{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T17:00:26Z","timestamp":1788973226274,"version":"build-2803163510"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T00:00:00Z","timestamp":1753142400000},"content-version":"vor","delay-in-days":202,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003246","name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["09150171910068"],"award-info":[{"award-number":["09150171910068"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Aging Brain"],"published-print":{"date-parts":[[2025]]},"DOI":"10.1016\/j.nbas.2025.100147","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T02:42:19Z","timestamp":1753843339000},"page":"100147","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Identification of novel candidate loci for Alzheimer\u2019s disease and related dementias by leveraging the shared genetic basis with hippocampal volume"],"prefix":"10.1016","volume":"8","author":[{"given":"Chenyang","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven J.","family":"van der Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niccol\u00f2","family":"Tesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wiesje M.","family":"van der Flier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty M.","family":"Tijms","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianne M.","family":"Reus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbas.2025.100147_b0135","doi-asserted-by":"crossref","first-page":"e105","DOI":"10.1016\/S2468-2667(21)00249-8","article-title":"Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019","volume":"7","author":"Nichols","year":"2022","journal-title":"Lancet Public Heal"},{"key":"10.1016\/j.nbas.2025.100147_b0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0281440","article-title":"What does heritability of Alzheimer\u2019s disease represent?","volume":"18","author":"Baker","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.nbas.2025.100147_b0020","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.stemcr.2021.01.019","article-title":"Adult Hippocampal Neurogenesis in Aging and Alzheimer\u2019s Disease","volume":"16","author":"Babcock","year":"2021","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.nbas.2025.100147_b0050","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/j.neuroimage.2004.12.036","article-title":"Preclinical detection of Alzheimer\u2019s disease: hippocampal shape and volume predict dementia onset in the elderly","volume":"25","author":"Csernansky","year":"2005","journal-title":"Neuroimage"},{"key":"10.1016\/j.nbas.2025.100147_b0145","doi-asserted-by":"crossref","first-page":"4337","DOI":"10.1002\/hbm.23654","article-title":"Heritability of hippocampal subfield volumes using a twin and non\u2010twin siblings design","volume":"38","author":"Patel","year":"2017","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.nbas.2025.100147_b0165","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1038\/s41593-021-00826-4","article-title":"An expanded set of genome-wide association studies of brain imaging phenotypes in UK Biobank","volume":"24","author":"Smith","year":"2021","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.nbas.2025.100147_b0080","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.biopsych.2016.02.033","article-title":"Multimodal Brain Imaging reveals Structural differences in Alzheimer\u2019s Disease Polygenic Risk Carriers: a Study in healthy Young adults","volume":"81","author":"Foley","year":"2017","journal-title":"Biol Psychiat"},{"key":"10.1016\/j.nbas.2025.100147_b0100","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.bpsc.2021.10.011","article-title":"Genomic Studies across the Lifespan Point to Early Mechanisms determining Subcortical Volumes","volume":"7","author":"Grand","year":"2022","journal-title":"Biological Psychiatry Cognitive Neurosci Neuroimaging"},{"key":"10.1016\/j.nbas.2025.100147_b0105","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1186\/s13195-023-01256-z","article-title":"Association between polygenic risk for Alzheimer\u2019s disease and brain structure in children and adults","volume":"15","author":"He","year":"2023","journal-title":"Alzheimer\u2019s Res Ther"},{"key":"10.1016\/j.nbas.2025.100147_b0190","doi-asserted-by":"crossref","first-page":"e506","DOI":"10.1212\/NXG.0000000000000506","article-title":"Genetic risk for Alzheimer disease predicts hippocampal volume through the human lifespan","volume":"6","author":"Walhovd","year":"2020","journal-title":"Neurology Genetics"},{"key":"10.1016\/j.nbas.2025.100147_b0110","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004926","article-title":"A Pleiotropy-Informed Bayesian False Discovery Rate adapted to a Shared Control Design Finds New Disease Associations from GWAS Summary Statistics","volume":"11","author":"Liley","year":"2015","journal-title":"PLoS Genet"},{"key":"10.1016\/j.nbas.2025.100147_b0045","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/ng.3211","article-title":"LD score regression distinguishes confounding from polygenicity in genome-wide association studies","volume":"47","author":"Consortium, S.W.G. of the P.G., Bulik-Sullivan, B.K., Loh, P.-R., Finucane, H.K., Ripke, S., Yang, J., Patterson, N., Daly, M.J., Price, A.L., Neale, B.M.","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.nbas.2025.100147_b0195","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008720","article-title":"Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses","volume":"16","author":"Wallace","year":"2020","journal-title":"PLoS Genet"},{"key":"10.1016\/j.nbas.2025.100147_b0125","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.biopsych.2021.12.007","article-title":"Boosting Schizophrenia Genetics by Utilizing Genetic Overlap with Brain Morphology","volume":"92","author":"van der Meer","year":"2022","journal-title":"Biol Psychiat"},{"key":"10.1016\/j.nbas.2025.100147_b0030","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer\u2019s disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat Genet"},{"key":"10.1016\/j.nbas.2025.100147_b0065","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S1474-4422(07)70178-3","article-title":"Research criteria for the diagnosis of Alzheimer\u2019s disease: revising the NINCDS\u2013ADRDA criteria","volume":"6","author":"Dubois","year":"2007","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.nbas.2025.100147_bib211","unstructured":"He Y, Koido M, Shimmori Y, Kamatani Y. GWASLab: a Python package for processing and visualizing GWAS summary statistics; 2023."},{"key":"10.1016\/j.nbas.2025.100147_b0150","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a Tool Set for Whole-Genome Association and Population-based Linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"10.1016\/j.nbas.2025.100147_b0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004383","article-title":"Bayesian Test for Colocalisation between Pairs of Genetic Association Studies using Summary Statistics","volume":"10","author":"Giambartolomei","year":"2014","journal-title":"PLoS Genet"},{"key":"10.1016\/j.nbas.2025.100147_b0180","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkab410","article-title":"snpXplorer: a web application to explore human SNP-associations and annotate SNP-sets","volume":"49","author":"Tesi","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.nbas.2025.100147_b0005","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nature24277","article-title":"Genetic effects on gene expression across human tissues","volume":"550","author":"Aguet","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.nbas.2025.100147_b0070","doi-asserted-by":"crossref","unstructured":"Elsworth, B., Lyon, M., Alexander, T., Liu, Y., Matthews, P., Hallett, J., Bates, P., Palmer, T., Haberland, V., Smith, G.D., Zheng, J., Haycock, P., Gaunt, T.R., Hemani, G., 2020. The MRC IEU OpenGWAS data infrastructure. bioRxiv 2020.08.10.244293. https:\/\/doi.org\/10.1101\/2020.08.10.244293.","DOI":"10.1101\/2020.08.10.244293"},{"key":"10.1016\/j.nbas.2025.100147_b0115","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1006\/mcne.2000.0940","article-title":"Sharpin, a Novel Postsynaptic Density Protein that Directly Interacts with the Shank Family of Proteins","volume":"17","author":"Lim","year":"2001","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.nbas.2025.100147_bib212","article-title":"GWAS meta-analysis of CSF Alzheimer's disease biomarkers 18,948 individuals reveal novel loci and genes regulating lipid metabolism, brain volume and autophagy","author":"Cruchaga","year":"2025","journal-title":"Research Square"},{"key":"10.1016\/j.nbas.2025.100147_bib213","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1038\/s41588-024-01939-9","article-title":"GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia","volume":"56","author":"Shade","year":"2024","journal-title":"Nat Genet"},{"key":"10.1016\/j.nbas.2025.100147_b0200","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1038\/s41588-021-00921-z","article-title":"A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer\u2019s disease","volume":"53","author":"Wightman","year":"2021","journal-title":"Nat Genet"},{"key":"10.1016\/j.nbas.2025.100147_b0035","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41467-017-00471-1","article-title":"Cross-ethnic meta-analysis identifies association of the GPX3-TNIP1 locus with amyotrophic lateral sclerosis","volume":"8","author":"Benyamin","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.nbas.2025.100147_b0085","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1007\/s00381-016-3087-1","article-title":"Variants in TNIP1, a regulator of the NF-kB pathway, found in two patients with neural tube defects","volume":"32","author":"Francesca","year":"2016","journal-title":"Child\u2019s Nerv Syst"},{"key":"10.1016\/j.nbas.2025.100147_b0140","doi-asserted-by":"crossref","unstructured":"Panyard, D.J., Reus, L.M., Ali, M., Liu, J., Deming, Y.K., Lu, Q., Kollmorgen, G., Suridjan, I., Wild, N., Visser, P.J., Bertram, L., Zetterberg, H., Blennow, K., Gobom, J., Western, D., Sung, Y.J., Carlsson, C.M., Johnson, S.C., Asthana, S., Cruchaga, C., Tijms, B.M., Engelman, C.D., Snyder, M.P., 2022. Post-GWAS multiomic functional investigation of the TNIP1 locus in Alzheimer\u2019s disease implicates mediation through GPX3. medRxiv 2022.11.04.22277162. https:\/\/doi.org\/10.1101\/2022.11.04.22277162.","DOI":"10.1101\/2022.11.04.22277162"},{"key":"10.1016\/j.nbas.2025.100147_b0120","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1007\/s11357-022-00717-x","article-title":"GTP energy dependence of endocytosis and autophagy in the aging brain and Alzheimer\u2019s disease","volume":"45","author":"Mart\u00ednez","year":"2023","journal-title":"GeroScience"},{"key":"10.1016\/j.nbas.2025.100147_b0205","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1038\/s41419-018-1168-7","article-title":"Ribosomal protein S27-like regulates autophagy via the \u03b2-TrCP-DEPTOR-mTORC1 axis","volume":"9","author":"Xiong","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.nbas.2025.100147_b0210","doi-asserted-by":"crossref","first-page":"e1031","DOI":"10.1212\/WNL.0000000000013252","article-title":"Neuropathologic Correlates of Human Cortical Proteins in Alzheimer Disease and Related Dementias","volume":"98","author":"Yu","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.nbas.2025.100147_b0015","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/s10038-021-00987-x","article-title":"A functional variant of SHARPIN confers increased risk of late-onset Alzheimer\u2019s disease","volume":"67","author":"Asanomi","year":"2022","journal-title":"J Hum Genet"},{"key":"10.1016\/j.nbas.2025.100147_b0170","doi-asserted-by":"crossref","first-page":"3737","DOI":"10.1002\/hbm.25083","article-title":"Imaging genomics discovery of a new risk variant for Alzheimer\u2019s disease in the postsynaptic SHARPIN gene","volume":"41","author":"Soheili-Nezhad","year":"2020","journal-title":"Hum Brain Mapp"},{"key":"10.1016\/j.nbas.2025.100147_b0175","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1111\/cns.13156","article-title":"KCTD: a new gene family involved in neurodevelopmental and neuropsychiatric disorders","volume":"25","author":"Teng","year":"2019","journal-title":"CNS Neurosci Ther"},{"key":"10.1016\/j.nbas.2025.100147_b0075","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nature24470","article-title":"Kctd13 deletion reduces synaptic transmission via increased RhoA","volume":"551","author":"Escamilla","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.nbas.2025.100147_b0010","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1093\/hmg\/ddy436","article-title":"Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions","volume":"28","author":"Arbogast","year":"2018","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.nbas.2025.100147_b0155","doi-asserted-by":"crossref","first-page":"3965","DOI":"10.1002\/alz.13088","article-title":"Associations of blood cell indices and anemia with risk of incident dementia: a prospective cohort study of 313,448 participants","volume":"19","author":"Qiang","year":"2023","journal-title":"Alzheimer\u2019s Dement"},{"key":"10.1016\/j.nbas.2025.100147_b0040","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1176\/appi.ajp.2011.10101509","article-title":"Association of the Alzheimer\u2019s Gene SORL1 with Hippocampal volume in Young","volume":"168","author":"Bralten","year":"2011","journal-title":"Healthy Adults Am J Psychiatry"},{"key":"10.1016\/j.nbas.2025.100147_b0055","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1001\/jamaneurol.2024.0469","article-title":"Trends in Intracranial and Cerebral Volumes of Framingham Heart Study Participants born 1930 to 1970","volume":"81","author":"DeCarli","year":"2024","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.nbas.2025.100147_b0090","first-page":"160","article-title":"MR-based in vivo hippocampal volumetrics: 2","volume":"10","author":"Geuze","year":"2005","journal-title":"Findings in neuropsychiatric disorders Mol Psychiatry"},{"key":"10.1016\/j.nbas.2025.100147_b0130","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3390\/biom11111635","article-title":"Symptomatic, Genetic, and Mechanistic Overlaps between Autism and Alzheimer\u2019s Disease","volume":"11","author":"Nadeem","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.nbas.2025.100147_b0185","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1093\/brain\/aww243","article-title":"Whole-brain analysis reveals increased neuroanatomical asymmetries in dementia for hippocampus and amygdala","volume":"139","author":"Wachinger","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.nbas.2025.100147_b0160","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/s41562-021-01069-w","article-title":"The genetic architecture of structural left\u2013right asymmetry of the human brain","volume":"5","author":"Sha","year":"2021","journal-title":"Nat Hum Behav"},{"key":"10.1016\/j.nbas.2025.100147_b0060","doi-asserted-by":"crossref","first-page":"347","DOI":"10.3233\/JAD-2011-110041","article-title":"Grey-Matter Atrophy in Alzheimer\u2019s Disease is Asymmetric but not Lateralized","volume":"25","author":"Derflinger","year":"2011","journal-title":"J Alzheimer\u2019s Dis"}],"container-title":["Aging Brain"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589958925000131?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589958925000131?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T20:28:40Z","timestamp":1772915320000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589958925000131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":45,"alternative-id":["S2589958925000131"],"URL":"https:\/\/doi.org\/10.1016\/j.nbas.2025.100147","relation":{},"ISSN":["2589-9589"],"issn-type":[{"value":"2589-9589","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of novel candidate loci for Alzheimer\u2019s disease and related dementias by leveraging the shared genetic basis with hippocampal volume","name":"articletitle","label":"Article Title"},{"value":"Aging Brain","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.nbas.2025.100147","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100147"}}