{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:24:00Z","timestamp":1792801440150,"version":"4.5.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,2,1]],"date-time":"2004-02-01T00:00:00Z","timestamp":1075593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2004,2]]},"DOI":"10.1016\/j.nbd.2003.09.011","type":"journal-article","created":{"date-parts":[[2003,12,4]],"date-time":"2003-12-04T12:02:13Z","timestamp":1070539333000},"page":"29-39","source":"Crossref","is-referenced-by-count":73,"title":["Mitochondrial abnormalities in cybrid cell models of sporadic Alzheimer's disease worsen with passage in culture"],"prefix":"10.1016","volume":"15","author":[{"given":"Patricia A.","family":"Trimmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula M.","family":"Keeney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.Kate","family":"Borland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic A.","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatanna","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell H.","family":"Swerdlow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janice P.","family":"Parks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"W.Davis","family":"Parker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr.","given":"James P.","family":"Bennett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2003.09.011_BIB28","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1080\/000164800750001026","article-title":"Synaptic alterations in the vestibulocerebellar system in Alzheimer's disease\u2014 a Golgi and electron microscope study","volume":"120","author":"Baloyannis","year":"2000","journal-title":"Acta Otolaryngol."},{"key":"10.1016\/j.nbd.2003.09.011_BIB1","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0197-4580(01)00314-1","article-title":"Cytochrome c oxidase and mitochondrial F(1)F(0)-ATPase (ATP synthase) activities in platelets and brain from patients with Alzheimer's disease","volume":"23","author":"Bosetti","year":"2002","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2003.09.011_BIB2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-0173(98)00046-0","article-title":"An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration","volume":"29","author":"Cassarino","year":"1999","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.nbd.2003.09.011_BIB3","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1006\/bbrc.1998.8866","article-title":"Cyclosporin A increases resting mitochondrial membrane potential in SY5Y cells and reverses the depressed mitochondrial membrane potential of Alzheimer's disease cybrids","volume":"248","author":"Cassarino","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.nbd.2003.09.011_BIB4","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1212\/WNL.57.2.260","article-title":"Mitochondrial enzyme-deficient hippocampal neurons and choroidal cells in AD","volume":"57","author":"Cottrell","year":"2001","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2003.09.011_BIB29","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1080\/019131201300343874","article-title":"As you like it, Part 3: A critique and historical review of calcification as seen with the electron microscope","volume":"25","author":"Ghadially","year":"2001","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.nbd.2003.09.011_BIB5","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1111\/j.1749-6632.1999.tb07825.x","article-title":"Use of cytoplasmic hybrid cell lines for elucidating the role of mitochondrial dyfunction in Alzheimer's disease and Parkinson's disease","volume":"893","author":"Ghosh","year":"1999","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.nbd.2003.09.011_BIB6","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.2741\/gibson","article-title":"Oxidative markers in the brain and non-neuronal tissues as biomarkers of Alzheimer's disease","volume":"7","author":"Gibson","year":"2002","journal-title":"Front. Biosci."},{"key":"10.1016\/j.nbd.2003.09.011_BIB7","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1523\/JNEUROSCI.21-09-03017.2001","article-title":"Mitochondrial abnormalities in Alzheimer's disease","volume":"21","author":"Hirai","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2003.09.011_BIB8","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1002\/1531-8249(200008)48:2<148::AID-ANA3>3.0.CO;2-7","article-title":"Alzheimer's disease cybrids replicate beta-amyloid abnormalities through cell death pathways","volume":"48","author":"Khan","year":"2000","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.nbd.2003.09.011_BIB9","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1471-4159.1992.tb09439.x","article-title":"Brain cytochrome oxidase in Alzheimer's disease","volume":"59","author":"Kish","year":"1992","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2003.09.011_BIB10","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1046\/j.1471-4159.1999.0720700.x","article-title":"Decreased brain protein levels of cytochrome oxidase subunits in Alzheimer's disease and in hereditary spinocerebellar ataxia disorders: a nonspecific change?","volume":"72","author":"Kish","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2003.09.011_BIB11","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1042\/0264-6021:3480425","article-title":"Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells","volume":"348","author":"Lee","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.nbd.2003.09.011_BIB12","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1093\/hmg\/11.2.133","article-title":"High aggregate burden of somatic mtDNA point mutations in aging and Alzheimer's disease brain","volume":"11","author":"Lin","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.nbd.2003.09.011_BIB30","doi-asserted-by":"crossref","first-page":"357","DOI":"10.3109\/01913129809103357","article-title":"Biology and pathology of the mitochondrion","volume":"22","author":"Lloreta-Trull","year":"1998","journal-title":"Ultrastruct. Pathol."},{"key":"10.1016\/j.nbd.2003.09.011_BIB13","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S0197-4580(00)00112-3","article-title":"A selective defect of cytochrome c oxidase is present in brain of Alzheimer disease patients","volume":"21","author":"Maurer","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.nbd.2003.09.011_BIB14","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1046\/j.1471-4159.1994.63062179.x","article-title":"Cortical cytochrome oxidase activity is reduced in Alzheimer's disease","volume":"63","author":"Mutisya","year":"1994","journal-title":"J. Neurochem."},{"key":"10.1016\/j.nbd.2003.09.011_BIB15","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1007\/s004010050997","article-title":"Mitochondrial enzyme expression in the hippocampus in relation to Alzheimer-type pathology","volume":"97","author":"Nagy","year":"1999","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2003.09.011_BIB16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1093\/emboj\/21.3.221","article-title":"The ATP synthase is involved in generating mitochondrial cristae morphology","volume":"21","author":"Oaumard","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.nbd.2003.09.011_BIB17","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1212\/WNL.44.6.1090","article-title":"Electron transport chain defects in Alzheimer's disease brain","volume":"44","author":"Parker","year":"1994","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2003.09.011_BIB18","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/S0006-2952(01)00919-4","article-title":"Alzheimer's disease and oxygen radicals: new insights","volume":"63","author":"Pratico","year":"2002","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.nbd.2003.09.011_BIB31","first-page":"459","article-title":"Mitochondrial abnormalities in cortical dendrites from patients with Alzheimer's disease","volume":"17","author":"Saraiva","year":"1985","journal-title":"J. Submicrosc. Cytol."},{"key":"10.1016\/j.nbd.2003.09.011_BIB32","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1523\/JNEUROSCI.17-12-04612.1997","article-title":"Calcium homeostasis and reactive oxygen species production in cells transformed by mitochondria from individuals with sporadic Alzheimer's disease","volume":"17","author":"Sheehan","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2003.09.011_BIB19","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0167-4889(00)00027-6","article-title":"Mitochondrial DNA-depleted neuroblastoma (Rho0) cells exhibit altered calcium signaling","volume":"1496","author":"Sherer","year":"2000","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.nbd.2003.09.011_BIB20","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0006-8993(00)03203-0","article-title":"Chronic reduction in complex I function alters calcium signaling in SH-SY5Y neuroblastoma cells","volume":"891","author":"Sherer","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.nbd.2003.09.011_BIB21","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/00005072-199311000-00004","article-title":"Functional alterations in Alzheimer's disease: dimunition of cytochrome oxidase in the hippocampal formation","volume":"52","author":"Simonian","year":"1993","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2003.09.011_BIB33","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3109\/07853899708999341","article-title":"Mitochondrial DNA and disease","volume":"29","author":"Suomalainen","year":"1997","journal-title":"Ann. Med."},{"key":"10.1016\/j.nbd.2003.09.011_BIB22","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1212\/WNL.49.4.918","article-title":"Cybrids in Alzheimer's disease: a cellular model of the disease?","volume":"49","author":"Swerdlow","year":"1997","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2003.09.011_BIB23","doi-asserted-by":"crossref","first-page":"3690","DOI":"10.1073\/pnas.072660299","article-title":"Conflicting levels of selection in the accumulation of mitochondrial defects in Saccharomyces cerevisiae","volume":"99","author":"Taylor","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.nbd.2003.09.011_BIB24","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1006\/exnr.2000.7333","article-title":"Abnormal mitochondrial morphology in sporadic Parkinson's and Alzheimer's disease cybrid cell lines","volume":"162","author":"Trimmer","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2003.09.011_BIB25","doi-asserted-by":"crossref","first-page":"4923","DOI":"10.1523\/JNEUROSCI.21-13-04923.2001","article-title":"Energy hypometabolism in posterior cingulated cortex of Alzheimer's patients: superficial laminar cytochrome oxidase associated with disease duration","volume":"21","author":"Valla","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2003.09.011_BIB26","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1006\/exnr.2000.7385","article-title":"Decreased hippocampal metabolic activity in Alzheimer patients is not reflected in the immunoreactivity of cytochrome oxidase subunits","volume":"163","author":"Verwer","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2003.09.011_BIB27","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1111\/j.1749-6632.2001.tb05640.x","article-title":"Increases of mitochondrial mass and mitochondrial genome in association with enhanced oxidative stress in human cells harboring 49,777 bp-deleted mitochondrial DNA","volume":"928","author":"Wei","year":"2001","journal-title":"Ann. N.Y. Acad. Sci."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096999610300192X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096999610300192X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T16:31:10Z","timestamp":1585326670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096999610300192X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,2]]}},"alternative-id":["S096999610300192X"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2003.09.011","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2004,2]]}}}