{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:05:34Z","timestamp":1768813534276,"version":"3.49.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurobiology of Disease"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.nbd.2004.10.001","type":"journal-article","created":{"date-parts":[[2004,12,16]],"date-time":"2004-12-16T08:07:31Z","timestamp":1103184451000},"page":"286-295","source":"Crossref","is-referenced-by-count":40,"title":["\u03b1-Internexin immunoreactivity reflects variable neuronal vulnerability in Alzheimer's disease and supports the role of the \u03b2-amyloid plaques in inducing neuronal injury"],"prefix":"10.1016","volume":"18","author":[{"given":"Tracey C.","family":"Dickson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jyoti A.","family":"Chuckowree","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Inn Chuah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian K.","family":"West","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James C.","family":"Vickers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.nbd.2004.10.001_bib1","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s004019900160","article-title":"The effects of taxol on the central nervous system response to physical injury","volume":"100","author":"Adlard","year":"2000","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2004.10.001_bib2","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/S0306-4522(00)00516-9","article-title":"Alzheimer's disease as a disorder of mechanisms underlying structural brain self-organization","volume":"102","author":"Arendt","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2004.10.001_bib3","series-title":"Culturing Nerve Cells","author":"Banker","year":"1998"},{"key":"10.1016\/j.nbd.2004.10.001_bib4","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/cne.903340203","article-title":"Evidence that transmitter-containing dystrophic neurites precede paired helical filament and Alz50 formation within senile plaques in the amygdala of nondemented elderly and patients with Alzheimer's disease","volume":"334","author":"Benzing","year":"1993","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2004.10.001_bib5","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF00308809","article-title":"Neuropathological staging of Alzheimer-related changes","volume":"82","author":"Braak","year":"1991","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2004.10.001_bib6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/cne.10760","article-title":"Progressive degeneration of nonphosphorylated neurofilament protein-enriched pyramidal neurons predicts cognitive impairment in Alzheimer's disease: stereologic analysis of prefrontal cortex area 9","volume":"463","author":"Bussiere","year":"2003","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2004.10.001_bib7","doi-asserted-by":"crossref","first-page":"3715","DOI":"10.1523\/JNEUROSCI.23-09-03715.2003","article-title":"Cytoskeletal and morphological alterations underlying axonal sprouting after localized transection of cortical neuron axons in vitro","volume":"23","author":"Chuckowree","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2004.10.001_bib8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0306-4522(01)00169-5","article-title":"The morphological phenotype of beta-amyloid plaques and associated neuritic changes in Alzheimer's disease","volume":"105","author":"Dickson","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.nbd.2004.10.001_bib9","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1006\/exnr.1998.7010","article-title":"Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer's disease","volume":"156","author":"Dickson","year":"1999","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2004.10.001_bib10","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1089\/neu.2000.17.1095","article-title":"Sequence of cellular changes following localized axotomy to cortical neurons in glia-free culture","volume":"17","author":"Dickson","year":"2000","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.nbd.2004.10.001_bib11","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1002\/cne.903420202","article-title":"Expression of the gene for the neuronal intermediate filament protein alpha-internexin coincides with the onset of neuronal differentiation in the developing rat nervous system","volume":"342","author":"Fliegner","year":"1994","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2004.10.001_bib12","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1093\/cercor\/2.1.56","article-title":"Nonphosphorylated neurofilament protein and calbindin immunoreactivity in layer III pyramidal neurons of human neocortex","volume":"2","author":"Hayes","year":"1992","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nbd.2004.10.001_bib13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1002\/cne.903010106","article-title":"Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: II. Primary and secondary visual cortex","volume":"301","author":"Hof","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2004.10.001_bib14","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1093\/cercor\/2.6.456","article-title":"Regional distribution of neurofilament and calcium-binding proteins in the cingulate cortex of the macaque monkey","volume":"2","author":"Hof","year":"1992","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.nbd.2004.10.001_bib15","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1002\/cne.903010105","article-title":"Quantitative analysis of a vulnerable subset of pyramidal neurons in Alzheimer's disease: I. Superior frontal and inferior temporal cortex","volume":"301","author":"Hof","year":"1990","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2004.10.001_bib16","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/(SICI)1096-9861(20000424)420:1<113::AID-CNE8>3.0.CO;2-N","article-title":"Numbers of Meynert and layer IVB cells in area V1: a stereologic analysis in young and aged macaque monkeys","volume":"420","author":"Hof","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2004.10.001_bib17","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1523\/JNEUROSCI.10-08-02735.1990","article-title":"a-Internexin, a novel neuronal intermediate filament protein, precedes the low molecular weight neurofilament protein (NF-L in the developing rat brains)","volume":"10","author":"Kaplan","year":"1990","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2004.10.001_bib18","first-page":"1663","article-title":"Physical damage to rat cortical axons mimics early Alzheimer's neuronal pathology","volume":"8","author":"King","year":"1997","journal-title":"NeuroReport"},{"key":"10.1016\/j.nbd.2004.10.001_bib19","first-page":"31","article-title":"Acute CNS axonal injury models a subtype of dystrophic neurite in Alzheimer's disease","volume":"3","author":"King","year":"2000","journal-title":"Alzheimer's Rep."},{"key":"10.1016\/j.nbd.2004.10.001_bib20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1046\/j.1365-2990.2001.00317.x","article-title":"Alterations in neurofilaments associated with reactive brain changes and axonal sprouting following acute physical injury to the rat neocortex","volume":"27","author":"King","year":"2001","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.nbd.2004.10.001_bib21","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0891-0618(02)00043-1","article-title":"Neurofilament triplet proteins are restricted to a subset of neurons in the rat neocortex","volume":"24","author":"Kirkcaldie","year":"2002","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.nbd.2004.10.001_bib22","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0169-328X(99)00104-7","article-title":"No requirement of alpha-internexin for nervous system development and for radial growth of axons","volume":"69","author":"Levavasseur","year":"1999","journal-title":"Brain Res., Mol. Brain Res."},{"key":"10.1016\/j.nbd.2004.10.001_bib23","first-page":"871","article-title":"An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease","volume":"142","author":"Masliah","year":"1993","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.nbd.2004.10.001_bib24","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The consortium to establish a registry for Alzheimer's disease part II standardisation of the neuropathologic assessment of Alzheimer's disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2004.10.001_bib25","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1212\/WNL.46.3.707","article-title":"Cerebral amyloid deposition and diffuse plaques in \u201cnormal\u201d aging: evidence from presymptomatic and very mild Alzheimer's disease","volume":"46","author":"Morris","year":"1996","journal-title":"Neurology"},{"key":"10.1016\/j.nbd.2004.10.001_bib26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0304-3940(97)00223-1","article-title":"Abnormal distribution of neurofilament L in neurons with Alzheimer's disease","volume":"225","author":"Nakamura","year":"1997","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.nbd.2004.10.001_bib27","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1006\/exnr.1997.6433","article-title":"The cellular basis for the relative resistance of parvalbumin and calretinin immunoreactive neocortical neurons to the pathology of Alzheimer's disease","volume":"145","author":"Sampson","year":"1997","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2004.10.001_bib28","first-page":"1","article-title":"Immonolocalisation of Beta-amyloid precursor protein to plaque-associated synaptic alterations in the early and late stages of Alzheimer's disease","volume":"1","author":"Saunders","year":"1998","journal-title":"Alzheimer's Rep."},{"key":"10.1016\/j.nbd.2004.10.001_bib29","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1097\/00005072-199409000-00003","article-title":"Alzheimer's disease: a central role for amyloid","volume":"53","author":"Selkoe","year":"1994","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2004.10.001_bib31","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/(SICI)1097-0169(1999)43:4<322::AID-CM5>3.0.CO;2-B","article-title":"Neuronal intermediate filament protein alpha-internexin facilitates axonal neurite elongation in neuroblastoma cells","volume":"43","author":"Shea","year":"1999","journal-title":"Cell Motil. Cytoskeleton"},{"key":"10.1016\/j.nbd.2004.10.001_bib32","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1097\/00001756-199601310-00015","article-title":"Up-regulation of Bcl-2 is associated with neuronal DNA damage in Alzheimer's disease","volume":"7","author":"Su","year":"1996","journal-title":"NeuroReport"},{"key":"10.1016\/j.nbd.2004.10.001_bib33","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s004010050920","article-title":"Plaque biogenesis in brain aging and Alzheimer's disease: II. Progressive transformation and developmental sequence of dystrophic neurites","volume":"96","author":"Su","year":"1998","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.nbd.2004.10.001_bib34","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/cne.1416","article-title":"Neurofilament protein: a selective marker for the architectonic parcellation of the visual cortex in adult cat brain","volume":"441","author":"van der Gucht","year":"2001","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.nbd.2004.10.001_bib35","first-page":"273","article-title":"Progressive transformation of the cytoskeleton associated with normal aging and Alzheimer's disease","volume":"594","author":"Vickers","year":"1992","journal-title":"BRES"},{"key":"10.1016\/j.nbd.2004.10.001_bib36","doi-asserted-by":"crossref","first-page":"5603","DOI":"10.1523\/JNEUROSCI.14-09-05603.1994","article-title":"Age-associated and cell-type-specific neurofibrillary pathology in transgenic mice expressing the human midsized neurofilament subunit","volume":"14","author":"Vickers","year":"1994","journal-title":"J. Neurosci."},{"key":"10.1016\/j.nbd.2004.10.001_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/exnr.1996.0133","article-title":"Dystrophic neurite formation associated with age-related \u03b2 amyloid deposition in the neocortex: clues to the genesis of neurofibrillary pathology","volume":"141","author":"Vickers","year":"1996","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.nbd.2004.10.001_bib38","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0301-0082(99)00023-4","article-title":"The cause of neuronal degeneration in Alzheimer's disease","volume":"60","author":"Vickers","year":"2000","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.nbd.2004.10.001_bib39","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/00005072-199507000-00009","article-title":"Qualitative and quantitative differences in senile plaque dystrophic neurites of Alzheimer's disease and normal aged brain [see comments]","volume":"54","author":"Wang","year":"1995","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.nbd.2004.10.001_bib40","doi-asserted-by":"crossref","first-page":"4506","DOI":"10.1073\/pnas.85.12.4506","article-title":"Isolation of a fragment of tau derived from the core of the paired helical filament of Alzheimer disease","volume":"85","author":"Wischik","year":"1988","journal-title":"Proc. Natl. Acad. Sci. U. S. A."}],"container-title":["Neurobiology of Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996104002347?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0969996104002347?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T00:51:54Z","timestamp":1548895914000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0969996104002347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0969996104002347"],"URL":"https:\/\/doi.org\/10.1016\/j.nbd.2004.10.001","relation":{},"ISSN":["0969-9961"],"issn-type":[{"value":"0969-9961","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}