{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:50:46Z","timestamp":1791579046255,"version":"4.3.4"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82374567"],"award-info":[{"award-number":["82374567"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300682"],"award-info":[{"award-number":["32300682"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010877","name":"Science, Technology and Innovation Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["JCYJ20210324093213035"],"award-info":[{"award-number":["JCYJ20210324093213035"]}],"id":[{"id":"10.13039\/501100010877","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["FRF-TP-22-007A1"],"award-info":[{"award-number":["FRF-TP-22-007A1"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515012779"],"award-info":[{"award-number":["2023A1515012779"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012401","name":"Beijing Science and Technology Planning Project","doi-asserted-by":"publisher","award":["20240484705"],"award-info":[{"award-number":["20240484705"]}],"id":[{"id":"10.13039\/501100012401","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZZYSM202411004"],"award-info":[{"award-number":["SZZYSM202411004"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZZYSM202311007"],"award-info":[{"award-number":["SZZYSM202311007"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.nano.2026.103028","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T23:18:57Z","timestamp":1790378337000},"page":"103028","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Targeting neuronal injury with intranasal Arc-engineered exosomes rescues cognitive deficits in Alzheimer's disease via the mTOR-autophagy pathway"],"prefix":"10.1016","volume":"78","author":[{"given":"Chunbin","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Sha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiwen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinmei","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongci","family":"Hang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cencan","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enli","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwu","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22","key":"10.1016\/j.nano.2026.103028_bb0005","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.1001\/jama.2017.6669","article-title":"Association between elevated brain amyloid and subsequent cognitive decline among cognitively normal persons","volume":"317","author":"Donohue","year":"2017","journal-title":"JAMA"},{"issue":"10","key":"10.1016\/j.nano.2026.103028_bb0010","doi-asserted-by":"crossref","first-page":"2990","DOI":"10.1038\/s41591-024-03122-3","article-title":"Sex-dependent APOE4 neutrophil\u2013microglia interactions drive cognitive impairment in Alzheimer\u2019s disease","volume":"30","author":"Rosenzweig","year":"2024","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.nano.2026.103028_bb0015","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1186\/s12974-023-02853-3","article-title":"Tau and neuroinflammation in Alzheimer\u2019s disease: interplay mechanisms and clinical translation","volume":"20","author":"Chen","year":"2023","journal-title":"J Neuroinflammation"},{"issue":"1","key":"10.1016\/j.nano.2026.103028_bb0020","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/alz.13490","article-title":"Senescence, brain inflammation, and oligomeric tau drive cognitive decline in Alzheimer\u2019s disease: Evidence from clinical and preclinical studies","volume":"20","author":"Gaikwad","year":"2024","journal-title":"Alzheimers Dement"},{"issue":"22","key":"10.1016\/j.nano.2026.103028_bb0025","doi-asserted-by":"crossref","first-page":"eadt1617","DOI":"10.1126\/sciadv.adt1617","article-title":"Whole-brain mapping of basal forebrain cholinergic neurons reveals a long-range reciprocal input-output loop between distinct subtypes","volume":"11","author":"Chen","year":"2025","journal-title":"Sci Adv"},{"issue":"9","key":"10.1016\/j.nano.2026.103028_bb0030","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1038\/s41591-023-02505-2","article-title":"Emerging diagnostics and therapeutics for Alzheimer disease","volume":"29","author":"Self","year":"2023","journal-title":"Nat Med"},{"issue":"10","key":"10.1016\/j.nano.2026.103028_bb0035","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/s41582-023-00869-0","article-title":"Treatments for AD: towards the right target at the right time","volume":"19","author":"van der Flier","year":"2023","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.nano.2026.103028_bb0040","doi-asserted-by":"crossref","first-page":"5873","DOI":"10.2147\/IJN.S506793","article-title":"Intranasal delivery of BACE1 siRNA and berberine via engineered stem cell exosomes for the treatment of Alzheimer\u2019s disease","volume":"20","author":"Sun","year":"2025","journal-title":"Int J Nanomedicine"},{"issue":"33","key":"10.1016\/j.nano.2026.103028_bb0045","doi-asserted-by":"crossref","first-page":"47497","DOI":"10.1021\/acsami.5c09843","article-title":"Engineered Stem Cell Membrane-Coated Nanodrugs for Targeted Therapy of Alzheimer\u2019s Disease","volume":"17","author":"Sha","year":"2025","journal-title":"ACS Appl Mater Interfaces"},{"issue":"1","key":"10.1016\/j.nano.2026.103028_bb0050","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1186\/s12974-025-03443-1","article-title":"Extracellular vesicles as therapeutic modulators of neuroinflammation in Alzheimer\u2019s disease: a focus on signaling mechanisms","volume":"22","author":"Han","year":"2025","journal-title":"J Neuroinflammation"},{"issue":"1","key":"10.1016\/j.nano.2026.103028_bb0055","article-title":"An anti-CD19-exosome delivery system navigates the blood-brain barrier for targeting of central nervous system lymphoma","volume":"23","author":"Zhao","year":"2025","journal-title":"J Nanobiotechnology"},{"issue":"11","key":"10.1016\/j.nano.2026.103028_bb0060","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70198","article-title":"Nose-to-Brain Delivery of Chlorella vulgaris Extracellular Vesicles for Antidepressant Effects","volume":"14","author":"Jin","year":"2025","journal-title":"J Extracell Vesicles"},{"issue":"8","key":"10.1016\/j.nano.2026.103028_bb0065","doi-asserted-by":"crossref","first-page":"2417","DOI":"10.1038\/s12276-026-01781-5","article-title":"Autonomous intranasal delivery systems for central nervous system therapeutics","volume":"58","author":"Shen","year":"2026","journal-title":"Exp Mol Med"},{"issue":"6","key":"10.1016\/j.nano.2026.103028_bb0070","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.70320","article-title":"Intranasal Delivery of Bacterial Extracellular Vesicles Enables RNA Cargo Entry Into the Brain","volume":"15","author":"Ha","year":"2026","journal-title":"J Extracell Vesicles"},{"key":"10.1016\/j.nano.2026.103028_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.890134","article-title":"Methyltransferase-Like 3 Rescues the Amyloid-beta protein-Induced Reduction of Activity-Regulated Cytoskeleton Associated Protein Expression via YTHDF1-Dependent N6-Methyladenosine Modification","volume":"14","author":"Xu","year":"2022","journal-title":"Front Aging Neurosci"},{"issue":"10","key":"10.1016\/j.nano.2026.103028_bb0080","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The Amyloid-\u03b2 Pathway in Alzheimer\u2019s Disease","volume":"26","author":"Hampel","year":"2021","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.nano.2026.103028_bb0085","doi-asserted-by":"crossref","DOI":"10.3389\/fnsyn.2023.1129036","article-title":"Alzheimer\u2019s disease as a synaptopathy: evidence for dysfunction of synapses during disease progression","volume":"15","author":"Meftah","year":"2023","journal-title":"Front Synaptic Neurosci"},{"issue":"6","key":"10.1016\/j.nano.2026.103028_bb0090","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1002\/alz.12890","article-title":"Presynaptic membrane protein dysfunction occurs prior to neurodegeneration and predicts faster cognitive decline","volume":"19","author":"Lan","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"10","key":"10.1016\/j.nano.2026.103028_bb0095","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1038\/nn.3199","article-title":"Orchestrated experience-driven Arc responses are disrupted in a mouse model of Alzheimer\u2019s disease","volume":"15","author":"Rudinskiy","year":"2012","journal-title":"Nat Neurosci"},{"issue":"4","key":"10.1016\/j.nano.2026.103028_bb0100","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/s41551-023-01150-x","article-title":"Extracellular vesicles incorporating retrovirus-like capsids for the enhanced packaging and systemic delivery of mRNA into neurons","volume":"8","author":"Gu","year":"2024","journal-title":"Nat Biomed Eng"},{"issue":"2\u20133","key":"10.1016\/j.nano.2026.103028_bb0105","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ejphar.2011.03.055","article-title":"Effect of brain-derived neurotrophic factor on activity-regulated cytoskeleton-associated protein gene expression in primary frontal cortical neurons. Comparison with NMDA and AMPA","volume":"660","author":"El-Sayed","year":"2011","journal-title":"Eur J Pharmacol"},{"issue":"1","key":"10.1016\/j.nano.2026.103028_bb0110","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1021\/acsnano.5c17413","article-title":"Mesoporous PdPt Nanozymes with Target Peptides and Cascade Reactive Oxygen Species Scavenging for Boosting Alzheimer\u2019s Disease Treatment","volume":"20","author":"Cai","year":"2026","journal-title":"ACS Nano"},{"issue":"8","key":"10.1016\/j.nano.2026.103028_bb0115","article-title":"A Blood-Brain Barrier-Penetrant Ag (III) Corrole Compound Rescues Alzheimer\u2019s Disease Pathology by Targeting A\u03b242-Induced Oxidative Stress","volume":"13","author":"Tarai","year":"2026","journal-title":"Adv Sci (Weinh)"},{"issue":"4","key":"10.1016\/j.nano.2026.103028_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/alz.71306","article-title":"TOMM40 suppression promotes neuronal cholesterol imbalance and molecular and behavioral phenotypes of Alzheimer\u2019s disease","volume":"22","author":"Yang","year":"2026","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.nano.2026.103028_bb0125","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/15548627.2026.2679639","article-title":"AI-driven discovery of brain-penetrant mTOR-independent autophagy enhancers for Alzheimer\u2019s disease","author":"Dong","year":"2026","journal-title":"Autophagy"},{"issue":"5","key":"10.1016\/j.nano.2026.103028_bb0130","doi-asserted-by":"crossref","first-page":"5033","DOI":"10.1021\/acsnano.2c12840","article-title":"Multiscale NIR-II Imaging-Guided Brain-Targeted Drug Delivery Using Engineered Cell Membrane Nanoformulation for Alzheimer\u2019s Disease Therapy","volume":"17","author":"Huang","year":"2023","journal-title":"ACS Nano"},{"issue":"18","key":"10.1016\/j.nano.2026.103028_bb0135","doi-asserted-by":"crossref","first-page":"11753","DOI":"10.1021\/acsnano.3c13150","article-title":"Biomimetic Nanovesicles as a Dual Gene Delivery System for the Synergistic Gene Therapy of Alzheimer\u2019s Disease","volume":"18","author":"Jiang","year":"2024","journal-title":"ACS Nano"},{"issue":"13","key":"10.1016\/j.nano.2026.103028_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/adma.202006357","article-title":"A nanoformulation-mediated multifunctional stem cell therapy with improved beta-amyloid clearance and neural regeneration for Alzheimer\u2019s disease","volume":"33","author":"Huang","year":"2021","journal-title":"Adv Mater"},{"issue":"1","key":"10.1016\/j.nano.2026.103028_bb0145","doi-asserted-by":"crossref","first-page":"20240147","DOI":"10.1002\/EXP.20240147","article-title":"Ganoderic Acids Alleviate Neuroinflammation by Targeting Myeloid Differentiation Factor 2 for Ischemic Stroke Therapy","volume":"6","author":"Ma","year":"2026","journal-title":"Exploration (Beijing)"}],"container-title":["Nanomedicine: Nanotechnology, Biology and Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963426001292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1549963426001292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T20:10:00Z","timestamp":1791576600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1549963426001292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":29,"alternative-id":["S1549963426001292"],"URL":"https:\/\/doi.org\/10.1016\/j.nano.2026.103028","relation":{},"ISSN":["1549-9634"],"issn-type":[{"value":"1549-9634","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeting neuronal injury with intranasal Arc-engineered exosomes rescues cognitive deficits in Alzheimer's disease via the mTOR-autophagy pathway","name":"articletitle","label":"Article Title"},{"value":"Nanomedicine: Nanotechnology, Biology and Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nano.2026.103028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"103028"}}