properties of niosomal pentoxifylline cream","volume":"151","author":"Aghajani","year":"2020","journal-title":"Eur J Pharm Sci"},{"issue":"3","key":"10.1016\/j.nano.2026.103019_bb0205","doi-asserted-by":"crossref","DOI":"10.3390\/gels9030185","article-title":"Application of collagen-based hydrogel in skin wound healing","volume":"9","author":"Zhang","year":"2023","journal-title":"Gels"},{"key":"10.1016\/j.nano.2026.103019_bb0210","series-title":"Preparation, Characterization, Properties and Application of Nanofluid","first-page":"47","article-title":"3 - stability and dispersion characterization of Nanofluid","author":"Mahbubul","year":"2019"},{"issue":"35","key":"10.1016\/j.nano.2026.103019_bb0215","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.2174\/0929867325666180601101859","article-title":"Coating matters: review on colloidal stability of nanoparticles with biocompatible coatings in biological media, living cells and organisms","volume":"25","author":"Schubert","year":"2018","journal-title":"Curr Med Chem"},{"key":"10.1016\/j.nano.2026.103019_bb0220","doi-asserted-by":"crossref","DOI":"10.1039\/C5RA17729D","article-title":"Chitosan-graft-PAMAM \/ alginate core-shell nanoparticles: a safe and promising oral insulin carrier in animal model","volume":"5","author":"Mukhopadhyay","year":"2015","journal-title":"RSC Adv"},{"issue":"10","key":"10.1016\/j.nano.2026.103019_bb0225","first-page":"849","article-title":"Green synthesis of iron oxide nanoparticles using Ceratonia siliqua L aqueous extract: improvement of colloidal stability by optimizing synthesis parameters, and evaluation of antibacterial activity against Gram-positive and Gram-negative bacteria","volume":"113","author":"Aksu Demirezen","year":"2022"},{"issue":"2","key":"10.1016\/j.nano.2026.103019_bb0230","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics11020055","article-title":"Advances of non-ionic surfactant vesicles (Niosomes) and their application in drug delivery","volume":"11","author":"Ge","year":"2019","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.nano.2026.103019_bb0235","article-title":"Comparative evaluation of niosome formulations prepared by different techniques","volume":"51","author":"Bhaskaran","year":"2009","journal-title":"Acta Pharmaceutica Sciencia"},{"key":"10.1016\/j.nano.2026.103019_bb0245","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s12247-022-09619-z","article-title":"Improving antibacterial efficiency of curcumin in magnetic polymeric nanocomposites","volume":"18","author":"Sadeghi-Ghadi","year":"2023","journal-title":"J Pharm Innov"},{"key":"10.1016\/j.nano.2026.103019_bb0255","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jddst.2019.01.012","article-title":"Process optimization of ecological probe sonication technique for production of rifampicin loaded niosomes","volume":"50","author":"Khan","year":"2019","journal-title":"J Drug Delivery Sci Technol"},{"issue":"1","key":"10.1016\/j.nano.2026.103019_bb0260","doi-asserted-by":"crossref","first-page":"6340","DOI":"10.1038\/s41598-017-06955-w","article-title":"Niosomes: a strategy toward prevention of clinically significant drug incompatibilities","volume":"7","author":"Mohamed","year":"2017","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.nano.2026.103019_bb0265","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1007\/s13346-020-00715-6","article-title":"Methylene blue-loaded niosome: preparation, physicochemical characterization, and in vivo wound healing assessment","volume":"10","author":"Farmoudeh","year":"2020","journal-title":"Drug Deliv Transl Res"},{"issue":"12","key":"10.1016\/j.nano.2026.103019_bb0270","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics12121188","article-title":"Hydrogels as drug delivery systems: a review of current characterization and evaluation techniques","volume":"12","author":"Vigata","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.nano.2026.103019_bb0275","doi-asserted-by":"crossref","DOI":"10.1039\/D2NH00574C","article-title":"pH-responsive wound dressings: advances and prospects","volume":"8","author":"Han","year":"2023","journal-title":"Nanoscale Horiz"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963426001206?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963426001206?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:30:04Z","timestamp":1791862204000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963426001206"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":50,"alternative-id":["S1549963426001206"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2026.103019","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Naringenin and collagen encapsulated alginate containing niosomes: A novel drug delivery system for wound healing","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2026.103019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"103019"}}